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Biophotonic sensors with integrated Si_(3)N_(4)-organic hybrid (SiNOH) lasers for point-of-care diagnostics

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Light(Science & Applications) 2021年第4期10卷 648-659页

作者： Daria Kohler Gregor Schindler Lothar hahn Johannes Milvich Andreas Hofmann Kerstin Lange Wolfgang Freude Christian Koos Institute of Photonics and Quantum Elearo nics(IPQ) Karlsruhe Institute of Technology(KIT)Engesserstrasse 576131 KarlsruheGermany lnstitute of Microstructure Technology(IMT) Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Robert Bosch GmbH Robert-Bosch-Campus 171272 RenningenGermany lnstitute for Autom ation and Applied Informatics(IAI) Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Early and efficient disease diagnosis with low-cost point-of-care devices is gaining importance for personalized medicine and public health *** this context,waveguide-(WG)-based optical biosensors on the siliconnitride(Si_(3)N_(4))platform represent a particularly promising option,offering highly sensitive detection of indicative biomarkers in multiplexed sensor arrays operated by light in the visible-wavelength ***,while passive Si_(3)N_(4)-based photonic circuits lend themselves to highly scalable mass production,the integration of low-cost light sources remains a *** this paper,we demonstrate optical biosensors that combine Si_(3)N_(4)sensor circuits with hybrid on-chip organic *** Si_(3)N_(4)-organic hybrid(SiNOH)lasers rely on a dye-doped cladding material that are deposited on top of a passive WG and that are optically pumped by an external light *** of the devices is simple:The underlying Si_(3)N_(4)WGs are structured in a single lithography step,and the organic gain medium is subsequently applied by dispensing,spin-coating,or ink-jet printing processes.A highly parallel read-out of the optical sensor signals is accomplished with a simple *** our proof-of-concept experiment,we demonstrate the viability of the approach by detecting different concentrations of fibrinogen in phosphate-buffered saline solutions with a sensor-length(L-)-related sensitivity of S/L=0.16 rad nM^(-1)mm^(-1).To our knowledge,this is the first demonstration of an integrated optical circuit driven by a co-integrated low-cost organic light *** expect that the versatility of the device concept,the simple operation principle,and the compatibility with cost-efficient mass production will make the concept a highly attractive option for applications in biophotonics and point-of-care diagnostics.

关键词： passive waveguide pumped

A comparison of Guibourtia copallifera Benn. stands in South West Burkina Faso-community structure and regeneration

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Journal of Forestry Research 2012年第1期23卷 29-38页

作者： Assan Gnoumou Fidèle Bognounou Karen hahn Adjima Thiombiano Ougadougou University Department of plant Biology and Physiology03 PO Box 7021 Ouagadougou 03.OuagadougouBurkina Faso Institute For Ecology Evolution and DiversityJ.W.Goethe-UniversitySiesmayerstr.70.60323 Frankfurt/MAllemagne

Shifting agriculture, fire, and over exploitation of wood and copal resin are the major causes of Guibourtia copallifera Benn. vulner- ability in the south-west of Burkina Faso. Conservation of endangered species requires a thorough understanding of the dynamics of small populations. In the present study, we investigated the diversity and the dynamics of G copallifera communities in two different types of land use history, a protected area （stated forest of Como6-Leraba） and an unprotected area （the woodlands of Toumi and Timba）. A total of 17 rectangular plots （50 m × 20 m） were sampled in both protected and unprotected areas. All woody species were systematically identified, measured and classified into diameter and height classes. In the two different types of land use, the dynamics of G. copallifera＇s communities were good, and the diversities were similar and low with high β diversity.

关键词： biodiversity conservation shifting agriculture vulnerablespecies West Africa

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船舶运动模型参数辨识研究综述

交通信息与安全 2022年第5期40卷 1-11,155页

作者：朱曼文元桥孙吴强张家辉 Axel hahn 武汉理工大学智能交通系统研究中心武汉430063 武汉理工大学三亚科教创新园海南三亚572025 武汉理工大学国家水运安全工程技术研究中心武汉430063 赛为智能有限公司人工智能研究院合肥230000 武汉理工大学航运学院武汉430063 奥登堡大学计算机科学学院德国奥登堡26121

创建精确且可靠的运动模型是有效分析船舶操纵性和保障船舶智能航行的关键。相较于常用的船舶运动建模方法(包括经验法、试验法、计算流体动力学数值法),参数辨识技术是1种实用有效、迁移性强的建模手段,但因受到诸如船舶强非线性运动... 详细信息

