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New insights on murineγδT cells from single-cell multi-omics

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Science Bulletin 2022年第11期67卷 1102-1104页

作者： Likai Tan Daniel Inácio Immo Prinz bruno silva-santos Institute of Systems Immunology University Medical Center Hamburg EppendorfHamburg 20251Germany Instituto de Medicina Molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisbon 1649-028Portugal

γδT cells are a second T cell lineage conserved throughout evolution and across animal species that express aγδT-cell receptor(TCR)consisting of a TCRγand a TCRδchain.γδT cells develop in the murine thymus into various subsets with distinct functional potential that preferentially home to specific peripheral tissues,rather than lymphoid organs[1].

关键词： organs γδT细胞多组学研究

Single-cell pan-omics, environmental neurology, and artificial intelligence:the time for holistic brain health research

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Neural Regeneration Research 2025年第6期20卷 1703-1704页

作者： Paolo Abondio Francesco bruno IRCCS Istituto delle Scienze Neurologiche di Bologna BolognaItaly Association for Neurogenetic Research(ARN) Lamezia TermeCatanzaroItaly

The brain,with its trillions of neural connections,different cellular types,and molecular complexities,presents a formidable challenge for researchers aiming to comprehend the multifaceted nature of neural *** traditional methods have provided valuable insights,emerging technologies offer unprecedented opportunities to delve deeper into the underpinnings of brain *** the everevolving landscape of neuroscience,the quest to unravel the mysteries of the human brain is bound to take a leap forward thanks to new technological improvements and bold interpretative frameworks.

关键词： function artificial landscape

High Order of Accuracy for Poisson Equation Obtained by Grouping of Repeated Richardson Extrapolation with Fourth Order Schemes

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Computer Modeling in Engineering & Sciences 2021年第8期128卷 699-715页

作者： Luciano Pereira da silva bruno Benato Rutyna Aline Roberta santos Righi Marcio Augusto Villela Pinto Graduate Program in Numerical Methods in Engineering Federal University of ParanaCuritiba81531-980Brazil Graduate Program in Space Sciences and Technologies Aeronautics Institute of TechnologySao Jose dos Campos12228-900Brazil Department of Mechanical Engineering Federal University of ParanaCuritiba81531-980Brazil

In this article,we improve the order of precision of the two-dimensional Poisson equation by combining extrapolation techniques with high order *** high order solutions obtained traditionally generate non-sparse matrices and the calculation time is very *** can obtain sparse matrices by applying compact *** this article,we compare compact and exponential finite difference schemes of fourth *** numerical solutions are calculated in quadruple precision(Real*16 or extended precision)in FORTRAN language,and iteratively obtained until reaching the round-off error magnitude around 1.0E−*** procedure is performed to ensure that there is no iteration *** Repeated Richardson Extrapolation(RRE)method combines numerical solutions in different grids,determining higher orders of *** main contribution of this work is based on a process that initializes with fourth order solutions combining with RRE in order to find solutions of sixth,eighth,and tenth order of *** multigrid Full Approximation Scheme(FAS)is also applied to accelerate the convergence and obtain the numerical solutions on the fine grids.

关键词： Tenth order accuracy RRE compact scheme exponential scheme multigrid finite difference

Influence of Sugarcane Bagasse Fiber Size on Biodegradable Composites of Thermoplastic Starch

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Journal of Renewable Materials 2018年第2期6卷 176-182页

作者： bruno Henrique dos santos Karen de Souza do Prado Asaph Armando Jacinto Marcia Aparecida da silva Spinace Federal University of ABC Center of Natural and Human SciencesAv.dos Estados5001Santa Terezinha09.210-170 Santo AndréSão PauloBrazil

Although thermoplastic starch(TPS)is biodegradable,its low mechanical resistance limits its wide *** bagasse(SB)fibers can be used as reinforcement in TPS matrix composites,but the influence of fiber size on the properties of the composite is still *** this study,TPS composites reinforced with SB short fibers of four sizes were processed and characterized in order to analyze the influence of fiber size on the mechanical properties of the TPS/SB *** was observed that the interaction between fiber and matrix was good and optimized when the fibers are sifted in sieves between 30 and 50 mesh,obtaining fibers with average length of 1569±640μm and average diameter of 646±166μ*** these composites,increases of more than 660%in the modulus and more than 100%in the maximum tension were verified when compared to the pure TPS.

