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Is chronic hepatitis c virus infection a risk factor for breast cancer?

World Journal of Gastroenterology 2010年第29期16卷 3687-3691页

作者： Dominique Larrey Marie-cécile Bozonnat Ihab Kain Georges-philippe Pageaux Eric Assenat Liver Unit and INSERM Unit 632 Saint-Eloi HospitalMontpellier University Department of Biostatistics Intitut Universitaire de Recherche CliniqueMontpellier University Liver Unit Saint-Eloi HospitalMontpellier University Medical Oncology Unit Saint-Eloi HospitalMontpellier University

AIM:To evaluate the prevalence of breast tumors in adult females with chronic hepatitis c virus(HcV) ***:Prospective,single-center study,based on female outpatients consulting in a liver unit,for 1 *** study group included females with present and/or past history of chronic infection by *** with spontaneous recovery were *** hepatitis had been proved by liver biopsy in the majority of cases and/or biological markers of inflammation and *** control group included female patients with other well documented chronic liver diseases:chronic hepatitis B,alcoholic liver disease,autoimmune hepatitis,hemochromatosis,non alcoholic liver disease,chronic *** patients were prospectively questioned during consultation about past breast history and follow-up by ***:Breast carcinoma was recorded in 17/294 patients with HcV infection(5.8%,95% cI:3.1-8.4) vs 5/107 control patients(4.7%,95% cI:0.67-8.67).Benign tumors of the breast(mastosis,nodules,cysts) were recorded in 75/294 patients with HcV infection(25.5%,95% cI:20.5-30.5) vs 21/107(19.6%,95% cI:12.1-27.1) in the control *** lesion was noted in 202 patients with HcV(68.7%,95% cI:63.4-74) vs 81 control patients(75.7%,95% cI:67.6-83.8).Despite a trend to an increased prevalence in the group with HcV infection,the difference was not significant compared to the control group(P=NS).In patients over 40 years,the results were,respectively,as follows:breast cancer associated with HcV:17/266 patients(6.3%,95% cI:3.4-9.3) vs 5/95 patients(5.2%,95% cI:0.7-9.7) in the control group;benign breast tumors:72/266 patients with HcV infection(27%,95% cI:21.7-32.4) vs 18/95 patients(18.9%,95% cI:11-26.8) in the control group;no breast lesion 177/266(66.5%,95% cI:60.9-72.2) in patients with HcV infection vs 72/95(75.7%,95% cI:67.1-84.4) in the control *** differences were not significant(P=NS).cONcLUSION:These results suggest that chronic HcV infectio

关键词： Breast tumors Breast cancer Hepatitis c virus infection Risk factor

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On Korn's Inequality

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chinese Annals of Mathematics,Series B 2010年第5期31卷 607-618页

作者： philippe G.cIARLET Department of Mathematics City University of Hong Kong

The author first reviews the classical Korn inequality and its *** recent works of ***,***,Jr.,and the author,it is shown how the Korn inequality can be recovered by an entirely different *** new proof hinges on appropriate weak versions of the classical Poincar'e and Saint-Venant *** fine,both proofs essentially depend on a crucial lemma of ***,recalled at the beginning of this paper.

关键词： Korn inequality J. L. Lions lemma

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Ground support design for dynamic loading conditions:A quantitative data-driven approach based on rockburst case studies

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第5期11卷 909-919页

作者： philippe Morissette John Hadjigeorgiou Agnico Eagle Mines Limited 10 200route de PreissacRouyn-NorandaJ0Y 1C0Canada University of Toronto TorontoM5S 3E3Canada

There are considerable challenges associated with the design of ground support for seismically-active underground *** is extremely difficult to establish the demand on ground support as well as the capacity of a ground support *** resulting dynamic or impact loads caused by mining-induced seismicity are difficult to anticipate and *** performance of a ground support system is defined by the load distribution and interaction between several reinforcement and surface support ***,the design of ground support in seismically-active mines tends to evolve,or be modified based on qualitative assessments of perceived performance or response to significant seismic events or *** research is motivated by a need to provide quantitative and data-driven design guidelines for ground support systems subjected to dynamic-loading *** data were collected from three deep and seismically-active underground mines in the Sudbury basin in *** constructed database comprises 209 seismic events that resulted in damage to mine excavations and ground *** events were associated with damage at 324 locations within the three *** developed ground support design strategy,based on these documented case studies,identifies areas where the use of dynamic or enhanced support should be *** developed design methodology provides guidelines for the zoning of mine locations in which installation of enhanced support is recommended,the specifications for an optimal ground support system,and the timing or sequence of installation.

