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Dietary supplementation with curcumin-loaded nanocapsules in lambs:Nanotechnology as a new tool for nutrition

Animal Nutrition 2021年第2期7卷 521-529页

作者： Hiam Marcon Luiz g.griss Vitor L.Molosse bruno g.o.cecere Davi F.Alba Karoline W.Leal gabriela M.galli Carine F.Souza Matheus D.Baldissera Samanta gundel Vitória de A.Bassotto Aline F.ourique Marcelo Vedovatto Aleksandro S.Da Silva Department of Animal Science Universidade Do Estado de Santa Catarina(UDESC)ChapecóSCBrazil graduate Program in Animal Science UDESCChapecóSCBrazil Department of Physiology and Pharmacology Universidade Federal de Santa Maria(UFSM)RSBrazil Universidade Franscicana Santa MariaRSBrazil graduate Program in Animal Science Universidade Estadual de Mato Grosso Do SulAquidauanaMSBrazil

Curcumin-containing nanocapsule powder formulations have not been used in ruminant feed to date,despite the fact that curcumin is known to be a functional food *** objective of this study was to determine whether ethyl polymethacrylate(Eudragit L-100)nanocapsules loaded with curcumin(N-CU)would improve health and growth of ***-two male Lacaune lambs(body weight[BW]=16±0.99 kg;45 d of age)were randomly assigned to 1 of 4 treatments:T0,T1,T2 and T4,representing supplementation of curcumin at 0,1,2,and 4 mg/kg concentrate,*** animals in each treatment were allocated in 4 pens of 2 lambs each(8 lambs per treatment).The experiment lasted 17 d,with samples and measurements collected on d 0,7,12,and *** T2 lambs had greater average daily gain than T0 *** analysis showed that the ideal dose of N-CU to enhance weight gain was 1.89 mg/kg *** were significant interactions(Por hematological variables,particularly for increases in erythrocytes(T2)and re-ductions in counts of leukocytes,neutrophils,and lymphocytes in T1 and *** were significant interactions between treatment×time for total protein,globulin,urea,and triglyceride ***-lation of the antioxidant system was also *** were increased levels of non-protein thiols(NPSH),as well as increased activities of superoxide dismutase(SoD)and glutathione S-transferase(gST)in the supplemented *** of reactive oxygen species(RoS)were lower in the serum of sup-plemented *** general,the 4 mg/kg dose had no positive effects on growth or *** was an unexpected result,given the known properties of *** together,these findings suggest that addition of low concentrations of nanoencapsulated curcumin(T1 and T2)in lamb feed improves health,minimizing oxidative stress and generates anti-inflammatory effects that may have contributed indi-rectly to greater weight *** potentiate the effe

关键词： Antioxidant Anti-inflammatory Curcuma longa Performance Sheep

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Effects of environmental variability and offspring growth on the movement ecology of breeding Scopoli＇s shearwater Calonectris diomedea

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Current Zoology 2014年第5期60卷 622-630页

作者： Jacopo g. cecere giorgia gAIBANI Simona IMPERIo ISPRA- Institute for Environmental Protection and Research Ozzano dell'Emilia Italy Conservation Department LIPU-BirdLife Italy Parma Italy ISAC-CNR - Institute of Atmospheric Sciences and Climate Consiglio Nazionale delle Ricerche Torino Italy

Most seabird species display colonial behavior during the breeding period which implies that food resources around breeding sites can easily go depleted. Seabirds need to both reach profitable areas, which can be located far from the colony, and return to the colony regularly. In this context, flexibility in movement behavior may be crucial for breeding success. During chick-rearing, Procellariformes species can alternate short trips lasting 1-4 days for chick provisioning with longer trips for self-provisioning in what has been called a dual-foraging strategy. We analyzed foraging trips from 136 Scopoli＇s shearwaters from three Mediterranean colonies tracked with gPS during 6 chick-rearing seasons to assess whether the adoption of a dual fo- raging strategy depends on the quality of habitat surrounding the colony. We found a marked dual-foraging strategy only in birds from the Linosa colony which was the largest colony in terms of breeding pairs and was characterized by having a lower marine habitat quality. Birds from this colony performed foraging trips that extended up to 369 km from the nest and lasted more than 10 days. In general, the decision to perform long lasting trips was triggered by lower values of primary production and higher offspring weight. Contrary to expectation, the decision to feed far from the colony was not related to the parents＇ weight. At the same time, despite the higher productivity offered by distant areas, the higher proportion of long trips performed by birds breeding in poor areas was not sufficient to maintain the same body mass as the ones breeding in richer areas [Current Zoology 60 （5）： 622-630, 2014].

