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Phytochemical analysis of Berberis lyceum methanolic extract and its antiviral activity through the restoration of MAPK signaling pathway modulated by HCV NS5A

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Asian Pacific Journal of Tropical Biomedicine 2021年第3期11卷 132-140页

作者： Koloko Brice Landry Shafiq Azam Sidra Rehman Somayya Tariq bushra iqbal Mateen Abbas Dieudonné Massoma Lembè bushra Ijaz Laboratory of Applied and Functional Genomic Centre of Excellence in Molecular BiologyUniversity of the PunjabLahorePakistan Department of Biosciences COMSATS University IslamabadIslamabadPakistan Quality Operations Laboratory University of Veterinary and Animal SciencesLahorePakistan Laboratory of Animal Biology and Physiology Faculty of ScienceUniversity of DoualaDoualaCameroon

Objective:To evaluate the antiviral activity and phytochemicals of selected plant extracts and their effect on the mitogen-activated protein kinase(MAPK)signaling pathway modulated by hepatitis C virus(HCV)nonstructural protein 5 A(NS5A).Methods:A total of ten plant extracts were initially screened for their toxicities against Hep G2 *** non-toxic plants were tested for their inhibitory effect on the expression of HCV NS5A at both m RNA and protein levels using real-time PCR and Western blotting assays,*** differential expression of the genes associated with MAPK pathway in the presence of NS5A gene and plant extract was measured through real-time ***,the identification of secondary metabolites was carried out by phytochemical and HPLC ***:The phytochemical profiling of Berberis lyceum revealed the presence of alkaloids,phenols,saponins,tannins,flavonoids,carbohydrates,terpenoids,steroids,and ***,quercetin,myricetin,gallic acid,caffeic acid,and ferulic acid were identified through HPLC *** methanolic extract of Berberis lyceum strongly inhibited HCV RNA replication with an IC50 of 11.44μg/m ***-PCR and Western blotting assays showed that the extract reduced the expression of HCV NS5A in a dosedependent *** lyceum extract also attenuated NS5A-induced dysregulation of the MAPK signaling ***:Our findings suggest that Berberis lyceum extract strongly inhibits HCV propagation by reducing HCV NS5A-induced perturbation of MAPK signaling.

关键词： Anti-HCV HCV NS5A Berberis lyceum MAPK pathway Phytochemicals HPLC

Weathering and accumulation of trace elements in the soils of the Porali Plain, Balochistan: repercussions in agriculture

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Acta Geochimica 2024年第2期43卷 214-234页

作者： Maria Kaleem Erum Bashir Shahid Naseem Tahir Rafique bushra Shahab Department of Geology University of KarachiKarachi 75270Pakistan Applied Chemistry Research Centre PCSIR Laboratories ComplexKarachi 75280Pakistan

This study is theﬁrst attempt to assess the nature of the soil,especially on the western side of the Porali Plain in Balochistan;a new emerging agriculture hub,using weathering and pollution indices supplemented by multi-variate analysis based on geochemical *** outcomes of this study are expected to help farmers in soil manage-ment and selecting suitable crops for the ***-ﬁve soil samples were collected,mainly from the arable land of the Porali *** drying and coning-quarter-ing,soil samples were analyzed for major and trace ele-ments using the XRF technique;sieving and hydrometric methods were employed for granulometric ***-mated data were analyzed using Excel,SPSS,and Surfer software to calculate various indices,correlation matrix,and spatial *** granulometric analysis showed that 76%of the samples belonged to loam types of soil,12%to sand type,and 8%to silt *** indices:CIA,CIW,PIA,PWI,WIP,CIX,and ICV were calculated to infer the level of *** indices reﬂect mod-erate to intense weathering;supported by K_(2)O/AI_(2)O_(3),Rb/K_(2)O,Rb/Ti,and Rb/Sr *** of the geo-ac-cumulation and Nemerow Pollution indices pinpoint rela-tively high concentrations of Pb,Ni,and Cr concentration in the *** correlation matrix and Principal Compo-nent Analysis show that the soil in this study area is mainly derived from the weathering of igneous rocks of Bela Ophiolite(Cretaceous age)and Jurassic sedimentary rocks of Mor Range having SEDEX/MVT type *** may result in the undesirable accumulation of certain trace elements which adversely affects crops.

