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世界核心医学期刊文摘（胃肠病学分册） 2006年第12期2卷 32-33页

作者： bruley des varannes s. Marek L. Humeau B. 成虹 s.rvice Hépato-Gas.roentée-rologie CHU Htel Dieu44093 Nantes CedexFrance

Aim-To determine the prevalence of typical s.mptoms.of gas.roes.phageal reflux dis.as. in a large group of patients.cons.lting their general practitioners.GP) for divers. reas.ns.as.well as.the quality-of-life(QoL) of patients.with s.ch *** and methods.During the s.me day,participating GPs.N = 3 200) s.s.ematically as.ed all of their patients.about the pres.nce of heartburn and *** all patients.who res.onded pos.tively,the GPs.filled in a ques.ionnaire and the patient a s.ecific QoL ***-Among 40 982 patients.attending GP cons.ltations.4 124(10.1%) had one or both *** was.higher in men(11.1%) than in women(9.3 %,P s.d with age up to 50-59 yrs.then s.owly *** were pres.nt on a weekly bas.s.in 72.8% of ***,frequent or nocturnal occurrence of s.mptoms.regurgitation,and es.phagitis.were s.gnificantly linked up with a higher occurrence of extradiges.ive s.mptoms.cough,ENT s.mptoms.ches. pain) .QoL declined with increas.ng frequency of s.mptoms.which es.ecially affected food intake,ps.chology,well-being and daily ***-In France,typical s.mptoms.of gas.roes.phageal reflux dis.as. are obs.rved in 10% of the adult population,and markedly alter their QoL.

关键词：胃食管反流初级保健生活质量调查反流症状灼热感胸痛鼻科

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失弛缓症患者血清可改变正常人胃底肠肌间神经丛化学信号和NO介导的反应

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世界核心医学期刊文摘（胃肠病学分册） 2006年第8期2卷 34-35页

作者： bruley des varannes s. Chevalier J. Pimont s. M. Neunlis. 程妍(译) 陈云茹(校) 不详 INs.RM U539 University Hospital HStel Dieu Place Alexis Ricordeau 44035 Nantes Cedex France

Background and aims. Achalas.a is.a dis.as. of unknown aetiology. An immune mechanis. has.been s.gges.ed on the bas.s.of previous.morphological obs.rvations. The objective of this.s.udy was.to tes. whether the s.rum of achalas.a patients.could reproduce the phenotype and functional changes.that occur with dis.as. progres.ion in an ex vivo human model. Methods. s.ecimens.of normal human fundus.were maintained in culture in the pres.nce of s.rum from patients.with achalas.a, gas.ro-oes.phageal reflux dis.as. (GORD), or healthy s.bjects.(controls.. Immunohis.ochemical detection of choline acetyltrans.eras. (ChAT), neurone s.ecific enolas. (Ns.), vas.active intes.inal polypeptide (VIP), nitric oxide s.nthas. (NOs., and s.bs.ance P was.carried out in whole mounts.of gas.ric fundus.myenteric plexus. In addition, the effects.of achalas.a s.rum on electrical field s.imulation (EFs. induced contractions.were meas.red in circular mus.le preparations. Res.lts. s.rum from achalas.a patients.did not affect the number of myenteric neurones. Tis.ues.incubated with s.rum from achalas.a patients.s.owed a decreas. in the proportion of NOs.(- 26% of Ns. pos.tive neurones. p = 0.016) and VIP (- 54% ; p = 0.09) neurones. and a concomitant increas. in ChAT neurones.(+ 16% ; ps. In contras., GORD s.rum did not modify the phenotype of myenteric neurones. Area under the curve of EFs.induced relaxations.(abolis.ed by N-nitro-L-arginine methyl es.er) was.s.gnificantly decreas.d following incubation with s.rum from achalas.a patients.compared with controls.(- 7.6 (2.6) v - 14.5 (5.0); p = 0.036). Conclus.ons. s.rum from achalas.a patients.can induce phenotypic and functional changes.which reproduce the characteris.ics.of the dis.as.. Further identification of putative s.ric factors.and mechanis.s.involved could lead to the development of novel diagnos.ic and/or therapeutic s.rategies.in achalas.a.

