检索结果-南通市图书馆

Estimation of the density of neural,glial,and endothelial lineage cells in the adult mouse dentate gyrus

Neural Regeneration Research 2022年第6期17卷 1286-1292页

作者： Joshua D.Rieskamp Patricia Sarchet bryon m.smith Elizabeth D.Kirby Neuroscience Graduate Program The Ohio State UniversityColumbusOHUSA Department of Psychology The Ohio State UniversityColumbusOHUSA Department of Neuroscience The Ohio State UniversityColumbusOHUSA Chronic Brain Injury Program The Ohio State UniversityColumbusOHUSA

The dentate gyrus subregion of the mammalian hippocampus is an adult neural stem cell niche and site of lifelong *** regarding the role of adult-born neuron synaptic integration in hippocampal circuit function are framed by robust estimations of adultborn versus pre/perinatally-born neuron *** contrast,the non-neurogenic functions of adult neural stem cells and their immediate progeny,such as secretion of bioactive growth factors and expression of extracellular matrix-modifying proteins,lack similar framing due to few estimates of their number versus other prominent secretory ***,we apply immunohistochemical methods to estimate cell density of neural stem/progenitor cells versus other major classes of glial and endothelial cell types that are potentially secretory in the dentate gyrus of adult *** the cell types quantified,we found that GFAP^(+)SOX2^(+)stellate astrocytes were the most numerous,followed by CD31^(+)endothelia,GFAP-SOX2^(+)intermediate progenitors,Olig2^(+)oligodendrocytes,Iba1+microglia,and GFAP^(+)SOX2^(+)radial glia-like neural stem *** did not observe any significant sex differences in density of any cell ***,neural stem/progenitor cells were present at a similar density as several cell types known to have potent functional roles via their *** findings may be useful for refining hypotheses regarding the contributions of these cell types to regulating hippocampal function and their potential therapeutic *** experimental protocols were approved by the Ohio State University Institutional Animal Care and Use Committee(protocol#2016A00000068)on July 14,2016.

关键词： adult neurogenesis dentate gyrus endothelia glia hippocampus neural stem cell secretome stereology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thermodynamic analysis of metal segregation in dual phase high entropy ceramics

引用

Journal of materiomics 2024年第4期10卷 889-895页

作者： Steven m.smith II William G.Fahrenholtz Gregory E.Hilmas Stefano Curtarolo missouri University of Science and Technology Materials Science and Engineering DepartmentRollaMO65409USA Duke University Department of Mechanical Engineering and Materials ScienceDurhamNC27708USA Duke University Center of Autonomous Materials DesignDurhamNC27708USA

Equilibrium Gibbs'free energy calculations were used to determine metal segregation trends between boride and carbide solid solutions containing two metals that are relevant to dual phase high entropy *** model predicted that Ti had the strongest tendency to segregate to the boride phase followed by Zr,Nb,mo,V,Hf,and Ta,which matches experimental results of measured *** ratio of a metal in the carbide phase to the content of the same metal in the corresponding metal boride had a linear trend with the change in standard Gibbs'free energy of reaction for a metal carbide reacting with B_(4)C to produce its corresponding metal boride and *** proposed model was used to predict the changes in standard Gibbs'free energy for CrC→CrB_(2) to be−260 kJ and WC→WB_(2) to be 148 kJ,which indicates that Cr has the strongest segregation to the boride and W has the strongest segregation to the *** proposed model can be used to estimate the segregation of metals in dual phase high entropy boride-carbide ceramics of any boride/carbide ratio or metal content.

关键词： Dual phase High entropy ceramic Boride Carbide Thermodynamics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

microstructure segmentation with deep learning encoders pre-trained on a large microscopy dataset

引用

npj Computational materials 2022年第1期8卷 1905-1916页

作者： Joshua Stuckner Bryan Harder Timothy m.smith materials and Structures Division NASA Glenn Research Center21000 Brookpark RdClevelandOH44135USA

This study examined the improvement of microscopy segmentation intersection over union accuracy by transfer learning from a large dataset of microscopy images called *** neural network encoder architectures were trained on over 100,000 labeled microscopy images from 54 material *** pre-trained encoders were then embedded into multiple segmentation architectures including UNet and DeepLabV3+to evaluate segmentation performance on created benchmark microscopy *** to ImageNet pre-training,models pre-trained on microNet generalized better to out-of-distribution micrographs taken under different imaging and sample conditions and were more accurate with less training *** training with only a single Ni-superalloy image,pre-training on microNet produced a 72.2%reduction in relative intersection over union *** results suggest that transfer learning from large in-domain datasets generate models with learned feature representations that are more useful for downstream tasks and will likely improve any microscopy image analysis technique that can leverage pre-trained encoders.