关键词： Weathering indices Pollution indices Accumulation Repercussions Trace elements Multivariate analyses Porali Plain Balochistan

Test particles and quasiperiodic oscillations around Kiselev black hole with cloud of strings

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Chinese Physics C 2024年第5期48卷 293-308页

作者： Javlon Rayimbaev Uktambek Eshimbetov bushra Majeed Ahmadjon Abdujabbarov Alisher Abduvokhidov Bakhrom Abdulazizov Akram Xalmirzayev School of Mathematics and Natural Sciences New Uzbekistan UniversityMovarounnahr Str.1Tashkent 100000Uzbekistan School of Engineering Central Asian UniversityTashkent 111221Uzbekistan University of Tashkent for Applied Sciences Str.Gavhar 1Tashkent 100149Uzbekistan Institute of Fundamental and Applied Research National Research University TIIAMEKori Niyoziy 39Tashkent 100000Uzbekistan National University of Uzbekistan Tashkent 100174Uzbekistan Ulugh Beg Astronomical Institute Astronomy Str.33Tashkent 100052Uzbekistan Tashkent State Technical University Tashkent 100095Uzbekistan College of Electrical and Mechanical Engineering(CEME) National University of Sciences and TechnologyRawalpindiPakistan Andijan State University Universitet Str.129Andijan 170100Uzbekistan Namangan State University Boburshoh Str.161Namangan 160107Uzbekistan

In the present study,we investigate the dynamics of test particles around a Schwarzschild black hole surrounded by quintessence and immersed in a scalar string cloud *** start our study by defining the possible values of the quintessence and cloud of string parameters corresponding to the existence of the black hole horizon for fixed values of the parameters of the equation of state for dark *** also study the effects of the effective potential on the circular motion,energy,and angular momentum of the test particles together with the innermost stable circular orbits(ISCOs).We investigate the fundamental frequencies in the particle oscillations along stable circular *** relate the stability of the orbits to the Lyapunov exponent,and the chaotic behavior is studied ***,we apply the fundamental frequencies to describe quasiperiodic oscillations(QPOs)and find that,in the presence of both fields,low-frequency twin-peak QPOs are not *** addition,we obtain the constraint values for the string cloud parameter and mass of the black hole candidates located in the center of the microquasars GRO J1655-40 and GRS 1915+105 as well as the Milky Way galaxy.

关键词： quintessential field black holes string cloud quasiperiodic oscillations

Expansion of human umbilical cord derived mesenchymal stem cells in regenerative medicine

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World Journal of Stem Cells 2024年第4期16卷 410-433页

作者： Shafiqa Naeem Rajput bushra Kiran Naeem Anwar Ali Asmat Salim Irfan Khan Dr.Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological SciencesUniversity of KarachiKarachi 75270SindhPakistan Surgical Unit 4 Dr.Ruth KM Pfau Civil HospitalKarachi 74400Pakistan Department of Physiology University of KarachiKarachi 75270Pakistan Center for Regenerative Medicine and Stem Cells Research and Department of Ophthalmology and Visual SciencesThe Aga Khan UniversityKarachi 74800SindhPakistan

BACKGROUND Stem cells are undifferentiated cells that possess the potential for self-renewal with the capacity to differentiate into multiple *** humans,their limited numbers pose a challenge in fulfilling the necessary demands for the regeneration and repair of damaged tissues or *** suggested that mesenchymal stem cells(MSCs),necessary for repair and regeneration via transplantation,require doses ranging from 10 to 400 million ***,the limited expansion of MSCs restricts their therapeutic *** To optimize a novel protocol to achieve qualitative and quantitative expansion of MSCs to reach the targeted number of cells for cellular transplantation and minimize the limitations in stem cell therapy *** Human umbilical cord(hUC)tissue derived MSCs were obtained and *** cultured cells were subjected to the following evaluation pro-cedures:Immunophenotyping,immunocytochemical staining,trilineage differentiation,population doubling time and number,gene expression markers for proliferation,cell cycle progression,senescence-associatedβ-galactosidase assay,human telomerase reverse transcriptase(hTERT)expression,mycoplasma,cytomegalovirus and endotoxin *** Analysis of pluripotent gene markers Oct4,Sox2,and Nanog in recultured hUC-MSC revealed no significant *** immunophenotypic markers CD90,CD73,CD105,CD44,vimentin,CD29,Stro-1,and Lin28 were positively expressed by these recultured expanded MSCs,and were found negative for CD34,CD11b,CD19,CD45,and *** recultured hUC-MSC population continued to expand through passage *** gene expression of Pax6,BMP2,and TGFb1 showed no significant variation between recultured hUC-MSC ***,a significant increase(P<0.001)in the mitotic phase of the cell cycle was observed in recultured *** senescence markers(hTERT expression andβ-galactosidase activity)did not show any negative effect on recultured hUC-

