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Canova medication changes TNF-α and IL-10 serum levels in mice infected with Trypanosoma cruzi Y strain

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Asian Pacific Journal of Tropical Medicine 2016年第9期9卷 838-843页

作者： áurea Regina Telles Pupulin Lívia Bracht Márcia Machado de Oliveira dalalio Francielli Maria de Souza Silva-Comar bruno Ambrósio da rocha Franciele Queiroz Ames Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado Laboratory of Parasitology Department of Basic Sciences of HealthState University of Maringá-PR Laboratory of Hepatic Metabolism Department of BiochemistryState University of Maringá-PR Laboratory of Immunology Department of Basic Sciences of HealthState University of Maringá-PR Laboratory of Inflammation Department of Pharmacology and TherapeuticState University of Maringá-PR

Objective:To identify whether Canova medication changes TNF-α and IL-10 serum levels in mice infected with Trypanosoma cruzi Y ***:Animals were divided into five groups:non-treated infected animals(I); benznidazole-treated infected animals(Bz; 100 mg/kg body weight,single daily dose by gavage); Canova medication(CM) treated infected animals(CM;0.2 mL/animal,single daily dose by gavage); benznidazole- and Canova medication–treated infected animals with the above-mentioned dose(Bz+CM);and non-infected animals(C).TNF-α and IL-10 levels were determined in serum aliquots after 4,7,10,13,and 29 days of *** ELISA technique was employed with R&D System *** ***:A high increase in TNF-α and IL-10 levels occurred in the infected and CM-treated groups within the treatment employed on the 10 th day after infection,coupled with a IL-10 decrease on the 13 th day after infection when compared with the other experimental ***:CM may change the balance between plasma cytokine levels(TNF-α and IL-10) in mice infected with Y strain ***,with important consequences leading towards a more severe infection.

关键词： Trypanosoma cruzi Canova medication Cytokines

An Updated Mini Review of Acute and Chronic Responses to Exercise Training-induced Irisin in Browning of White Fat

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Journal of Endocrinology Research 2019年第1期1卷 1-7页

作者： Sílvia rocha-Rodrigues bruno Silva Polytechnic Institute of Viana do Castelo School of Sport and LeisureMelgacoPortugal Laboratory of Metabolism and Exercise Research Centre in Physical ActivityHealth and Leisure(CIAFEL)Faculty of Sport SciencesUniversity of PortoPortugal Research Center in Sports Sciences Health and Human Development(CIDESD)Vila RealPortugal

Nowadays,is well established that the benefits induced by exercise training(ET)affects not only skeletal muscle,but also other non-contractile organs over *** potential mechanism underlying this crosstalk is the synthesis and secretion of several biological active factors,such as irisin,by muscle contractile *** hormone has been described to be able to induce a brown adipocyte-like phenotype in white adipose(WAT),increase whole-body metabolic rate,and therefore prevent and/or treat obesity-related metabolic ***,the modulatory impact of ET on WAT may also occur through skeletal muscle-adipose organ *** this review,we summarize the acute and chronic adaptations to ET-induced irisin synthesis and secretion on the development of browning of white fat and,thus,providing an overview of the potential preventive and therapeutic role of ET on the obesity-related underlying pathways.

关键词： Hormones Exercise PGC-1α UCP1

Nonalcoholic fatty liver disease in asymptomatic Brazilian adolescents

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World Journal of Gastroenterology 2009年第4期15卷 473-477页

作者： Raquel rocha Helma Pinchemel Cotrim Almir Galvo Vieira Bitencourt daniel Batista Valente Barbosa Adméia Souza Santos Alessandro de Moura Almeida bruno Cunha Isabel Guimares Postgraduate Course in Medicine and Health Federal University of BahiaSchool of Medicine Federal University of Bahia School of Medicine NASH Project University Hospital Professor Edgard SantosFederal University of Bahia

