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Tweaking the acid-sensitivity of transiently thermoresponsive polyacrylamides with cyclic acetal repeating units

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Science China Chemistry 2020年第4期63卷 504-512页

作者： simon Van Herck bruno G.De Geest Department of Pharmaceutics Ghent UniversityGhentBelgium

Merging the characteristics of thermoresponsive and stimuli-degradable polymers yields so-called transiently thermoresponsive polymers, which can find application for the design of injectable gels, nanoparticles, etc. within a biomedical context. Among these polymers, only a limited number is reported which shows selective degradation under mild acidic conditions. However,extension of the library of transiently thermoresponsive polymers is desired to broadening the biomaterials toolbox to suit specific needs. Three monomers were developed by modification of 2-hydroxyethylacrylamide(HEAm) via tetrahydropyranylation or-furanylation with 3,4-dihydro-2 H-pyran(DHP), 2,3-dihydrofuran(DHF) or 2,3-dihydro-5-methylfuran(MeDHF). The presence of an acetal or ketal bond provided the monomers a pH-dependent hydrolysis behavior ranging from minutes to days. RAFT polymerisation allowed for the construction of homopolymers with temperature responsive behavior and pH-dependent hydrolysis which was strongly influenced by nature of the monomeric repeating units.

关键词： acetals polyacrylamides stimuli-responsive

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Relative importance of long-term changes in climate and land-use on the phenology and abundance of legume crop specialist and generalist aphids

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Insect Science 2019年第5期26卷 881-896页

作者： Martin Luquet Maurice Hulle Jean-Christophe simon Nicolas Parisey Christelle Buchard2 bruno Jaloux Agrocampus Ouest Centre of AngersInstitute of GeneticsEnvironment and Plant Protection (IGEPP-Joint Research Unit 1349) AngersFrance INRA Institute of GeneticsEnvironment and Plant Protection (IGEPP-Joint Research Unit 1349)Le Rheu France

Abstract Insect populations are prone to respond to global changes through shifts in phenology, distribution and abundance. However, global changes cover several factors such as climate and land-use, the relative importance of these being largely unknown. Here, we aim at disentangling the effects of climate, land-use, and geographical drivers on aphid abundance and phenology in France, at a regional scale and over the last 40 years. We used aerial data obtained from suction traps between 1978 and 2015 on five aphid species varying in their degree of specialization to legumes, along with climate, legume crop area and geographical data. Effects of environmental and geographical variables on aphid annual abundance and spring migration dates were analyzed using generalized linear mixed models. We found that within the last four decades, aphids have advanced their spring migration by a month, mostly due to the increase in temperature early in the year, and their abundance decreased by half on average, presumably in response to a combination of factors. The influence of legume crop area decreased with the degree of specialization of the aphid species to such crops. The effect of geographical variation was high even when controlling for environmental variables, suggesting that many other spatially structured processes act on aphid population characteristics. Multifactorial analyses helped to partition the effects of different global change drivers. Climate and land-use changes have strong effects on aphid populations, with important implications for future agriculture. Additionally, trait-based response variation could have major consequences at the community scale.

关键词： abundance climate warming degree of specialization land-use change legume aphids phenology

Assessment of Spermatic Chromatin Decondensation by the Toluidine Blue Assay in Infertile Patients in Cotonou

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Advances in Reproductive Sciences 2022年第2期10卷 37-48页

作者： Yaude Alfred Azonbakin simon Aweh bruno Dangbemey Patrice Sissoko Sidi Boula Dossou Jean-Paul Flore Gangbo Laleye Anatole Laboratory of Histology Reproductive Biology Cytogenetics and Medical Genetics Faculty of Health Sciences Cotonou Benin Department of Gynaecology-Obstetrics Mother and Child Teaching Hospital of Cotonou Cotonou Benin Pathological Anatomy and Cytology Department of the point’s G Teaching Hospital in Bamako Mali Laboratory of Andrology Human Reproduction and Demography Research Center CERRHUD Cotonou Benin

