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Experimental nerve transfer model in the neonatal rat

Neural Regeneration Research 2022年第5期17卷 1088-1095页

作者： Matthias E.Sporer Martin Aman konstantin D.Bergmeister Dieter Depisch katharina M.Scheuba Ewald Unger bruno k.podesser Oskar C.Aszmann Christian Doppler Laboratory for the Restoration of Extremity Function Department of SurgeryMedical University of ViennaViennaAustria Clinical Laboratory for Bionic Extremity Reconstruction Department of SurgeryMedical University of ViennaViennaAustria Division of Biomedical Research Medical University of ViennaViennaAustria Department of Plastic Aesthetic and Reconstructive SurgeryUniversity Hospital of St.PoeltenKarl Landsteiner University of Health SciencesSt.PoeltenAustria Center for Medical Physics and Biomedical Engineering Medical University of ViennaViennaAustria Division of Plastic and Reconstructive Surgery Medical University of ViennaViennaAustria

Clinically,peripheral nerve reconstructions in neonates are most frequently applied in brachial plexus birth *** surgical concepts,however,have investigated nerve reconstructions in adult animal *** immature neuromuscular system reacts differently to the effects of nerve lesion and surgery and is poorly investigated due to the lack of reliable experimental ***,we describe an experimental forelimb model in the neonatal rat,to study these effects on both the peripheral and central nervous *** 24 hours after birth,three groups were prepared:In the nerve transfer group,a lesion of the musculocutaneous nerve was reconstructed by selectively transferring the ulnar *** the negative control group,the musculocutaneous nerve was divided and not reconstructed and in the positive control group,a sham surgery was *** animal's ability to adapt to nerve lesions and progressive improvement over time were depict by the Bertelli test,which observes the development of *** weeks postoperatively,animals were fully matured and the nerve transfer successfully reinnervated their target muscles,which was indicated by muscle force,muscle weight,and cross sectional area *** the contrary,no spontaneous regeneration was found in the negative control *** the positive control group,reference values were *** labeling indicated that the motoneuron pool of the ulnar nerve was reduced following nerve *** to this post-axotomy motoneuron death,a diminished amount of motoneurons reinnervated the biceps muscle in the nerve transfer group,when compared to the native motoneuron pool of the musculocutaneous *** findings indicate that the immature neuromuscular system behaves profoundly different than similar lesions in adult rats and explains reduced muscle ***,pathophysiologic adaptations are *** maturing neuromuscular system,however,utilizes neonatal capacity of regener

关键词： brachial plexus birth injury experimental rat model extremity reconstruction methodological paper neonatal rat nerve reconstruction nerve regeneration nerve transfer neural plasticity peripheral nerve surgery

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