AIM： To evaluate the prevalence and clinical characteristics of Nonalcoholic fatty liver disease （NAFLD） among asymptomatic Brazilian adolescents. METHODS： Transversal observational study included asymptomatic adolescents with central obesity from private and public schools in Salvador-Bahia, northeastern Brazil. The children answered a questionnaire that in- cluded age, gender, race, and medical history, and were submitted to a complete physical exam and abdominal ultrasound. Biochemical exams included： ALT, AST, GGT, C reactive protein （CRP）, fasting glucose, insulin, cholesterol and triglycerides. Criteria for NAFLD included： the presence of steatosis in ultrasound and/or high level of ALT, negative or occasional historic of intake of alcohol （4 140 g/wk）, negative investigation for hepatitis A, B, C, auto-immune hepatitis, Wilson disease and ***： From October, 2005 to October, 2006, the study included 1801 subjects between 11 and 18 years of age and a mean age of 13.7± 2.0 years. One hun- dred ninety-nine had central obesity. The prevalence of NAFLD was 2.3%, most of whom were male and white. Insulin resistance （IR） was observed in 22.9% of them and had positive correlations with ALT and GGT （P 〈 0.05）. Elevated CRP was observed in 6.9% of the cases; however, it was not associated with WC, IR or liver enzymes. CONCLUSION： The prevalence of NAFLD in Brazilian adolescents was low. The ethnicity may have influence this frequency in the population studied, which had a large proportion of African descendents.

关键词： Nonalcoholic fatty liver disease Insulinresistance Central obesity Ethnicity Adolescents

Maternal hyperthyroidism increases the synthesis activity and the osteogenic markers expression of calvarial osteoblasts from offspring in a murine model

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BIOCELL 2023年第2期47卷 423-430页

作者： FABIANA rocha ARAÚJO bruno MACHADO BERTASSOLI ISABELLA CRISTINA SOUZA FÉLIX DOUGLAS MARINHO ABREU NATÁLIA MELO OCARINO AMANda MARIA SENA REIS JUNEO FREITAS SILVA ROGÉRIA SERAKIDES Núcleo de Células Tronco e Terapia Celular Animal(NCT-TCA) Veterinay SchoolUniversidade Federal de Minas GeraisBelo HorizonteMinas Gerais31270-901Brasil Universidade de Uberaba(UNIUBE) UberabaMinas Gerais38065-300Brasil Instituto de Ciências Biológicas Universidade Federal de Minas GeraisBelo HorizonteMinas Gerais31270-901Brasil Universidade Estadual de Santa Cruz Campus Soane Nazare de AndradeIlheusBahiaBrasil

To evaluate the characteristics and synthesis activity of osteoblasts extracted from the calvaria of offspring of rats exposed to maternal *** adult Wistar rats were divided into two groups,one control and one treated with daily administration of L-thyroxine by an orogastric tube(50μg/animal/day)during *** days after delivery and confirmation of the mothers’hyperthyroidism,the offspring were euthanized for the extraction of osteoblasts from the *** 7,14,and 21 days,proliferation activity was assessed using MTT assay,while alkaline phosphatase(ALP)activity was assessed by the BCIP/NBT *** 21 days,the total area of the mineralized matrix stained by von Kossa was evaluated by *** expression of gene transcripts for Runx2,Bmp2,Fgfr1,collagen type 1(Col1),osteocalcin(Oc),and osteopontin(Op)were evaluated by real-time *** were compared using the Student’s *** activity was significantly higher at 14 and 21 days in cultures of osteoblasts extracted from offspring exposed to maternal hyperthyroidism,while MTT conversion was significantly lower at 21 days in this *** cultures of neonates exposed to maternal hyperthyroidism also showed a larger total area of mineralized matrix and greater expression of gene transcripts for Oc and *** hyperthyroidism increases the activity of matrix synthesis,alkaline phosphatase activity,and expression of gene transcripts for osteocalcin and osteopontin in the osteoblasts,extracted from the calvaria of the offspring,which may be one of the mechanisms of premature fusion of cranial sutures.

关键词： Craniosynostosis Intramembranous growth Ossification Rat Thyroid dysfunction

Cyclic and other poly(peptoids) copolymers as promising antimicrobial agents

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Cyclic and other poly(peptoids) copolymers as promising anti...

