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Mental health status among COVID-19 patients survivors of critical illness in Saudi Arabia:A 6-month follow-up questionnaire study

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World Journal of Clinical Cases 2024年第15期12卷 2560-2567页

作者： Abdullah M Alhammad Namareq F Aldardeer Abdulaziz Alqahtani Mohammad H Aljawadi bushra alnefaie Raghad Alonazi Mansour Almuqbil Abdulrahman Alsaadon Rakan M Alqahtani Rashid Alballaa Bader Alshehri Mohammed I Alarifi Fahad D Alosaimi Department of Clinical Pharmacy College of PharmacyKing Saud UniversityRiyadh 12372Saudi Arabia Department of Pharmacy Services King Faisal Specialist Hospital and Research CentreJeddah 21499Saudi Arabia Corporate Department of Pharmacy Services King Saud University Medical CityRiyadh 12372Saudi Arabia College of Pharmacy King Saud UniversityRiyadh 12372Saudi Arabia Department of Critical Care Medicine College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia Department of Psychiatry College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia

BACKGROUND Psychological assessment after intensive care unit(ICU)discharge is increasingly used to assess patients'cognitive and psychological ***,few studies have examined those who recovered from coronavirus disease 2019(COVID-19).There is a paucity of data from the Middle East assessing the post-ICU discharge mental health status of patients who had *** To evaluate anxiety and depression among patients who had severe *** This is a prospective single-center follow-up questionnaire-based study of adults who were admitted to the ICU or under ICU consultation for>24 h for *** patients were contacted via *** patient’s anxiety and depression six months after ICU discharge were assessed using the Hospital Anxiety and Depression Scale(HADS).The primary outcome was the mean HADS *** secondary outcomes were risk factors of anxiety and/or *** Patients who were admitted to the ICU because of COVID-19 were screened(n=518).Of these,48 completed the *** mean age was 56.3±17.2 *** patients(62.5%)were *** main comorbidities were endocrine(n=24,50%)and cardiovascular(n=21,43.8%)*** mean overall HADS score for anxiety and depression at 6 months post-ICU discharge was 11.4(SD±8.5).A HADS score of>7 for anxiety and depression was detected in 15 patients(30%)and 18 patients(36%),*** from the multivariable ordered logistic regression demonstrated that vasopressor use was associated with the development of anxiety and depression[odds ratio(OR)39.06,95% confidence interval:1.309-1165.8;P<0.05].CONCLUSION Six months after ICU discharge,30% of patients who had COVID-19 demonstrated a HADS score that confirmed anxiety and *** compare the psychological status of patients following an ICU admission(with vs without COVID-19),further studies are warranted.

关键词： COVID-19 Critically ill Anxiety Depression HADS Saudi Arabia

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Weathering and accumulation of trace elements in the soils of the Porali Plain, Balochistan: repercussions in agriculture

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Acta Geochimica 2024年第2期43卷 214-234页

作者： Maria Kaleem Erum Bashir Shahid Naseem Tahir Rafique bushra Shahab Department of Geology University of KarachiKarachi 75270Pakistan Applied Chemistry Research Centre PCSIR Laboratories ComplexKarachi 75280Pakistan

This study is theﬁrst attempt to assess the nature of the soil,especially on the western side of the Porali Plain in Balochistan;a new emerging agriculture hub,using weathering and pollution indices supplemented by multi-variate analysis based on geochemical *** outcomes of this study are expected to help farmers in soil manage-ment and selecting suitable crops for the ***-ﬁve soil samples were collected,mainly from the arable land of the Porali *** drying and coning-quarter-ing,soil samples were analyzed for major and trace ele-ments using the XRF technique;sieving and hydrometric methods were employed for granulometric ***-mated data were analyzed using Excel,SPSS,and Surfer software to calculate various indices,correlation matrix,and spatial *** granulometric analysis showed that 76%of the samples belonged to loam types of soil,12%to sand type,and 8%to silt *** indices:CIA,CIW,PIA,PWI,WIP,CIX,and ICV were calculated to infer the level of *** indices reﬂect mod-erate to intense weathering;supported by K_(2)O/AI_(2)O_(3),Rb/K_(2)O,Rb/Ti,and Rb/Sr *** of the geo-ac-cumulation and Nemerow Pollution indices pinpoint rela-tively high concentrations of Pb,Ni,and Cr concentration in the *** correlation matrix and Principal Compo-nent Analysis show that the soil in this study area is mainly derived from the weathering of igneous rocks of Bela Ophiolite(Cretaceous age)and Jurassic sedimentary rocks of Mor Range having SEDEX/MVT type *** may result in the undesirable accumulation of certain trace elements which adversely affects crops.

关键词： Weathering indices Pollution indices Accumulation Repercussions Trace elements Multivariate analyses Porali Plain Balochistan

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Test particles and quasiperiodic oscillations around Kiselev black hole with cloud of strings

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Chinese Physics C 2024年第5期48卷 293-308页

作者： Javlon Rayimbaev Uktambek Eshimbetov bushra Majeed Ahmadjon Abdujabbarov Alisher Abduvokhidov Bakhrom Abdulazizov Akram Xalmirzayev School of Mathematics and Natural Sciences New Uzbekistan UniversityMovarounnahr Str.1Tashkent 100000Uzbekistan School of Engineering Central Asian UniversityTashkent 111221Uzbekistan University of Tashkent for Applied Sciences Str.Gavhar 1Tashkent 100149Uzbekistan Institute of Fundamental and Applied Research National Research University TIIAMEKori Niyoziy 39Tashkent 100000Uzbekistan National University of Uzbekistan Tashkent 100174Uzbekistan Ulugh Beg Astronomical Institute Astronomy Str.33Tashkent 100052Uzbekistan Tashkent State Technical University Tashkent 100095Uzbekistan College of Electrical and Mechanical Engineering(CEME) National University of Sciences and TechnologyRawalpindiPakistan Andijan State University Universitet Str.129Andijan 170100Uzbekistan Namangan State University Boburshoh Str.161Namangan 160107Uzbekistan

In the present study,we investigate the dynamics of test particles around a Schwarzschild black hole surrounded by quintessence and immersed in a scalar string cloud *** start our study by defining the possible values of the quintessence and cloud of string parameters corresponding to the existence of the black hole horizon for fixed values of the parameters of the equation of state for dark *** also study the effects of the effective potential on the circular motion,energy,and angular momentum of the test particles together with the innermost stable circular orbits(ISCOs).We investigate the fundamental frequencies in the particle oscillations along stable circular *** relate the stability of the orbits to the Lyapunov exponent,and the chaotic behavior is studied ***,we apply the fundamental frequencies to describe quasiperiodic oscillations(QPOs)and find that,in the presence of both fields,low-frequency twin-peak QPOs are not *** addition,we obtain the constraint values for the string cloud parameter and mass of the black hole candidates located in the center of the microquasars GRO J1655-40 and GRS 1915+105 as well as the Milky Way galaxy.

关键词： quintessential field black holes string cloud quasiperiodic oscillations

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Expansion of human umbilical cord derived mesenchymal stem cells in regenerative medicine

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World Journal of Stem Cells 2024年第4期16卷 410-433页

作者： Shafiqa Naeem Rajput bushra Kiran Naeem Anwar Ali Asmat Salim Irfan Khan Dr.Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological SciencesUniversity of KarachiKarachi 75270SindhPakistan Surgical Unit 4 Dr.Ruth KM Pfau Civil HospitalKarachi 74400Pakistan Department of Physiology University of KarachiKarachi 75270Pakistan Center for Regenerative Medicine and Stem Cells Research and Department of Ophthalmology and Visual SciencesThe Aga Khan UniversityKarachi 74800SindhPakistan

BACKGROUND Stem cells are undifferentiated cells that possess the potential for self-renewal with the capacity to differentiate into multiple *** humans,their limited numbers pose a challenge in fulfilling the necessary demands for the regeneration and repair of damaged tissues or *** suggested that mesenchymal stem cells(MSCs),necessary for repair and regeneration via transplantation,require doses ranging from 10 to 400 million ***,the limited expansion of MSCs restricts their therapeutic *** To optimize a novel protocol to achieve qualitative and quantitative expansion of MSCs to reach the targeted number of cells for cellular transplantation and minimize the limitations in stem cell therapy *** Human umbilical cord(hUC)tissue derived MSCs were obtained and *** cultured cells were subjected to the following evaluation pro-cedures:Immunophenotyping,immunocytochemical staining,trilineage differentiation,population doubling time and number,gene expression markers for proliferation,cell cycle progression,senescence-associatedβ-galactosidase assay,human telomerase reverse transcriptase(hTERT)expression,mycoplasma,cytomegalovirus and endotoxin *** Analysis of pluripotent gene markers Oct4,Sox2,and Nanog in recultured hUC-MSC revealed no significant *** immunophenotypic markers CD90,CD73,CD105,CD44,vimentin,CD29,Stro-1,and Lin28 were positively expressed by these recultured expanded MSCs,and were found negative for CD34,CD11b,CD19,CD45,and *** recultured hUC-MSC population continued to expand through passage *** gene expression of Pax6,BMP2,and TGFb1 showed no significant variation between recultured hUC-MSC ***,a significant increase(P<0.001)in the mitotic phase of the cell cycle was observed in recultured *** senescence markers(hTERT expression andβ-galactosidase activity)did not show any negative effect on recultured hUC-

关键词： Human umbilical cord Mesenchymal stem cells Expansion Cell proliferation In vitro expansion Senescence

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Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease

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Genes & Diseases 2024年第1期11卷 67-71页

作者： Souvik Kar Andrea Perrelli Kiran Kumar Bali Raffaella Mastrocola Arpita Kar bushra Khan Luis Gand Arnab Nayak Christian Hartmann Wolfram SKunz Amir Samii Helmut Bertalanffy Saverio Francesco Retta International Neuroscience Institute Rudolf-PichlmayrStrasse 4Hannover 30625Germany Department of Clinical and Biological Sciences University of TorinoOrbassano(TO)10043Italy CCM Italia Research Network National Coordination Center at the Department of Clinical and Biological SciencesUniversity of TorinoOrbassano(TO)10043Italy Department of Experimental Pain Research Mannheim Center for Translational Neuroscience(MCTN)Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Department of Kidney Liver and Metabolic DiseasesChildren’s HospitalHannover Medical SchoolHannover 30625Germany Ricarda-Huch-Street-10B Hannover 30880Germany Institute of Molecular and Cell Physiology Hannover Medical SchoolHannover 30625Germany Department of Neuropathology Institute of PathologyHannover Medical SchoolHannover 30625Germany Institute of Experimental Epileptology and Cognition Research and Department of Epileptology University Hospital BonnVenusberg-Campus 1Bonn 53127Germany epartment of Pharmacology and Physiology University of Rochester Medical CenterRochesterNY 14642USA

cerebrovascular disease of genetic origin characterized by abnormally dilated capillaries and a wide spectrum of symptoms,including headaches,seizures,neurological deficits,and intracerebral *** unpredictable clinical course and the current lack of therapies make the identification of prognostic and predictive biomarkers an imperative research challenge.1 Herein,we provide evidence that galectin-3(Gal-3),a major tissue and circulating biomarker of oxidative stress and inflammation,is significantly up-regulated both in CCM patients and ***,wholetranscriptome sequencing,qRT-PCR,and Western blotting studies demonstrated a significant up-regulation of Gal-3 expression levels both in surgical CCM specimens and in blood samples of CCM patients.

关键词： inflammation cerebral dilated

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Des-gamma-carboxy prothrombin and alpha-fetoprotein levels as biomarkers for hepatocellular carcinoma and their correlation with radiological characteristics

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World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 37-43页

作者： Muhammad Ali Qadeer Zaigham Abbas Shaima Amjad bushra Shahid Abeer Altaf Mehreen Siyal Department of Hepatogastroenterology Dr.Ziauddin University Hospital CliftonKarachi 75600Pakistan Medicine Dr.Ziauddin University Hospital CliftonKarachi 75600Pakistan Internal Medicine Dr.Ziauddin University Hospital CliftonKarachi 75600Pakistan

BACKGROUND Alpha-fetoprotein(AFP),a commonly used biomarker for hepatocellular carcinoma(HCC),is normal in up to one-third of *** To evaluate the diagnostic performance of des-gamma-carboxy-prothrombin(DCP)alone and in combination with *** In this study,202 patients with radiologically proven HCC were enrolled,and their DCP and AFP levels were evaluated for their diagnostic *** The mean age of the enrolled patients was 58.5 years;72.0%were *** was elevated in 86.6%(n=175)of all patients,100.0%(n=74)of patients with portal vein thrombus,and 87.4%(n=111)of patients with multicentric *** was elevated in 64.3%(n=130)of all the patients,74%(n=55)of the patients with portal vein thrombus,and 71.6%(n=91)of the patients with multicentric HCC(P=0.030,0.001,and 0.015,respectively).In tumors less than 2 cm in size(n=46),DCP was increased in 32(69.5%)patients,and AFP was increased in 25(54.3%)patients(P=0.801).There was good pairing between DCP and AFP for HCCs of 2 cm size or larger(P2 cm was 0.74 for DCP and 0.59 for AFP;combining both markers resulted in an AUROC of *** tumors<2 cm,the AUROC was 0.25 for DCP and 0.40 for *** DCP,as an individual marker,had a better diagnostic performance in many cases of ***,DCP may replace AFP as the primary HCC biomarker.

