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Severe Botulism after Intragastric Botulinum Toxin-A Injection: A Case Series

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World Journal of Neuroscience 2024年第2期14卷 73-83页

作者： Sadiye Gumusyayla gonul Vural Department of Neurology Faculty of Medicine Ankara Yildirim Beyazit University AnkaraTürkiye Department of Neurology Ankara City Hospital Ankara Türkiye

Intragastric botulismus toxin-A (BoNT-A) is one of the new approaches in the treatment of obesity. We aimed to contribute to the literature by presenting the clinical features, laboratory findings and treatment responses of iatrogenic botulism cases due to intragastric BoNT-A administered in our clinic. All detailed medical information was obtained by accessing the medical records of the patients who were hospitalized and followed up and treated between September 2022 and December 2022, and the diagnosis of A.05.1 Botulism was entered according to ICD-10, and whose clinical findings were compatible with botulism disease and who underwent intragastric BoNT-A application beforehand. These records were obtained by examining this information. 10 patients who developed botulism after intragastric BoNT-A application between 01/09/2022 and 28/02/2023 were followed up in our clinic. All of the patients were women. The mean age was 35. The mean hospital stay was 9 days. Only 1 of our cases required intensive care. Good response to treatment was accepted as a complete or near-complete improvement in the clinical findings of the patients and all of them had a good response to treatment. Intragastric BoNT-A administration is a procedure that requires careful indication with a profit/loss calculation considering the potential side effects. In addition, attention should be paid to dilution rates and dose amounts.

关键词： Intragastric Botulismus Toxin-A Botulism Single Fiber Electromyography

Median Nerve Somatosensory Evoked Potentials in Patients with Chiari Malformation

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World Journal of Neuroscience 2024年第1期14卷 24-32页

作者： Mustafa Harun Sahin gonul Vural Serdar Barakli Sadiye Gumusyayla Department of Neurology Ankara City Hospital Ankara Türkiye Department of Neurology Sinop Ataturk State Hospital Sinop Türkiye Department of Neurology Faculty of Medicine Ankara Yildirim Beyazit University Ankara Türkiye Department of Neurology Sungurlu State Hospital Corum Türkiye

Abnormal SEP reflects dysfunction of the medial lemniscus and posterior cervical cord. These structures are likely to be affected in Chiari malformation. Therefore, SEP abnormalities may provide valuable information in patients with CM. However, the consistency of SEP abnormality or normality with the damage is a matter of research. Knowing whether median nerve somatosensory evoked potential (SEP) is useful in revealing subclinical damage in patients with Chiari malformation is important in the treatment and follow-up plan of the disease. The aim of this study was to investigate the relationship between median nerve SEP values and the severity of cerebellar ectopia in patients with Chiari type 1 malformation. Median nerve SEP values were obtained from 30 healthy individuals and 146 individuals with Chiari malformation. The cerebellar ectopia degree and McRae line length were measured. SEP values were not significantly different between groups. The McRae line was found to be significantly shorter in the control group than in the Chiari malformation group (p = 0.031). There was no correlation between the degree of cerebellar ectopia and the length of the McRae line (r = 0.002, p = 0.979). Neither cerebellar ectopy degree nor McRae line length had a relationship with SEP values (r = -0.153, p = 0.066;r = -0.056, p = 0.500, respectively). There was no difference in cerebellar ectopy degree or SEP values between the groups with cerebellar ectopy with and without a syrinx (p = 0.899;p = 0.080, respectively). Likewise, McRae line length was not found to be related to the presence of a syrinx (p = 0.139). Median nerve SEP examination was not beneficial for diagnosing asymptomatic-oligosymptomatic Chiari malformation as a subclinical injury, whether accompanied by syringomyelia or not.

