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A case Study of heat Transfer from hot Runner Mould to the Fix Platen of the Injection-moulding Machine

厦门大学学报（自然科学版） 2002年第S1期41卷 97-98页

作者： c h tan K S Lee School of Mechanical & Manufacturing Engineering Department of Mechanical Engineering National University of Singapore Singapore Polytec hnic SingaporeSingapore

In an injection moulding process, the parallelism b et ween the tie bars of the injection moulding machine is very important as it will affect the mould closing and clamping system. In recent years, more and more ho t runner systems are being applied in the moulding industry to save material and decrease the losses of injection pressure. heat transfer from hot runner system from the fixed half which is secured in the fix machine platen could transmit s o much heat that it may cause high temperature differential between the machine fix platen and moving platen. This will cause the tie bar to become unparallel. Part quality will be compromised and the wear of the tie bar will be excessive. Overhaul of the tie bar may be necessary after a short period of time which is c ostly. This raises the need to analyze the heat transfer from the hot runner sys tem to the machine fix platen and the methods of isolating or minimizing the hea t transfer. In this case study, a photo lens article mould was used. The mould w as built with a direct hot runner nozzle system. heat conduction from hot runner and machine screw to machine fix platen were studied based on either using high temperature heat insulating plate put in placed between the mould and the mould ing machine fix platen or drill cooling channels in the front mould clamping pla te. The high temperature insulator is very costly as it is made out of glass re inforced polymer composite material. Experimental results were obtained and anal yzed to find the best method to minimize the unwanted heat transfer using the ch eapest and most effective method.

关键词： injection moulding cooling hot runner system i njection moulding machine platen tie bar

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The comparison Between Finite Element Analysis and Experimental Results of the cooling of Injection Moulds with hot Runner System

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厦门大学学报（自然科学版） 2002年第S1期41卷 110-111页

作者： Y F Sun K S Lee c h tan A Y c Nee Department of Mechanical Engineering National University of Singap oreDepartment of Mechanical Engineering National University of Singap oreSchool of Mechanical & Manufacturing EngineeringDepartment of Mechanical Engineering National University of Singapore SingaporeSingaporeSingapore Polytechnic Singapore Singapore

In an injection moulding process, the mould cooling s ystem is very important as an efficient and uniform cooling effect can improve b oth the productivity and part quality. Due to the complexity of the process, muc h research on the mould cooling analysis and cooling design optimization has bee n focused on the core and the cavity, excluding other systems of injection mould s. however, the runner system introduces a considerable amount of heat into the mould. In recent years, more and more hot runner systems are being applied in th e moulding industry to save material and decrease losses of injection pressure. This raises the need to include the hot runner system in the cooling analysis. I n this paper, a photo frame part was studied. The mould was built with a hot run ner system. Two thermal sensors were installed: one measures the temperature of lateral surface of hot runner nozzle; the other measures the plastic temperature from the core side. A pressure sensor was also installed to measure the pressur e of the core impression. cooling analysis was performed using ABAQUS, ananalysi s software based on the Finite Element Method (FEM). The assembly including core , cavity and plastic part was modeled. heat conduction from hot runner to cavity and from polymer melt to the mould and force convection on the cooling channel surfaces were studied. The natural convection between the ambient air and the ex terior mould surface was ignored. The simulations were adjusted with the experim ental results to find out the heat input from hot runner and its influence on mo uld cooling. Finally, the optimal cooling design and optimal injection condition were obtained.

关键词： injection moulding cooling injection mould cool ing finite element method hot runner

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copper-catalyzed c–h bond functionalization enabled by programmed alternating current

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Science china chemistry 2025年第1期 10-11页

作者： Zhoumei tan Kun Xu chengchu Zeng Beijing Key Laboratory of Environmental and Viral Oncology College of Chemistry and Life Science Beijing University of Technology

Synthetic electrochemistry has been selected as one of the Top Ten Emerging Technologies in chemistry in 2023 by International Union of Pure and Applied chemistry (IUPAc)[1]. It has emerged as a sustainable platform for organic synthesis and has exhibited a wide range of applications from academia to industry [2]. however, electrosynthesis has been predominantly performed by using direct current (Dc).

