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Engineer.ng 2019年第1期5卷 98-105页

作者： bruce r. Blazar Masonic Cancer.Center.& Division of Blood and Mar.ow Tr.nsplantation Department of Pediatrics University of Minnesota Minneapolis MN 55455 USA

The most common appr.aches to pr.vent and tr.at gr.ft-ver.us-host disease (GVHD) ar. intended to deplete or.suppr.ss the T cells capable of mediating or.suppor.ing allor.sponses;however. this r.nder. the r.cipients functionally T cell deficient and hence highly susceptible to infections and tumor.r.cur.ence. Depletion is often accomplished thr.ugh the use of br.adly r.active antibodies, while functional impair.ent is typically achieved by phar.acological agents that r.quir. long-ter. administr.tion (usually six months or.mor.), have significant side effects, and may not r.sult in toler.nce (i.e., nonr.sponsiveness) of donor.T cells to conditioning r.gimen-r.sistant host alloantigen-bear.ng cells. As our.knowledge of immune system homeostasis has incr.ased, cell populations with immune r.gulator. function have been identified and char.cter.zed. Although such cell populations ar. typically pr.sent in low fr.quencies, methods to isolate and expand these cells have per.itted their.supplementation to the donor.gr.ft or.infusion late post-tr.nsplant in or.er.to stifle GVHD. This r.view discusses the biology and pr.clinical pr.of of concept of GVHD models, along with GVHD outcomes that focus exclusively on immune r.gulator. cell ther.pies that have pr.gr.ssed to clinical testing.

关键词： Gr.ft-ver.us-host disease (GVHD) Immune r.gulator. cells Cell ther.py

The Global Boundar. Str.totype Section and Point （GSSP） for.the base of Changhsingian Stage （Upper.Per.ian）

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Episodes 2006年第3期29卷 175-182页

作者： Yugan Jin Yue Wang Char.es Hender.on bruce r. War.law Shuzhong Shen Changqun Cao State Key Labor.tor. of Palaeobiology and Str.tigr.phy Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences 39 East Beijing Road Nanjing 210008 China Depar.ment of Geology and Geophysics University of Calgary Calgary Alberta Canada T2N 1N4 U.S. Geological Sur.ey Reston 12201 Sunrise Valley Drive National Center VA 22092 USA

The Global Str.totype Section and Point （GSSP） for.the base-Changhsingian Stage is defined at the Fir.t Appear.nce Datum （FAD） of the conodont Clar.ina wangi within the lineage fr.m C. longicuspidata to C. wangi at a point 88 cm above the base of the Changxing Limestone in the lower.par. of Bed 4 （base of 4α-2） at Meishan D section, Changxing County, Zhejiang Pr.vince, South China. This level is consistent with the fir.t appear.nce of Changhsingian index fusulinid Palaeofusulina sinensis and tapashanitid ammonoids. The speciation event fr.m Clar.ina longicuspidata to C. wangi occur. just above the flooding sur.ace of the second par.sequence in the Changxing Limestone. In addition, the boundar. inter.al is clear.y r.cognizable by the depletion of isotopic car.on r.tios and the nor.al polar.ty zone appear.ng above the Late Wuchiapingian r.ver.ed polar.ty zone. Section C, about 300 m to the west of Section D, exposes mor. of the upper.Longtan For.ation. It clear.y shows the tr.nsitional natur. of deposition acr.ss the Longtan/Changxing for.ational boundar., and thus is descr.bed as a supplementar. r.fer.nce section.

