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Bone marrow-derived products: A classification proposal – bone marrow aspirate, bone marrow aspirate concentrate or hybrid?

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World Journal of Stem Cells 2020年第4期12卷 241-250页

作者： Joseph Purita JoséFábio Santos Duarte Lana Morey Kolber bruno lima rodrigues Tomas Mosaner Gabriel Silva Santos Carolina Caliari-Oliveira Stephany Cares Huber Institute of Regenerative Medicine Boca RatonFL 33432United States Institute of Bone and Cartilage IndaiatubaSP 13334-170Brazil Department of Physical Therapy Nova Southeastern UniversityFort LauderdaleFL 33314United States University of Campinas CampinasSP 13083-970Brazil In Situ Cell Therapy Ribeirao PretoSP 14056-680Brazil

Degenerative musculoskeletal disorders are one of the top causes of pain and disability in the adult *** available alternatives to mitigate symptoms include conservative treatments such as the administration of pharmacological agents and an educative approach towards lifestyle *** use of certain analgesics,such as opiates and corticosteroids,delivers short term results but do not address the etiological source of pain and ***,prolonged use of such medications may cause additional ***,the demand for musculoskeletal tissue regeneration has led to an alternative approach referred to as“orthobiologics”.This alternative is based on cellular and molecular components capable of inducing and promoting tissue *** marrow(BM)aspirate(BMA)and concentrate are well-known orthobiologics used to treat musculoskeletal *** derived from the BM have been discussed in the literature;however,the lack of standardization regarding collection and processing protocols presents a challenge for generalization of study outcomes and determination of *** BM-derived orthobiologics have not yet been classified,to our knowledge,this manuscript proposes the ACH classification system,which speaks to BMA(A),BMA and concentrate(C)and hybrid(H),which combines A and *** classification proposes and describes 8 parameters that are relevant for the quality of biological *** more parameters used would imply greater characterization and complexity of the evaluation of the biological product *** ACH classification envisages a necessary contribution to the comprehension of both clinical procedures and research outcomes,ultimately ushering in a standardization of best practice.

关键词： Bone-marrow classification Bone-marrow aspirate concentrate Regenerativemedicine Stem cells Musculoskeletal disorders Orthobiologics

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Assessment of disease activity in inflammatory bowel diseases:Non-invasive biomarkers and endoscopic scores

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World Journal of Gastrointestinal Endoscopy 2020年第12期12卷 504-520页

作者： bruno lima rodrigues Marcia Carolina Mazzaro Cristiane Kibune Nagasako Maria de Lourdes SetsukoAyrizono Joao Jose Fagundes Raquel Franco Leal Inflammatory Bowel Disease Research Laboratory GastrocenterColorectal Surgery UnitDepartment of SurgerySchool of Medical SciencesUniversity of Campinas(UNICAMP)Campinas 13083-878São PauloBrazil Department of Gastroenterology GastrocenterSchool of Medical SciencesUniversity of Campinas(UNICAMP)Campinas 13083-878Sao PauloBrazil

Inflammatory bowel diseases(IBD)comprise two major forms:Crohn’s disease and ulcerative *** diagnosis of IBD is based on clinical symptoms combined with results found in endoscopic and radiological *** addition,the discovery of biomarkers has significantly improved the diagnosis and management of *** potential genetic,serological,fecal,microbial,histological and immunological biomarkers have been proposed for IBD,and they have been evaluated for clinical routine and clinical ***,especially with biopsy collection,has been considered the standard method to diagnose IBD and to assess clinical activity of the disease,but it is limited to the colon and terminal ileum and is considered *** this reason,non-invasive biomarkers are necessary for this type of chronic inflammatory disease,which affects mostly young individuals,as they are expected to have a long follow-up.

