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Covalent functionalization of decellularized tissues accelerates endothelialization

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Bioactive Materials 2021年第11期6卷 3851-3864页

作者： Eleonora Dal Sasso Annj Zamuner Andrea Filippi Filippo Romanato Tiziana Palmosi Luca Vedovelli Dario Gregori Jose Luís Gòmez Ribelles Teresa Russo antonio Gloria Laura Iop Gino Gerosa Monica Dettin Department of Cardiac Thoracic and Vascular Sciences and Venetian Institute of Molecular MedicinePaduaItaly Department of Industrial Engineering University of PaduaPaduaItaly LIFELAB Program Consorzio per la Ricerca SanitariaCORISVeneto RegionItaly Department of Physics and Astronomy“G.Galilei” University of PaduaPaduaItaly Fondazione bruno Kessler TrentoItaly Institute of Pediatric Research Citt`a della Speranza PaduaItaly Center for Biomaterials and Tissue Engineering CBITUniversitat Polit`ecnica de Val`enciaVal`enciaSpain Biomedical Research Networking Center on Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)ValenciaSpain Institute of Polymers Composites and BiomaterialsNational Research Council of ItalyNaplesItaly

In the field of tissue regeneration,the lack of a stable endothelial lining may affect the hemocompatibility of both synthetic and biological *** drawbacks might be prevented by specific biomaterial functionalization to induce selective endothelial cell(EC)*** bovine pericardia and porcine aortas were selectively functionalized with a REDV tetrapeptide at 10^(-5)M and 10^(-6)M working *** scaffold-bound peptide was quantified and REDV potential EC adhesion enhancement was evaluated in vitro by static seeding of human umbilical vein *** viable cells and MTS production were statistically higher in functionalized tissues than in *** histoarchitecture,geometrical features,and mechanical properties were unaffected by peptide *** selective immobilization of REDV was effective in accelerating ECs adhesion while promoting proliferation in functionalized decellularized tissues intended for blood-contacting applications.

关键词： Decellularized pericardium Decellularized aorta Covalent functionalization Endothelialization REDV Mechanical analysis

Self-worth and psychological adjustment of obese children:An analysis through the Draw-A-Person

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World Journal of Psychiatry 2016年第3期6卷 329-338页

作者： Giuseppe Scimeca Amelia Alborghetti antonio bruno Giulia Maria Troili Gianluca Pandolfo Maria Rosaria Anna Muscatello Rocco antonio Zoccali Psychiatric Unit Department of BiomedicalDental Sciences and Morpho-functional ImagingUniversity of Messina "Don Carlo Gnocchi" Foundation

AIM To investigate psychopathological correlates of child obesity via the Draw-A-Person test(DAP).METHODS The participants were 50 children with a mean age of 9.74 *** mass index(BMI) was used as a measure of body *** were divided into normal(n = 17),overweight(n = 14) and obese(n = 19).Two qualitative methods of scoring the DAP based on an integrative approach were used to assess self-concept(ESW) and overall level of children's adjustment(EAC).A procedure for judging interpretative skills of clinicians was implemented before they evaluated children's *** As predicted by our hypothesis,BMI was negatively correlated with ESW,r(50) =-0.29,P < 0.05,but not with EAC,r(50) =-0.08,P = *** evaluate the effect of gender,Pearson correlations were re-computedregrouping the sample accordingly:BMI and EAC reached a significant negative correlation in female subjects,r(24) =-0.36,P < 0.05,and a positive correlation in male subjects,r(26) = 0.37,P = < 0.05;negative correlation between BMI and ESW became stronger in females,r(24) =-0.51,P < 0.01 but not in males,whose correlation disappeared resulting not-significant,r(26) =-0.06,P = *** effect of age was *** indicate that obesity has a negative correlation exclusively on overall adjustment and self-concept in female *** It was concluded that there is a negative bias toward females that reveals how the stigma of obesity is widespread in Western society.

