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Frontiers of Structural and Civil Engineering 2022年第4期16卷 506-514页

作者： Jinyoung YOON byoung il choi Jae Hong KIM Department of Structural Engineering Research Korea Institute of Civil Engineering and Building Technology(KICT)Goyang 10223Republic of Korea System Safety Research Department Korea Shipbuilding and Offshore EngineeringSeongnam 13591Republic of Korea Department of Civil and Environmental Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea

The cement dispersion performance of a polycarboxylate(PCE)-based superplasticizer is highly related to their adsorption behaviors as a function of *** study evaluated effects of PCEs on rheological properties of cementitious ***,characteristics of PCEs were characterized via permeation chromatography(GPC)and Fourier-transform infrared spectrometry(FT-IR).The adsorption behavior of single and blended PCEs on cementitious composites was identified using total organic carbon analyzer(TOC).Based on the measurement of PCE adsorption,the changes of rheological properties of cementitious materials as well as the number of dispersed cement particles were characterized using a rheometer and laser spectroscopy,*** experimental results support the systematic mechanism of PCE adsorption,cement dispersion,and the decrease in viscosity of cementitious materials.

关键词： adsorption polycarboxylate superplasticizer rheology dispersion

Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee Kim Rudolph ETanzi Se Hoon choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-Ho choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

Shear deformable finite beam elements for composite box beams

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Acta Mechanica Sinica 2014年第2期30卷 223-240页

作者： Nam-il Kim Dong-Ho choi Department of Architectural Engineering Sejong University Department of Civil and Environmental Engineering Hanyang University

The shear deformable thin-walled composite beams with closed cross-sections have been developed for coupled flexural, torsional, and buckling analyses. A theoretical model applicable to the thin-walled laminated composite box beams is presented by taking into account all the structural couplings coming from the material anisotropy and the shear deformation effects. The current composite beam includes the transverse shear and the restrained warping induced shear deformation by using the first-order shear deformation beam theory. Seven governing equations are derived for the coupled axial-flexural-torsional-shearing buckling based on the principle of minimum total potential energy. Based on the present analytical model, three different types of finite composite beam elements, namely, linear, quadratic and cubic elements are developed to analyze the flexural, torsional, and buckling problems. In order to demonstrate the accuracy and superiority of the beam theory and the finite beam elements developed by this study,numerical solutions are presented and compared with the results obtained by other researchers and the detailed threedimensional analysis results using the shell elements of ABAQUS. Especially, the influences of the modulus ratio and the simplified assumptions in stress-strain relations on the deflection, twisting angle, and critical buckling loads of composite box beams are investigated.

关键词： Thin-walled Composite box beam Deflection Twisting angle Buckling load Shear deformation

Homogenization on solution treatment and its effects on the precipitation-hardening of selective laser melted 17-4PH stainless steel

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Journal of Materials Science & Technology 2023年第35期166卷 47-57页

作者： Sohee An Du-Rim Eo il Sohn Kyunsuk choi Department of Materials Science and Engineering Yonsei UniversitySeoul03722Republic of Korea Advanced Joining&Additive Manufacturing R&D Department Korea Institute of Industrial Technology(KITECH)529 Seohaean-roSiheung 15014Republic of Korea Department of Industry-University Convergence Hanbat National UniversityYuseongDaejeon34158Republic of Korea

17-4 precipitation-hardened(PH)stainless steel(SS)exhibits high strength and good corrosion resistance via Cu-precipitation *** conventional wrought 17-4PH SS,Cu segregation andε-Cu pre-cipitates are observed in additively manufactured(AM)17-4PH SS owing to the repeated rapid cooling after heating,which characterizes the AM *** this study,solution treatment was conducted under various temperatures(1,000,1,050,1,100,and 1,200℃)and durations(1,2,4,and 8 h)to minimize the negative effects of Cu segregation andε-Cu precipitates on precipitation *** mechanical prop-erties and microstructures of each condition for the Cu precipitation behavior were *** theε-Cu precipitates did not disappear after solution treatment,the average diameter of theε-Cu precipi-tates tended to decrease with increasing solution treatment temperature and ***,solution treatment at a temperature of 1,200℃ for 8 h was the best,resulting in improved strength compared to the conventional solution treatment at 1,050℃.Solution treatment on at least 1,100℃ is effective in AM.