关键词： Inflammatory bowel diseases Biomarkers Endoscopic scores Crohn's disease Ulcerative colitis Inflammation

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Ferric carboxymaltose for anemia in Crohn’s disease patients at a tertiary center:A retrospective observational cohort study

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World Journal of Clinical Cases 2023年第12期11卷 2740-2752页

作者： Natália Souza Nunes Siqueira Livia Bitencourt Pascoal bruno lima rodrigues Marina Moreira de Castro Alan Sidnei Corrêa Martins Dante Orsetti Silva Araújo Luis Eduardo Miani Gomes Michel Gardere Camargo Maria de Lourdes Setsuko Ayrizono Raquel Franco Leal Inflammatory Bowel Disease Research Laboratory GastrocenterColorectal Surgery UnitSchool of Medical SciencesUniversity of Campinas(Unicamp)Campinas 13083-878São PauloBrazil

BACKGROUND Although the gastrointestinal tract is the most affected by Crohn’s disease(CD),the condition triggers other consequent manifestations,and iron deficiency anemia(IDA)is one of the most ***(IV)iron replacement is currently available through several drugs,such as ferric hydroxide sucrose and ferric carboxymaltose(FCM).However,the clinical management of these conditions can be *** To elucidate the drug’s effectiveness,the present study analyzed,through medical records,the clinical and epidemiological data of a cohort of patients with active CD who received IV FCM for the IDA *** This retrospective observational study included 25 patients with active CD,severe anemia,and refractory to previous conventional *** were evaluated two times:During the last treatment with ferric hydroxide sucrose and treatment with *** After treatment with FCM,parameters of IDA assessment significantly improved,serum hemoglobin(Hb)levels increased in 93%of patients(P<0.0001),and in 44%,there was an increase of≥2 g/dL in a single *** addition,86%of the patients showed an increase in serum iron(P<0.0001)and ferritin(P=0.0008)and 50%in transferrin saturation(P=0.01).The serum iron levels at baseline showed a negative association with the ileal and colonic CD and use of biologics and a positive association with patients who developed CD later in life after the age of 40(A3)and with a stenosing(B2)and fistulizing(B3)*** values of Hb and hematocrit after ferric hydroxide sucrose treatment remained similar to those found before *** This study demonstrated that FCM is an important therapeutic strategy for treating IDA in CD patients,achieving satisfactory results in refractory cases.

关键词： Ferric carboxymaltose Iron deficiency anemia Crohn’s disease Inflammatory bowel disease Anemia Clinical management

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Photobiomodulation therapy for osteoarthritis: Mechanisms of action

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World Journal of Translational Medicine 2022年第3期10卷 29-42页

作者： Fábio Pericinoto Giolo Gabriel Silva Santos Victor Fontes Pacheco Stephany Cares Huber Kaue Franco Malange bruno lima rodrigues Fernanda Bassora Tomas Mosaner Gabriel Azzini Lucas Leite Ribeiro Carlos Amilcar Parada JoséFábio Santos Duarte Lana Department of Physical Therapy Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170Brazil Biomedical Science Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170Brazil Department of Orthopedics Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170Brazil Neurobiology of Pain and Regenerative Medicine The University of CampinasCampinas 13083-862Brazil Department of Hematology The University of CampinasCampinas 13083-878Brazil

Photobiomodulation(PBM)is a non-invasive therapeutic modality with demonstrated effects in many fields related to regenerative *** the field of orthopedics,in particular,PBM at various wavelengths has demonstrated the capacity to trigger multiple biological effects associated with protective mechanisms in musculoskeletal *** articles cited in this review show that devices operating close to or within the near infrared range at low intensities can provoke responses which favor the shift in the predominant catabolic microenvironment typically seen in degenerative joint diseases,especially osteoarthritis(OA).These responses include proliferation,differentiation and expression of proteins associated with stable cell ***,PBM can also modulate oxidative stress,inflammation and pain by exerting regulatory effects on immune cells and blocking the transmission of pain through sensory neuron fibers,without adverse ***,these effects are essential in order to control the progression of OA,which is in part attributed to exacerbated inflammation and degradative enzymatic reactions which gradually contribute to the destruction of joint *** may offer medical experts ease of application,financial viability,efficacy and lack of serious adverse ***,it may prove to be a suitable ally in the management of mild to moderate degrees of *** review explores and discusses the principal biological mechanisms of PBM and how the produced effects may contribute to the amelioration of osteoarthritic *** was reviewed using PubMed and Google Scholar in order to find studies describing the mechanisms of *** investigation included a combination of nomenclature such as:“photobiomodulation”,“phototherapy”,“laser therapy”,“PBM”,“osteoarthritis”,low level light therapy”,“inflammation”and“cartilage”.We considered only articles written in English,with access to the full text.