关键词： Sugarcane bagasse thermoplastic starch composite fiber size

Spatial-temporal distribution of fatal yellowing in different oil palm genetic materials in eastern amazon

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Information Processing in Agriculture 2022年第3期9卷 365-377页

作者： bruno Borella Anhe Artur Vinicius Ferreira dos santos Thiago Alan Ferreira da silva Lana Leticia Barbosa de Carvalho Paulo Roberto silva Farias Universidade Federal Rural da Amazonia Geoestatistics Department66.077-830 BelemBrazil Universidade Federal Rural da Amazonia Entomology Department66.077-830 BelemBrazil

Oil palm (Elaeis guineensis Jacq.) is one of the agricultural crops with the greatest potentialfor vegetable oil production in Brazil. However, a disease of unknown etiology popularlyknown as Fatal Yellowin (FY) has caused damage to Brazilian farmers particularly in theeastern region of the Amazon. So, the objective of this study was to evaluate the spatialdependence of FY on three oil palm genotypes, grown for many years in an organic produc-tion system in the Amazon region. The study area had 4104 ha, divided into 139 plots. Ineach plot, the monthly incidence of disease was monitored forming a database. The num-ber of diseased plants per year, number of accumulated diseased plants, number of dis-eased plants per hectare, growth rate of diseased plants and incidence of accumulateddisease were evaluated. The results indicated spatial distribution of the variables adjustedto the gaussian, spherical and exponential models, with predominance of the first *** increases the purpose that FY is caused by biotic factors. The highest range achievedin the study was 2929 m indicating the susceptibility of the tested genotypes. Some plotsclose to the river had the highest incidence of the disease on the study, probably associatedwith higher soil moisture.

关键词： Elaeis guineensis Geostatiscal analysis Kriging Palm oil Spatial dependence

Learning to combine multiple string similarity metrics for effective toponym matching

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International Journal of Digital Earth 2018年第9期11卷 913-938页

作者： Rui santos Patricia Murrieta-Flores bruno Martins Instituto Superior Técnico and INESC-ID University of LisbonLisbonPortugal Digital Humanities Research Center University of ChesterChesterUK

Several tasks related to geographical information retrieval and to the geographical information sciences involve toponym matching,that is,the problem of matching place names that share a common *** this article,we present the results of a wide-ranging evaluation on the performance of different string similarity metrics over the toponym matching *** also report on experiments involving the usage of supervised machine learning for combining multiple similarity metrics,which has the natural advantage of avoiding the manual tuning of similarity *** with a very large dataset show that the performance differences for the individual similarity metrics are relatively small,and that carefully tuning the similarity threshold is important for achieving good *** methods based on supervised machine learning,particularly when considering ensembles of decision trees,can achieve good results on this task,significantly outperforming the individual similarity metrics.

关键词： Toponym matching supervised learning string similarity metrics duplicate detection ensemble learning geographic information retrieval

Taxing Digital Economy:A Critical View around the GloBE(Pillar Two)

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Frontiers of Law in China-Selected Publications from Chinese Universities 2020年第2期15卷 111-141页

作者： bruno da silva University of Amsterdam AmsterdamThe Netherlands Amsterdam Centre for Tax Law University of AmsterdamAmsterdam 1018WB

The Organisation for Economic Co-operation and Development(OECD)proposal for taxation of digital economy constitutes one of the most ambitious projects in the field of taxation and may lead to the most significant reform to international tax rules in the 20th *** on a two-pillar approach,Pillar Two of the proposal suggests the adoption of Global Anti-Base Erosion(GloBE)provisions that are aimed at introducing a worldwide minimum *** this article,a critical analysis is based that the GloBE proposal suggests that it represents a shift in the OECD *** compared to base erosion and profit shifting(BEPS),it jeopardizes the tax sovereignty of jurisdictions and it raises fundamental challenges of implementation,both in terms of amendments to domestic law and conflicts with tax treaties.