Green Tea(Camellia sinensis):Hypocholesterolemic Effects in Humans and Anti-Inflammatory Effects in Animals

ASTF2023（第五届）抗菌科学与技术论坛

作者： Pedro Salas-ambrosio Antoine Tronnet bruno Dupuy PierreVerhaeghe Colin Bonduelle Univ.Bordeaux CNRSBordeaux INPLCPO LCC-CNRS UPR8241Université de ToulouseCNRSUPS LPBA Institut PasteurUMR-CNRS 2001Université de Paris

Antimicrobial peptides(AMPs) are naturally occurring macromolecules made of amino acids that are potent broad-spectrum antibiotics with potential as novel therapeutic *** structure guide the design of protein-like polymers which combine proteins features with improved stability and processability.[1,2] In this field,polypeptoids,or poly N-substituted-glycines,are a promising class of polymers that offer unique properties in biology.[3] So far,the design of peptoid polymer backbones is an approach that is scarcely explored in infectology(figure 1).[4]In this work,we developed cyclic and other polypeptoids by ring-opening and ring-expansion polymerization(ROP/REP),processes mediated by different catalytic systems or initiating systems such as lithium bis(trimethylsilyl)amide(LiHMDS,figure 1).[5] Our new approach to cyclic and other poly(α-peptoids) from N-alkylated-N-carboxyanhydrides(NNCA) involved simple polymerization steps in DMF and the unprecedented use of lysine-like monomers to design bioactive ***-tuning over their chemical composition has allowed to design antimicrobial copolymers showing good activity,for instance against ***,the main causative agent of nosocomial diarrheas of adults in developed countries.

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Food and Nutrition Sciences 2014年第22期5卷 2185-2194页

作者： Márcia Reto Cristina Almeida Joao rocha bruno Sepodes Maria-Eduardo Figueira Research Institute for Medicines(iMed.ULisboa) Faculty of PharmacyUniversity of LisbonLisbonPortugal

In its essence, tea is an infusion of Camellia sinensis leaves and it is the most widely consumed beverage in the world, aside water. Animal and epidemiological studies have associated green tea consumption with several health benefits, which include hypocholesterolemic effect and anti-in-flammatory activity. In this study catechins levels of green tea and its effect on the lipid profile of humans were evaluated as well as the protective effects against H2O2-mediated damage in human fibroblasts and anti-inflammatory activity of (–)-epigallocatechingallate (EGCG). The daily consumption of 1200 mL of green tea for 30 days by 15 human volunteers promoted the decrease of cholesterol and LDL levels after 15 days, but this effect was not persistent after 30 days. No changes were observed in lipid profile after the consumption of green tea capsules. EGCG, a major green tea catechin, demonstrated an anti-inflammatory action in rats and an antioxidant effect in cultured human fibroblasts.

关键词： Green Tea Infusions Hypocholesterolemic Effect Anti-Inflammatory Activity Antioxidant Activity

Evaluation of the Therapeutic Response and Improvement in the Quality of Life of the Patient with darier Disease to Acitretin through an Analogy between Close Relatives

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Journal of Biosciences and Medicines 2017年第8期5卷 48-54页

作者： Thiago Sande Miguel Mateus de Oliveira Reis bruno Fonseca dos Santos Aline da Silva rocha Nayrton Kalys Cruz dos Anjos Lívia Cristina de Melo Pino daniel Almeida da Costa The Medical School at the Center of Higher Education of Valenca Valenca Brazil

darier disease (DD), also known as follicular keratosis, is a rare autosomal dominant hereditary acantholytic dermatosis caused by a mutation in the ATP2A2 gene. Skin lesions are characterized by persistent confluent papules, preferentially located on the seborrheic areas of the face, chest and back. The hands, feet and nails are also commonly affected. DD has a chronic course with frequent relapses. Their treatment is often difficult and unsatisfactory. We present the case of a 54-year-old male with a history of keratotic papules with a brownish-black color, with a foul-smelling, pruritic and ardent appearance on the back and trunk, since the age of 19, which worsen in the summer. His 27-year-old daughter has a similar picture with her skin lesions started at age of 17 in the region below the breast, back, trunk, feet and hands. After the skin biopsy, the diagnosis was confirmed and acitretin 30 mg/day was instituted. The importance of this case report is to alert health professionals that the diagnosis of DD should be considered in family members of patients, especially those in the first degree, and also in patients with follicular keratolytic dermatoses, being an important differential diagnosis of this group of patients diseases.