关键词： Ground support design Mining-induced seismicity Rockburst

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3-D NUMERIcAL SIMULATION OF cONVOY-GENERATED WAVES IN A RESTRIcTED WATERWAY

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Journal of Hydrodynamics 2012年第3期24卷 420-429页

作者： OUAHSINE Abdellatif SMAOUI Hassan SERGENT philippe Université de Technologie de compiègne Laboratoire Roberval UMR CNRS/UTC 7337 Centre de Recherches Royallieu BP 20529 60206 Compiègne cedex France cETMEF 2boulevard Gambetta BP 60039 60321 Compiègne Cedex France cETMEF 2 boulevard Gambetta BP 60039 60321 Compiègne Cedex France

We consider waves generated by the passing of convoys in a restricted waterway. The magnitude of these waves depends mainly on the geometrical and kinematical parameters of the convoy, such as the speed and the hull geometry. The objective of this study is to predict the relationship between these geometrical and kinematical parameters and the amplitude of ship-generated waves as well as the water plane drawdown. Numerical simulations are conducted by solving the 3-D Navier-Stokes equations along with the standard k-c model for turbulent processes. The results are compared first with the empirical model and second with experimental measurements performed by the French company compagnie National du Rhone （cNR）.

关键词： ship-generated waves waterway cFD free surface gravity waves

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Preparation and Structural chemistry of a Series of Rare Earth compounds REPS_4

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Journal of Rare Earths 1999年第1期17卷 7-12页

作者： Huang, Zhongle cajipe, Victoria Molinic, philippe Xiamen Univ Xiamen China

The thiophosphates of the rare earths REPS 4(RE=Y, La～Lu) were prepared by solid state reaction. Their unit cell parameters and the structures of HoPS 4, ErPS 4 and TmPS 4 were determined by X ray powder diffraction. All REPS 4(RE=Y, La～Yb) crystallize in the tetragonal space group I4 1/acd , a ≈1 1 nm, c ≈1 9 nm, Z =16 . Each RE 3+ is surrounded by eight sulfurs and thus forms a distorted tetragonal antiprism. This kind of structures has significant Van Der Waals′ vacant space with a diameter of about 0 625 nm along c axis and of 0 35 nm along a and b axis. But LuPS 4 crystallizes in a monoclinic structure which is most probably layered. The influence of lanthanide contraction on the stability of the tetragonal REAX 4 structure was studied and a criterion for the existence of the tetragonal structure in the REAX 4 series compounds is proposed. There is 2 4 d A X / r 1 9.

关键词： Rare earths Thiophosphate crystal structure

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针对大规模动态图流三角形计数的边哈希分布式抽样算法

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计算机研究与发展 2024年第8期61卷 1882-1903页

作者：何玉林吴波吴定明黄哲学菲律普弗尼尔-维格人工智能与数字经济广东省实验室(深圳) 广东深圳518107 深圳大学计算机与软件学院广东深圳518060

三角形计数是大图分析的一个经典问题,近年的研究工作主要集中在针对静态流式图的三角形数量估计上,相关流式图抽样算法只能处理边的插入操作,无法处理边的删除操作;而现有的动态流式图抽样算法估计准确性又偏低.针对上述问题,提出了基... 详细信息

三角形计数是大图分析的一个经典问题,近年的研究工作主要集中在针对静态流式图的三角形数量估计上,相关流式图抽样算法只能处理边的插入操作,无法处理边的删除操作;而现有的动态流式图抽样算法估计准确性又偏低.针对上述问题,提出了基于边哈希分配的分布式抽样(edge hashing assignmentbased distributed sampling,EHADS)算法,它是一个用于估计动态流式图中三角形数量的分布式流算法,可以快速准确地估计动态流式图中的全局三角形数量以及每个顶点的局部三角形数量.EHADS算法只对输入的图流进行1次处理,并在多台机器上对边进行抽样.与先进的单机流算法相比,EHADS算法具有2点优势:1)在相同样本容量的情况下,EHADS算法以更短的运行时间获得了更小的估计误差,估计全局三角形数量的误差平均降低了31.79%,估计局部三角形数量的误差平均降低了23.35%;2)EHADS算法能够提供流式图中三角形数量的无偏估计,并且严格的数学证明显示该无偏估计具有更小的方差.

关键词：三角形计数动态图流边抽样分布式流算法边哈希分配

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Endogenous retinal neural stem cell reprogramming for neuronal regeneration

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Neural Regeneration Research 2017年第11期12卷 1765-1767页

作者： Romain Madelaine philippe Mourrain Stanford center for Sleep Sciences and Medicine Department of Psychiatry and Behavioral SciencesStanford University INSERM 1024 Ecole Normale SupérieureParisFrance