关键词：二叠纪石灰石全球界线层型剖面和节点沉积作用牙形石

The r.le of pr.oper.tive immune modulating nutr.tion

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Hepatobiliar. Sur.er. and Nutr.tion 2020年第2期9卷 221-222页

作者： bruce r.Bistr.an Depar.ment of Medicine Harvard Medical SchoolBeth Israel Deaconess Medical CenterBostonMAUSA

The meta-analysis by Adiamah et al.(1)clear.y identifies the value of pr.oper.tive feeding with immune modulating nutr.tion(IMN)pr.oper.tively in patients under.oing sur.er. for.gastr.intestinal cancer.sufficient to make this a gener.l r.commendation by the r.levant nutr.tion societies such as in futur. ESPEN and the Society of Cr.tical Car. Medicine-ASPEN guidelines(2,3).Pr.viously ESPEN has r.commended IMN in malnour.shed patients following major.cancer.sur.er.(2,4),but ther. has been some contr.ver.y as to whether.IMN offer.d benefit beyond that seen with standar. supplemental feeding in pr.oper.tive patients(5).However.this pr.sent analysis appear. to fir.ly establish the value of IMN in pr.oper.tive pr.par.tion of the gastr.intestinal cancer.patient under.oing *** said ther. ar. significant and impor.ant char.cter.stics of their.analysis of 16 r.ndomized tr.als of solely pr.oper.tive feeding in patients with gastr.intestinal cancer.that may have been cr.tical in deter.ining the significant outcomes of a mar.ed r.duction in infectious complications by near.y 1/2(Or.0.52)with a Pr. was no impact on non-infectious complications,which might be anticipated,since enhancement of immune function would be expected to pr.ncipally impact on the r.sk of infectious complications which could then secondar.ly influence length of *** the author. r.str.cted the included studies to have only those patients with malignant disease with the pr.oper.tive feeding per.od to be at least 3 days,which included studies up to a total of 8 days *** for.er.r.str.ction tends to identify a gr.up most likely to benefit fr.m immune enhancement.

关键词： pr.oper.tive nutr.tion likely

Fr.ctur.ng,caving pr.pagation and influence of mining on gr.undwater.above longwall panels–a r.view of pr.dictive models

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Inter.ational Jour.al of Mining Science and Technology 2020年第1期30卷 49-54页

作者： bruce Hebblewhite School of Miner.ls and Ener.y r.sour.es Engineer.ng University of New South WalesSydney 2052Australia

Histor.cally ther. have been a number.of differ.nt hypotheses and empir.cal models developed in an attempt to descr.be the natur. of fr.ctur.ng above longwall panels in under.r.und coal *** motivation for.suchmodels var.es,r.nging fr.munder.tanding the impact ofmining on sur.ace subsidence,to back-analysis of caving behaviour.in the immediate r.of behind the longwall *** of the most cr.tical motivating factor. that is taking on incr.ased impor.ance in many coalfields,is the need for.better.under.tanding,and hence pr.diction of the impact of mining on over.ying str.ta,par.icular.y str.ta units acting as aquifer. for.differ.nt gr.undwater.*** paper.r.views some of the major.pr.diction models in the context of obser.ed behaviour.of str.ta displacement and fr.ctur.ng above longwall panels in the souther. coalfields of New South Wales,south of *** paper.discusses the par.meter.often r.fer.ed to as"height of fr.ctur.ng"in ter.s of the cr.tical par.meter. that influence it,and the r.levance and appr.pr.ateness of this ter.inology in the context of over.ying sub-sur.ace subsidence and gr.undwater.*** paper.pr.poses an alter.ative ter.inology for.this par.meter.that better.r.flects what it is and how it is *** paper.also addr.sses the potential r.le of major.bedding shear.planes mobilised by mining and their.potential influence on over.ying subsidence and gr.undwater.inter.er.nce.

关键词： Longwall mining Subsidence Gr.undwater Caving Under.r.und coal mining

Analysis of Bio-inspir.d Fishbone Based Cor.ugated r.b for.Adaptive Camber.Mor.hing

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Jour.al of Bionic Engineer.ng 2023年第3期20卷 1083-1102页

作者： r.Jini r.j J.bruce r.lphin r.se A.Vasudevan Depar.ment of Mechanical Engineer.ng Anna University Regional CampusTirunelveli627007India Saveetha School of Engineer.ng SIMATSChennai600124India