关键词： darier’s Disease Follicular Keratosis Hereditary Dermatosis

Effects of Biodegradable Detergents in Morphological Parameters of Liver in Two Neotropical Fish Species(Prochilodus lineatus and Astyanax altiparanae)

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Microscopy Research 2014年第2期2卷 39-49页

作者： bruno Fiorelini Pereira Rebeca Mamede da Silva Alves Anderson Luis Alves Jose Augusto Senhorini Rita de Cassia Gimenes de Alcantara rocha Priscilla Hakime Scalize Dimitrius Leonardo Pitol Flavio Henrique Caetano Universidade Estadual Paulista“Julio de Mesquita Filho”-UNESP Campus de Rio Claro Sao PauloBrazil EMBRAPA PalmasBrazil ICMBio/CEPTA PirassunungaBrazil Faculdade de Odontologia de Ribeirao Preto FORP/USPRibeirao PretoBrazil

Indiscriminate disposal of residues of domestic and/or industrial origin in aquatic ecosystems resulting from urban activities causes concern about their effects on the fauna. Substances absorbed by animals, such as those cited above, are metabolized by the liver, as it is the main target organ of several pollutants and also exercises basic vital functions in the organism. For this reason the liver is used as the main and most reliable biomarker in environmental studies. Thus the objective of the present study was to identify hepatic alterations resulting from exposure to water contaminated by a few commercial brands of biodegradable detergents and their effects when present together with several other contaminants found in nature. For such, a solution of 1 ppm of biodegradable detergents and water from an urban lake were tested on two widely distributed native Brazilian fish (Astyanax altiparanae and Prochilodus lineatus). Several alterations were found on the liver, including cytoplasm vacuolization, nuclear displacement, macrophage recruitment and reduced liver glycogen, showing a degenerative process in the liver of the fish, due to the action of contaminants.

关键词： Liver Fish Detergent Urban Lake Pollution

Creatine HCl and Creatine Monohydrate Improve Strength but Only Creatine HCl Induced Changes on Body Composition in Recreational Weightlifters

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Food and Nutrition Sciences 2015年第17期6卷 1624-1630页

作者： Elias de Franç a bruno Avelar Caroline Yoshioka Jeferson Oliveira Santana Diana Madureira Leandro Yanase rocha Cesar Augustus Zocoler Fabrí cio Eduardo Rossi Fabio Santos Lira bruno Rodrigues érico Chagas Caperuto University Sã o Judas Tadeu S&atilde o Paulo Brazil Exercise and Immunometabolism Research Group Department of Physical Education Universidade Estadual Paulista (UNESP) Presidente Prudente Brazil Faculty of Physical Education University of Campinas (FEF/Unicamp) Campinas Brazil University Presbiteriana Mackenzie S&atilde o Paulo Brazil

Background: Creatine supplementation is a subject that is very well studied. New forms of creatine are suggesting improvements in this supplement performance. Creatine HCl is supposed to have better solubility and absorption than creatine. The aim of this study was to compare the effects of two different doses of creatine HCl with creatine monohydrate on the strength and body composition in recreational weightlifters and to verify the relationship between strength and body composition. Methods: 40 subjects were divided in four groups: Creatine Monohydrate (CMG) 5 g/daily;Creatine HCl-1 (HCl-1) 5 g/daily, Creatine HCl-2 (HCl-2) 1.5 g/daily and Control group (CG) = 5 g of resistant starch/daily. All groups performed a resistance training program during 4 weeks. Body composition and strength were evaluated pre and post intervention. Results: The 1 RM at the Leg press was increased significantly in all groups (CMG: pre = 264.4 ± 83.8 × post = 298.1 ± 90.9;HCl-1: pre = 295.0 ± 88.3 × post = 338.3 ± 86.8 and HCl-2: pre = 274.3 ± 57.1 × post = 305.7 ± 59.4;p p = 0.003), however, there was no statistically significant difference between groups. Fatmass was significantly decreased in HCl-1 (pre = 14.5 ± 8.0 × post = 13.3 ± 8.3;p = 0.034) and HCl-2 (pre = 13.8 ± 5.8 × post = 12.7 ± 5.6;p = 0.005) but fat-free mass was increased only in HCl-1 (pre = 52.2 ± 8.9 × post = 53.8 ± 8.9;p = 0.031), with no differences between groups again. We observed strong correlations between upper limb strength and fat mass (r = 0.93, p p < 0.05) only in HCl-1 group. Conclusions: We concluded that creatine HCl and creatine Monohydrate improve performance but only creatine HCl induces changes on body composition in recreational weightlifters with differences between creatine HCl doses.

关键词： Creatine Hidrochloride Creatine Resistance Training Fat Free Mass Fat Mass