关键词： Human umbilical cord Mesenchymal stem cells Expansion Cell proliferation In vitro expansion Senescence

Composite Fractional Trapezoidal Rule with Romberg Integration

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2729-2745页

作者： iqbal M.Batiha Rania Saadeh iqbal H.Jebril Ahmad Qazza Abeer A.Al-Nana Shaher Momani Department of Mathematics Al Zaytoonah University of JordanAmman11733Jordan Nonlinear Dynamics Research Center(NDRC) Ajman UniversityAjman 346United Arab Emirates Department of Mathematics Faculty of ScienceZarqa UniversityZarqa13110Jordan Department of Mathematics Prince Sattam Bin Abdulaziz UniversityAlkharj11942Saudi Arabia Department of Mathematics The University of JordanAmman11942Jordan

The aim of this research is to demonstrate a novel scheme for approximating the Riemann-Liouville fractional integral *** would be achieved by first establishing a fractional-order version of the 2-point Trapezoidal rule and then by proposing another fractional-order version of the(n+1)-composite Trapezoidal *** particular,the so-called divided-difference formula is typically employed to derive the 2-point Trapezoidal rule,which has accordingly been used to derive a more accurate fractional-order formula called the(n+1)-composite Trapezoidal ***,in order to increase the accuracy of the proposed approximations by reducing the true errors,we incorporate the so-called Romberg integration,which is an extrapolation formula of the Trapezoidal rule for integration,into our proposed *** numerical examples are provided and compared with a modern definition of the Riemann-Liouville fractional integral operator to illustrate the efficacy of our scheme.

关键词： Composite fractional Trapezoidal rule Romberg integration

Effects of grain's shape-and size-polydispersities,orientation,and area fraction on tortuosity and permeability of 2D granular media

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Particuology 2024年第7期90卷 535-557页

作者： Ke Cao Huisu Chen Mohammad iqbal Khan Mingqi Li Lin Liu Jiangsu Key Laboratory of Construction Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China Department of Civil Engineering College of EngineeringKing Saud UniversityP.O.Box 800Riyadh 11421Saudi Arabia School of Civil and Transportation Engineering Hebei University of TechnologyTianjin 300401China College of Civil and Transportation Engineering Hohai UniversityNanjing210098China

The microstructure of granular media, including grain's shape- and size-polydispersities, orientation, and area fraction can potentially affect its permeability. However, few studies consider the coupling effects of these features. This work employs geometrical probability and stereology to establish quantitative relationships between the above microstructural features and the geometric tortuosity of the two-dimensional granular media containing superellipse, superoval, and polygon grains. Then the lattice Boltzmann method (LBM) is used to determine the permeabilities of these granular media. By combining the tortuosity model and the LBM-derived permeabilities, modified K–C equations are formulated to predict the permeability and the shape factor, considering the grain's shape- and size-polydispersities, orientation, and area fraction. The reliability of these methods can be verified by comparing them with both our simulations and available experimental, theoretical, and numerical data reported in the literature. The findings implicate that the tortuosity and permeability of the granular media are strongly correlated with the grain's shape, orientation, and area fraction but unaffected by the size polydispersity and spatial arrangement of grains. Only circularity is not enough to derive a unified formula for considering the impact of grain shape on tortuosity and permeability, other shape parameters need to be explored in the future.

