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SVEAT score outperforms HEART score in patients admitted to a chest pain observation unit

World Journal of Cardiology 2022年第8期14卷 454-461页

作者： Daniel Antwi-Amoabeng Chanwit Roongsritong Moutaz Taha bryce david beutler Munadel Awad Ahmed Hanfy Jasmine Ghuman Nicholas T Manasewitsch Sahajpreet Singh Claire Quang Nageshwara Gullapalli Department of Internal Medicine Reno School of MedicineUniversity of NevadaRenoNV 89502United States Institute for Heart and Vascular Health Renown Regional Medical CenterRenoNV 89502United States

BACKGROUND Timely and accurate identification of subgroup at risk for major adverse cardiovascular events among patients presenting with acute chest pain remains a *** available risk stratification scores are ***,a new scoring system called the Symptoms,history of Vascular disease,Electrocardiography,Age,and Troponin(SVEAT)score has been shown to outperform the History,Electrocardiography,Age,Risk factors and Troponin(HEART)score,one of the most used risk scores in the United *** To assess the potential usefulness of the SVEAT score as a risk stratification tool by comparing its performance to HEART score in chest pain patients with low suspicion for acute coronary syndrome and admitted for overnight *** We retrospectively reviewed medical records of 330 consecutive patients admitted to our clinical decision unit for acute chest pain between January 1st to April 17th,*** avoid potential biases,investigators assigned to calculate the SVEAT,and HEART scores were blinded to the results of 30-d combined endpoint of death,acute myocardial infarction or confirmed coronary artery disease requiring revascularization or medical therapy[30-d major adverse cardiovascular event(MACE)].An area under receiving-operator characteristic curve(AUC)for each score was then calculated.C-statistic and logistic model were used to compare RESULTS A 30-d MACE was observed in 11 patients(3.33%of the subjects).The AUC of SVEAT score(0.8876,95%CI:0.82-0.96)was significantly higher than the AUC of HEART score(0.7962,95%CI:0.71-0.88),P=*** logistic model,SVEAT score with cut-off of 4 or less significantly predicts 30-d MACE(odd ratio 1.52,95%CI:1.19-1.95,P=0.001)but not the HEART score(odd ratio 1.29,95%CI:0.78-2.14,P=0.32).CONCLUSION The SVEAT score is superior to the HEART score as a risk stratification tool for acute chest pain in low to intermediate risk patients.

关键词： Acute chest pain Risk stratification tool Symptoms,history of Vascular disease,Electrocardiography,Age,and Troponin score History,Electrocardiography,Age,Risk factors and Troponin score

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Anti-N-methyl-D-aspartate receptor-associated encephalitis: A review of clinicopathologic hallmarks and multimodal imaging manifestations

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World Journal of Radiology 2024年第1期16卷 1-8页

作者： bryce david beutler Alastair E Moody Jerry Mathew Thomas Benjamin Phillip Sugar Mark B Ulanja Daniel Antwi-Amoabeng Lucas Anthony Tsikitas Department of Radiology University of Southern CaliforniaKeck School of MedicineLos AngelesCA 90033United States Department of Anesthesiology University of UtahSalt Lake CityUT 84132United States Department of Internal Medicine Christus Ochsner St.Patrick HospitalLake CharlesLA 70601United States

Anti-N-methyl-D-aspartate receptor-associated encephalitis(NMDARE)is a rare immune-mediated neuroinflammatory condition characterized by the rapid onset of neuropsychiatric symptoms and autonomic *** mechanism of pathogenesis remains incompletely understood,but is thought to be related to antibodies targeting the GluN1 subunit of the NMDA receptor with resultant downstream dysregulation of dopaminergic *** adults are most frequently affected;the median age at diagnosis is 21 *** is a strong female predilection with a female sex predominance of 4:*** often develops as a paraneoplastic process and is most commonly associated with ovarian ***,NMDARE has also been described in patients with small cell lung cancer,clear cell renal carcinoma,and other benign and malignant *** is based on correlation of the clinical presentation,electro-encephalography,laboratory studies,and *** tomography,positron emission tomography,and magnetic resonance imaging are essential to identify an underlying tumor,exclude clinicopathologic mimics,and predict the likelihood of long-term functional *** imaging may be of value for prognostication and to assess the response to *** may involve high-dose corticosteroids,intravenous immunoglobulin,and plasma ***,we review the hallmark clinicopathologic features and imaging findings of this rare but potentially devastating condition and summarize diagnostic criteria,treatment regimens,and proposed pathogenetic mechanisms.