关键词： Cory's shearwater Dual foraging strategy gPS tracking Procellariformes Seabird

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Extra food provisioning does not affect behavioral lateralization in nestling lesser kestrels

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Current Zoology 2023年第1期69卷 66-75页

作者： Camilla Soravia Angelo Bisazza Jacopo g.cecere Diego Rubolini Centre for Evolutionary Biology(M092) University of Western Australia35 Stirling HighwayPerthWA 6009Australia Department of general Psychology University of Padovavia Venezia 8Padova I-35131Italy Padova Neuroscience Center University of PadovaVia Orus 2/BPadova I-35129Italy ISPRA—The Italian Institute for Environmental Protection and Research via CàFornacetta 9Ozzano dell’EmiliaBologna I-40064Italy Dipartimento di Scienze e Politiche Ambientali Universitàdegli Studi di Milanovia Celoria 26MilanoI-20133Italy Istituto di Ricerca Sulle Acque IRSA-CNRVia del Mulino 19Brugherio I-20861Italy

Costs and benefits of brain lateralization may depend on environmental *** evidence indicates that the development of brain functional asymmetries is adaptively shaped by the environmental conditions experienced during early *** availability early in life could act as a proxy of the environmental conditions encountered during adulthood,but its potential modulatory effect on lateralization has received little *** increased food supply from egg laying to early nestling rearing in a wild population of lesser kestrels Falco naumanni,a sexually dimorphic raptor,and quantified the lateralization of preening behavior(head turning direction).As more lateralized individuals may perform better in highly competitive contexts,we expected that extra food provisioning,by reducing the level of intra-brood competition for food,would reduce the strength of *** found that extra food provisioning improved nestling growth,but it did not significantly affect the strength or direction of nestling *** addition,maternal body condition did not explain variation in nestling *** of extra food provisioning,the direction of lateralization differed between the sexes,with female nestlings turning more often toward their *** findings indicate that early food availability does not modulate behavioral lateralization in a motor task,suggesting limited phenotypic plasticity in this trait.

关键词： development laterality preening raptor sex-differences

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Candidate genes have sex-specific effects ontiming of spring migration and moult speedin a long-distance migratory bird

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Current Zoology 2017年第5期63卷 479-486页

作者： gaia BAZZI Stefano PoDoFILLINI Emanuele gATTI Luca gIANFRANCESCHI Jacopo g. cecere Fernando SPINA Nicola SAINo Diego RUBoLINI Dipartimento di Bioscienze Universita degli Studi di Milano via Celoria 26 Milan 1-20133 Italy ISPRA--Istituto Superiore per la Protezione e la Ricerca Ambientale via Ca Fornacetta 9 Ozzano dell'EmiliaB0 1-40064 Italy

The timing of major life-history events, such as migration and moult, is set by endogenous circa-dian and circannual clocks, that have been well characterized at the molecular level. Conversely,the genetic sources of variation in phenology and in other behavioral traits have been sparsely ad-dressed. It has been proposed that inter-individual variability in the timing of seasonal events mayarise from allelic polymorphism at phenological candidate genes involved in the signaling cascadeof the endogenous clocks. In this study of a long-distance migratory passerine bird, the willowwarbler Phylloscopus trochilus, we investigated whether allelic variation at 5 polymorphic loci of 4candidate genes （Adcyapl, Clock, Crebl, and Npas2）, predicted 2 major components of the annualschedule, namely timing of spring migration across the central Mediterranean sea and moultspeed, the latter gauged from ptilochronological analyses of tail feathers moulted in the Africanwinter quarters. We identified a novel Clockgene locus （Clock region 3） showing polyQ polymorph-ism, which was however not significantly associated with any phenotypic trait. Npas2 allele sizepredicted male （but not female） spring migration date, with males bearing longer alleles migratingsignificantly earlier than those bearing shorter alleles. Crebl allele size significantly predicted male（but not female） moult speed, longer alleles being associated with faster moult. All othergenotype-phenotype associations were statistically non-significant. These findings provide newevidence for a role of candidate genes in modulating the phenology of different circannual activ-ities in long-distance migratory birds, and for the occurrence of sex-specific candidate gene effects.

关键词： Adcyapl, avian migration, candidate genes, clock, phenology, ptilochronology.