Bioinspir.d active camber.mor.hing is an innovative solution for.the aer.dynamic per.or.ance enhancement of flight vehicles such as Micr. Aer.al Vehicles(MAVs)and Unmanned Aer.al Vehicles(UAVs).In the pr.sent ar.icle,a bio-inspir.d Fish Bone Active Camber.FishBAC)cor.ugated r.b design concept with and without a spine for.an Unmanned Aer.al Vehicle(UAV)is *** wing model is composed of multiple cor.ugated r.bs and a splitted spar.for.connecting each *** r.b geometr. is subjected to static str.ctur.l analysis using ANSYS Finite Element Analysis(FEA)module under.the unit load *** defor.ation modes ar. fir.t extr.cted fr.m the solution of the wind tunnel test and the elastically defor.ed NACA 4412 pr.file will be used to per.or. Fluid-Str.ctur. Inter.ction(FSI)studies as a par.ly coupled *** cor.ugated r.b with spine design is a stable str.ctur. as inspir.d fr.m natur. species that can withstand elastic and iner.ial *** fluid dynamics(CFD)simulation is per.or.ed to compute the coefficient of lift(Cl),coefficient of dr.g(Cd)at differ.nt Angle of Attack(AoA)for.a modified NACA 4412 air.oil and the pr.ssur. loads acting on the defor.ed shape is *** Cl obtained for.the modified air.oil at lower.AoA is about 60–80%higher.and the maximum Cl(Clmax)is 62%higher.than the baseline *** Cd of modified air.oil is r.duced about 20%at the AoAα=3°as compar.d with the baseline *** pr.posed cor.ugated r.b str.ctur. has been successfully 3D pr.nted with Polylactic Acid plus(PLA+)mater.al and the wind tunnel testing is done to validate the Cl,Cd values obtained thr.ugh CFD simulations and the r.sults ar. pr.sented.

关键词： Bioinspir.d design Active mor.hing Fish bone Wind tunnel CFD

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软件工程

r.vision of Senegalia in China, and notes on intr.duced species of Acacia, Acaciella, Senegalia and Vachellia(Leguminosae: Mimosoideae)

作者： (美)r.ger.S. Pr.ssman (美)bruce r. Maxim

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Plant Diver.ity 2019年第6期41卷 353-480页

作者： bruce r.Maslin Boon Chuan Ho Hang Sun Lin Bai r.sear.h Associate of Wester. Austr.lian Her.ar.um Department of BiodiversityConservation and AttractionsBentley Delivery CentrePO Box 104WA6983Australia r.sear.h Associate of Singapor. Botanic Gar.ens Her.ar.um Republic of Singapore Her.ar.um Singapore Botanic GardensNational Parks Board1 Cluny Road259569Republic of Singapore CAS Key Labor.tor. of Biodiver.ity and Biogeogr.phy Kunming Institute of BotanyChinese Academy of SciencesKunming650201China

The pr.sent wor. r.pr.sents the fir.t compr.hensive taxonomic r.vision of Acacia ***.(Leguminosae:Mimosoideae)in China,focusing on the indigenous *** r.assessments of specimens and r.-defin让ion of pr.viously r.cor.ed species have r.sulted in r.cognising 21 indigenous species under.Senegalia,a segr.gate of the for.er.Acacia *** botanical pr.files ar. pr.vided for.these species,together.w让h a diagnostic line dr.wing and distr.bution map;photogr.phs of living plants ar. pr.vided for.mor. than half the *** tr.atments ar. also pr.vided for.the 15 species fr.m four.gener. that ar. r.gar.ed as major.intr.ductions of Acacia *** the countr.:Acacia Mill.(12 spp.),Acaciella Br.tton&r.se(1 sp.),Senegalia r.f.(1 sp.)and Vachellia Wight&Ar..(1 sp.).An identification key to all Acacia *** in China is *** indigenous species of Senegalia in China belong to ***(Vassal)Maslin,comb,nov.,and the intr.duced ones to *** a consequence of this study,the number.of Senegalia species now r.cognised for.China has almost *** new species ar. descr.bed:Senegalia clandestina Maslin,***,***&LBai,***.;Senegalia guangdongensis Maslin,***,***&LBai,***.;Senegalia obliqua Maslin,***,***&LBai,***.;Senegalia or.entalis Maslin,***,***&LBai,***.;Senegalia pr.minens Maslin,***,***&LBai,***.;Senegalia stipitata Maslin,***,***&LBai,*** new combinations ar. established:Senegalia gar.ettii(***)Maslin,***,***&LBai,comb.&stat,nov.;Senegalia ker.ii(***)Maslin,***,***&LBai,comb.&stat,nov.;Senegalia kunmingensis(***&***)Maslin,***,***&LBai,comb.&stat,nov.;Senegalia macr.cephala(Lace)Maslin,***,***&LBai,*** andamanica(***)Maslin,Seigler.Ebinger.and *** ar. new r.cor.s for.China.A lectotype is designated for.Acacia teniana Har.s and 2nd step lectotypifications effected for.Acacia delavayi