关键词： Obesity Draw a person Draw-A-Person test Projective techniques Psychopathology

Optical diagnostics for density measurement in high-quality laser-plasma electron accelerators

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High Power Laser Science and Engineering 2019年第2期7卷 40-50页

作者： Fernando Brandi Leonida antonio Gizzi Intense Laser Irradiation Laboratory(ILIL) Istituto Nazionale di Ottica-Consiglio Nazionale delle Ricerche(INO-CNR)Sede Secondaria di PisaVia Moruzzi156124PisaItaly Istituto Nazionale di Fisica Nucleare(INFN) Sezione di PisaLargo Bruno PontecorvoLargoBruno Pontecorvo356127PisaItaly

Implementation of laser-plasma-based acceleration stages in user-oriented facilities requires the definition and deployment of appropriate diagnostic methodologies to monitor and control the acceleration *** overview is given here of optical diagnostics for density measurement in laser-plasma acceleration stages,with emphasis on wellestablished and easily implemented *** for both neutral gas and free-electron number density are considered,highlighting real-time measurement *** interferometry,in its various configurations,from standard two-arm to more advanced common-path designs,is discussed,along with spectroscopic techniques such as Stark broadening and Raman scattering.A critical analysis of the diagnostics presented is given concerning their implementation in laser-plasma acceleration stages for the production of high-quality GeV electron bunches.

关键词： gas target interferometry laser-plasma laser wake-field acceleration Raman scattering Stark broadening

Bone marrow progenitor cells do not contribute to liver fibrogenic cells

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World Journal of Hepatology 2012年第10期4卷 274-283页

作者： bruno Diaz Paredes Lanuza Alaby Pinheiro Faccioli Luiz Fernando Quintanilha Karina Dutra Asensi Camila Zaverucha do Valle Paulo César Canary Christina Maeda Takiya antonio Carlos Campos de Carvalho Regina Coeli dos Santos Goldenberg Carlos Chagas Filho Biophysics Institute Rio de Janeiro 21941-902Brazil Radiology Department Clementino Fraga Filho University HospitalRio de Janeiro 22909-538Brazil

AIM:To investigate the contribution of bone marrow(BM) cells to hepatic ***:To establish a model of chimerism,C57Bl/6 female mice were subjected to full-body irradiation(7 Gy) resulting in BM *** mononuclear cells obtained from male transgenic mice expressing enhanced green fluorescent protein(GFP) were used for *** was confirmed by flow *** induce liver injury,chimeric animals received carbon tetrachloride(CCl4) 0.5 mL/kg intraperitoneally twice a week for 30 d(CCl4 30 d) and age-matched controls received saline(Saline 30 d).At the end of this period,animals were sacrificed for post mortem *** samples were stained with hematoxylin and eosin to observe liver architectural changes and with Sirius red for collagen quantification by morphometric analysis.α-smooth muscle actin(α-SMA) was analyzed by confocal microscopy to identify GFP+ cells with myofibroblast(MF) *** tissue,BM and peripheral blood were collected and prepared for flow cytometric analysis using specific markers for detection of hepatic stellate cells(HSCs) and precursors from the ***:Injury to the liver induced changes in the hepatic parenchymal architecture,as reflected by the presence of inflammatory infiltrate and an increase in collagen deposition(Saline 30 d = 11.10% ± 1.12% vs CCl4 30 d = 12.60% ± 0.73%,P = 0.0329).Confocal microscopy revealed increased reactivity against α-SMA in CCl4 30 d compared to Saline 30 d,but there was no co-localization with GFP+ cells,suggesting that cells from BM do not differentiate to *** flow cytometric analysis showed a significant increase of CD45+/GFP+ cells in liver tissue(Saline 30 d = 3.2% ± 2.2% vs CCl4 30 d = 5.8% ± 1.3%,P = 0.0458),suggesting that this increase was due to inflammatory cell infiltration(neutrophils and monocytes).There was also a significant increase of common myeloid progenitor cells(CD117+/CD45+) in the livers of CCl4-treated animals(Saline 3

关键词： Bone marrow Liver Fibrosis Progenitor cells Chimeric mice Green fluorescent protein+ cells

QTL analysis for ascorbic acid content in strawberry fruit reveals a complex genetic architecture and association with GDP-L-galactose phosphorylase