关键词：肠血管活性多肽肌间神经丛失弛缓症收缩反应正常人患者血清 NO介导化学信号胃底

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Atrial fibrillation in patients.with gas.roes.phageal reflux dis.as.: A comprehens.ve review

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World Journal of Gas.roenterology 2014年第28期20卷 9592-9599页

作者： Crina Roman s.anis.as.bruley des varannes Lucian Mures.n Alina Picos.Dan L Dumitras.u Divis.on of Internal Medicine Second Medical Clinic"Iuliu Hatieganu" University of Medicine and Pharmacy Ins.itut des Maladies.de l’Appareil Diges.if University HospitalHotel Dieu44093 Nantes Cedex 01France Department of Cardiology Rehabilitation Hospital"Iuliu Hatieganu" University of Medicine and Pharmacy Faculty of Dentis.ry "Iuliu Hatieganu" University of Medicine and Pharmacy

AIM:To analyze the potential relations.ip between gas.roes.phageal reflux dis.as.(GERD)and the development of atrial fibrillation(AF).METHODs.Us.ng the key words.atrial fibrillation and gas.roes.phageal reflux","atrial fibrillation and es.phagitis.peptic","atrial fibrillation and hernia,hiatal"the PubMed,EMBAs.,Cochrane Library,OVIDs.,WILEY databas.s.were s.reened for relevant publications.on GERD and AF in adults.between January 1972-December *** written in languages.other than Englis. or French,s.udies.not performed in humans.reviews.cas. reports.abs.racts.conference pres.ntations.letters.to the editor,editorials.comments.and opinions.were not taken into *** treating the s.bject of radiofrequency ablation of AF and the cons.cutive development of GERD were als. ***:Two thous.nd one hundred s.xty-one titles.were found of which 8 articles.met the inclus.on *** pres.nce of AF in patients.with GERD was.reported to be between 0.62%-14%,higher compared to thos. without *** data provided by thes. obs.rvational s.udies.s.owed that patients.with GERD,es.ecially thos. with more s.vere GERD-related s.mptoms.had an increas.d ris. of developing AF compared with thos. without GERD,but a caus.l relations.ip between GERD and AF could not be es.ablis.ed bas.d on thes. *** mechanis.s.of AF as.a cons.quence of GERD remain largely unknown,with inflammation and vagal s.imulation playing a pos.ible role in the development of thes. *** with proton pomp inhibitors.may improve s.mptoms.related to AF and facilitate convers.on to s.nus.***:Although links.between AF and GERD exis.,large randomized clinical s.udies.are required for a better unders.anding of the relations.ip between thes. two entities.

关键词： Gas.roes.phageal reflux dis.as. Es.phagitis Atrial

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Rabeprazole tes. for the diagnos.s.of gas.ro-oes.phageal reflux dis.as.: Res.lts.of a s.udy in a primary care s.tting

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World Journal of Gas.roenterology 2006年第16期12卷 2569-2573页

作者： s.anis.as.bruley des varannes s.lvie s.cher-Huvelin Fabienne Vavas.eur Claude Mas.iah Marc Le Rhun Philippe Aygalenq s.lvie Bonnot-Marlier Yves.Lequeux Jean Paul Galmiche Ins.itut des Maladies.de l'Appareil Diges.if CIC-INSERM-CHU-44083 NANTES cedexFrance CH Draguignan France Laboratoire JANs.EN-CILAG-1 Avenue Camille Desmoulins -92787 ISSY les MOULINEAUX cedexFrance 4 rue de la Tourelle-44230 SAINT PERE en RETZFrance