关键词： Chiari Malformation Cerebellar Ectopy Somatosensory Evoked Potential

Foreign direct investment and economic policy uncertainty in China

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Economic and Political Studies 2022年第3期10卷 279-289页

作者： Lidan Zhang gonul Colak Department of Finance and Economics Hanken School of EconomicsHelsinkiFinland Department of Accounting and Finance Business SchoolUniversity of SussexBrightonUK

The trend of foreign direct investment(FDI)in China has switched from inflow to outflow following the rapid economic growth dur-ing the past several *** by government policies,in recent years China’s firms have actively sought overseas invest-ment *** paper examines the relationship between economic policy uncertainty(EPU)and cross-border cap-ital flow decisions for listed firms in *** findings demon-strate that EPU originating from China does not seem to dissuade FDI inflow into China,but it does curtail FDI outflow from the *** appears that government policies and the uncertainty the policies bring are deterministic for FDI.

关键词： Foreign direct investment(FDI) political uncertainty economic policy uncertainty(EPU) China

Effects of COVID-19 fear and anxiety on attitudes towards complementary and alternative medicine use in women with gynecological cancer during the COVID-19 pandemic

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Journal of Integrative Medicine 2023年第4期21卷 377-384页

作者： Fatma Uslu-Sahan Ilknur Yesilcınar gonul Kurt Elif Hancer Gulten Guvenc Department of Obstetrics and Gynecologic Nursing Faculty of NursingHacettepe UniversityAnkara 06100Turkey Department of Obstetrics and Gynecologic Nursing Faculty of Health SciencesIzmir Katip Celebi UniversityIzmir 35620Turkey Department of Obstetrics and Gynecology Nursing Gulhane Faculty of NursingUniversity of Health SciencesAnkara 06018Turkey Department of Obstetrics and Gynecology Gynecologic Oncology ClinicHacettepe University Faculty of MedicineAnkara 06800Turkey

Objective:Patients with gynecological cancer commonly use complementary and alternative medicine(CAM)methods to cope with the ***,despite the existence of treatment strategies,the effect of fear and anxiety caused by coronavirus disease 2019(COVID-19)pandemic on attitudes about CAM use is *** study was carried out to investigate the effect of fear and anxiety experienced by patients with gynecological cancer during the COVID-19 pandemic on their attitudes towards the use of ***:This is a cross-sectional and descriptive study that included 177 women with gynecological cancer;participants were recruited from a social networking site for cancer patients in Turkey between June and December *** were collected using an online survey that included the Personal Information Form,the Fear of COVID-19 Scale,the Coronavirus Anxiety Scale,and the Attitude Towards Holistic Complementary and Alternative Medicine *** statistics,t-test,Pearson’s correlation test,and simple linear and multiple regression analyses were performed to analyze the ***:During the pandemic,55.4%of the participants reported using CAM methods,but only 22.6%were using CAM before the *** participants who used CAM during the pandemic also scored higher on the fear of COVID-19 and coronavirus anxiety scales(20.69±5.37 and 13.09±6.29,respectively)compared to the participants who did not use CAM(9.29±2.72 and 6.35±2.06,respectively).Fear of COVID-19 accounted for 52%of the CAM attitude score,while coronavirus anxiety accounted for 15%of the CAM attitude *** of COVID-19 and coronavirus anxiety together accounted for 53%of CAM ***:Gynecological cancer patients with high levels of COVID-19-related anxiety and fear during the pandemic used CAM *** that the psychological effects of the pandemic will continue in the coming years,CAM use should be evaluated as a coping strategy,especially due to the COVID-19-related anxiety an

关键词： Complementary and alternative medicine Anxiety COVID-19 Fear Gynecological cancer

Exact Treatment of l≠0 States

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Chinese Physics Letters 2004年第9期21卷 1685-1688页

作者： B.gonul DepartmentofEngineeringPhysics FacultyofEngineeringUniversityofGaziantep27310Gaziantep-Turkiye

Using the basic ingredient of supersymmetry, we present a general procedure for the treatment of quantum states having nonzero angular momenta.