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Home,dirty home:effect of old nest material on nest-site selection and breeding performance in a cavity-nesting raptor

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Current Zoology 2018年第6期64卷 693-702页

作者： Stefano PoDoFILLINI Jacopo g.cecere Matteo gRIggIo Andrea CURCIo Enrico L DE CAPUA Egidio FULCo Simone PIRRELLo Nicola SAINo Lorenzo SERRA Matteo VISCEgLIA Diego RUBoLINI Dipartimento di Scienze e Politiche Ambientali Universita degli Studi di Milanovia Celoria 26MilanoI-20133Italy Istituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA) Ozzano Emilia (BO)Italy Dipartimento di Biologia Universita degli Studi di PadovaItaly Provincia di Matera -Parco della Murgia Materana Italy Studio Naturalistico Milvus Pignola (PZ)Italy De Rerum Natura Montescaglioso (MT)Italy

The quality of a breeding site may have major fitness consequences.A fundamental step to understanding the process of nest-site selection is the identification of the information individuals use to choose high-quality nest *** secondary cavity-nesting bird species that do not add nest lining material,organic remains (faeces,pellets)accumulated inside nest cavities during previous breeding events may be a cue for high-quality nest-sites,as they contain information about past successful breeding and may improve thermal insulation of eggs during ***,cavities in which breeding was successful might also contain more nest-dwelling ectoparasites than unoccupied cavities, offering an incentive for prospective parents to avoid *** exposed breeding cavity-nesting lesser kestrels (Falco naumanni)to nestbox dyads consisting of a dirty (with a thick layer of organic substrate) and a clean nestbox (without organic material).Dirty nestboxes were strongly preferred,being occupied earlier and more frequently than clean *** success in dirty nestboxes was significantly higher than in clean ones,suggesting a positive effect of organic nest material on incubation efficiency, while nestbox dirtiness did not significantly affect clutch and brood *** from dirty nestboxes had significantly higher ectoparasite load than those from clean nestboxes soon after egg hatching,but this difference was not evident a few days *** substrate did not significantly affect nestling *** concluded that nest substrate is a key driver of nest-site choice in lesser kestrels,although the adaptive value of such a strong preference appears elusive and may be context-dependent.

关键词： Camus hemapterus ectoparasites nestbex nest substrate nest-site selection

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Propulsion tests on ultra-high-temperature ceramic matrix composites for reusable rocket nozzles

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Journal of Advanced Ceramics 2023年第7期12卷 1345-1360页

作者： Diletta Sciti Antonio Vinci Luca Zoli Pietro galizia Simone Failla Stefano Mungiguerra giuseppe D.Di Martino Anselmo cecere Raffaele Savino Institute of Science Technology and Sustainability for Ceramics-National Research CouncilFaenza 48018Italy Department of Industrial Engineering University of Naples Federico IINaples 80125Italy

Ultra-high-temperature ceramic matrix composites(UHTCMCs)based on a ZrB_(2)/SiC matrix have been investigated for the fabrication of reusable nozzles for *** de Laval nozzle prototypes,obtained by sintering with either hot pressing(HP)or spark plasma sintering(SPS),were tested 2-3 times in a hybrid rocket motor for proving *** were extracted after oxidation tests to study the microstructural changes and oxidative and thermomechanical stresses induced by the repeated *** to a reference graphite nozzle,no measurable erosion was observed for the UHTCMC-based *** oxidation mechanism consisted in the formation of a Zro_(2)intermediate layer,with a liquid silicon oxide(Sio_(2))layer on the surface that was displaced by the action of the gas flux towards the divergent part of the nozzle,protecting it from further *** specimens obtained by HP and SPS displayed similar performance,with very slight differences,which were attributed to small changes in *** tests demonstrated the capability of complex-shaped prototypes made of the developed UHTCMCs to survive repeated exposure to environments representative of a realistic space propulsion application,for overall operating time up to 30 s,without any failure nor measurable erosion,making a promising step towards the development of reusable rocket components.

关键词： ultra-high-temperature ceramics(UHTCs) ceramic matrix composites(CMCs) propulsion oxidation resistance nozzle prototypes

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ovarian cancer standard of care: are there real alternatives?