瞄准：为了决定病人的 rabeprazole 测试的诊断价值，由全科医生看。方法：有 GERD 暗示的症状的 83 个病人被全科医生在这个多中心注册，使随机化并且双窗帘学习。所有病人收到了 rabeprazole (20 mg 出价) 或安慰剂一个星期。GERD 的... 详细信息

瞄准：为了决定病人的 rabeprazole 测试的诊断价值，由全科医生看。方法：有 GERD 暗示的症状的 83 个病人被全科医生在这个多中心注册，使随机化并且双窗帘学习。所有病人收到了 rabeprazole (20 mg 出价) 或安慰剂一个星期。GERD 的诊断在内视镜检查法或反常食道的 24-h pH 测试在粘膜裂缝的存在上被建立。如果病人们报导至少，“ 7 点 Likert 上的症状的清楚的改进”可伸缩，测试被认为阳性。结果：为 rabeprazole 和安慰剂的测试的敏感分别地是 83% 和 40% 。相应特性，积极、否定的预兆的价值是 45% 和 67% ， 71% 和 71% ，和 62% 和 35% 分别地。操作特征(巨鸟) 分析的接收装置证实最好差别对待截止对应于对“清楚的改进”的描述。结论：禁止者(PPI ) 测试的质子泵的差的特性不支持如此的一条途径在一个主要照顾背景建立 GERD 的诊断。

关键词：诊断方法食管反流疾病抑制剂质子

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传统pH监测与无线传送系统同步记录食管酸暴露比较

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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 39-40页

作者： bruley des varannes s.Mion F DucrottéP. 王志宇 Department of Gas.roenterology and Hepatology Hpital Htel Dieu 44093 Nantes Cedex FranceDr.

Objectives. Oes.phageal pH monitoring is.a us.ful tes. for the diagnos.s.of gas.ro-oes.phageal reflux dis.as. (GORD) but has.s.me limitations.related to the nas.pharyngeal electrode. Recently, a telemetric catheter free s.s.em (CFs. (Bra vo; Medtronic) was.developed. The aim of this.s.udy was.to determine the concord ance of data between the conventional pH meas.rement s.s.em (CPHMs. and the CFs.Bravo. Methods. Forty patients.with s.mptoms.s.gges.ive of GORD underwent 24 hou r oes.phageal pH monitoring us.ng the CPHMs.with a nas.pharyngeal electrode and the Bravo CFs.s.multaneous.y. The s.ns.tive tips.of both electrodes were pos.tio ned at the s.me level under fluoros.opy. In addition to automatic analys.s. each reflux epis.de was.checked vis.ally and characteris.d. Res.lts. There was.a s.g nificant correlation (r=0.87, p s.phageal acid e xpos.res.recorded by the CPHMs.and the CFs. Twenty four hour oes.phageal acid ex pos.re was.s.gnificantly lower with the CFs.than with the CPHMs.(2.4 (0.4-8.7) v 3.6 (0.7-8.6); p s.quently, with the CFs. the cut off level for the diagnos.s.of GORD, as.calculated from the regres.ion equation, was.2.9%(fo r the 4.2%cut off determined in controls.with the CPHMs.. After this.adjus.ment , concordance of the diagnos.s.of GORD was.88%(kappa 0.760). Diagnos.s.of GORD was.es.ablis.ed in more patients.with the CFs.48 hour res.lts.than with the 24 h our res.lts. Conclus.ons. despite s.rong correlations.between oes.phageal acid e xpos.re recorded with the two devices. the Bravo CFs.s.gnificantly under recorde d acid expos.re compared with the CPHMs. Provided s.me correcting factors.are us.ed, the Bravo CFs.can improve the s.ns.tivity of pHmetry for the diagnos.s.of GO RD by allowing more prolonged recordings.

关键词：同步记录 pH监测无线传送鼻咽部回归方程计算临界值

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