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Emerging issues in peripheral nerve repair

Neural Regeneration Research 2012年第29期7卷 2267-2272页

作者： Stefano Geuna Pierluigi Tos bruno battiston Neuroscience Institute of the "Cavalieri Ottolenghi" Foundation (NICO) & Department of Clinical and Biological Sciences University of TurinTorino 10043 Italy Department of Traumatology Microsurgery UnitC.T.O. HospitalTorino 10126Italy

It is today widely acknowledged that nerve repair is now more than a matter of perfect microsurgical reconstruction only and that, to further improve clinical outcome, the involvement of different scientific disciplines is required. This evolving reconstructive/regenerative approach is based on the interdisciplinary and integrated pillars of tissue engineering such as reconstructive microsurgery, transplantation and biomaterials. In this paper, some of the most promising innovations for the tissue engineering of nerves, emerging from basic science investigation, are critically overviewed with special focus on those approaches that appear today to be more suitable for clinical translation.

关键词： nerve reconstruction tissue engineering cell and tissue transplantation gene therapy biomaterials peripheral nervous system microsurgery artificial hollow tubes muscle-vein-combined tubes non-nervous guides neural regeneration

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Soft tissue defects of the hand:etiology and classification

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Plastic and Aesthetic Research 2023年第1期10卷 381-388页

作者： bruno battiston Camillo Fulchignoni U.O.C Orthopaedics Traumatology and Hand SurgeryU.O.D.MicrosurgeryC.T.O.HospitalTurin 10126Italy Orthopedics&Hand Surgery Unit Department of OrthopedicsFondazione Policlinico Universitario A.GemelliIRCCS-Catholic University of the Sacred HearthRome 00168Italy

Soft tissue defects of the hand may result from trauma,oncological procedures,or severe *** etiologies have been *** all cases,an accurate clinical examination is mandatory to understand which structures are involved and what must be *** can be helpful to simplify the decision-making process to classify these ***,there is no consensus on which classification is best to be used among those described in the *** review presents the most common ones,differentiating those classically used to describe tissue loss consequential to a traumatic event from those used to classify soft tissue defects consequent to other events.

关键词： Soft tissue defect trauma oncological infection tissue loss

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Nerve transfers in distal forearm and in the hand

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Plastic and Aesthetic Research 2020年第6期7卷 38-49页

作者： Alfio Luca Costa Paolo Titolo bruno battiston Michele Rosario Colonna Department of Human Pathology of the Adult the Child and the AdolescentUniversity of MessinaMessina 98125Italy Depatment of Traumatology Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di TorinoTurin 10126Italy

Nerve transfers were used,originally,to restore shoulder and elbow function in brachial plexus *** concept has been developed over the years and applied to distal nerve injuries in which lower functionality was expected because of the gap between the injury site and the target *** aim of this review is to describe nerve transfers in the distal forearm and hand for isolated lesions of the median,ulnar and radial *** different advantages achieved by transposition of a functional nerve stump near the effector muscle have opened up new options for the management of nerve *** of these alternatives have only been recently reported and a few are exclusively case reports.

关键词： Nerve transfers nerve injury hand surgery babysitting coaptation microsurgery

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Chitosan tubes enriched with fresh skeletal muscle fibers for delayed repair of peripheral nerve defects

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Neural Regeneration Research 2019年第6期14卷 1079-1084页

作者： AlessANDro Crosio Benedetta Elena Fornasari Giovanna Gambarotta Stefano Geuna Stefania Raimondo bruno battiston Pierluigi Tos Giulia Ronchi Department of Orthopedics and Traumatology II-Surgery for Hand and Upper Limb-AOU Città della Salute e della Scienza di Torino-CTO Hospital Department of Clinical and Biological Sciences University of Torino Neuroscience Institute Cavalieri Ottolenghi University of Torino UO Microchirurgia e Chirurgia della Mano Ospedale Gaetano Pini

Nerve regeneration after delayed nerve repair is often unsuccessful. Indeed, the expression of genes associated with regeneration, including neurotrophic and gliotrophic factors, is drastically reduced in the distal stump of chronically transected nerves; moreover, Schwann cells undergo atrophy, losing their ability to sustain regeneration. In the present study, to provide a three-dimensional environment and trophic factors supporting Schwann cell activity and axon re-growth, we combined the use of an effective conduit(a chitosan tube) with a promising intraluminal structure(fresh longitudinal skeletal muscle fibers). This enriched conduit was used to repair a 10-mm rat median nerve gap after 3-month delay and functional and morphometrical analyses were performed 4 months after nerve reconstruction. Our data show that the enriched chitosan conduit is as effective as the hollow chitosan conduit in promoting nerve regeneration,and its efficacy is not statistically different from the autograft, considered the "gold standard" technique for nerve reconstruction. Since hollow tubes not always lead to good results after long defects(> 20 mm), we believe that the conduit enriched with fresh muscle fibers could be a promising strategy to repair longer gaps, as muscle fibers create a favorable three-dimensional environment and release trophic factors. All procedures were approved by the Bioethical Committee of the University of Torino and by the Italian Ministry of Health(approval number: 864/2016/PR) on September 14, 2016.