关键词： Photobiomodulation Low-level laser therapy Osteoarthritis Inflammation Regenerative medicine

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King's College criteria and the Clichy-Villejuif criteria require adjustments for assessing acute liver failure due to yellow fever

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World Journal of Transplantation 2025年第1期15卷 124-134页

作者： bruno da Silva Athanasio Antonio Marcio de Faria Andrade Vivian Vasconcelos Costa Juliano Felix Castro Silverio Leonardo Macedo Garcia Mauro Martins Teixeira Daniele da Gloria Souza Paula Vieira Teixeira Vidigal Cristiano Xavier lima Department of Surgery Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Liver Transplantation Unit Felicio Rocho HospitalBelo Horizonte 30110-934Minas GeraisBrazil Department of Morphology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Pathology Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Acute liver failure(ALF)is a severe condition characterized by rapid deterioration of liver function in individuals without preexisting liver *** transplantation(LT)is the most impactful *** fever(YF)is an infectious disease that primarily affects the liver and has a high mortality ***,LT can be a viable option for treating rare cases with extensive liver ***,the criteria for assessing the severity of ALF and determining the indications for transplantation have not been specifically validated for cases caused by *** To present necessary adjustments to established scoring systems for ALF secondary to *** This was an observational,retrospective,single-center *** consecutive patients with confirmed ALF due to YF were monitored in the intensive care unit by a specialized liver transplant team during a three-month epidemic outbreak in *** hospitalization,general supportive therapeutic measures were implemented,and the patients were regularly assessed using the King's College criteria and the Clichy-Villejuif criteria to determine the severity of liver *** is considered a viable measure for patients with signs of end-stage liver *** Eight of 14(57%)patients developed severe neurological alterations within the first 96 hours after hospital *** patients underwent emergency LT,and despite a moderate viral infection of the graft after transplantation,the 5-year survival rate was 50%.Although the King's College criteria and the Clichy-Villejuif criteria are the main scoring systems for ALF,they are insufficient for predicting the risk of mortality in this context,primarily because of low serum bilirubin levels in the final stage of the disease and significant disparities between coagulation abnormalities and patient *** To ensure good applicability in cases of YF-induced ALF,the authors suggest adaptations to the King's College and Clichy-Vill

关键词： Yellow fever Acute liver failure Liver transplantation King's College criteria Clichy-Villejuif criteria

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Muscle strength and its association with cardiometabolic variables in adolescents:does the expression of muscle strength values matter?

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World Journal of Pediatrics 2021年第6期17卷 597-608页

作者： Tiago rodrigues de lima Xuemei Sui Luiz Rodrigo Augustemak de lima Diego Augusto Santos Silva Research Center in Kinanthropometry and Human Performance Federal University of Santa CatarinaTrinity University CampusFlorianopolisSC CEP 88010-970Brazil Department of Exercise Science Arnold School of Public HealthUniversity of South CarolinaColumbiaSCUSA Research Group On Biodynamics of Human Performance and Health Institute of Physical Education and SportFederal University of AlagoasMaceioBrazil