关键词： Organisation for Economic Co-operation and Development(OECD) base erosion and profit shifting(BEPS) digital economy,minimum tax Pillar Two Global Anti-Base Erosion(GloBE) Global Intangible Low-Taxed Income(GILTI) Base Erosion Anti-Abuse Tax(BEAT) tax treaties

EVOLUTION OF THE BENEFICIAL OWNERSHIP CONCEPT： MORE THAN HALF OF CENTURY OF UNCERTAINTY AND WHAT HISTORY CAN TELL US

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Frontiers of Law in China-Selected Publications from Chinese Universities 2017年第4期12卷 501-523页

作者： bruno da silva Ph.D. in International Tax Law Faculty of Law University of Amsterdam Amsterdam

The beneficial ownership concept has constituted for more than half a century one of the most fundamental and debated issues in the application of tax treaties. This article goes back to routes of this term explaining the reason of its original inclusion in the OECD Model Tax Convention and why ultimately such inclusion may have not been necessary. Then it analyses the historical developments of beneficial ownership in the OECD Model Tax Convention. For that purpose it considers different interpretations adopted by jurisdictions （particularly in China） and local courts delving into some of the landmark cases on the subject. Finally it provides a detailed analysis of the current meaning of beneficial ownership considering the most recent developments in the Commentary to the OECD Model Tax Convention.

关键词： beneficial ownership OECD Model Tax Convention Commentary,interpretation case-law China

Bone marrow-derived products: A classification proposal – bone marrow aspirate, bone marrow aspirate concentrate or hybrid?

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World Journal of Stem Cells 2020年第4期12卷 241-250页

作者： Joseph Purita JoséFábio santos Duarte Lana Morey Kolber bruno Lima Rodrigues Tomas Mosaner Gabriel silva santos Carolina Caliari-Oliveira Stephany Cares Huber Institute of Regenerative Medicine Boca RatonFL 33432United States Institute of Bone and Cartilage IndaiatubaSP 13334-170Brazil Department of Physical Therapy Nova Southeastern UniversityFort LauderdaleFL 33314United States University of Campinas CampinasSP 13083-970Brazil In Situ Cell Therapy Ribeirao PretoSP 14056-680Brazil

Degenerative musculoskeletal disorders are one of the top causes of pain and disability in the adult *** available alternatives to mitigate symptoms include conservative treatments such as the administration of pharmacological agents and an educative approach towards lifestyle *** use of certain analgesics,such as opiates and corticosteroids,delivers short term results but do not address the etiological source of pain and ***,prolonged use of such medications may cause additional ***,the demand for musculoskeletal tissue regeneration has led to an alternative approach referred to as“orthobiologics”.This alternative is based on cellular and molecular components capable of inducing and promoting tissue *** marrow(BM)aspirate(BMA)and concentrate are well-known orthobiologics used to treat musculoskeletal *** derived from the BM have been discussed in the literature;however,the lack of standardization regarding collection and processing protocols presents a challenge for generalization of study outcomes and determination of *** BM-derived orthobiologics have not yet been classified,to our knowledge,this manuscript proposes the ACH classification system,which speaks to BMA(A),BMA and concentrate(C)and hybrid(H),which combines A and *** classification proposes and describes 8 parameters that are relevant for the quality of biological *** more parameters used would imply greater characterization and complexity of the evaluation of the biological product *** ACH classification envisages a necessary contribution to the comprehension of both clinical procedures and research outcomes,ultimately ushering in a standardization of best practice.

关键词： Bone-marrow classification Bone-marrow aspirate concentrate Regenerativemedicine Stem cells Musculoskeletal disorders Orthobiologics