Background: A high level of sperm chromatin decondensation results in loss of DNA quality and it is associated with poor embryonic prognosis in Assisted Reproductive Technology (ART). This had lead to introduction of sperm DNA compaction testing in assessment of clinical male infertility. Toluidine blue assay is one of most commonly used tests to measure chromatin decondensation in research studies and also in clinical routine use. So the objective of our study was to assess the level of sperm chromatin decondensation by toluidine blue assay in men dealing with couple infertility. Methods: The sperm samples of 96 patients referred for infertility, over a 4-month period from September 2020 to January 2021, were stained with toluidine blue and observed under an optical microscope. These were evaluated according to the World Health Organization. Results: The 25 - 34 age group was the most represented among infertile men. There was a non-significant correlation between age and the level of spermatic chromatin condensation (r = 0.0348). Spermatic parameters had averages above standards norms, apart from that of low vitality. Spermatic chromatin decondenization affected 96% of infertile patients. Asthenozoospermia was the most common abnormality. Among standard parameters of spermogram, only the concentration of spermatozoa in the semen was weakly correlated (r = 0.18) with sperm chromatin decondensation. Conclusion: The level of sperm chromatin condensation is, on the one hand, a parameter independent of the age of the subject; on the other hand, allows to evaluate male infertility, like the classic parameters of the spermogram and spermocytogram. However, in view of the high probability of changes in the nuclear quality of sperm intrinsic to the analysis process and sperm concentration, an improvement of the toluidine blue test using the swim-up technique and associated with image processing software is possible.

关键词： Male Infertility Decondensation Spermatic Chromatin Toluidine Blue

Management of occluded self-expanding biliary metal stents in malignant biliary disease

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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 49-54页

作者： simon Nennstiel Isolde Tschurtschenthaler bruno Neu Hana Algül Monther Bajbouj Roland M. Schmid Stefan von Delius Andreas Weber Klinik und Poliklinik fur Innere Medizin Ⅱ Klinikum rechts der Isar der Technischen Universitar Manchen Ismaninger Straβe 22 Munich 81675 Germany Medizinische Klinik II Krankenhaus Landshut-Achdorf Academic Teaching Hospital Technische Universitar Munchen Achdorferweg 3 Landshut 84036Germany

Background: Occlusion of self-expanding metal stents(SEMS) in malignant biliary obstruction occurs in up to 40% of patients. This study aimed to compare the different techniques to resolve stent occlusion in our collective of ***: Patients with malignant biliary obstruction and occlusion of biliary metal stent at a tertiary referral endoscopic center were retrospectively identified between April 1, 1994 and May 31, 2014. The clinical records were further analyzed regarding the characteristics of patients, malignant strictures, SEMS,management strategies, stent patency, subsequent interventions, survival time and case ***: A total of 108 patients with biliary metal stent occlusion were identified. Seventy-nine of these patients were eligible for further analysis. Favored management was plastic stent insertion in 73.4% patients. Second SEMS were inserted in 12.7% patients. Percutaneous transhepatic biliary drainage and mechanical cleansing were conducted in a minority of patients. Further analysis showed no statistically significant difference in median overall secondary stent patency(88 vs. 143 days, P = 0.069), median survival time(95 vs. 192 days, P = 0.116), median subsequent intervention rate(53.4% vs. 40.0%, P = 0.501)and median case charge(€5145 vs. €3473, P = 0.803) for the treatment with a second metal stent insertion compared to plastic stent insertion. In patients with survival time of more than three months,significantly more patients treated with plastic stents needed re-interventions than patients treated with second SEMS(93.3% vs. 57.1%, P = 0.037).Conclusions: In malignant biliary strictures, both plastic and metal stent insertions are feasible strategies for the treatment of occluded SEMS. Our data suggest that in palliative biliary stenting, patients especially those with longer expected survival might benefit from second SEMS insertion. Careful patient selection is important to ensure a proper decision for either management