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Interactions of complement proteins c1q and factor h with lipid A and Escherichia coli:further evidence that factor h regulates the classical complement pathway

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Protein & cell 2011年第4期2卷 320-332页

作者： Lee Aun tan Andrew c.Yang Uday Kishore Robert B.Sim Medical Research council Immunochemistry Unit Department of BiochemistryUniversity of OxfordSouth Parks RoadOxford OX13QUUK Present address:Department of Immunology Faculty of MedicineImperial College LondonHammersmith HospitalDu Cane RoadLondon W120NNUK St Peter’s college New Inn Hall St.Oxford OX12DLUK Present address:SUNY Downstate college of Medicine 450 Clarkson Avenue BrooklynNY 11203USA Weatherall Institute of Molecular Medicine John Radcliffe HospitalUniversity of OxfordHeadingtonOxford OX39DSUK Present address:center for Infection Immunity and Disease MechanismsBiosciencesSchool of Health Sciences and Social CareBrunel UniversityUxbridge UB83PH West LondonUK Present address:Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK

Proteins of the complement system are known to interact with many charged *** recently characterized binding of c1q and factor h to immobilized and liposomal anionic *** h inhibited c1q binding to anionic phospholipids,suggesting a role for factor h in regulating activation of the complement classical pathway by anionic *** extend this finding,we examined interactions of c1q and factor h with lipid A,a well-characterized activator of the classical *** report that c1q and factor h both bind to immobilized lipid A,lipid A liposomes and intact Escherichia coli *** h competes with c1q for binding to these ***,increasing the factor h:c1q molar ratio in serum diminished c4b fixation,indicating that factor h diminishes classical pathway *** recombinant forms of the cterminal,globular heads of c1q A,B and c chains bound to lipid A and *** in a manner qualitatively similar to native c1q,confirming that c1q interacts with these targets via its globular head *** observations reinforce our proposal that factor h has an additional complement regulatory role of down-regulating classical pathway activation in response to certain *** is distinct from its role as an alternative pathway *** suggest that under physiological conditions,factor h may serve as a downregulator of bacterially-driven inflammatory responses,thereby finetuning and balancing the inflammatory response in infections with Gram-negative bacteria.

关键词： complement lipid A bacteria factor h c1q

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The application of c–h bond functionalization in the total syntheses of indole natural products

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Organic chemistry Frontiers 2022年第4期9卷 1195-1210页

作者： Dong-Xing tan Fu-She han cAS Key Lab of high-Performance Synthetic Rubber and its composite Materials Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchunJilin 130022China

The direct functionalization of unactivated c–h bonds has been a rapidly growing field in organic chem-istry in recent years because of its indisputable advantages in bond forming reactions in terms of step and atom-... 详细信息

关键词： functionalization bonds bond

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4 面神经功能对腮腺癌患者预后的影响

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中国口腔颌面外科杂志 2007年第2期5卷 103-103页

作者： Terhaard c Lubsen h tan B

该文旨在探讨面神经功能状况对腮腺癌患者预后的影响。方法：对荷兰头颈协作组324例腮腺癌患者进行回顾性研究，77％的患者术前不存在面神经受侵犯症状．部分和全部受侵的比例分别为14％、7％。88％的患者采用手术治疗，77％术后行辅助... 详细信息

该文旨在探讨面神经功能状况对腮腺癌患者预后的影响。方法：对荷兰头颈协作组324例腮腺癌患者进行回顾性研究，77％的患者术前不存在面神经受侵犯症状．部分和全部受侵的比例分别为14％、7％。88％的患者采用手术治疗，77％术后行辅助放疗，21％牺牲面神经，其中1/3的患者行面神经重建。结果：判断治疗前面神经功能障碍的独立危险因素为肿瘤所在部位、颈淋巴结、疼痛、年龄及神经束膜受侵情况；神经完全麻痹影响肿瘤的区域性控制率；面神经功能状态影响患者的无瘤生存率．面神经功能正常、部分功能障碍、完全麻痹者的生存率分别为69％、37％和13％，治疗后22％的患者存在面神经部分麻痹，13％的患者面神经功能完全丧失。结论：治疗前面神经功能状况是腮腺癌患者生存率的预后因素。