关键词： Geometric tortuosity Konzey-Carman equation Shape and size ploydispersities Grain orientation Lattice Boltzmann method Granular media

Understanding the Impact of H_(2) Diffusion Energy on the Formation Efficiency of H_(2) on the Interstellar Dust Grain Surface

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Research in Astronomy and Astrophysics 2024年第9期24卷 190-198页

作者： Xiaoying Guo Wasim iqbal Qiang Chang Xiao-Hu Li School of Physics and Optoeletronic Engineering Shandong University of TechnologyZibo 255000China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesUrumqi 830011China

We use microscopic Monte Carlo simulation techniques to investigate the impact of H_(2)diffusion energy on the recombination efficiency of H_(2)on interstellar dust grain surfaces under diffuse and translucent cloud *** constructed five models representing different possible conditions encountered by adsorbed H and H_(2)on interstellar dust *** implemented adsorption sites with multiple binding energies for surface species;the Encounter-Desorption mechanism was also *** study focused on silicate surfaces in diffuse clouds and water ice surfaces in translucent *** results show that the recombination efficiency of H_(2)on dust surfaces decreases as H_(2)diffusion energy *** interesting finding of this work is that considering different binding sites for H and H_(2)gives rise to multiple steady phases,during which the recombination efficiency remains constant with a change in H_(2)diffusion energy.

关键词： astrochemistry atomic processes ISM:molecules

Impact of natural resource mining on sustainable economic development:The role of education and green innovation in China

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Geoscience Frontiers 2024年第3期15卷 346-357页

作者： Xing Li Lina Ma Asif M.Ruman Najaf iqbal Wadim Strielkowski School of Media&Linguistics Anhui University of Finance&EconomicsBengbuAnhuiChina Graduate School of Management&Information Technology Hannan UniversityJapan School of Accounting Wuhan Textile UniversityWuhanHubeiChina Business School University of OuluOuluFinland School of Finance Anhui University of Finance and EconomicsBengbu 233030AnhuiChina Africa-Asia Centre for Sustainability Business SchoolUniversity of AberdeenScotlandUK Department of Trade and Finance Faculty of Economics and ManagementCzech University of Life Sciences PragueKamycká129Prague 616500 PragueCzech Republic Centre for Energy Studies Cambridge Institute for Advanced StudiesKing str.23CB11AH CambridgeUK

As the extraction and usage of natural resources continue to be a double-edged sword-supporting economic growth but deteriorating the environment-we study the impact of natural resource mining on sustainable economic development in the largest(PPP)*** use province-level data from 2001 to 2020 and employ econometric panel techniques,such as fixed effects,two-stage least squares,and a battery of robustness *** further explore the potential effects of education and green innovation in mitigating/exacerbating the role of natural resources in the Chinese provincial *** results show that:(1)Natural resource mining hurts sustainable development,verifying the“resource curse”effect.(2)Green innovation and education restrain the negative impact of resource mining on sustainable development,turning the curse into a blessing.(3)A regional heterogeneity is observed in the impact of resource mining on sustainable development,showing more significant effects in the Western and low-urbanized regions.(4)Green innovation and education can assuage the curse effect of natural resources into gospel *** implications and recommendations are proposed in light of the findings to promote sustainable economic development in China.

关键词： Natural resource mining Sustainable economic growth Education Green innovation Resource curse China

Weber Law Based Approach for Multi-Class Image Forgery Detection

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Computers, Materials & Continua 2024年第1期78卷 145-166页

作者： Arslan Akram Javed Rashid Arfan Jaffar Fahima Hajjej Waseem iqbal Nadeem Sarwar Department of Computer Science Superior UniversityLahore54000Pakistan Information Technology Services University of OkaraOkara56300Pakistan Departmet of Computer Science MLC LabOkara56300Pakistan Department of CS&SE International Islamic UniversityIslamabad44000Pakistan Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia Department of Software Engineering Superior UniversityLahore54000Pakistan Department of Computer Science Bahria UniversityLahore CampusLahore54600Pakistan

Today’s forensic science introduces a new research area for digital image analysis formultimedia ***,Image authentication issues have been raised due to the wide use of image manipulation software to obtain an illegitimate benefit or createmisleading publicity by using tempered *** forgery detectionmethods can classify only one of the most widely used Copy-Move and splicing ***,an image can contain one or more types of *** study has proposed a hybridmethod for classifying Copy-Move and splicing images using texture information of images in the spatial ***,images are divided into equal blocks to get scale-invariant *** law has been used for getting texture features,and finally,XGBOOST is used to classify both Copy-Move and splicing *** proposed method classified three types of forgeries,i.e.,splicing,Copy-Move,and ***(CASIA 2.0,MICCF200)and RCMFD datasets are used for training and *** average,the proposed method achieved 97.3% accuracy on benchmarked datasets and 98.3% on RCMFD datasets by applying 10-fold cross-validation,which is far better than existing methods.

关键词： Copy-Move and splicing non-overlapping block division texture features weber law spatial domain xgboost