In humans, optic nerve injuries and associated neurodegenerative diseases are often followed by perma- nent vision loss. consequently, an important challenge is to develop safe and effective methods to replace retinal neurons and thereby restore neuronal functions and vision. Identifying cellular and molecular mechanisms allowing to replace damaged neurons is a major goal for basic and translational research in regenerative medicine. contrary to mammals, the zebrafish has the capacity to fully regenerate entire parts of the nervous system, including retina. This regenerative process depends on endogenous retinal neural stem cells, the Miiller glial cells. Following injury, zebrafish Miiller cells go back into cell cycle to proliferate and generate new neurons, while mammalian Mtiller cells undergo reactive gliosis. Recently, transcription factors and microRNAs have been identified to control the formation of new neurons derived from ze- brafish and mammalian Mtiller cells, indicating that cellular reprogramming can be an efficient strategy to regenerate human retinal neurons. Here we discuss recent insights into the use of endogenous neural stem cell reprogramming for neuronal regeneration, differences between zebrafish and mammalian Mtiller cells, and the need to pursue the identification and characterization of new molecular factors with an instructive and potent function in order to develop theurapeutic strategies for eye diseases.

关键词： neuronal regeneration retina Muller glial cells neural stem cell reprogramming achaete-scute homolog 1 microRNA-9 Tlx Onecut

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Magnetic Properties of Rare Earth Thiophosphates REPS_4

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Journal of Rare Earths 1999年第2期17卷 32-35页

作者： Huang, Zhongle cajipe, Victoria Molinie, philippe Xiamen Univ Xiamen China

The magnetic susceptibilities of REPS4(RE=LaYb) compounds series were measured in the temperature range of 2300 K. The variations of the susceptibility and the inverse susceptibility along with the temperature were studied for each case. The curieWeiss constants(c and and the effect moment eff for each paramagnetic RE3+ were obtained by simulating the susceptibility data measured in the temperature range of 50300 K.

关键词： Rare earths REPS4 Magnetic susceptibility curieWeiss law Magnetic moment

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crypt abscess-associated microbiota in inflammatory bowel disease and acute self-limited colitis

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World Journal of Gastroenterology 2010年第5期16卷 583-587页

作者： Harry Sokol Nadia Vasquez Nadia Hoyeau-Idrissi philippe Seksik Laurent Beaugerie Anne Lavergne-Slove philippe Pochart philippe Marteau Gastro-enterology and Nutrition Department Saint Antoine HospitalPierre et Marie Curie-Paris6 UniversityAP-HP184 rue du Faubourg Saint-Antoine75571ParisFrance Laboratoire de Biologie EA 3199 CNAM2 rue Conte75003ParisFrance Pathology Department Saint Antoine HospitalPierre et Marie Curie-Paris6 UniversityAP-HP184 rue du Faubourg Saint-Antoine75571ParisFrance Gastro-enterology and Nutrition Department Saint Antoine HospitalPierre et Marie Curie-Paris6 UniversityAP-HP184 rue duFaubourg Saint-Antoine75571ParisFrance Pathology Department Lariboisière Hospital&Paris 7 University2 rue Ambroise-Paré75475ParisFrance Medicosurgical Department of Digestive Diseases Lariboisière HospitalAP-HP&Paris 7 University2rue Ambroise-Paré75475ParisFrance

AIM:To evaluate whether crypt abscesses frominflammatory bowel disease(IBD)patients containbacteria and to establish their ***:We studied 17 ulcerative colitis patients,11 crohn's disease patients,7 patients with acute selflimited colitis(ASLc)and normal colonic biopsies from5 subjects who underwent colonoscopy for colon cancer screening.A fluorescent in situ hybridization techniquewas applied to colonic biopsies to assess the microbiotacomposition of the crypts and crypt ***:crypts colonized by bacteria were observedin 42.9%and 3.6%of ASLc and IBD patients,respectively(P=0.019).crypt abscesses colonized bybacteria were observed in 28.6%and 0.0%of ASLcand IBD patients,respectively(P=0.035).cONcLUSION:These results do not support thehypothesis that crypt abscesses in IBD are the resultof localized dysbiosis arising from persistence of livingbacteria colonizing the crypts.

关键词： Inflammatory bowel diseases crohn’sdisease Ulcerative colitis crypt abscess Microbiota

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Rankin-Selberg coefficients in large arithmetic progressions

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Science china Mathematics 2023年第12期66卷 2767-2778页

作者： Emmanuel Kowalski Yongxiao Lin philippe Michel Department of Mathematics ETH ZurichZurich CH-8092Switzerland Data Science Institute Shandong UniversityJinan 250100China EPFL/MATH/TAN Lausanne CH-1015Switzerland

Let(λ_f(n))_(n≥1)be the Hecke eigenvalues of either a holomorphic Hecke eigencuspform or a Hecke-Maass cusp form *** prove that,for any fixedη>0,under the Ramanujan-Petersson conjecture for GL_(2)Maass forms,the Rankin-Selberg coefficients(λ_f(n)^(2))_(n≥1)admit a level of distributionθ=2/5+1/260-ηin arithmetic progressions.

关键词： arithmetic progressions Rankin-Selberg L-functions δ-method

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