检索结果-南通市图书馆

Longitudinal vibration of pile in layered soil based on Rayleigh-Love rod theory and fictitious soil-pile model

在线全文

学校读者我要写书评

暂无评论

journal of central South University 2015年第5期22卷 1909-1918页

作者：吕述晖王奎华吴文兵 c.j.leo Key Laboratory of Soft Soils and Geoenvironmental Engineering of Ministry of Education(Zhejiang University) Engineering Faculty China University of Geosciences School of computing Engineering and Mathematics University of Western SydneyLocked Bag 1797 Penrith Sydney NSW 2751 Australia

The dynamic response of pile in layered soil is theoretically investigated when considering the transverse inertia ***, the fictitious soil-pile model is employed to simulate the dynamic interaction between the pile and the soil layers beneath pile toe. The dynamic interactions of adjacent soil layers along the vertical direction are simplified as distributed Voigt ***, the pile and fictitious soil-pile are assumed to be viscoelastic Rayleigh-Love rods, and both the radial and vertical displacement continuity conditions at the soil-pile interface are taken into consideration. On this basis, the analytical solution for dynamic response at the pile head is derived in the frequency domain and the corresponding quasi-analytical solution in the time domain is then obtained by means of the convolution theorem. Following this, the accuracy and parameter value of the hypothetical boundaries for soil-layer interfaces are discussed. comparisons with published solution and measured data are carried out to verify the rationality of the present solution. Parametric analyses are further conducted by using the present solution to investigate the relationships between the transverse inertia effects and soil-pile parameters.

关键词： viscoelastic pile layered soil longitudinal vibration fictitious soil-pile transverse inertia effect

在线全文

学校读者我要写书评

暂无评论

变荷载下饱和软黏土一维大应变固结解析理论

水利学报 2003年第10期34卷 6-13页

作者：谢康和郑辉 c j leo 浙江大学岩土工程研究所浙江杭州310027 School of civic Engineering and Environment Univ.of Western Sydney

基于软黏土一维非线性大应变固结基本理论,建立了能考虑荷载变化、土层自重等因素影响的拉格朗日坐标下以超静孔压u为变量的一维大应变固结控制方程,并通过对土体压缩性和渗透性的假定获得了方程的解析解。基于此解,分析了单级等速加荷... 详细信息

基于软黏土一维非线性大应变固结基本理论,建立了能考虑荷载变化、土层自重等因素影响的拉格朗日坐标下以超静孔压u为变量的一维大应变固结控制方程,并通过对土体压缩性和渗透性的假定获得了方程的解析解。基于此解,分析了单级等速加荷条件下软黏土一维大应变固结性状。从中可见,大应变固结过程中土体变形的发展要快于超静孔压的消散;荷载增大,超静孔压消散趋慢;加荷速率越大,土体固结越快;考虑土层自重影响时孔隙比的分布更为合理。此外,本文的解析解也可用于验证各种大应变固结数值解法的正确性。

关键词：饱和软黏土变荷载非线性大应变一维固结解析理论

在线全文

学校读者我要写书评

暂无评论

软黏土一维非线性大应变固结解析理论

岩土工程学报 2002年第6期24卷 680-684页

作者：谢康和郑辉 c.j.leo 浙江大学岩土工程研究所浙江杭州310027 School of civic Engineering and Environment

给出了软黏土一维大应变固结中土体总应力、有效应力、孔隙水压力、孔隙比和沉降等一般相互关系,通过对土体压缩性和渗透性的假定得到了拉格朗日坐标下以超静孔压为变量的一维非线性大应变固结方程及其解析解。利用此解分析了土体一维... 详细信息

给出了软黏土一维大应变固结中土体总应力、有效应力、孔隙水压力、孔隙比和沉降等一般相互关系,通过对土体压缩性和渗透性的假定得到了拉格朗日坐标下以超静孔压为变量的一维非线性大应变固结方程及其解析解。利用此解分析了土体一维非线性大应变固结性状,并与传统的小应变固结理论作了比较。此解也可用于对大应变固结问题的各种数值解法的验证。

关键词：软黏土非线性大应变一维固结解析理论

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Status and prospects for symmetric organic redox flow batteries

在线全文

学校读者我要写书评

暂无评论

journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer c.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang j.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Oncogenic Signaling Adaptor Proteins

在线全文

学校读者我要写书评

暂无评论

journal of Genetics and Genomics 2015年第10期42卷 521-529页

作者： leo Y.Luo William c.Hahn Health Sciences and Technology Program Harvard Medical School Department of Medical Oncology Dana-Farber Cancer Institute Broad Institute of Harvard and Massachusetts Institute of Technology center for cancer Genome Discovery Dana-Farber Cancer Institute Department of Medicine Brigham and Women's Hospital