关键词： Des-gamma-carboxy prothrombin Protein induced by vitamin K absence-II Cirrhosis Alpha-fetoprotein Biomarkers Hepatocellular carcinoma Portal vein thrombus

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Novel Positive Multi-Layer Graph Based Method for Collaborative Filtering Recommender Systems

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Journal of Computer Science & Technology 2022年第4期37卷 975-990页

作者： bushra Alhijawi Ghazi AL-Naymat Department of Computer Science Princess Sumaya University for TechnologyAmman 11941Jordan Artificial Intelligence Research Center College of Engineering and Information TechnologyAjman UniversityAjman 20550U.A.E.

Recommender systems play an increasingly important role in a wide variety of applications to help users find favorite products. Collaborative filtering has remarkable success in terms of accuracy and becomes one of the most popular recommendation methods. However, these methods have shown unpretentious performance in terms of novelty, diversity, and coverage. We propose a novel graph-based collaborative filtering method, namely Positive Multi-Layer Graph-Based Recommender System (PMLG-RS). PMLG-RS involves a positive multi-layer graph and a path search algorithm to generate recommendations. The positive multi-layer graph consists of two connected layers: the user and item layers. PMLG-RS requires developing a new path search method that finds the shortest path with the highest cost from a source node to every other node. A set of experiments are conducted to compare the PMLG-RS with well-known recommendation methods based on three benchmark datasets, MovieLens-100K, MovieLens-Last, and Film Trust. The results demonstrate the superiority of PMLG-RS and its high capability in making relevant, novel, and diverse recommendations for users.

关键词： recommender system collaborative filtering graph theory path search novelty coverage diversity

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Novel Decision Making Methodology under Pythagorean Probabilistic Hesitant Fuzzy Einstein Aggregation Information

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Computer Modeling in Engineering & Sciences 2023年第8期136卷 1785-1811页

作者： Shahzaib Ashraf bushra Batool Muhammad Naeem Institute of Mathematics Khwaja Fareed University of Engineering&Information TechnologyRahim Yar Khan64200Pakistan Department of Mathematics University of SargodhaSargodha40100Pakistan Department of Mathematics Deanship of Applied SciencesUmm Al-Qura UniversityMakkah24382Saudi Arabia

This research proposes multicriteria decision-making(MCDM)-based real-time Mesenchymal stem cells(MSC)transfusion *** testing phase of the methodology denotes the ability to stick to plastic surfaces,the upregulation and downregulation of certain surface protein markers,and lastly,the ability to differentiate into various cell ***,two scenarios of an enhanced dataset based on a medical perspective were created in the development phase to produce varying levels of ***,for real-timemonitoring ofCOVID-19 patients with different emergency levels(i.e.,mild,moderate,severe,and critical),an automated triage algorithmbased on a formal medical guideline is proposed,taking into account the improvement and deterioration procedures fromone level to the *** this strategy,Einstein aggregation information under the Pythagorean probabilistic hesitant fuzzy environment(PyPHFE)is *** operations on PyPHFE such as Einstein sum,product,scalar multiplication,and their properties are ***,several Pythagorean probabilistic hesitant fuzzy Einstein aggregation operators,namely the Pythagorean probabilistic hesitant fuzzy weighted average(PyPHFWA)operator,Pythagorean probabilistic hesitant fuzzy Einstein weighted geometric(PyPHFEWG)operator,Pythagorean probabilistic hesitant fuzzy Einstein ordered weighted average(PyPHFEOWA)operator,Pythagorean probabilistic hesitant fuzzy Einstein ordered weighted geometric(PyPHFEOWG)operator,Pythagorean probabilistic hesitant fuzzy Einstein hybrid average(PyPHFEHA)operator and Pythagorean probabilistic hesitant fuzzy Einstein hybrid geometric(PyPHFEHG)operator are *** the above-mentioned operators are helpful in design the algorithm to tackle uncertainty in decision making *** last,a numerical case study of decision making is presented to demonstrate the applicability and validity of the proposed ***,the comparison of the existing and the proposed technique is

关键词： Pythagorean probabilistic hesitant fuzzy set aggregation operators decision making

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Prevention and treatment of hypoxia-induced colorectal cancer damage in albino Wister rats

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Life Research 2024年第1期7卷 16-23页

作者： Ishrat Jahan Manju Pandey Shalini Pal bushra Jabi Mohd Yaqub Khan Gaurav Kaithwas Department of Pharmaceutical Sciences Babasaheb Bhimrao Ambedkar UniversityLucknow 226025 India Institute of Pharmacy Shri Ramswaroop Memorial UniversityBarabanki 225003India School of Pharmaceutical Education&Research Jamia HamdardNew Delhi 110062India Institute of Pharmacy Azad Institute of Pharmacy and ResearchLucknow 226008India