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Chinese Journal of Cancer 2015年第1期34卷 17-27页

作者： Chiara Della Pepa giuseppe Tonini Carmela Pisano Marilena Di Napoli Sabrina Chiara cecere Rosa Tambaro gaetano Facchini Sando Pignata Department of Medical oncology Campus BioMedico University of RomeVia Alvaro Del Portillo200Rome 00128Italy Department of Urology and gynecology Istituto Nazionale Tumori Fondazione Pascale-Istituto Di Ricovero E Cura A Carattere ScientificoVia Mariano Semmola52Naples 80131Italy

ovarian cancer remains a major issue for gynecological oncologists, and most patients are diagnosed when the disease is already advanced with a poor chance of survival. Debulking surgery followed by platinum-taxane chemotherapy is the current standard of care, but based on several different strategies currently under evaluation, some encouraging data have been published in the last 4 to 5 years. This review provides a state-of-the-art overview of the available alternatives to conventional treatment and the most promising new combinations. For example, neoadjuvant chemotherapy does not seem to be inferior to primary debulking. Despite its outcome improvements, intraperitoneal chemotherapy struggles for acceptance due to the heavy toxicity. Dose-dense chemotherapy, after showing an impressive efficacy in Asian populations, has not produced equal results in a European cohort, and the results of alternative platinum doublets are not superior to those of carboplatin and paclitaxel. In this setting, adherence to a maintenance therapy after first-line treatment and multiple(primarily antiangiogenic) agents appears to be effective. Although many questions, including the duration of maintenance treatment and the use of bevacizumab beyond progression, remain unanswered, new biologic agents, such as poly(ADP-ribose) polymerase(PARP) inhibitors, nintedanib, and mitogen-activated protein/extracellular signal-regulated kinase(MEK) inhibitors, have emerged as potential therapeutic options in the very near future. Based on the multiplicity of available strategies, the histological and molecular features of the tumor, in addition to patient's clinical condition and disease state, continue to gain importance in guiding treatment choices.

关键词：卵巢癌标准护理治疗方案抗血管生成丝裂原活化持续时间生物制剂

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Hallux rigidus treated with adipose-derived mesenchymal stem cells:A case report

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World Journal of orthopedics 2021年第1期12卷 51-55页

作者： Adriano Braile giuseppe Toro Annalisa De Cicco Antonio Benedetto cecere Fabio Zanchini Alfredo Schiavone Panni Department of Medical and Surgical Specialties and Dentistry University of Campania“Luigi Vanvitelli”Naples 80138Italy

BACKgRoUND First metatarsophalangeal joint arthritis(FMTPA),also known as hallux rigidus,is the most frequent degenerative disease of the *** is made through both clinical and radiological *** medicine showed promising results in the treatment of early *** aim of the present study was to report the results of a case of FMTPA treated with the injection of autologous adipose-derived mesenchymal stem *** SUMMARY A gentleman of 50 years of age presented with a painful hallux rigidus grade 2 resistant to any previous conservative treatment(including nonsteroidal antiinflammatory drugs and hyaluronic acid injections).An injection of autologous adipose-derived mesenchymal stem cells into the first metatarsophalangeal joint was *** adverse events were reported,and both function and pain scales improved after 9 mo of *** The FMTP joint injection of mesenchymal stem cells improved symptoms and function in our patient with FMTPA at 9 mo of follow-up.

关键词： First metatarsophalangeal joint arthritis Hallux rigidus Stem cells Regenerative medicine Early osteoarthritis Adipose derived-mesenchymal stem cells Case report

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供应链量化管理

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作者： (美)Lora M. cecere

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外资水务企业在华直接投资浅析

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水利经济 2016年第4期34卷 17-20,73-74页

作者：周伟 Boulanger Mathieu Adel Ben Youssef grazia cecere 武汉大学经济与管理学院湖北武汉430072 武汉大学中国产学研合作问题研究中心湖北武汉430072 尼斯大学法国尼斯060000 巴黎电信管理学院法国巴黎91000

对外资水务企业在我国直接投资的发展阶段进行研究,认为外资水务企业在我国的直接投资大致经历了初期、扩张与撤退并存、停滞与渗透并存3个阶段;探讨了外资水务企业进入我国市场带来的主要问题,即:水务产业安全、与我国水务企业的竞争... 详细信息

对外资水务企业在我国直接投资的发展阶段进行研究,认为外资水务企业在我国的直接投资大致经历了初期、扩张与撤退并存、停滞与渗透并存3个阶段;探讨了外资水务企业进入我国市场带来的主要问题,即:水务产业安全、与我国水务企业的竞争加剧、公众利益保护等。最后提出解决以上问题的方案:根据水务产业的特征将水务产业链细分成自然垄断环节和非自然垄断环节,对自然垄断环节进行严格的管制,而非自然垄断环节,可以适度引入竞争机制;通过示范效应和人才流动学习外资水务企业先进的管理经营和技术,构建我国水务企业的竞争优势;提高公众和企业的参与度,加强对外资水务企业的监督管理。

关键词：外资水务企业对外直接投资(FDI) 发展阶段

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