关键词： Self-expanding metal stents Biliary tract neoplasms Endoscopic retrograde cholangiopancreatography Biliary tract diseases Complications

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Precision Phenotyping Reveals Novel Loci for Quantitative Resistance to Septoria Tritici Blotch

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Plant Phenomics 2019年第1期1卷 58-68页

作者： Steven Yates Alexey Mikaberidze simon GKrattinger Michael Abrouk Andreas Hund Kang Yu bruno Studer simone Fouche Lukas Meile Danilo Pereira Petteri Karisto Bruce A.McDonald Molecular Plant Breeding Institute of Agricultural SciencesETH ZurichZurichSwitzerland Plant Pathology Institute of Integrative BiologyETH ZurichZurichSwitzerland Biological and Environmental Science and Engineering Division King Abdullah University of Science and Technology(KAUST)ThuwalSaudi Arabia Crop Science Institute of Agricultural SciencesETH ZurichZurichSwitzerland

Accurate,high-throughput phenotyping for quantitative traits is a limiting factor for progress in plant *** developed an automated image analysis to measure quantitative resistance to septoria tritici blotch(STB),a globally important wheat disease,enabling identification of small chromosome intervals containing plausible candidate genes for STB resistance.335 winter wheat cultivars were included in a replicated field experiment that experienced natural epidemic development by a highly diverse but fungicide-resistant pathogen *** than 5.4 million automatically generated phenotypes were associated with 13,648 SNP markers to perform the *** identified 26 chromosome intervals explaining 1.9-10.6%of the variance associated with four independent resistance *** of the intervals overlapped with known STB resistance intervals,suggesting that our phenotyping approach can identify simultaneously(i.e.,in a single experiment)many previously defined STB resistance *** of the intervals were less than 5 Mbp in size and encoded only 173 genes,including many genes associated with disease *** intervals contained four or fewer genes,providing high priority targets for functional *** chromosome intervals were not previously associated with STB resistance,perhaps representing resistance to pathogen strains that had not been tested in earlier *** SNP markers associated with these chromosome intervals can be used to recombine different forms of quantitative STB resistance that are likely to be more durable than pyramids of major resistance *** experiment illustrates how high-throughput automated phenotyping can accelerate breeding for quantitative disease resistance.

关键词： resistance limiting globally

HLA-G 3’UTR 14 bp Insertion Is Associated with a Decreased Risk of Developing Human African Trypanosomiasis in the Côte d’Ivoire Population

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Open Journal of Genetics 2019年第2期9卷 31-41页

作者： Bernardin Ahouty Mathurin Koffi David Courtin Ilboudo Hamidou Didier Sokouri Innocent Abé Laure Gineau Thomas Konan Lingué Kouakou Tidou Abiba Sanogo Enock Matovu bruno Bucheton Vincent Jamonneau simon-Pierre N’Guetta Felix Houphouet Boigny University (UFHB) Cocody Abidjan C&#244 te d’Ivoire Jean Lorougnon Guédé University (UJLoG) Daloa C&#244 te d’Ivoire Institut de Recherche pour le Développement (IRD) Mère et Enfant face aux Infections Tropicales Faculté de Pharmacie Université Paris Descartes Sorbonne Paris Cité France Centre International de Recherche-Développement sur l’Elevage en Zone Subhumide (CIRDES) Bobo-Dioulasso Burkina Faso Programme National d’élimination de la Trypanosomiase Humaine Africaine Abidjan C&#244 te d’Ivoire School of Veterinary Medicine Makerere University Kampala Uganda Institut de Recherche pour le Développement (IRD) IRD-CIRAD 177 Intertryp Université de Montpellier Montpellier France Institut Pierre Richet Bouaké C&#244 te d’Ivoire