关键词： union intersection image

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Strigolactones redefine plant hormones

引用

Science China(Life Sciences) 2016年第10期59卷 1083-1085页

作者： Lu Wang Steven m.smith School of Biological Sciences University of Tasmania Institute of Genetics and Developmental Biology Chinese Academy of sciences

A commonly accepted view of plant growth hormones is that their interaction with the cognate receptor protein is reversible, so that each hormone molecule can potentially interact multiple times with a receptor and so either amplify the hormone signal or maintain it over an extended period of time. The signal can be ＇cancelled＇ by degrading the hormone. Strigolactones present us with a potentially new paradigm. The receptor is a serine hydrolase-type protein which attacks the strigolactone resulting in covalent modi- fication of the receptor, while at the same time destroying the hormone. Strigolactone is apparently a one-use ＇dispos- able＇ hormone.

关键词：植物激素受体蛋白定义植物生长激素相互作用激素信号酸水解

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acetylation as a mechanism that regulates axonal regeneration

引用

Neural Regeneration Research 2015年第7期10卷 1034-1036页

作者： Shen Lin George m.smith Shriners Hospitals for Pediatric Research Center Department of Neuroscience Temple University

The capacity for adult axons to regenerate after injury is diminished compared with developing *** the case of central nervous system（CNS）axons,injury causes a total failure to *** failure is due to both the intrins... 详细信息

关键词： gene HDAC Acetylation as a mechanism that regulates axonal regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

History and evaluation of national-scale geochemical data sets for the United States

引用

Geoscience Frontiers 2013年第2期4卷 167-183页

作者： David B.smith Steven m.smith John D.Horton U.S.Geological Survey.Denver Federal Center MS 973.DenverCO 80225USA

Six national-scale,or near national-scale,geochemical data sets for soils or stream sediments exist for the United *** earliest of these,here termed the ＇Shacklette＇ data set,was generated by a U.S. Geological Survey（USGS） project conducted from 1961 to *** project used soil collected from a depth of about 20 cm as the sampling medium at 1323 sites throughout the conterminous *** National Uranium Resource Evaluation Hydrogeochemical and Stream Sediment Reconnaissance（NUREHSSR） Program of the *** of Energy was conducted from 1975 to 1984 and collected either stream sediments,lake sediments,or soils at more than 378,000 sites in both the conterminous *** *** sampled area represented about 65%of the *** Natural Resources Conservation Service（NRCS）,from 1978 to 1982,collected samples from multiple soil horizons at sites within the major crop-growing regions of the conterminous *** data set contains analyses of more than 3000 *** National Geochemical Survey,a USGS project conducted from 1997 to 2009,used a subset of the NURE-HSSR archival samples as its starting point and then collected primarily stream sediments, with occasional soils,in the parts of the *** covered by the NURE-HSSR *** data set contains chemical analyses for more than 70,000 *** USGS,in collaboration with the mexican Geological Survey and the Geological Survey of Canada,initiated soil sampling for the North American Soil Geochemical Landscapes Project in *** of three horizons or depths at more than 4800 sites in the *** completed in 2010,and chemical analyses are currently *** NRCS initiated a project in the 1990s to analyze the various soil horizons from selected pedons throughout the *** data set currently contains data from more than 1400 *** paper（1） discusses each data set in terms of its purpose,sample collection protocols,and analytical methods;and（2） evaluates each data set in terms

关键词： Geochemical mapping National-scale geochemical data Geochemical baselines United States

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Breeding high-yield superior quality hybrid super rice by rational design

引用

National Science Review 2016年第3期3卷 283-294页

作者： Qian Qian Longbiao Guo Steven m.smith Jiayang Li State Key Laboratory for Rice Biology China National Rice Research InstituteChinese Academy of Agricultural Sciences State Key Laboratory of Plant Genomics and National Center for Plant Gene Research(Beijing) Institute of Genetics and Developmental BiologyChinese Academy of Sciences Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences School of Biological Sciences University of Tasmania

The challenge of meeting the increasing demand for worldwide rice production has driven a sustained quest for advances in rice breeding for yield. Two breakthroughs that led to quantum leaps in productivity last century were the introduction of semidwarf varieties and of hybrid rice. Subsequent gains in yield have been incremental. The next major leap in rice breeding is now upon us through the application of rational design to create defined ideotypes. The exploitation of wide-cross compatibility and intersubspecific heterosis,combined with rapid genome sequencing and the molecular identification of genes for major yield and quality traits have now unlocked the potential for rational design.

关键词： Oryza sativa L super rice hybrids molecular breeding grain yield grain quality

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Reactive astrocyte scar and axon regeneration:suppressor or facilitator?