Background We investigate the association between different muscle strength(MS)indices with cardiometabolic variables in *** Cross-sectional study comprising 351 adolescents(male 44.4%,age 16.6±1.0 years)from *** was assessed by handgrip strength and analyzed in live difrerent ways:absolute MS and MS normalized for body weight,body mass index(BMI),height,and fat mass,*** variables investigated as outcomes were systolic and diastolic blood pressure(DBP),waist circumference(WC),high-sensitive C-reactive protein(hs-CRP),lipid and glucose metabolism *** linear regression models adjusted for confounding factors were *** Absolute MS and/or MS normalized for height was directly associated with WC[up to 32.8 *** error(SE)=4.7]and DBP(up to 8.8 mmHg,SE=0.8),and inversely associated with high-density lipoprotein cholesterol(up to-8.0 mg/***=14.1).MS normalized for body *** or fat inass was inversely associated with WC(up to-17.5 cm,SE=2.2).According tesex,MS normalized for fat mass was inversely associated with triglycerides(male:0.02 times lower,SE=0.01;female:0.05 times lower,SE=0.01)and homeostatic model assessment for insulin resistance(male:0.02 times lower,SE=0.01;female:0.06 times ***=0.01).and inversely associated with hs-CRP only among male(0.03 times lower,SE=0.01).Conclusion When normalized for body weight,BMI or fat mass,MS was superior to absolute MS or MS normalized for height in representing adequately cardiometabolic variables among adolescents.

关键词： Abdominal C-reactive protein Hand strength Insulin resistance Obesity Triglycerides

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Association of sleep quality with sociodemographic factors and lifestyle in adolescents from southern Brazil

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World Journal of Pediatrics 2018年第4期14卷 383-391页

作者： Tiago rodrigues de lima Diego Augusto Santos Silva Physical Education Department Federal University of Santa CatarinaProfessor Clementino de Britto Street362 ap 334 CapoeirasFlorianópolisSanta CatarinaBrazil

Background Good sleep quality is an essential component for growth, development, and physical and mental health of the individual, in addition to being a positive indicator of health and well-being. The objective of this study was to estimate the prevalence of poor sleep quality and to identify the association of poor sleep quality with sociodemographic factors, lifestyle, weight status, and associated aerobic fitness in adolescents. Methods This study included 1110 students aged 14–19 years from city of S?o José/SC, Brazil. Sleep quality of the subjects was assessed using a questionnaire and classified as adequate and low. Independent variables were gender, age, monthly household income, maternal education, school shift, global physical activity, proper diet, screen time, sleeping hours of full week, sleeping hours of weekdays, sleeping hours of weekends, weight status, and aerobic fitness. Binary logistic regression was used to estimate odds ratios and confidence intervals of 95%. Results Prevalence of poor sleep quality was 60.4%. More likely to have poor sleep quality were identified in female students (OR 1.68, 95% CI 1.11–2.55), whose mothers had higher levels of education (OR 1.44, 95% CI 1.20–1.73) and low aerobic fitness (OR 1.80, 95% CI 1.02–3.19). Conclusion Adolescents who were most likely to report poor sleep quality were female, those whose mothers had a higher educational level and had low aerobic fitness. Students with sedentary risk behavior were less likely of reporting poor sleep quality.

关键词： Adolescents Brazil Cross-sectional studies Demographic indicators Sleep hygiene

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Resampling in neural networks with application to spatial analysis

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Geo-Spatial Information Science 2022年第3期25卷 413-424页

作者： bruno Póvoa rodrigues Vinicius Francisco Rofatto Marcelo Tomio Matsuoka Talita Teles Assunção Graduate Program in Agriculture and Geospatial Information Federal University of UberlândiaMonte CarmeloBrazil Institute of Geography Federal University of UberlândiaMonte CarmeloBrazil

In developing Artificial Neural Networks(ANNs),the available dataset is split into three categories:training,validation and ***,an important problem arises:How to trust the predic-tion provided by a particular ANN?Due to the randomness related to the network itself(architecture,initialization and learning procedure),there is usually no best *** this issue,we provide a framework,which captures the randomness related to the network *** idea is to perform several training and test trials based on the Jackknife resampling *** consists of iteratively deleting a single observation each time from the sample and recomputing the ANN on the rest of the sample ***,interval prediction is available instead of point *** proposed method was applied and tested using pH,Ca and P data obtained by analyzing 118 georeferenced soil *** results,based on the dataset size simulation,showed that 60%reduction in available dataset offers compatible accuracy in relation to full dataset,and therefore a higher cost of sampling in the field would not be *** re-sampling method spatially characterizes the points of greater or lesser accuracy and *** re-sampling method increased the success rate by using interval prediction instead of using the mean as the most probable *** we restrict it to the regression neural network model,the resampling method proposed can also be extended to other modern statistical tools,such as Kriging,Least Squares Collocation(LSC),Convolutional Neural Network(CNN),and so on.