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Horticulture Research 2023年第3期10卷 136-150页

作者： Pilar Muñoz Cristina Castillejo Joséantonio Gómez Luis Miranda Silke Lesemann Klaus Olbricht Aurélie Petit Philippe Chartier Annika Haugeneder Johanna Trinkl Luca Mazzoni Agnieszka Masny Edward Zurawicz Freya Maria Rosemarie Ziegler Björn Usadel Wilfried Schwab Béatrice Denoyes bruno Mezzetti Sonia Osorio JoséFSánchez-Sevilla Iraida Amaya Centro IFAPA de Málaga Instituto Andaluz de Investigación y Formación Agraria y Pesquera(IFAPA)29140MálagaSpain PhD program in Advanced Biotechnology Universidad de Málaga29071MálagaSpain Finca el Cebollar Centro IFAPA las Torres04745HuelvaSpain Hansabred GmbH&Co.KG 01108DresdenGermany INVENIO 33800BordeauxFrance Biotechnology of Natural Products Technische Universität München85354FreisingGermany Dipartimento di Scienze Agrarie Alimentari e AmbientaliUniversitàPolitecnica delle Marche60131AnconaItaly Department of Horticultural Crop Breeding the National Institute of Horticultural ResearchKonstytucji 3 Maja 1/396-100SkierniewicePoland Institute of Bio-and Geosciences Bioinformatics(IBG-4)Forschungszentrum Jülich GmbH52428JülichGermany Univ.Bordeaux INRAEBiologie du Fruit et PathologieUMR 1332F-33140France Departamento de Biología Molecular y Bioquímica Instituto de Hortofruticultura Subtropical y Mediterránea"La Mayora"Universidad de Málaga-Consejo Superior de Investigaciones CientíficasCampus de Teatinos29071 MálagaSpain Unidad Asociada de I+D+i IFAPA-CSIC Biotecnología y Mejora en Fresa 29010MálagaSpain.

Strawberry(Fragaria×ananassa)fruits are an excellent source of L-ascorbic acid(AsA),a powerful antioxidant for plants and *** the genetic components underlying AsA accumulation is crucial for enhancing strawberry nutritional ***,we unravel the genetic architecture of AsA accumulation using an F1 population derived from parental lines‘Candonga’and‘Senga Sengana’,adapted to distinct Southern and Northern European *** account for environmental effects,the F1 and parental lines were grown and phenotyped in five locations across Europe(France,Germany,Italy,Poland and Spain).Fruit AsA content displayed normal distribution typical of quantitative traits and ranged five-fold,with significant differences among genotypes and *** content in each country and the average in all of them was used in combination with 6,974 markers for quantitative trait locus(QTL)*** stable QTLs for AsA content were detected in linkage group(LG)3A,LG 5A,LG 5B,LG 6B and LG *** genes were identified within stable QTL intervals and expression analysis in lines with contrasting AsA content suggested that GDP-L-Galactose Phosphorylase FaGGP(3A),and the chloroplast-located AsA transporter gene FaPHT4;4(7C)might be the underlying genetic factors for QTLs on LG 3A and 7C,*** show that recessive alleles of FaGGP(3A)inherited from both parental lines increase fruit AsA ***,expression of FaGGP(3A)was two-fold higher in lines with high *** here identified represent a useful resource for efficient selection of new strawberry cultivars with increased AsA content.

关键词： straw cultivar content

Role of capsule endoscopy in suspected celiac disease: A European multi-centre study

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World Journal of Gastroenterology 2017年第4期23卷 703-711页