关键词： Selective laser melting Cu segregation Solution treatment 17-4 Precipitation-hardened stainless steel Additive manufacturing

Two climate factors in May that affect Korean rainfall in September

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Acta Oceanologica Sinica 2013年第1期32卷 32-47页

作者： choi Ki-Seon MOON il-Ju National Typhoon Center Korea Meteorological Administration College of Ocean Science/Ocean and Environment Research Institute Jeju National University

This study revealed a high positive correlation between rainfall in Korea during September and the trade wind （TW）/Arctic Oscillation （AO） index in May that combines two climate factors, low-level TWs and the AO. This correlation was identified on the basis of the difference in the 850 hPa streamline analysis between the positive and negative phases selected using the combined TW/AO index. In May, the spatial pattern of the anomalous pressure systems is similar to that in the positive AO phase. These anomalous pressure sys- tems continue in June to August （JJA） and September, but the overall spatial distribution shifts a little to the south. Particularly in September, a huge anomalous anticyclone centered over the southeast seas of Japan strengthens in most of the western north Pacific region and supplies a large volume of warm and humid air to the region near Korea. This characteristic is confirmed by the facts that during the positive TW/AO phase, the subtropical western north Pacific high （SWNPH） is more developed to the north and that the continu- ous positioning of the upper troposphere jet over Korea from May to September strengthens the anomalous upward flow, bringing warm and humid air to all layers. These factors contribute to increasing September rainfall in Korea during the positive TW/AO phase. Because the SWNPH develops more to the north in the positive phase, tropical cyclones tend to make landfall in Korea frequently, which also plays a positive role in increasing September rainfall in *** above features are also reflected by the differences in average rainfall between the six years that had the highest May Nifio 3.4 indices （El Niflo phase） and the six years that had the lowest May Niflo 3.4 indices （La Nifia phase）.

关键词： anomalous pressure Arctic Oscillation Korea low-level trade wind rainfall tropical cyclone

Acousto-Optics Tunable Filter Based on a Hollow Optical Fiber for Broadband Polarization Switch Application

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光学学报 2003年第S1期23卷 193-194页

作者： Jaewon Lee Jaewang Yu Sangsoo choi Kyunghwan Oh Dong il Yum byoung Yoon Kim Department of Information and Communications Kwang- Ju Institute of Science and Technology Kwangju Buk-gu 500-712 Rep. of Korea Department of Physics Korea Advanced Institute Science and Technology Taejon 305701 Rep. of Korea

A novel acousto-optic tunable filter (AOTF) using a hollow optical fiber (HOF) is proposed. Its broadband rejection over 100nm was observed and high polarization dependence as a polarization switch is discussed.

关键词： Hollow Optical Fiber hollow optical fiber tunable filter

Crustal growth history of the Korean Peninsula: Constraints from detrital zircon ages in modern river sediments

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Geoscience Frontiers 2016年第5期7卷 707-714页

作者： Taejin choi Yong il Lee Yuji Orihashi Department of Energy and Resources Engineering Chosun University School of Earth and Environmental Sciences Seoul National University Earthquake Research Institute The University of Tokyo

U-Pb analyses were carried out on detrital zircon grains from major river-mouth sediments draining South Korea to infer provenance characteristics and the crustal growth history of the southern Korean Peninsula, using a laser ablation inductively coupled plasma mass spectrometer（LA-ICP-MS）. The Korean Peninsula is located in the East Asian continental margin and mainly comprises three Precambrian massifs and two metamorphic belts in between them. We obtained 515 concordant to slightly discordant zircon ages ranging from ca. 3566 to ca. 48 Ma. Regardless of river-mouth location, predominance of Mesozoic（249e79 Ma） and Paleoproterozoic（2491e1691 Ma） ages with subordinate Archean ages indicates that the zircon ages reflect present exposures of plutonic/metamorphic rocks in the drainage basins of the South Korean rivers and the crustal growth of the southern Korean Peninsula was focused in these two periods. Comparison of detrital zircon-age data between the North and South Korean river sediments reveals that the Paleoproterozoic zircon age distributions of both regions are nearly identical,while the Neoproterozoice Paleozoic ages exist and the Mesozoic ages are dominant in southern Korean Peninsula. This result suggests that Precambrian terrains in Korea record the similar pre-Mesozoic magmatic history and that the influence of Mesozoic magmatism was mainly focused in South Korea.

关键词： Detrital zircon U-Pb age dating Crustal growth Korean Peninsula Provenance

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration