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High Altitude: A Possible Reason for Postoperative Bleeding after Coronary Artery Bypass Graft Operations

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World Journal of Cardiovascular Diseases 2015年第4期5卷 79-86页

作者： burcin Abud Süreyya Talay Kemal Karaarslan Soysal Turhan Celal Selcuk ünal Emre Kubat Cardiovascular Surgery Department Izmir Tepecik Research and Teaching Hospital Izmir Turkey Cardiovascular Surgery Department Canakkale State Hospital Izmir Turkey Cardiovascular Surgery Department Karabük University Research and Teaching Hospital Karabük Turkey

Background: This study evaluated the possible hypothesis that high altitude might be a reason of excessive postoperative drainage after coronary artery bypass graft operations (CABG). Methods: 212 patients were operated by the same surgical team and included to the study with retrospective data scan on postoperative bleeding after elective CABG with cardiopulmonary bypass (CPB). Study was derived from two different altitude centers: Group A patients (n = 107) from the center at an altitude of 1985 meters and Group B patients (n = 105) from the center in approximately sea level with 150 meters altitude. Multiple preoperative, intraoperative and postoperative characteristics with postoperative bleeding amounts were reviewed and calculated to determine a result through the aim of our study. Results: Preoperative, operative and intraoperative parameters for both groups were almost identical. Statistically significance occurred on intensive care unit treatment period, total hospitalization days, usage of erythrocyte suspension and fresh frozen plasma among postoperative periods on behalf of Group B. Parameters such as CABG numbers, Cross clamp and CPB time were not significant. High altitude patients were considered to be with a higher outcome in preoperative hematocrit (Htc) levels which did not occur in the study group. Htc levels presented a slight elevation for Group A as in the preoperative values but a statistically significance was not calculated. Postoperative bleeding volumes and calculated mean values were statistically significantly different among both groups in days of 1, 2 and 3. Reoperations for hemorrhage occurred in 9 cases (8.4%) in Group A and 4 cases (3.8%) in Group B. Conclusions: We want to attract attention to the relation between high altitude and postoperative bleeding after CABG surgery. But yet uncertain and unidentified physiological and biochemical conditions can be a reason as an uncontrollable perioperative factor in this patients. Operatio

关键词： High Altitude Postoperative Bleeding Elective Coronary Artery Bypass Graft Surgery

Comparison of the Modified Eversion Carotid Endarterectomy Technique with the Conventional Carotid Endarterectomy Technique: Early Results

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World Journal of Cardiovascular Diseases 2015年第4期5卷 87-94页

作者： burcin Abud Süreyya Talay Celal Selcuk ünal Emre Kubat Kemal Karaarslan Soysal Turhan Cardiovascular Surgery Department Izmir Tepecik Research and Teaching Hospital Izmir Turkey Cardiovascular Surgery Department Canakkale State Hospital Izmir Turkey Cardiovascular Surgery Department Karabük University Research and Teaching Hospital Karabük Turkey

Objectives: In this study, we aimed to compare early results of the modified eversion carotid endarterectomy technique with the conventional carotid endarterectomy technique. The modified eversion carotid endarterectomy technique consisted of a longitudinal arteriotomy that was begun from the common carotid artery proximally to the origin of external carotid artery. We also avoided applying a carotid shunt during surgery in both techniques. Methods: Each patient was evaluated for coronary artery stenosis and valve replacement indications. Diagnosis of significant coronary artery stenosis or valve disease directed us to a combination of CEA and cardiac surgery (CABG/Valvular). We generally had a tendency to perform these two surgical procedures separately. Patients which had surgery for both at the same session were excluded in this study. As a result, our study included 120 patients and 137 carotid interventions. We performed the modified eversion carotid endarterectomy technique in 61 patients (68 carotid interventions) (Group A) and the conventional CEA technique in 59 patients (69 carotid interventions) (Group B). At follow-up, the patients were evaluated by physical examination and color Doppler USG. Results: There was no significant difference between the groups in terms of demographic data. Statistically significant difference was observed in one operative parameter between Group A and Group B;patchplasty requirements during surgery (12 carotid interventions in group B and 4 carotid interventions in group A, p = 0.036). We recorded temporary tongue deviation in five cases, facial asymmetry in eight cases, hoarseness in four cases, neurocognitive impairment in three cases and transient neurologic in two cases with no significant difference between the groups. There was in one case of permanent neurologic deficit (1 in group B). There were two postoperative deaths (1 in group A and 1 in group B). The death in group A occurred because of subarachnoid haemorrhage

关键词： Conventional Carotid Endarterectomy Modified Eversion Carotid Endarterectomy Technique Avoiding Carotid Shunt

An Optimum Dose of Olive Leaf Extract Improves Insulin Receptor Substrate-1,Tyrosine Kinase,and Glucose Transporters,While High Doses Have Genotoxic and Apoptotic Effects

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American Journal of Plant Sciences 2019年第11期10卷 1933-1948页

作者： Abdurrahim Kocyigit burcin Kasap Eray Metin Guler Humeyra Nur Kaleli Mustafa Kesmen Murat Dikilitas Ersin Karatas Department of Medical Biochemistry Medical FacultyBezmialem Vakif UniversityIstanbulTurkey Traditional and Complementary Medicine Advanced Research and Application Center(GETAMER) Bezmialem Vakif UniversityIstanbulTurkey Department of Molecular Biology Geneticsand BioengineeringSabanci UniversityIstanbulTurkey Republic of Turkey Ministry of Agriculture and Forestry Istanbul Pendik Veterinary Control Institute IstanbulTurkey Department of Plant Protection Agricultural FacultyHarran UniversityS.UrfaTurkey 6Department of Molecular Biology and GeneticsGebze Technical UniversityKocaeliTurkey

Type 2 diabetes is the most common type of diabetes. Conventionally many drugs are used for the treatment of diabetes such as biguanides, sulfonylureas, meglitinides, etc. But the desired effective treatment is still not to be achieved. So researches are going on for the development of effective alternative therapy against diabetes. Olive leaves are traditionally used in the treatment of the disease. However, studies on its mechanism of action are not yet enough. The aim of this study was to investigate whether olive leaf extract (OLE) improves insulin receptor substrate-1 (IRS-1), tyrosine kinase (TK), GLUT-2, and GLUT-4. Oleuropein levels were analyzed from OLE obtained by using four different solvents, and the highest content of methanol extract was selected for the study. Different concentrations of OLE (2.5 to 320 μg/mL) were incubated with hepatocellular carcinoma (HepG2) cells for 24 hours. After incubation, cell viability was assessed based on luminometric ATP cell viability assay kit. Intracellular reactive oxygen species (ROS) generating level was detected using 2,7dichlorodihydrofluorescein-diacetate (H2DCF-DA) fluorescent probes. Apoptosis was evaluated by acridine orange/ethidium bromide double staining method. Genotoxicity was evaluated by alkaline single cell gel electrophoresis assay (Comet Assay). Protein expression levels of IRS-1, TK, GLUT-2, and GLUT-4 were analyzed by western blotting technique from the obtained cell lysates. Although an optimum doses of OLE (10 μg/mL) maximally increased cell proliferation, decreased ROS generation improved IRS-1, TK, GLUT-2, and GLUT-4 protein expression levels (about fivefold), higher doses (10 to 320 μg/mL) markedly decreased the cell viability, increased DNA damage, apoptosis and ROS generation in a concentration-dependent manner. OLE can be used in the treatment of type 2 diabetes. However, in order to find the most effective and non-toxic concentration, dose optimization is required.

关键词： Phytotherapy Diabetes Mellitus Olive Leaf Extract Glucose Transporters Insulin Receptors

Outcomes following liver transplantation in intensive care unit patients

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World Journal of Hepatology 2013年第1期5卷 26-32页

作者： Lena Sibulesky Michael G Heckman C burcin Taner Juan M Canabal Nancy N Diehl Dana K Perry Darren L Willingham Surakit Pungpapong Barry G Rosser David J Kramer Justin H Nguyen Department of Transplantation Mayo ClinicJacksonvilleFL 32225United States Biostatistics Unit Mayo ClinicJacksonvilleFL 32225United States Departments of Transplantation and Critical Care Medicine Mayo ClinicJacksonvilleFL 32225United States Department of Critical Care Medicine and Internal Medicine Aurora Health CareMilwaukeeWI 53204United States

AIM:To determine feasibility of liver transplantation in patients from the intensive care unit (ICU) by estimating graft and patient ***:This single center retrospective study included 39 patients who had their first liver transplant directly from the intensive care unit and 927 non-ICU patients who were transplanted from hospital ward or home between January 2005 and December ***:In comparison to non-ICU patients,ICU patients had a higher model for end-stage liver disease (MELD) at transplant (median:37 vs 20,P < 0.001).Fourteen out of 39 patients (36%) required vasopressor support immediately prior to liver transplantation (LT) with 6 patients (15%) requiring both vasopressin and *** ICU patients (41%) were ventilator dependent immediately prior to LT with 9 patients undergoing percutaneous tracheostomy prior to ***-five ICU patients (64%) required dialysis *** 1,3 and 5 years after LT,graft survival was 76%,68% and 62% in ICU patients vs 90%,81% and 75% in non-ICU *** survival at 1,3 and 5 years after LT was 78%,70% and 65% in ICU patients vs 94%,85% and 79% in non-ICU *** formally comparing graft survival and patient survival between ICU and nonICU patients using Cox proportional hazards regression models,both graft survival [relative risk (RR):1.94,95%CI:1.09-3.48,P=0.026] and patient survival (RR:2.32,95%CI:1.26-4.27,P=0.007) were lower in ICU patients vs non-ICU patients in single variable *** findings were consistent in multivariable *** not statistically significant,graft survival was worse in both patients with cryptogenic cirrhosis (RR:3.29,P=0.056) and patients who received donor after cardiac death (DCD) grafts (RR:3.38,P=0.060).These findings reached statistical significance when considering patient survival,which was worse for patients with cryptogenic cirrhosis (RR:3.97,P=0.031) and patients who were transplanted with DCD livers (

关键词： Donor pool Donor outcomes Onor after cardiac death grafts Liver graft survival Patient survival

The Performance of Abnormal Digital Rectal Examination for the Detection of Prostate Cancer at Stratified Prostate Specific Antigen Levels

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Open Journal of Urology 2011年第4期1卷 67-71页

作者： Guven Aslan Bora Irer Sertac Cimen Yigit Goktay Ilhan Celebi burcin Tuna Kutsal Yorukoglu 不详

Objective: Our aim was to determine the performance of abnormal digital rectal examination (DRE) in prostate cancer detection at different PSA levels. Methods: A total of 1612 patients having abnormal DRE and/or elevated PSA whom underwent TRUS guided prostate biopsies were included in the study. Any palpable induration or nodularity was accepted as abnormal DRE findings. Pathologic features of biopsy specimens were compared within groups according to DRE findings and serum PSA level groups of 2.5 - 4, 4 - 10 and >10 ng/ml. Results: Abnormal DRE was detected in 339 patients;of whom 48.7% were determined to have cancer. Cancer detection rates of patients having abnormal DRE were found to be 20%, 31.5% and 68% at PSA ranges 2.5-4, 4-10 and > 10 ng/ml, respectively. Significantly higher grade cancers were detected by abnormal DRE at each PSA group. The positive and negative predictive values of abnormal DRE according to groups of PSA 2.5 - 4, 4 - 10 and > 10 ng/ml were 20% and 84.1%, 31.5% and 80.6%, 68% and 66.6%, respectively. Conclusion: At each PSA group DRE resulted in detecting significantly more cancers with Gleason score > 7. Although predictive value of abnormal DRE diminishes with concomitantly decreasing PSA levels, significance of DRE in the diagnosis of prostate cancer cannot be ignored.

关键词： Prostate Prostate Cancer Prostate Specific Antigen Digital Rectal Examination Predictive Value

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2020年建筑与工程领域科技趋势预测

软件和集成电路 2020年第1期 28-29页

作者： Frank Weiss burcin Kaplanoglu 甲骨文

2020年伊始,甲骨文针对新兴科技对建筑与工程行业的影响预测了四大趋势。四大趋势分别如下所示:数字孪生:BIM技术将在数据的基础上持续演进,而不只是建筑设计。为了进一步促进BIM技术的发展,最为基本的因素是建立标准,这主要体现在鼓励... 详细信息

2020年伊始,甲骨文针对新兴科技对建筑与工程行业的影响预测了四大趋势。四大趋势分别如下所示:数字孪生:BIM技术将在数据的基础上持续演进,而不只是建筑设计。为了进一步促进BIM技术的发展,最为基本的因素是建立标准,这主要体现在鼓励整个项目供应链对建筑信息建模进行更广泛的应用,从而有效提高生产力和创造力。这样的技术演进只有当信息向项目的所有相关方开放,不再由单一实体掌控时,才有可能真正实现。其中的关键在于数据,而不只是建筑设计。

关键词：建筑设计建筑信息建模新兴科技提高生产力技术演进影响预测数字孪生趋势预测

PLATELET AGGREGATION IN HUMANS AND NONHUMAN PRIMATES:RELEVANCE TO XENOTRANSPLANTATION

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PLATELET AGGREGATION IN HUMANS AND NONHUMAN PRIMATES:RELEVAN...

Short-Term Outcomes of Two Surgical Techniques for the Treatment of Coarctation of the Aorta in Infants: Subclavian Flap Repair and Resection with Extended End-to-End Anastomosis Technique

2012中国器官移植大会

作者： Hayato Iwase burcin Ekser Eefje Dons David K.C.Cooper Mohamed Ezzelarab Thomas E Starzl Transplantation Institute University of PittsburghPittsburghPAUSA Department of Surgery Transplantation and Advanced TechologiesVascular Surgery and Organ Transplant UnitUniversity Hospital of CataniaCataniaItaly

【Introduction】Platelet activation/aggregation plays a key role in the dysregulation of coagulation and the development of thrombotic microangiopathy in nonhuman primate recipients of pig *** a preliminary to the study of anti-platelet therapy in vitro and in vivo,the present study aimed to compare platelet aggregation in whole blood from humans,baboons,and cynomolgus monkeys.【Methods】Using ’Chrono-log’ technology(two-sample four-channel Chrono-log Whole Blood Aggregometer),we studied

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World Journal of Cardiovascular Diseases 2015年第1期5卷 1-8页

作者： Mustafa Karacelik¹ burcin Abud Ugur Karagoz¹ Pelin Ozturk¹ Gokhan Albayrak Onur Doyurgan Koray Aykut Mehmet Guzeloglu Eyup Hazan Osman Nejat Sarıosmanoglu Department of Pediatric Cardiac Surgery Behcet Uz Children’s HospitalIzmirTurkey Department of Cardiovascular Surgery Izmir Tepecik Research and Training HospitalIzmirTurkey Department of Cardiovascular Surgery Izmir University School of MedicineIzmirTurkey

Background: The aims of the study were to analyze the importance of two different surgical procedures, and to determine outcomes for neonates with coarctation of the aorta in two newly established centers. Methods: Outcomes of two different surgical repairs for coarctation of the aorta in 43 infants were evaluated retrospectively. The study was designed as a nonrandomized, cross-sectional study. The subclavian flap repair was applied to 22 patients (51%) and resection with extended end-to-end anastomosis technique to 21 patients (49%). After all operative survivors were followed up with a mean follow-up of 1.8 ± 0.8 years, data analyzed with t-test and the p value < 0.05 were considered statistically significant. Results: The overall mortality rate was 4.6%. Forty mmHg gradients were determined in a patient from Resection Group postoperatively in the fifteenth month. After the balloon angioplasty, the gradient decreased to 25 mmHg. The presence of ventricular septal defect (p = 0.094) was the only significant predictor of adverse short-term outcome among the associated cardiac defects analyzed. The first-year survival rate was 100% in both groups in isolated coarctation (p = 0.965), however;such rate was found as 100% and 93.25% in Waldhausen Group and Resection Group, respectively in complex coarctation (p = 0.294). Conclusions: Both the subclavian flap repair and resection with extended end-to-end anastomosis for coarctation of the aorta in infants provide excellent short-term outcomes with lower recurrence rates requiring surgery or angioplasty.

关键词： Congenital Heart Disease Coarctation of Aorta Infant

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《建筑能效实时活动识别》

建筑节能(中英文) 2018年第2期 144-144页

作者： Simin Ahmadi-Karvigh Ali Ghahramani burcin Becerik-Gerber Lucio Soibelman

居住建筑和商业建筑的电耗过半用于采光和电器设备。这些系统的耗电直接与使用者行为活动有关。通过识别活动与确认相关可能的节能要点,可研发更多的有效策略从而设计更好的建筑和自动化系统。根据这一目的,采用归纳推理方法,引入一个... 详细信息

居住建筑和商业建筑的电耗过半用于采光和电器设备。这些系统的耗电直接与使用者行为活动有关。通过识别活动与确认相关可能的节能要点,可研发更多的有效策略从而设计更好的建筑和自动化系统。根据这一目的,采用归纳推理方法,引入一个框架来检测居民活动和潜在能耗浪费问题,以及可以实时转换到非高峰时段的高峰时段耗能情况。框架由三个子算法组成,用于行为检测、活动识别和浪费预估。作为实时输入,动作检测算法从传感系统接收数据,该传感系统由插头式计量器和传感器组成,以通过无监督聚类模型检测发生的动作(例如打开电器)。被检测的活动随后通过对构建本体的语义推理用于了活动识别算法。基于公认的活动,浪费估算算法可识别潜在浪费行为,并估算出节能潜力。为了评估本文设计的框架的性能,对1个5人办公室和2个单人住房进行了为期两周的实验研究。实验之后,采用了用于动作和活动的地面实况标签,评估了动作检测和动作识别算法的性能。采用了主成分分析法的高斯混合模型,对动作检测的平均准确率达97.6%,对活动识别的平均准确率为96.7%。此外,平均电器或照明系统消费的35.5%的电被认为是潜在的节约项。

关键词：建筑节能楼宇自动化活动识别家电控制废物检测