Human African trypanosomiasis (HAT), or sleeping sickness, caused by Trypanosoma brucei gambiense, is associated with diverse clinical outcomes. Host’s genetic factors involved in immunity are potential factors that can regulate infection. Genetic polymorphisms within HLA-G could influence the level of HLA-G expression and therefore play a critical role in infection outcomes. The goal of our study was to investigate the association of 14 bp Indel HLA-G polymorphism with the susceptibility/resistance to HAT. DNA samples were collected from 119 cases, 221 controls and 43 seropositive individuals living in Ivorian HAT foci. The 14 bp Indel polymorphism was determined by PCR. Homozygous individuals for 14 bp insertion had a lower risk of progressing to active HAT (p = 0.012, OR = 0.27, 95% CI: 0.09 - 0.8). Moreover, the frequency of 14 bp insertion homozygous genotype was higher in the seropositive group (11%) than in the HAT cases group (3%) (p = 0.043, OR = 0.27, 95% CI: 0.07 - 0.99), which suggested a protective effect of 14 bp insertion homozygous genotype. Genetic polymorphisms in HLA-G may be associated with a variable risk to develop HAT. The 14 bp insertion appears to favour the occurrence of long-lasting T. b. gambiense latent infections.

关键词： HLA-G Human African Trypanosomiasis Trypanosoma brucei gambiense Genetic Association Study

Geochemical Characterization and Mineralogy of Babouri-Figuil Oil Shale,North-Cameroon

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Journal of Surface Engineered Materials and Advanced Technology 2014年第6期4卷 359-368页

作者： Alexis Jacob Nyangono Abolo simon Ngos III Augustin Desire Balla Ondoa bruno Garcia Maria Fernanda-Sarmiento Olive Cecile Mbesse Guy Martin Abolo Daniel Mackaire Eloung Nna Augustin Ephraim Nkengfack Emmanuel Ndjeng Jialin Qian Faculty of Sciences University of Yaounde IYaoundeCameroon Faculty of Sciences University of MarouaMarouaCameroon Faculty of Sciences University of NgaoundereNgaoundereCameroon Geosciences Division Institut Francais du PetroleEnergies Nouvelles(IFPEN)Rueil-MalmaisonFrance Faculty of Sciences University of DoualaDoualaCameroon National Hydrocarbons Corporation YaoundeCameroon Department of Chemistry China University of PetroleumBeijingChina

Organic geochemistry methods such as high temperature combustion, Rock-Eval pyrolysis and gas analysis were used to analyze oil shale from Babouri-Figuil Basin. Results show that the average content of organic matter is 36.25 %wt, while that of mineral matter is 63.75 %wt. The total organic carbon (TOC) is between 15.93 %wt and 26.82 %wt. The HI vs. Tmax diagram indicates an immature Type I kerogen. The average value of the oil potential (S2b) is 149.95 mg HC/g rock. The gases obtained by retort process are H2, CO2, CO and CnH2n, CnH2n+2. Finally, it emerges that, the organic matter of Babouri-Figuil shales was immature or has just reached the beginning of the oil window. The mineralogical study of Babouri-Figuil oil shale has been carried out by means of XRD (X-Ray Diffractometry) and XRF (X-Ray Fluorescence spectrometry). The results show that mineral matrix contains silica, carbonates, sulphates, oxides and clay minerals. Besides, compounds contain metals and metalloids like Fe, In, Ca. The main oxides are SiO2 (majority), CaO, Fe2O3, Al2O3, SO3, and K2O.