作者： Marisol Luján-Sanchis Enrique Pérez-Cuadrado-Robles Javier Garcia-Lledo José-Francisco Juanmartinena Fernandez Luca Elli Victoria-Alejandra Jiménez-García Juan Egea-Valenzuela Julio Valle-Munoz Cristina Carretero-Ribón Ignacio Fernández-Urién-Sainz antonio López-Higueras Noelia Alonso-Lazaro Mileidis Sanjuan-Acosta Francisco Sanchez-Ceballos bruno Rosa Santiago González-Vázquez Federica Branchi Lucía Ruano-Díaz César Prieto-de-Frías Vicente Pons-Beltrán Pilar Borque-Barrera Begona González-Suárez Sofía Xavier Federico Argüelles-Arias Juan-Manuel Herrerías-Gutiérrez Enrique Pérez-Cuadrado-Martínez Javier Sempere-García-Argüelles Digestive Diseases Unit General University Hospital of Valencia Small Bowel Unit Hospital Morales Meseguer Digestive Diseases Unit General University Gregorio Maranón Unit of Gastroenterology and Endoscopy Complejo Hospitalario de Navarra Center for prevention and Diagnosis of Celiac Disease Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico Unit of Gastroenterology and Endoscopy University Hospital Virgen Macarena Gastroenterology department Hospital Virgen de la Arrixaca Department of Gastroenterology Complejo Hospitalario de Toledo Department of Gastroenterology University of Navarra Clinic1 Endoscopy Digestive Unit Digestive Diseases AreaUniversitari i Politècnic La Fe Hospital1 Digestive Diseases Unit University Hospital Nuestra Senora de Candelaria1 Digestive Diseases Unit Clinical Hospital San Carlos1 Digestive Diseases Unit Hospital da Senhora da Oliveira-Guimaraes1 Endoscopy Digestive Unit Hospital Clinic de Barcelona

AIMTo analyze the diagnostic yield (DY), therapeutic impact (TI) and safety of capsule endoscopy (CE).METHODSThis is a multi-centre, observational, analytical, retrospective study. A total of 163 patients with suspicion of celiac disease (CD) (mean age = 46.4 ± 17.3 years, 68.1% women) who underwent CE from 2003 to 2015 were included. Patients were divided into four groups: seronegative CD with atrophy (Group-I, n = 19), seropositive CD without atrophy (Group-II, n = 39), contraindication to gastroscopy (Group-III, n = 6), seronegative CD without atrophy, but with a compatible context (Group-IV, n = 99). DY, TI and the safety of CE were *** overall DY was 54% and the final diagnosis was villous atrophy (n = 65, 39.9%), complicated CD (n = 12, 7.4%) and other enteropathies (n = 11, 6.8%; 8 Crohn’s). DY for groups I to IV was 73.7%, 69.2%, 50% and 44.4%, respectively. Atrophy was located in duodenum in 24 cases (36.9%), diffuse in 19 (29.2%), jejunal in 11 (16.9%), and patchy in 10 cases (15.4%). Factors associated with a greater DY were positive serology (68.3% vs 49.2%, P = 0.034) and older age (P = 0.008). On the other hand, neither sex nor clinical presentation, family background, positive histology or HLA status were associated with DY. CE results changed the therapeutic approach in 71.8% of the cases. Atrophy was associated with a greater TI (92.3% vs 45.3%, P < 0.001) and 81.9% of the patients responded to diet. There was one case of capsule retention (0.6%). Agreement between CE findings and subsequent histology was 100% for diagnosing normal/other conditions, 70% for suspected CD and 50% for complicated *** has a high DY in cases of suspicion of CD and it leads to changes in the clinical course of the disease. CE is safe procedure with a high degree of concordance with histology and it helps in the differential diagnosis of CD.

关键词： Capsule endoscopy Celiac disease Anti-transglutaminase antibodies Gluten-free diet Non-celiac gluten sensitivity

Murine model to study brain,behavior and immunity during hepatic encephalopathy

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World Journal of Hepatology 2014年第4期6卷 243-250页

作者： Lindisley Ferreira Gomides Pedro Elias Marques bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes antonio Lúcio Teixeira Gustavo Batista Menezes Laboratório de Imunobiofotonica Department of MorphologyICBUFMGBelo Horizonte 31270-901Brazil School of Medicine UFMGBelo Horizonte 31270-901Brazil Department of Physiology ICBUFMGBelo Horizonte 31270-901Brazil Department of Morphology UFMGBelo Horizonte 31270-901Brazil Department of Biochemistry and Immunology UFMGBelo Horizonte 31270-901Brazil

AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the ***:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital *** was evaluated using prolonged prothrombin and partial thromboplastin *** parameters were measured through tail *** levels were quantified in serum and brain ***(EEG) and psychomotor activity score were performed to show brain *** edema was evaluated using magnetic resonance ***:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver *** intense hepatic neutrophil accumulation occurred in response to TAA-induced liver *** led to mice mortality and weight loss,which was associated with severe ***,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance *** agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in *** this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction ***:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment.