关键词： tubulization Schwann cells scaffold tissue engineering nerve reconstruction morphometrical analyses grasping test secondary repair median nerve nerve regeneration

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Principles of *** with like and flap thinning:two essential tools

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Plastic and Aesthetic Research 2023年第1期10卷 64-73页

作者： Davide Ciclamini Leopoldo Arioli Francesco Giacalone bruno battiston Francesca Fissore S.C.Orthopaedic and Traumatology Ⅱ-Hand and Microsurgery Surgery Unit AOU"Cittàdella Salute e della Scienza di Torino"Turin 10100Italy “Sapienza”University of Rome-Orthopaedic and Traumatology Department of Sant’Andrea University Hospital Rome 00189Italy

The"like with like"and the"flap thinning"are two workhorse principles the surgeon must keep in mind to achieve a functional and cosmetic reconstruction of the *** principles are underpinned by a thorough knowledge of anatomy and functional hand units,with a wide range of reconstructive procedures that must be finalized to the necessity of the impaired structures."Like with like"means that a lost tissue must be replaced with another one that can be compared in appearance and *** addition,good cosmetic is often associated with good function because the complex attempt to get a proper aesthetic always traduces itself into a better functional reconstruction."Flap thinning"is essential because soft tissue injuries of the hand represent a more difficult reconstructive challenge than similar injuries elsewhere,and the need for thin tissue to wrap the superficial noble structures of the hand is ***,the procedure of thinning a flap can be dangerous and must adhere to the vascular architecture of the *** paper aims to review and briefly summarize the current literature in this field.

关键词： Hand reconstruction like-to-like flap flap thinning

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The HEPD particle detector of the CSES satellite mission for investigating seismo-associated perturbations of the Van Allen belts

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Science China(Technological Sciences) 2018年第5期61卷 643-652页

作者： AMBROSI Giovanni BARTOCCI Simona BASARA Laurent battiston Roberto BURGER William J. CARFORA Luca CASTELLINI Guido CIPOLLONE Piero CONTI Livio CONTIN Andrea DE DONATO Cinzia DE SANTIS Cristian FOLLEGA Francesco M. GUANDALINI Cristina IONICA Maria IUPPA Roberto LAURENTI Giuliano LAZZIZZERA Ignazio LOLLI Mauro MANEA Christian MARCELLI Laura MASCIANTONIO Giuseppe MERGE Matteo OSTERIA Giuseppe PACINI Lorenzo PALMA Francesco PALMONARI Federico PANICO Beatrice PATRIZII Laura PERFETTO Francesco PICOZZA Piergiorgio POZZATO Michele PUEL Matteo RASHEVSKAYA Irina RICCI Ester RICCI Marco RICCIARINI Sergio bruno SCOTTI Valentina SOTGIU Alessando SPARVOLI Roberta SPATARO bruno VITALE Vincenzo Istituto Nazionale di Fisica Nucleare (INFN) Sezione di Perugia Perugia 06123 Italy Uninettuno University Rome 00186 Italy Istituto Nazionale di Fisica Nucleare (INFN) Sezione di Roma Tor Vergata Rome 00133 Italy Istituto Nazionale di Fisica Nucleare (INFN) TIFPA Povo (TN) 38123 Italy Dipartimento di Fisica Universita di Trento Povo (TN) 38123 Italy Dipartimento di Fisica Universita di Roma Tor Vergata Rome 00133 Italy IFAC-CNR Sesto Fiorentino (FI) 50019 Italy Dipartimento di Fisica e Astronomia Universita di Bologna Bologna 40127 Italy Istituto Nazionale di Fisica Nucleare (INFN) Sezione di Bologna Bologna 40127 Italy Istituto Nazionale di Fisica Nucleare (INFN) Sezione di Napoli Naples 80126 Italy Istituto Nazionale di Fisica Nucleare (INFN) LNE Frascati (RM) 00044 Italy Agenzia Spaziale Italiana (ASI) SSDC Rome 00133 Italy

CSES(China Seismo-Electromagnetic Satellite) is a mission developed by CNSA(Chinese National Space Administration) and ASI(Italian Space Agency), to investigate the near-Earth electromagnetic, plasma and particle environment, for studying the seismo-associated disturbances in the ionosphere-magnetosphere transition zone. The anthropogenic and electromagnetic noise,as well as the natural non-seismic electromagnetic emissions is mainly due to tropospheric activity. In particular, the mission aims to confirming the existence of possible temporal correlations between the occurrence of earthquakes for medium and strong magnitude and the observation in space of electromagnetic perturbations, plasma variations and precipitation of bursts with highenergy charged particles from the inner Van Allen belt. In this framework, the high energy particle detector(HEPD) of the CSES mission has been developed by the Italian LIMADOU Collaboration. HEPD is an advanced detector based on a tower of scintillators and a silicon tracker that provides good energy and angular resolution and a wide angular acceptance, for electrons of 3–100 Me V, protons of 30–200 Me V and light nuclei up to the oxygen. CSES satellite has been launched on February 2^(nd), 2018 from the Jiuquan Satellite Launch Center(China).

关键词： earthquake seismic-precursors particle detector Van Allen belts magnetosphere ionosphere space weather cosmic rays

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