关键词： Oil Shale Babouri-Figuil Organic Matter Mineral Matter Rock-Eval Pyrolysis X-Ray Diffractometry X-Ray Fluorescence Spectrometry

Assessment of Ozone or Not-Treated Wastewater Ecotoxicity Using Mechanism-Based and Zebrafish Embryo Bioassays

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Journal of Environmental Protection 2018年第4期9卷 325-346页

作者： Adriana Wigh Selim Ait-Aissa Nicolas Creusot Hugo Terrisse Marie-Laure Delignette-Muller Alexandre Bergé Emmanuelle Vulliet bruno Domenjoud Adriana Gonzalez-Ospina Vanessa Brosselin Alain Devaux Sylvie Bony Universite de Lyon INRA USC 1369CNRS UMR 5023 LEHNAVaulx-en-VelinFrance INERIS Unite d’Ecotoxicologie in vitro et in vivo(ECOT)Verneuil-en-HalatteFrance Universite de Lyon CNRSUMR 5558Laboratoire de Biometrie et Biologie EvolutiveVilleurbanneFrance Universite de Lyon Vet Agro Sup Campus Veterinaire de LyonMarcy l’EtoileFrance Universite de Lyon Institut des Sciences AnalytiquesUMR5280 CNRSVilleurbanneFrance SUEZ International-Treatment Infrastructure Wastewater Technical DivisionRueil-MalmaisonFrance

Toxicity of wastewater treatment plant (WWTP) effluents is usually assessed with standardized bioassays, as e.g. the Fish Embryo Toxicity test (FET), but assessment of sub-lethal toxic effects requires to develop more adapted tests. The present work aimed to add the recording of several sub-lethal endpoints in exposed zebrafish embryo-larval stages in order to increase the sensitivity of residual toxicity evaluation of WWTP effluents using a semi-quantitative method (iFET score). This approach was complemented with the genotoxicity assessment on the exposed embryos, a sub-acute hazard particularly relevant to evaluate a potential chronic toxicity risk of low and multi-contaminated environmental matrices. Additionally, endocrine activities of effluents were quantified using human reporter cell lines. This test battery was applied to the assessment of the residual toxicity of five biological treatment effluents, further treated or not using various ozonation treatments intended to improve pharmaceutical compounds removal. Acute toxicity towards zebrafish embryos was very low. However, iFET score approach proposed was able to reveal residual toxicity through the presence of developmental abnormalities in all samples tested. Additionally, a low residual genotoxicity was measured in embryos exposed to two of the WWTP effluents when all excepted one exhibited a residual endocrine activity potential in the ng/L range providing complementary information on the occurrence of endocrine active chemicals and their reduction by different processes. To sum up, such a simplified and ecologically relevant test battery was found sensitive enough to characterize and differentiate various residual effluent’s ecotoxicity at contaminant levels of environmental concern.

关键词： Wastewater Ozonation Genotoxicity Endocrine Activity Zebrafish Early Life Stage Pharmaceutical Surfactant

Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV

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Nuclear Science and Techniques 2013年第5期24卷 82-88页

作者： FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R bruno M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L INFN Laboratori Nazionali del Sud-LNS Catania 95123Italy Dipartimento di Fisica Universitàdi Catania I-95129Italy INFN Sezione di Trieste Trieste I-34127Italy Dipartimento di Fisica Universitàdi FirenzeINFN Sezione di Firenze 1-50139Italy LPC Caen IN2P3-CNRS/ENSICAEN and UniversitéF-14050 Caen cedex 5-140France Dipartimento di Fisica Universitàdi Bologna and INFN Sezione di Bologna 4-50121Italy INFN Sezione di Catania I-95129 Italy INFN Sezione di Firenze I-50139 Italy Dipartimento di Fisica Universitàdi Milano and INFN Sezione di Milano1-20126Italy INFN Laboratori Nazionali di Legnaro 1-35020 Italy Centro Siciliano di Fisica Nucleare e Struttura della Materia Catania 1-95129Italy UniversitàKore Enna 1-94100Italy

The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy *** a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy *** the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been *** main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their *** emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear *** evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport *** approaches have been envisaged(dynamical stochastic BNV calculations + sequential simon code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy *** deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light *** simulations are in *** experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having

关键词：多重碎裂中心碰撞蒸发过程 MeV 竞争熔合国际货币基金组织事件分析

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