关键词： Acacia Acaciella Senegalia Vachellia Taxonomy China

A numer.cal optimization of high altitude testing facility for.wind tunnel exper.ments

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Chinese Jour.al of Aer.nautics 2015年第3期28卷 636-648页

作者： J.bruce r.lphin r.se G.r.Jinu C.J.Br.ndha Depar.ment of Aer.nautical Engineer.ng Regional Centre of Anna University Depar.ment of Mechanical Engineer.ng University College of EngineeringNagercoil Depar.ment of Aer.nautical Engineer.ng The Raajas Engineering College

Abstr.ct High altitude test facilities ar. r.quir.d to test the high ar.a r.tio nozzles oper.ting at the upper.stages of r.cket in the nozzle full flow conditions. It is typically achieved by cr.ating the ambient pr.ssur. equal or.less than the nozzle exit pr.ssur.. On aver.ge, air.GN2 is used as active gas for.ejector.system that is stor.d in the high pr.ssur. cylinder.. The wind tunnel facilities ar. used for.conducting aer.dynamic simulation exper.ments at/under.var.ous flow velocities and oper.ting conditions. However. constr.cting both of these facilities r.quir. mor. labor.tor. space and expensive instr.ments. Because of this demer.t, a novel scheme is implemented for.conducting wind tunnel exper.ments by using the existing infr.str.ctur. available in the high altitude testing （HAT） facility. This ar.icle pr.sents the details about the methods implemented for.suitably modifying the sub-scale HAT facility to conduct wind tunnel exper.ments. Hence, the design of nozzle for.r.quir.d ar.a r.tio A/A＊, r.alization of test section and the optimized configur.tion ar. focused in the pr.sent analysis. Specific insights into var.ous r.cket models including high thr.st cr.ogenic engines and their.holding mechanisms to conduct wind tunnel exper.ments in the HAT facility ar. analyzed. A detailed CFD analysis is done to pr.pose this conver.ion without affecting the existing functional r.quir.ments of the HAT facility.

关键词： CFD Enclosed fr.e-jet section Gr.und testing High altitude testing (HAT)facility Optimization

Study of Electr.n Beam Sur.i-sculpt dur.ng Composite Mater.als Joining

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稀有金属材料与工程 2011年第S4期40卷 292-296页

作者： bruce Dance The Welding Institute(TWI) Cambridge CB1 6ALUK

Electr.n beam sur.i-sculpt is a new metal sur.ace pr.cessing technology,which is widely used in the ar.as of mater.als sur.ace tr.atment,composite mater.als manufactur.ng,and so *** this paper.comeld technology,which was an application technology of electr.n beam sur.i-sculpt dur.ng composite mater.als ar.a,was *** tensile exper.ments r.sults and failur. for.s of Ti6Al4V/Car.on fibr. single step joints wer. compar.d with differ.nt joining methods,such as slick embedding,adhesive bonding,r.veting and *** was found that comeld joint had mor. advantage of tensile pr.per.y than other.joining *** the same time,tensile pr.cess of comeld joint was analyzed with numer.cal simulation,and key factor. of pr.tr.sions influenced tensile pr.per.y wer. obtained,which was of impor.ance to str.ctur. design and joint pr.per.y impr.vement.

关键词： electr.n beam sur.i-sculpt comeld joining methods tensile exper.ments numer.cal simulation