Background:In the early metastasis of colon cancer,cancer cells detach,migrate,and infiltrate surrounding tissues,including lymph vessels and blood *** heterogeneity arises from both tumor cells and distinct *** of blood vessels,creates hypoxic regions within the tumors,fostering cancer stem cell-like properties due to reduced oxygen and nutrient *** hypoxia,tumor cells shift to a glycolytic pathway,producing more lactic acid that acidifies the microenvironment and leads to unstable heart rate variability(HRV)factors,weight disparity,and a higher incidence of aberrant crypt foci(ACF).These hypoxic-induced parameters promote cancer cell invasion,increase radiation resistance,and facilitate cancer cell ***:In this study,we induced hypoxia-preneoplastic colon damage in albino Wister rats by administrating 1,2-dimethyl hydrazine(DMH).After successfully creating a hypoxic environment in albino Wister rats,resulting in preneoplastic colon damage,we randomly allocated Wistar albino rats into seven groups,each containing 8 animals,and conducted a 6-week *** 1-Normal control(administered 1 mM EDTA+saline,2 ml/kg/day,p.o.);group 2-Toxic control(administered DMH,30 mg/kg/week,s.c.);group 3-Standard treatment(DMH,30 mg/kg/week,*** 6 weeks),followed by 5-fluorouracil and Leucovorin(25 mg/kg each on 1^(st),3^(rd),7^(th),and 10^(th) days,*** 6 weeks administration of DMH);group 4-Low dose of P1(DMH,30 mg/kg/week,s.c.+P1,2 mg/kg,i.v.,weekly for 3 weeks);group 5-High dose P1(DMH,30 mg/kg/week,s.c.+P1,4 mg/kg,i.v.,weekly for 3 weeks),group 6-Low dose of P2(DMH,30 mg/kg/week,s.c.,+P2,2 mg/kg,i.v.,weekly for 3 weeks),group 7-High dose of P2(DMH,30 mg/kg/week,s.c.,+P2,4 mg/kg,*** for 3 weeks).Results:DMH-treated rats exhibited alterations in HRV factors,weight disparity,elevated gastric pH,increased total acidity,a higher incidence of ACF,and changes in antioxidant markers(TBARs,SOD,catalase,GSH).Bri

关键词： colon cancer 1,2,4-triazine derivatives oxidative stress hypoxia-induced colon carcinogenesis

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Effect of Cadmium Stress on the Growth,Physiology,Stress Markers,Antioxidants and Stomatal Behaviour of Two Genotypes of Chickpea(Cicer arietinum L.)

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Phyton-International Journal of Experimental Botany 2022年第9期91卷 1987-2004页

作者： Sayyada bushra Shahla Faizan Zeenat Mushtaq Alisha Hussain Khalid Rehman Hakeem Environmental Physiology Laboratory Department of BotanyAligarh Muslim UniversityAligarh202002India Department of Biological Sciences Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia Princess Dr NajlaBint Saud Al-Saud Center for Excellence Research in Biotechnology King Abdulaziz UniversityJeddah21589Saudi Arabia Department of Public Health Daffodil International UniversityDhaka1341Bangladesh

The current work was performed to know the impact of cadmium(Cd)toxicity on two different genotypes of chickpea(Cicer arietinum L.)namely Pusa-BG1053 and *** was applied in the form of cadmium chloride(CdCl_(2)),in varying levels,0,25,50,75,and 100 mg Cd kg^(-1)*** growth as well as physiological attributes were decreased with increasing concentration of *** genotypes showed the maximum and significant reduction at the maximum dose of Cd(100 mg Cd kg^(-1)soil).Results of this study proved that the genotype Pusa-BG1053 was more tolerant and showed a lower decline in growth,photosynthetic and biochemical attributes than *** later genotype showed the maximum reduction and was sensitive to Cd stress.A better activity of antioxidants protected Pusa-BG1053 from Cd toxicity;on the other hand,the activity of antioxidants was much lower in *** electron microscopic studies showed differences in both *** Pusa-BG1053,stomatal quantity was higher and stomata were slightly close to the characteristic guard *** Pusa-BG372 stomata were lower,slightly open and with highly affected guard *** cell mortality due to the harsh effects of Cd appeared to be more evident in Pusa-BG372 than Pusa-BG1053,which was visible under a confocal *** a result of this study,Pusa-BG1053 was a more tolerant genotype,and exhibited a minimum reduction in terms of all studied parameters than Pusa-BG372,which was a sensitive genotype to Cd toxicity.

关键词： Antioxidants cadmium chickpea genotypes oxidative stress

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