关键词： Chpher(0) Nonzero Angle Countries (nations) QUANTUM STATES Angular momentum supersymmetry Exact

Optical properties and Judd-Ofelt analysis of Nd2O3 nanocrystals embedded in polymethyl methacrylate

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Journal of Rare Earths 2018年第2期36卷 170-178页

作者： Sevcan Tabanli Gokhan Bilir gonul Eryurek Istanbul Technical University Faculty of Science and Letters Department of Physics Engineering 34469 Istanbul Turkey Kafkas University Faculty of Science and Letters Department of Physics 36100 Kctrs Turkey

PMMA matrices were doped with nano-crystalline neodymium oxides synthesized by thermal decomposition process. X-ray diffraction and high-resolution transmission electron microscopy measurements were carried out to investigate the structure, phase, and the morphology of the Nd_2O_3 nanocrystals and those embedded in the PMMA matrix. The average grain sizes were estimated 35 ± 6 nm and 46 ± 4 nm for non-annealed and annealed Nd_2O_3 particles, respectively. The grain size distributions（GSD） were calculated from the diffraction peaks of the annealed and non-annealed Nd_2O_3 powders and doped PMMA samples. The mass density, refractive index. UV-Visible absorption spectra were measured and the data were analyzed using the Judd-Ofelt approach to determine the oscillator strengths, the spontaneous emission probabilities and the branching ratios as a function of the nano-crystalline Nd_2O_3 content in the range of 0.1 wt.%-20 wt.% of MMA. Luminescence spectra upon 808 nm diode laser excitation were carried out in the wavelength range of 850-1550 nm at room temperature. The photoluminescence study has shown that the reasonably sharp emission peaks were observed upon heat treatment at 800 ℃ for 24 h for all concentrations of Nd_2O_3 nanopowders in PMMA. The infrared laser transition of Nd^（3＋） ions at about 1.06 μm due to the ~4F_（3/2）→~4I_（11/2） transition was analyzed and discussed in Nd_2O_3 system for their possible applications in the photonic technology.

关键词： Polymer-matrix composites(PMCs) Polymethyl methacrylate(PMMA) Nd2O3 nanocrystal Judd-Ofelt parameters Laser spectroscopy rare earths

Apoptosis in the iris and trabecular meshwork of medically treated and untreated primary open angle glaucoma patients

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 827-830页

作者： Zeynep Aktas Emine Esra Karaca Ipek Isik gonul Murat Hasanreisoglu Merih Onol Department of Ophthalmology Gazi University Medical Faculty Department of Pathology Gazi University Medical Faculty Department of Ophthalmology World Eye Hospital

AIM:To compare the trabecular meshwork(TM)and iris apoptosis of treated and untreated primary open angle glaucoma(POAG)***:Eight treatment-naive,newly diagnosed(group 1)and 11 medlcaiy treated(group 2)patients with POAG were included in the *** patient underwent a limbus-based *** TM and peripheral iris specimens were dissected out and were snap-frozen in liquid nitrogen and stored at-80t until they were *** in each group was assesed by TUNEL ***:The mean patient age was 60.6±5.8 years(53-68 years)vs 58.9±8.9 years(47-70 years)in group 1and group 2(P=0.859).The mean treatment time in group 2 was 22.2±7.3 months(12-34 months).Apoptotic indexes in TM and iris were significantly higher in POAG patients using medication(group 2)compared to treatment-naive POAG patients(group 1)(P=0.004,0.015;respectively).CONCLUSION:Long term administration of topical antiglaucoma medications causes additional toxic effects on TM.

关键词： glaucoma trabecular meshwork apoptosis

Effect of age on computed tomography findings:Specificity and sensitivity in coronavirus disease 2019 infection

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World Journal of Virology 2022年第5期11卷 331-340页

作者： Erdal Karavas Edhem Unver Sonay Aydın gonul Seven Yalcin Erdem Fatihoglu Ufuk Kuyrukluyildiz Yusuf Kemal Arslan Mustafa Yazici Department of Radiology Erzincan Binali Yildirim UniversityErzincan 24100Turkey Department of Pulmonology Erzincan Binali Yildirim UniversityErzincan 24100Turkey Department of Anesthesiology and Reanimation Erzincan Binali Yıldırım UniversityErzincan 24100Turkey Department of Biostatistics Erzincan Binali Yildirim UniversityErzincan 24100Turkey Department of Dermatology Erzincan Binali Yildirim UniversityErzincan 24100Turkey