创建精确且可靠的运动模型是有效分析船舶操纵性和保障船舶智能航行的关键。相较于常用的船舶运动建模方法(包括经验法、试验法、计算流体动力学数值法),参数辨识技术是1种实用有效、迁移性强的建模手段,但因受到诸如船舶强非线性运动特性、时变耦合的环境干扰、内外多重不确定性等众多复杂因素的影响而面临极大挑战。围绕船舶运动模型参数辨识技术的4个核心内容,即最优输入设计、船舶运动数学模型、参数估计算法、辨识模型测试验证,重点梳理了富含操控特性的激励数据获取、多型船舶运动模型、经典-智能-混合参数辨识方法、辨识模型评估方法相关的研究现状,剖析了噪声干扰、参数漂移、参数时变、评价指标选取等主要问题,发现面对操纵与航行特征复杂的船舶,获取覆盖广域运动特征的高质量数据仍无较好方法,参数漂移现象与模型复杂度紧密相关,且无法完全避免。面向数据高质量化、辨识实时性、航行场景复杂化等的发展要求,对船舶运动模型参数辨识技术在船舶操纵运动数据获取与处理,如鲁棒估计与信息融合、鲁棒在线参数辨识、多新息智能算法、复杂场景下的船舶运动辨识建模如受限条件下船舶运动辨识建模等重点方面进行了展望。

关键词：智能航运船舶智能化运动模型参数辨识方法渐进法

Smart Proactive Caching Scheme for Fast Authenticated Handoff in Wireless LAN

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Journal of Computer Science & Technology 2007年第3期22卷 476-480页

作者： Sin-Kyu Kim Jae-Woo Choi Dae-Hun Nyang Gene-Beck hahn Joo-Seok Song Electronics Telecommunications Research Institute Daejeon Korea Graduate School of Information Technology and Telecommunications Inha University IncheonKorea Mobile Communication Technology Research Lab LG Electronics AnyangKorea Department of Computer Science Yonsei University SeoulKorea

Handoff in IEEE 802.11 requires the repeated authentication and key exchange procedures, which will make the provision of seamless services in wireless LAN more difficult. To reduce the overhead, the proactive caching schemes have been proposed. However, they require too many control packets delivering the security context information to neighbor access points. Our contribution＇ is made in two-fold： one is a significant decrease in the number of control packets for proactive caching and the other is a superior cache replacement algorithm.

关键词： wireless local area network (LAN) security authentication simulation

Genetic diversity and differentiation follow secondary succession in a multi-species study on woody plants from subtropical China

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Journal of Plant Ecology 2017年第1期10卷 213-221页

作者： Christoph Z.hahn Stefan G.Michalski Markus Fischer Walter Durka Department of Community Ecology(BZF) Helmholtz Centre for Environmental Research—UFZTheodor-Lieser-Straße 4D-06120 HalleGermany Institute of Plant Sciences University of BernAltenbergrain 21CH-3013 BernSwitzerland German Centre for Integrative Biodiversity Research(iDiv)Halle-Jena-Leipzig Deutscher Pl.5E04103 LeipzigGermany

Aims Species diversity and genetic diversity may be affected in parallel by similar environmental ***,genetic diversity may also be affected independently by habitat *** aim at disentangling relationships between genetic diversity,species diversity and habitat characteristics of woody species in subtropical *** We studied 11 dominant tree and shrub species in 27 plots in Gutianshan,China,and assessed their genetic diversity(A_(r))and population differentiation(F′_(ST))with microsatellite *** tested if Ar and population specific F′_(ST) were correlated to local species diversity and plot ***-model inference and model averaging were used to determine the relative importance of each ***,we tested for isolation-by-distance(IBD)and isolation-by-elevation by regressing pairwise F′_(ST) against pairwise spatial and elevational *** Findings Genetic diversity was not related to species diversity for any of the study ***,our results do not support joint effects of habitat characteristics on these two levels of ***,genetic diversity in two understory shrubs,Rhododendron simsii and Vaccinium carlesii,was affected by plot age with decreasing genetic diversity in successionally older *** differentiation increased with plot age in *** and Lithocarpus *** shows that succession can reduce genetic diversity within,and increase genetic diversity between ***,we found four cases of IBD and two cases of *** former indicates inefficient pollen and seed dispersal by animals whereas the latter might be due to phenological *** patterns indicate that succession can affect genetic diversity without parallel effects on species diversity and that gene flow in a continuous subtropical forest can be restricted even at a local scale.