关键词： Anti-N-methyl-D-aspartate receptor-associated encephalitis Autoimmune encephalitis Encephalitis Ovarian teratoma Paraneoplastic syndrome Teratoma

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Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells

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Protein & Cell 2023年第8期14卷 591-602页

作者： Liangwen Zhong Miriam Gordillo Xingyi Wang Yiren Qin Yuanyuan Huang Alexey Soshnev Ritu Kumar Gouri Nanjangud Daylon James C.david Allis Todd Evans bryce Carey Duancheng Wen Department of Reproductive Medicine Ronald O.Perelman and Claudia Cohen Center for Reproductive MedicineWeill Cornell MedicineNew YorkNY 10065USA Department of Surgery Weill Cornell Medical College1300 York AvenueNew YorkNY 10065USA Laboratory of Chromatin Biology and Epigenetics The Rockefeller UniversityNew YorkNY 10065USA Cold Spring Harbor Laboratory Cold Spring HarborNY 11724USA Molecular Cytogenetics Core.Memorial Sloan Kettering Cancer Center New YorkNY 10065USA Department of Neuroscience Developmental and Regenerative BiologyUniversity of Texas at San AntonioOne UTSA CircleSan AntonioTX 78249USA Gladstone Institutes 1650 Owens StSan FranciscoCA94158USA

While Mek1/2 and Gsk3βinhibition("2i")supports the maintenance of murine embryonic stem cells(EsCs)in a homogenous naive state,prolonged culture in 2i results in aneuploidy and DNA hypomethylation that impairs developmental ***,2i fails to support derivation and culture of fully potent female *** we find that mouse ESCs cultured in 2i/LIF supplemented with lipid-rich albumin(AlbuMAx)undergo pluripotency transition yet maintain genomic stability and full potency over long-term ***,lipids in AlbuMAx impact intracellular metabolism including nucleotide biosynthesis,lipid biogenesis,and TCA cycle intermediates,with enhanced expression of DNMT3s that prevent DNA *** induce a formative-like pluripotent state through direct stimulation of Erk2 phosphorylation,which also alleviates X chromosome loss in female ***,both male and female"all-ESc"mice can be generated from de novo derived ESCs using AlbuMAXbased *** findings underscore the importance of lipids to pluripotency and link nutrient cues to genome integrity in early development.

关键词： mouse pluripotent stem cells lipids pluripotency transition genomic stability developmental potency nucleotide pool depletion 2i medium X chromosome loss femaleall-EsC mice

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澳大利亚认证经营者项目研究

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中国海关 2015年第10期 68-69页

作者： david Widdowson bryce Blegen Mikhail Kashubsky Andrew Grainger 徐伟

澳大利亚国际贸易和运输行业完成了一项研究，旨在对目前正在使用或正在执行的各类认证经营者项目（AO）进行调研，并研究各项目的澳大利亚的适用性。研究表明，那些未参与达到全球贸易安全与便利标准（SAFE框架）项目的澳大利亚出口商... 详细信息

澳大利亚国际贸易和运输行业完成了一项研究，旨在对目前正在使用或正在执行的各类认证经营者项目（AO）进行调研，并研究各项目的澳大利亚的适用性。研究表明，那些未参与达到全球贸易安全与便利标准（SAFE框架）项目的澳大利亚出口商存在潜在劣势，并提出在出口贸易中引进以供应链安全为重点的项目，在进口贸易中引进以贸易合规性为重点的项目。

关键词：澳大利亚经营者项目研究认证国际贸易贸易安全运输行业 SAFE

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世界贸易组织《贸易便利化协定》背景下的单一窗口

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海关与经贸研究 2021年第3期42卷 28-53页

作者： david Widdowson bryce Blegen Geoff Short Gareth Lewis Eduardo Garcia-Godos Mikhail Kashubsky 徐君(译) 谢昕宇(译) 张树杰(校) 澳大利亚查尔斯·斯图特大学海关与消费税研究中心国际海关大学世界海关组织PICARD咨询小组和科学委员会信任贸易联盟澳大利亚海关署法律处全球会计师事务所贸易便利化研究所国际海关大学网络秘书处海关总署国际司上海海关学院海关与公共管理学院上海海关学院党校工作部

本篇论文立足于一个研究项目的结果,而该研究旨在通过向贸易利益攸关方提供有助于澳大利亚建立服务于贸易单一窗口的视角,来支持澳大利亚政府的贸易便利化议程。此外,澳大利亚的报告回顾了公认权威的国际机构就这一问题颁布的标准和最... 详细信息

本篇论文立足于一个研究项目的结果,而该研究旨在通过向贸易利益攸关方提供有助于澳大利亚建立服务于贸易单一窗口的视角,来支持澳大利亚政府的贸易便利化议程。此外,澳大利亚的报告回顾了公认权威的国际机构就这一问题颁布的标准和最佳做法,包括世界贸易组织的《贸易便利化协定》(TFA)。这可能是自《贸易便利化协定》实施以来,第一个由主要发达贸易国的私营部门推动的单一窗口研究,该研究的一些方面在该协定更广阔的全球背景下似乎显现出相关性,而本文讨论的正是这些方面。本文结论是,所有TFA签署方都需要认真考虑其根据协定执行的优先事项。为此,本文提出了基于原始研究项目的系列结论,这些结论与TFA的所有签署成员都有关,无论它们处于什么样的发展水平。

关键词：贸易便利化单一窗口协调边境管理边境机构合作

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高利润市场攻坚战略

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工程经济 2007年第6期23卷 13-13页

作者： david J．bryce Jeffrey H．Dyer

利润不具吸引力的市场，人们对它的兴趣不大，而利润吸引人的市场却是一个难解的谜：你觊觎良久，但要真正进入就不容易了，因为市场领先者们早巳竖起重重壁垒。这就给我们提出了一个问题：公司究竟有没有办法进入高利润市场并赢利呢？

关键词：市场领先者高利润攻坚战吸引力壁垒公司

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