关键词：面神经功能障碍预后因素癌患者腮腺神经功能状况无瘤生存率独立危险因素神经功能状态

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Visible-Light-Mediated c(sp^3)-h Thiocarbonylation for Thiolactam Preparation with Potassium Sulfide

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chinese Journal of chemistry 2019年第12期37卷 1234-1238页

作者： Wei tan cuihong Wang Xuefeng Jianga Shanghai Key Laboratory of Green chemistry and chemical Process School of Chemistry and Molecular EngineeringEast China Normal University3663 North Zhongshan RoadShanghai 200062China State Key Laboratory of Organometallic chemistry Shanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling RoadShanghai 200032China

Summary of main observation and conclusion We report herein a protocol for thiolactam preparation with potassium sulfide via visible-light-mediated c(sp3)-h thiocarbonylation,in which polysulfide dianions and radical anions generated from potassium sulfide were the key active species.A variety of thiolactams were straightforward established under mild ***,it was successfully applied to structural modification of tetrahydroberberine.

关键词： conditions. sulfide potassium

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1型神经纤维瘤病的皮质和皮质下区域的异常形态选择

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国际医学放射学杂志 2019年第1期 108-108页

作者： M.J.Barkovich c.h.tan R.M.Nillo Y.Li D.Xu c.M.Glastonbury 武肖玲 Departments of Radiology and Biomedical Imaging University of CaliforniaSan Francisco

摘要目的1型神经纤维瘤病(NF1)是多系统神经发育障碍性疾病,有多种影像表现,包括深部灰质核团、脑干和小脑的局部一过性的髓空泡形成。本文旨在评估NF1病人的皮

关键词：皮质下 NF ROI 神经纤维瘤病

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Low-temperature heat capacities and standard molar enthalpy of formation of N-methylnorephedrine c11h17NO（s）

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chinese Physics B 2008年第9期17卷 2859-2866页

作者： Di You-Ying Wang Da-Qi Shi Quan tan Zhi-cheng college of chemistry and chemical Engineering Liaocheng University Liaocheng 252059 China Thermochemistry Laboratory Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China

This paper reports that low-temperature heat capacities of N-methylnorephedrine c11h17NO（s） have been measured by a precision automated adiabatic calorimeter over the temperature range from T=78K to T=400K. A solid to liquid phase transition of the compound was found in the heat capacity curve in the temperature range of T=342-364 K. The peak temperature, molar enthalpy and entropy of fusion of the substance were determined. The experimental values of the molar heat capacities in the temperature regions of T=78-342 K and T=364-400 K were fitted to two poly- nomial equations of heat capacities with the reduced temperatures by least squares method. The smoothed molar heat capacities and thermodynamic functions of N-methylnorephedrine c11h17NO（s） relative to the standard refer- ence temperature 298.15 K were calculated based on the fitted polynomials and tabulated with an interval of 5 K. The constant-volume energy of combustion of the compound at T=298.15 K was measured by means of an isoperibol precision oxygen-bomb combustion calorimeter. The standard molar enthalpy of combustion of the sample was calculated. The standard molar enthalpy of formation of the compound was determined from the combustion enthalpy and other auxiliary thermodynamic data through a hess thermochemical cycle.

关键词： N-methylnorephedrine c11h17NO(s) heat capacity constant-volume energy of combus-tion standard molar enthalpy of formation

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PREPARATION AND chARAcTERIZATION OF hEAVILY DOPED μc-Si:F:h FILMS BY WINDOWLESS PhOTO-cVD

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chinese Physics Letters 1989年第12期6卷 563-565页

作者： GUO shuwen tan shongsheng WANG Weiyuan Laboratories of Transducer Technology Academia SinicaShanghai Shanghai Institute of Metallurgy Academia SinicaShanghai 200050 Department of Physics Jiangxi UniversityNanchang 320029

A novelμc-Si:F:h film growth technique has been developed using a windowless photo-enhanced chemical vapor deposition(photo-cVD)*** films contain of two phases with the microcrystallites embedded in amorphous *** films contain the crystallites with volume of fraction of 0.17-0.23 and average grain size of *** conductivity up to 16(Ω.cm)^(-1) and gauge factor(GF)of about 12 are obtained.

关键词： materials. gauge conductivity

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