关键词： Artificial Neural Network(ANN) data splitting resampling delete-1 Jackknife spatial analysis

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Characterization and electrochemical performance of CeO2 and Eu-doped CeO2 films as a manganese redox flow battery component

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Journal of Rare Earths 2018年第10期36卷 1074-1083页

作者： Monica A.rodrigues Ariadne C.Catto Elson Longo Edson Nossol Renata C.lima Institute of Chemistry.Federal University of Uberlandia 38400-902UberlandiaMGBrazil Institute of Chemistry Sao Paulo State UniversityP.O.Box 35514801-907Araraquara.SPBrazil LIEC Department of ChemistryFederal University of Sao Carlos13565-905Sao CarlosSPBrazil

Hexagonal CeO2 and Eu-doped CeO2 nanoparticles were obtained using a facile microwave-hydro thermal method under mild conditions and their application towards manganese redox flow battery component were studied. The structural properties were studied by X-ray diffraction and indicate that samples present a fluorite structure. Raman spectroscopy shows Eu3＋ ions substitute Ce4＋ and generate oxygen vacancies. Electrochemical properties of pure and Eu-doped CeO2 films deposited at graphite substrates investigated by cyclic voltammetry and galvanostatic charge-discharge indicate that dopant concentration affects the electrochemical properties of CeO2. The increase in the reversibility redox of electrochemical systems observed is attributed to coexistence of Ce4＋/Ce3＋ redox couple confirmed by ***-discharge tests display coulombic and voltage efficiency values of above 80% and 90%, respectively. The obtained specific capacity for Ce（0.99）Eu（0.01）O2（372.49 mAh/g） and pure oxide（334.84 mAh/g）indicates that both samples are promising for application in Mn-batteries.

关键词： Cerium oxide Europium Nanoparticles Electrochemical properties Batteries Rare earths

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Influence of fire on woody vegetation of savanna and forest formations in the Cerrado biome

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Journal of Forestry Research 2023年第5期34卷 1207-1216页

作者： Aline das Gracas Costa Fillipe Tamiozzo Pereira Torres Gumercindo Souza lima Fabiano rodrigues de Melo Carlos Moreira Miquelino Eleto Torres bruno Leao Said Schettini Vicente Paulo Santana Neto AndréLuiz Lopes de Faria Department of Forest Engineering Federal University of VicosaUFVVicosaMG 36570-900Brazil Department of Geography Federal University of VicosaUFVVicosaMG 36570-900Brazil

Wildfires have environmental,economic,and social impacts,and can shape the landscape and benefit ecosystems such as the *** study evaluated the diversity,similarity,and floristic and structural differences of woody savanna and forest formations of the Cerrado,when affected and not affected by ***-eight 25-400m2 plots were randomly allocated and divided into Burnt Cerrado and Unburnt Cerrado,Burnt Forest,and Unburnt Forest,and divided into three levels of inclusion according to diameter class(smaller than 2 cm,2-5 cm and larger than5 cm).Species were identified,DBH and height measured,and phyto sociological parameters such as volume,diversity,and floristic similarity *** Cerrado had lower diversity,density,and dominance at all inclusion levels compared to the Unburnt Cerrado,and showed similarities between treatments at the inclusion *** Forest had smaller differences in diversity,density,and dominance than Unburnt *** formation was similar at level 1 of inclusion and in the total ***,it was dissimilar at lower *** lower density and diversity of species at the lowest levels of inclusion was associated with mortality from fire.

关键词： Biodiversity Brazil Burning Floristic Phytosociology

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