关键词： Allelic richness population differentiation habitat characteristics gene flow species-genetic diversity correlation SGDC

Lightweight in Automotive Components by Forming Technology

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Automotive Innovation 2020年第3期3卷 195-209页

作者： Stephan Rosenthal Fabian Maaß Mike Kamaliev Marlon hahn Soeren Gies A.Erman Tekkaya Institute of Forming Technology and Lightweight Components(IUL) TU Dortmund University44227 DortmundGermany

Lightweight design is one of the current key drivers to reduce the energy consumption of *** methodologies for lightweight components,strategies utilizing materials with favorable specific properties and hybrid materials are used to increase the performance of parts for automotive *** this paper,various forming processes to produce light parts are *** lightweight design is discussed,covering the manufacturing processes to produce hybrid components like fiber-metal,polymer-metal and metal-metal composites,which can be used in subsequent deep drawing or combined forming *** to increasing the specific strength and stiffness with thermomechanical forming processes as well as the in situ control of the microstructure of such components are *** lightweight design discusses possibilities to plastically form high-strength or high-performance materials like magnesium or titanium in sheet,profile and tube forming *** join those materials and/or dissimilar materials,new joining by forming technologies are *** economically produce lightweight parts with gears or functional elements,incremental sheet-bulk metal forming is *** an important part property,the damage evolution during the forming operations will be discussed to enable even lighter parts through a more reliable *** methods for predicting and tailoring the mechanical properties like strength and residual stresses will be *** possibilities of system lightweight design with forming technologies are presented.A combination of additive manufacturing and forming to produce highly complex parts with integrated functions will be *** integration of functions by a hot extrusion process for the manufacturing of shape memory alloys is *** in-depth understanding of the newly developed processes,methodologies and effects allows for a more accurate dimen-sioning of *** facilitates a reduction in th

关键词： Forming technology Lightweight design Energy efficiency Manufacturing processes

Understanding your health / 6th ed.

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Spatial heterogeneity of flesh-cell osmotic potential in sweet cherry affects partitioning of absorbed water

2000年

作者： Wayne A. Payne Dale B. hahn.

来源：畅想之星图书光盘版（南... 评论

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Horticulture Research 2020年第1期7卷 2104-2113页

作者： Eckhard Grimm Daniel Pflugfelder Jan hahn Moritz Jonathan Schmidt Hendrik Dieckmann Moritz Knoche Institut für Gartenbauliche Produktionssysteme Leibniz Universität HannoverAbteilung ObstbauHerrenhäuser Straße 2D-30419 HannoverGermany Forschungszentrum Jülich IBG-2:PflanzenwissenschaftenWilhelm-Johnen-StraßeD-52428 JülichGermany Laser Zentrum Hannover e.V. Hollerithallee 8D-30419 HannoverGermany

A fleshy fruit is commonly assumed to resemble a thin-walled pressure vessel containing a homogenous carbohydrate *** sweet cherry(Prunus avium L.)as a model system,we investigate how local differences in cell water potential affect H2O and D2O(heavy water)*** partitioning of H2O and D2O was mapped nondestructively using magnetic resonance imaging(MRI).The change in size of mesocarp cells due to water movement was monitored by optical coherence tomography(OCT,non-destructive).Osmotic potential was mapped using microosmometry(destructive).Virtual sections through the fruit revealed that the H2O distribution followed a net pattern in the outer mesocarp and a radial pattern in the inner *** patterns align with the disposition of the vascular bundles.D2O uptake through the skin paralleled the acropetal gradient in cell osmotic potential gradient(from less negative to more negative).Cells in the vicinity of a vascular bundle were of more negative osmotic potential than cells more distant from a vascular *** revealed net H2O uptake was the result of some cells loosing volume and other cells increasing volume.H2O and D2O partitioning following uptake is non-uniform and related to the spatial heterogeneity in the osmotic potential of mesocarp cells.

关键词： potential Spatial bundle

Extraperitoneal Rectal Laceration Secondary to Blunt Trauma： Successful Transanal Endoscopic Repair with Hemoclips

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Chinese Medical Journal 2017年第19期130卷 2384-2385页

作者： Koo-Yong hahn Soon-Young Ko Woo-Surng Lee Yong-Hun Kim 'Department of Surgery School of Medicine Konkuk University Konkuk University Chungju Hospital Chungju-si Chungbuk Korea Department of Internal Medicine School of Medicine Konkuk University Konkuk University Chungju Hospital Chungju-si Chungbuk Korea Department of Thoracic and Cardiovascular Surgery School of Medicine Konkuk University Konkuk University Chungju Hospital Chungju-si Chungbuk Korea

Rectal injuries are caused by a variety of causes, such as stab wounds, gunshot injuries, blunt trauma, and foreign bodies. In particular, extraperitoneal rectal injury secondary to blunt trauma is very rare in the civilian setting and usually seen in association with comminuted fractures of the pelvis or sacrum and evidence of intraperitoneal injury.[1] The management of extraperitoneal rectal injury is treated either surgically or conservatively depending on the level and extent of the injury.[2] Currently, management of less severe extraperitoneal rectal injury is not standardized, but primary closure of the wound should be performed whenever possible. Therefore, we present a patient with a laceration of the midrectum secondary to blunt trauma who was successfully treated with endoscopic hemoclipping.

关键词： Endoscopy Nonpenetrating Rectum Wounds