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Journal of Pharmacy and Pharmacology 2017年第8期5卷 565-571页

作者： Daniel Amaral Alves Marliere Caio Bellini Lovisi Alan Robert Moreira Schmitt bruno salles sotto-maior Henrique Duque de Miranda Chaves Netto MSc in Clinical Dentistry- Juiz de Fora Dental School Federal University of Juiz de Fora Juiz de Fora 36036-300 Brazil MSc in Dentistry - Dental School University of the State of Rio de Janeiro Rio de Janeiro 20551-030 Brazil Lecturer in Dentistry- Juiz de Fora Dental School Federal University of Juiz de Fora Juiz de Fora 36036-300 Brazil

Orthognathic surgery involves correction of functional and often esthetic disharmonies. The purpose of this case report is topresent the case of a 22 years-old female with class III dentofacial deformity that required orthognathic surgery to treat hermalocclusion and buccal fat pad excision for optimizing soft-tissue facial contour. Treatment planning involved a counterclockwiserotation of the maxilomandibular complex with genioplasty based on digital 3D surgical planning using the Dolphin Imaging 11.7 3DPremium software. Prototyping splints allowed surgical procedures （bilateral sagital mandibular osteotomy associated to a Le fort Iosteotomy） that corrected position of the gnathic bones. In the same surgical procedure, the buccal fat pad was partially removed for asharp cheek contour giving a slimmer appearance to her face. After 5 months, the patient was reassessed and reported no complaintsregarding esthetics or function. This case illustrates that a combination oforthognathic surgery and an esthetic procedure can result in astable and harmonious facial as well as occlusal outcomes.

关键词： Orthognathic surgery, occlusal plane, malocclusion, buccal fat pad, aesthetic procedure.

Evaluation of the Size and Location of the Genial Plexus,Related to Age,Sex and Dental Presence,in Implant Surgeries

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Journal of Biomedical Science and Engineering 2017年第10期10卷 456-465页

作者： Joao Henrique Scotti Alerico Neuza Maria Souza Picorelli Assis Carlos Eduardo Francischone Karina Lopes Devito Francisco Antoninho Alerico bruno salles sotto-maior Department of Implantology Sao Leopoldo Mandic Dental Research CenterSao LeopoldoBrazil Department of Dental Clinic Federal University of Juiz de ForaJuiz de ForaBrazil Department of Diagnosis Paranaense UniversityFrancisco BeltraoBrazil Department of Restorative Dentistry Federal University of Juiz de ForaJuiz de ForaBrazil

Generally being considered as a safe area for surgical approaches, the region between the mental foramina presents important anatomical structures. The objective of this study was to measure the dimensions of the genial plexus and its three-dimensional location in CBCT images, correlating the characteristics of this structure with dental presence, sex and age of patients. A total of 149 cone beam computer tomography (CBCT) scans of dentate (n = 74) and edentulous patients (n = 75) were selected, 59 male and 90 female, aged 18 - 86 years. Measurements of width and length of the genial canal were performed, and the shortest distances of the genial plexus were determined in relation to the alveolar bone crest, the buccal cortical bone and the base of the mandible. The results indicated significant differences between the dentate and edentulous groups for the mandibular canal length (p = 0.030), distance from alveolar crest (p < 0.001), and distance from buccal cortical bone (p < 0.001), with significantly higher values in dentate patients. As for gender, the distances between the genial plexus and the alveolar bone crest (p < 0.001) and the buccal cortical bone (p = 0.028) were significantly shorter for females. Regarding age, only the distance between the genial plexus and the alveolar crest showed a significant difference (p < 0.001), and the smallest values were measured in the older patients. It can be concluded that there are variations of the genial plexus in relation to gender, age and between edentulous and dentate patients. Therefore, the anterior region of the mandible, especially the midline should be observed with caution when undergoing surgical procedures, such as removal of bone grafts and installation of dental implants.

关键词： Genial Canal Cone-Beam Computed Tomography Dental Implants Measurement Paresthesia

无牙颔患者计算机导板引导下不翻瓣种植体植入手术的临床准确性研究

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中国口腔医学继续教育杂志 2016年第3期19卷 127-131页

作者： Dalton Marinho Vieir bruno salles sotto-maior Carlos Alberto Villaga de Souza Barrow Elson Simoes Reis Carlos Eduardo Francischone 王培汤春波不详南京医科大学口腔医学院种植修复科江苏省南京市汉中路136号 210029

目的：尽管计算机导板引导不翻瓣种植体植入的方法拥有巨大优势，但种植体植入无牙颌牙弓的位点偏离原计划位置的风险可能会明显提高。这项研究评估了计算机导板引导下不翻瓣种植手术方法的可靠性与准确性。材料和方法：通过锥体束CT扫... 详细信息