BACKGROUND Coronavirus disease 2019(COVID-19)is a pandemic caused by the severe acute respiratory syndrome coronavirus in *** the real-time reverse transcription PCR test for viral nucleic acids is the gold standard for COVID-19 diagnosis,computed tomography(CT)has grown in *** To evaluate the sensitivity and specificity of thoracic CT findings of COVID-19 pneumonia according to age *** PCR and CT results from 411 patients were *** diagnosis of COVID-19 pneumonia was made by three ***,pericardial effusion,pleurisy,pleural thickening,pleural effusion,location features of the lesions,ground glass,consolidation,air bronchogram,vascular enlargement,bronchial dilatation,halo finding,inverted halo sign,nodularity,air bubble,subpleural band(curvilinear density),reticular density,crazy paving pattern,and fibrosis findings were *** patients were divided into nine groups by decades while calculating the sensitivity,specificity,and diagnostic efficacy for CT *** The mean age of the cases was 48.1±22.7 *** CT finding with the highest diagnostic power was ground *** enlargement and bronchial dilatation followed ground *** effusion was the finding with the lowest diagnostic *** incidence of lymphadenopathy,pleurisy,pleural thickening,peripheral localization,bilateral,ground glass,vascular enlargement,bronchial dilatation,subpleural band,reticular density,crazy paving appearance,and fibrosis all increased increase significantly with age in patients with positive real-time reverse transcription PCR *** There are few publications comparing sensitivity and specificity of thoracic CT findings according to *** cases of COVID-19 pneumonia,there is an increase in the variety and frequency of CT findings with age,and parallel to this the sensitivity and specificity of the findings ***-19 cases in the pediatric age group have fewer lung

关键词： Thoracic computerized tomography SARS-CoV-2 COVID-19 Diagnosis Pediatric age

Inflammatory bowel disease in Turkish children

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World Journal of Pediatrics 2015年第4期11卷 331-337页

作者： Murat Cakir Fatih Unal gonul Dinler Masallah Baran Hasan Ali Yuksekkaya Gokhan Tumgor Erhun Kasirga Ayhan Gazi Kalayci Sema Aydogdu Department of Pediatric Gastroenterology Hepatology and Nutrition Faculty of MedicineKaradeniz Technical UniversityTrabzonTurkey Dortcelik Children Hospital BursaTurkey 19 Mayis University SamsunTurkey Tepecik Education and Research Hospital IzmirTurkey Necmettin Erbakan University KonyaTurkey Cukurova University AdanaTurkey Celal Bayar University ManisaTurkey Ege University IzmirTurkey

Background:This study was undertaken to evaluate demographics,clinical manifestations,laboratoryfi ndings and outcomes of children with inflammatory bowel disease(IBD)in ***:We analyzed the medical records of 127 children diagnosed with IBD(under 18 years old)between January 2004 and January 2012 in 8 pediatric gastroenterology ***:Of the 127 patients,90(70.9%)suffered from ulcerative colitis(UC),29(22.8%)from Crohn's disease(CD),and 8(6.3%)from IBD *** mean age of the 127 patients was 11.6±4.1 years,and 11.8%of the patients were below 5 years *** the patients,49.6%were male,and males were more predominant in patients with CD than in those with UC(72.4%vs.42.2%,P=0.008;a male/female ratio of 2.62 in CD,P=0.0016).Approximately one fifth of the patients had extra-intestinal manifestations and 13.3%of the patients had associated *** manifestations and associated diseases were more common in early onset disease[P=0.017,odds ratio(OR)=4.02;P=0.03,OR=4.1].Of the patients,15%had normal laboratory parameters including anemia,high platelet count,hypoalbuminemia,hypoferritinemia,and high sedimentation *** under receiver operation characteristics was used to predict pancolitis in patients with *** values of C-reactive protein,sedimentation rate and pediatric ulcerative colitis activity were 0.61(P=0.06),0.66(P=0.01)and 0.76(P=0.0001),***(4.4%)patients with UC underwent colectomy,andfi nally two(1.5%,95%confidence interval:0-3.7%)patients died from primary disease or ***:IBD is an increasing clinical entity in *** of IBD are similar to those in other populations,but prospective multicenter studies are needed to analyze the true incidence of IBD in Turkish children.

关键词： associated diseases Crohn's disease infl ammatory bowel disease outcome ulcerative colitis