引用

Neural Regeneration Research 2016年第7期11卷 1050-1051页

作者： Yosuke Ohtake George m.smith Shuxin Li Shriners Hospitals Pediatric Research Center Department of Anatomy and Cell BiologyDepartment of NeuroscienceLewis Katz School of Medicine at Temple University

Several major factors are known to contribute to CNS axon regenerative failure after injury, including reduced intrinsic growth capacity of developed neurons and extrinsic factors mediating axon outgrowth. For the latter, a non-permissive environment around the lesion and the lack of sufficient neurotrophic support within the adult CNS play important roles （Silver et al., 2015）. In addition to generation of various inhibitory substrates by oligodendrocytes, fibrotic tissues, inflammatory cells and other cell types, reactive astrocytes surrounding lesions are thought to highly suppress regeneration of injured CNS axons （Silver and miller, 2004; Ohtake and Li, 2014）. A great number of studies suggest that reactive astrocytic scars form one of the major barriers preventing axon regeneration after CNS iniuries, including spinal cord injury （SCI）. However, reactive astrocytes were reported to provide a beneficial role by reducing infiltrating immunoreactive cells into adjacent domains, protecting bordering neural tissue from damage and generating numerous supportive extracellular matrix （ECm） components to promote cell survival and growth （Bush et al., 1999）. Previ- ous data showed that ablation of reactive astrocytes increased inflammation and secondary tissue damage, prevented blood- brain barrier formation and increased local neurite growth. Interestingly, a recent study by Anderson et al （2016） provides evidence that reactive astrocytes around the lesioned spinal cord support axon regeneration after SCI, rather than block regrowth （Anderson et al., 2016）.

关键词： astrocyte regeneration suppressor neurotrophic extrinsic latter intrinsic glial injured sensory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Automated SNP Genotype Clustering Algorithm to Improve Data Completeness in High-Throughput SNP Genotyping Datasets from Custom Arrays

引用

Genomics, Proteomics & Bioinformatics 2007年第3期5卷 256-259页

作者： Edward m.smith Jack Littrell michael Olivier Human and molecular Genetics Center Medical College of WisconsinMilwaukeeWI 53226USA.

High-throughput SNP genotyping platforms use automated genotype calling algorithms to assign genotypes. While these algorithms work efficiently for individual platforms, they are not compatible with other platforms, and have individual biases that result in missed genotype calls. Here we present data on the use of a second complementary SNP genotype clustering algorithm. The algorithm was originally designed for individual fluorescent SNP genotyping assays, and has been optimized to permit the clustering of large datasets generated from custom-designed Affymetrix SNP panels. In an analysis of data from a 3K array genotyped on 1,560 samples, the additional analysis increased the overall number of genotypes by over 45,000, significantly improving the completeness of the experimental data. This analysis suggests that the use of multiple genotype calling algorithms may be advisable in high-throughput SNP genotyping experiments. The software is written in Perl and is available from the corresponding author.

关键词： clustering SNP genotyping algorithm

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A stability evaluation method for deep-seated toppling in the upper Lancang river,Southwestern China

引用

Journal of Rock mechanics and Geotechnical Engineering 2024年第7期16卷 2388-2410页

作者： Yibing Ning Huiming Tang Jianbing Peng Yanjun Shen John V.smith Bocheng Zhang College of Geological Engineering and Geomatics Chang’an UniversityXi’an710054China Academy of Yellow River Sciences of Shaanxi Province Chang’an UniversityXi’an710054China Badong National Observation and Research Station of Geohazards China University of GeosciencesWuhan430074China School of Engineering RMIT UniversityMelbourne3001Australia

Deep-seated toppling in the upper reaches of the Lancang River,southwest China involves deformations exceeding 100 m in *** slope deformation is initiated by river downcutting and evolves distinctive characteristics with a depth of river *** this study,we propose a system for evaluating the stability of deep-seated toppled slopes in different evolutionary *** system contains identification criteria for each evolutionary stage and provides the corresponding stability evaluation *** on the mechanical and kinematic analysis of slope blocks,the specific stage of slope movement can be identified in the field through outcrop mapping,in situ tests,surface displacement monitoring,and adit and borehole *** stability evaluation methods are established based on the limiting equilibrium theory and the strain compatibility between the undisturbed zone and the toppled ***,several sample slopes in different evolution stages have been investigated to verify the applicability and accuracy of the proposed stability evaluation *** results indicate that intense tectonic activity and rapid river incision lead to a maximum principal stress ratio exceeding 10 near the slope surface,thus triggering widespread toppling deformations along the river *** considering the losses of joint cohesion during the further rotation process,the safety factor of the slope drops by 7%e28%.The self-stabilization of toppling deformation can be recognized by the layer symmetry configuration after the free rotation of the deflected *** toppled rock blocks mainly suffer sliding failures beyond the layer symmetry *** factor of safety of the K73 rockslide decreased from 1.17 to 0.87 by considering the development of the potential sliding surface and the toesaturated zone.

关键词： Stability evaluation Deep-seated toppling Evolutionary process Reservoir impoundment Rock slope

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：