Signal transduction pathways activated by receptor tyrosine kinases （RTK） play a critical role in many aspects of cell function. Adaptor proteins serve an important scaffolding function that facilitates key signaling transduction events downstream of RTKs. Recent work integrating both structural and functional genomic approaches has identified several adaptor proteins as new oncogenes. In this review, we locus on the discovery, structure and function, and therapeutic implication of three of these adaptor oncogenes. cRKL. GAB2, and FRS2. Each of the three genes is recurrently amplified in lung adenocarcinoma or ovarian cancer, and is essential to cancer cell lines that harbor such amplification. Overexpression of each gene is able to transform immortalized human cell lines in in vitro or in vivo models. These observations identify adaptor protein as a distinct class of oncogenes and potential therapeutic targets.

关键词： Adaptor protein cancer: Oncogene

Superhydrophobic PVDF/TiO_2-SiO_2 Membrane with Hierarchical Roughness in Membrane Distillation for Water Recovery from Phenolic Rich Solution containing Surfactant

在线全文

学校读者我要写书评

暂无评论

chinese journal of Polymer Science 2019年第6期37卷 609-616页

作者： N.Hamzah c.P.leo B.S.Ooi School of chemical Engineering Engineering Campus Universiti Sains Malaysia

Superhydrophobic poly(vinylidene fluoride)(PVDF) membrane incorporated with nanoparticles was applied in membrane distillation to recover water from phenolic rich solution containing surfactant. The membranes coated on woven support were fabricated using phase inversion with dual bath coagulation and post-modified using silane. The membranes incorporated with TiO_2, SiO_2, or a mixture of TiO_2-SiO_2 nanoparticles achieved the water contact angle higher than 160°. The addition of TiO_2-SiO_2 mixture into PVDF matrix further enhanced the hierarchical roughness of membrane. Hence, PVDF/TiO_2-SiO_2 membrane achieved the highest permeation flux and rejected 99.9% of gallic acid in the feed(100 g/L). PVDF/TiO_2-SiO_2 membrane also maintained a relative flux(j/j0) higher than0.9 after 8 h of operation. Even with the presence of surfactant in phenolic rich solution, PVDF/TiO_2-SiO_2 membrane was able to exhibit relative flux above 0.8. The significant changes on the hydrophobicity and chemical properties of PVDF/TiO_2-SiO_2 membrane due to fouling were not observed after 50 h of static adsorption test.

关键词： Superhydrophobic PVDF Nano particles Roughness Membrane distillation

Visual ＂playback＂ of colorful signals in the field supports sensory drive for signal detectability

在线全文

学校读者我要写书评

暂无评论

current Zoology 2018年第4期64卷 493-498页

作者： Alex R. GUNDERSON leo j. FLEISHMAN Manuel LEAL Department of Integrative Biology University of California Berkeley CA 94720 USA Department of Biology Union College Schenectady NY 12308 USA Division of Biological Sciences University of Missouri 105 Tucker Hall Columbia MO 65211 USA

colorful visual signals are important systems for investigating the effects of signaling environ ments and receiver physiology on signal evolution as predicted by the sensory drive hypothesis. Support for the sensory drive hypothesis on color signal evolution is mostly based on document ing correlations between the properties of signals and habitat conditions under which the signals are given （i.e., a correlational approach） and less commonly on the use of mathematical models that integrate representations of visual environments, signal properties, and sensory systems （i.e., a functional approach）. Here, we used an experimental approach in the field to evaluate signal efficacy of colorful lizard throat fans called dewlaps that show geographic variation in the lizard Anolis cristatellus. We used a remote controlled apparatus to display ＂fake dewlaps＂ to wild lizards to test for adaptive divergence in dewlap brightness （i.e., perceived intensity） among populations in situ. We found evidence of local adaptation in dewlap brightness consistent with the sensory drive hypothesis. Specifically, dewlaps that had the brightness characteristics of local lizards were more likely to be detected than those with the brightness characteristics of nonlocal lizards. Our findings indicate that simplified mathematical representations of visual environments may allow robust estimates of relative detectability or conspicuousness in natural habitats. We have shown the feasibility of evaluating color signal efficacy experimentally under natural conditions and dem onstrate the potential advantages of presenting isolated components of signals to an intended re ceiver to measure their contribution to signal function.

关键词： Anolis color signal sensory drive signal evolution