关键词： Hepatic encephalopathy Liver injury Thioacetamide Neurological dysfunction Neuropsychomotor abnormalities Intracranial hypertension Cerebral herniation

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白杨道(13区) 节点

城市环境设计 2017年第1期 358-361页

作者： Vincent Parreira antonio Virga Patrick Blanc Paul Arène AAVP建筑事务所

场地信息:预期功能:没有具体的预期地址:Sainte-Hélène路（13区）所有权人:巴黎市政府地块面积:2 272m2限高:25m,要求保护巴黎城市景观获奖团队:项目运营:Compagnie de Phalsbourg项目支持:ITF bruno Georges、Ateve Ingénierie、Tra... 详细信息

场地信息:预期功能:没有具体的预期地址:Sainte-Hélène路（13区）所有权人:巴黎市政府地块面积:2 272m2限高:25m,要求保护巴黎城市景观获奖团队:项目运营:Compagnie de Phalsbourg项目支持:ITF bruno Georges、Ateve Ingénierie、Transitec、Interface Transport、EVP、Bet、Bureau Michel Forgue历史与现状场地位于巴黎边缘,13区的南部,占地逾2 000m2,

关键词：入口物流平台巴黎市殡仪馆服务设施白杨城市景观城市形态

Endoscopic retrograde cholangiography for pediatric choledocholithiasis: Assessing the need for endoscopic intervention

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World Journal of Gastrointestinal Endoscopy 2016年第11期8卷 425-432页

作者： Douglas S Fishman bruno P Chumpitazi Isaac Raijman Cynthia Man-Wai Tsai E O’Brian Smith Mark V Mazziotti Mark A Gilger Section of Pediatric Gastroenterology Hepatology and Nutrition Baylor College of Medicine Texas Children’s Hospital Houston TX 77030 United States Digestive Associates of Houston Houston TX 77098 United States Department of Surgery Section of Pediatric Surgery Baylor College of Medicine Houston TX 77030 United States Department of Surgery Section of Pediatric Surgery Baylor College of MedicineHouston TX 77030 United States Department of Pediatrics Baylor College of Medicine Children’s Hospital of San Antonio San Antonio TX 78207 United States

AIM:To assess pediatric patients for *** applied current adult guidelines to identify predictivefactors in ***:A single-center retrospective analysis was performed at a tertiary children's *** evaluated 44 consecutive pediatric patients who underwent endoscopic retrograde cholangiography(ERCP) for suspected *** were stratified into those with common bile duct stones(CBDS) at ERCP vs those that did not using the American Society of Gastrointestinal Endoscopy(ASGE) guidelines(Very Strong and Strong criteria) for suspected ***:CBDS were identified in 84% at the time of *** ultrasound identified CBDS in 36% of *** bilirubin ≥ 0.5 mg/d L was an independent risk factor for CBDS(P = 0.003).The Very Strong(59.5%) and Strong(48.6%) ASGE criteria identified the majority of patients(P = 0.0001).A modified score using conjugated bilirubin had a higher sensitivity(81.2% vs 59.5%) and more likely to identify a stone than the standard criteria,odds ratio of 25.7 compared to *** aminotransferase and gamma-glutamyl transferase values identified significant differences in a subset of patients with odds ratio of 4.1 and 3.25,***:Current adult guidelines identified the majority of pediatric patients with CBDS,but specific pediatric guidelines may improve detection,thus decreasing risks and unnecessary procedures.

关键词： Endoscopic retrograde cholangiography Pediatric Endoscopy Choledocholithiasis Children Gallstones Abdominal ultrasound