目的：尽管计算机导板引导不翻瓣种植体植入的方法拥有巨大优势，但种植体植入无牙颌牙弓的位点偏离原计划位置的风险可能会明显提高。这项研究评估了计算机导板引导下不翻瓣种植手术方法的可靠性与准确性。材料和方法：通过锥体束CT扫描患者术前和术后的颌骨．来比较术前计算机设计的种植体计划植入的位置与实际植入位置的差异。一个非常合适的全口义齿或匹配良好的修复体将被使用或转换成放射模板。在扫描之前，要先进行美学和功能学方面的临床检查。种植体拟植入的位点实际上是由与牙槽骨结构和预期牙齿位置相关的种植体植入规划软件决定的。当种植体植入以后．重新进行锥体束CT扫描。随后．软件会将种植体计划植入和实际植入的图像融合．并且从位置和坐标轴两方面进行比较。通过Kolmogorov—Smirnov检验来评价数据分布的正态性。通过基于上、下颌独立样本的f检验来对不同分组的平均值进行比较。显著性水平固定在5％。结果：运用立体打印外科导板引导方法．将62颗种植体植入14名无牙颌患者颌骨内。由于导板的使用，未观察到种植体植入损伤到任何重要的解剖结构。与计划植入的种植体相比，已经植入的种植体表现出其颈部．中部和尖部区域的平均值与标准差的线性测量在上颌分别为2．17（±087）mm、232（±152）mm、286（±217）mm，在下颌分别为142（±0．76）mm、142（±O76）mm、1．42（±O76）mm。上、下颌的角度偏差分别为193（±O．17）。和185（±0．75）°。上、下颌角度偏差之间的差异不大．但线性偏差在上、下颔之间却有显著的差异。结论：计算机导板引导下不翻瓣手术将会成为无牙颌牙弓重建修复的一种可行的治疗方法。

关键词：准确性牙弓萎缩计算机导板引导下手术模拟植入规划

Role of coatings and materials of external fixation pins on the rates of pin tract infection:A systematic review and meta-analysis

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World Journal of Orthopedics 2021年第11期12卷 920-930页

作者： Cristhopher Stoffel bruno Eltz Mauro Jose salles Department of Orthopedic Surgery Instituto de Ortopedia e Traumatologia do Rio Grande do SulPasso Fundo 99010110Rio Grande do SulBrazil Department of Orthopedic Surgery Hospital São FranciscoConcordia 89700-000Santa CatarinaBrazil Musculoskeletal Infection Group Internal Medicine DepartmentSanta Casa de Sao Paulo School of Medical SciencesSao Paulo 01221-020Brazil Musculoskeletal Infection Group Division of Infectious DiseasesEscola Paulista de MedicinaUniversidade Federal de Sao PauloSao Paulo 01221-020Brazil

BACKGROUND Infection at the pin tract is a frequent and feared complication of external fixators(EF).The type of pin material and coatings have been regarded as possibly influencing infection *** the last 20 years,few prospective clinical studies and systematic reviews addressed the role of coated pins on the rate of pin site infection in human clinical *** To assess the EF literature over the past 20 years on the clinical benefits of pins manufactured from varied materials and coating systems and their possible role in pin tract infection *** We performed a systematic review according to the PRISMA and PICOS guidelines using four scientific platforms:PubMed,LiLacs,SciELO,and *** searched the literature for related publications over the past 20 *** A literature search yielded 29 articles,among which seven met the inclusion *** studies compared stainless-steel pins and pins coated with hydroxyapatite(HA),titanium and *** pin tract infection definitions were arbitrary and not standardized among *** studies included a low number of patients in the analysis and used a short follow-up *** metaanalyses were carried out,comparing stainless steel vs silver pins,stainless steel vs HA-coated pins,and titanium vs HA-coated *** of this analysis resulted in statistically significant differences in pin tract infection *** Currently,no clinical evidence supports the advantage of EF pins manufactured with materials other than stainless steel or coated over uncoated pins in reducing the rates of pin tract infections.A standardized definition of pin tract infection in external fixation is still lacking.

关键词： External fixator Pin tract infection Stainless steel pin Coated pin Coating systems Pin site infection

Mangiferin,a natural xanthone,accelerates gastrointestinal transit in mice involving cholinergic mechanism

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World Journal of Gastroenterology 2012年第25期18卷 3207-3214页

作者： Talita Cavalcante Morais Synara Cavalcante Lopes Karine Maria Martins Bezerra Carvalho bruno Rodrigues Arruda Francisco Thiago Correia de Souza Maria Teresa salles Trevisan Vietla Satyanarayana Rao Flávia Almeida Santos Department of Physiology and Pharmacology Brazilian SemiArid Institute of BiomedicineFaculty of MedicineFederal University of CearáFortaleza 60430-270Brazil Post-Graduate Programme in Medical Sciences Faculty of MedicineFederal University of CearáFortaleza 60430-140Brazil Department of Organic and Inorganic Chemistry Federal University of CearáFortaleza 60451-970Brazil

AIM： To investigate the effects of mangiferin on gas- trointestinal transit （GIT） in normal and constipated mice, together with the possible ***： Intragastrically-administered charcoal mealwas used to measure GIT in overnight starved Swiss mice. In the first experiments, mangiferin （3 mg/kg, 10 mg/kg, 30 mg/kg, and 100 mg/kg, po） or tegaserod （1 mg/kg, ip） were administered 30 min before the char- coal meal to study their effects on normal transit. In the second series, mangiferin （30 mg/kg） was tested on delayed GIT induced by several different pharma- cological agonists （morphine, clonidine, capsaicin） or antagonists （ondansetron, verapamil, and atropine） whereas in the third series, mangiferin （30 mg/kg, 100 mg/kg and 300 mg/kg） or tegaserod （1 mg/kg） were tested on 6 h fecal pellets outputted by freely fed mice. The ratio of wet to dry weight was calculated and used as a marker of fecal water content. RESULTS： Mangiferin administered orally significantly （P 〈 0.05） accelerated GIT at 30 mg/kg and 100 mg/kg （89% and 93%, respectively）, similarly to 5-hydroxytrypta- mine4 （5-H%） agonist tegaserod （81%） when compared to vehicle-treated control （63%）. Co-administered man- giferin （30 mg/kg） totally reversed the inhibitory effect of opioid agonist morphine, 5-HT3-receptor antagonist ondansetron and transient receptor potential vanilloid-1 receptor agonist capsaicin on GIT, but only to a partial extent with the GIT-delay induced by ~2-adrenoceptor agonist clonidine, and calcium antagonist verapamil. However, co-administered atropine completely blocked the stimulant effect of mangiferin on GIT, suggesting the involvement of muscarinic acetylcholine receptor activation. Although mangiferin significantly enhanced the 6 h fecal output at higher doses （245.5±10.43 mg vs 161.9±10.82 mg and 227.1±20.11 mg vs 161.9±10.82 mg of vehicle-treated control, at 30 and 100 mg/ kg, P 〈 0.05, respectively）, the effect of tegaserod was more potent （297.4±7.42 mg vs 161.9±1

关键词： Mangiferin Glucosylxanthone Gastrointes-tinal transit Prokinetic action Cholinergic mechanism

Phytochemical bioprospecting, antioxidant, antimicrobial and cytotoxicity activities of saline extract from Tithonia diversifolia(Hemsl) *** leaves

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Asian Pacific Journal of Tropical Biomedicine 2018年第5期8卷 245-253页

作者： bruno Rafael Barboza Bárbara Rafaela da Silva Barros Bárbara de Azevedo Ramos Maiara Celine de Moura Thiago Henrique Napoleao Maria Tereza dos Santos Correia Luana Cassandra Breitenbach Barroso Coelho Iranildo José da Cruz Filho Ana Maria Souto maior Túlio Diego da Silva Leylianne de Cássia Rodrigues Nerys Edson Renan Barros de Santana Cláudia Sampaio de Andrade Lima Virgínia Maria Barros de Lorena Cristiane Moutinho Lagos de Melo Department of Antibiotics Biosciences Centre Federal University of Pernambuco Department of Biochemistry Biosciences Centre Federal University of Pernambuco Center for Strategic Techmologies of the Northeast Department of Biophysics Biosciences Centre Federal University of Pernambuco Aggeu Magalhaes Institute IAM/FIOCRUZ

Objective:To evaluate antimicrobial and antioxidant properties of saline extract from Tithonia diversifolia leaves by phytochemical bioprospecting,and investigate its safety against animal ***:The saline extract was prepared,with NaCl(0.15 M),by constant stirring of the dried and pulverized leaves,followed by volume reduction by *** extract was phytochemical characterized using ultra-performance liquid chromatography,and total phenol and flavonoid analysis also was *** antioxidant capacity was determined through DPPH*radical,the antimicrobial property was evaluated against standard bacteria and fungi,and the viability assays were performed against mice ***:Fifteen compounds were identified belonging to two main classes terpenoids and *** extract showed 22.185 mg GAE/g of total phenolic compounds and 3.220 mg QE/g of ***,extract showed higher antioxidant ability similar to butylated hydroxytoluene a standard molecule[(3.042±0.019)mg AAE/g and(4.12±0.10)mg AAE/g to saline extract and butylated hydroxytoluene,respectively].The antimicrobial assays demonstrated that the extract had a significant antifungal potential against Candida species and could be used with safety against mice splenocytes,in concentrations lower than 50μg/mL,promoting higher proliferation in these ***:Saline extract from Tithonia diversifolia leaves presents potential antioxidant,antifungal properties and induces immunostimulation in mice splenocytes.

关键词： Tithonia diversifolia Extract Antioxidant Antifungal properties Immunostimulation