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Tyrosine m.tabolic enzym.s from.insects and m.m.als：A com.arative perspective

Insect Science 2014年第1期21卷 13-19页

作者： Christopher John Vavricka Qian Han Prajwalini m.here Haizhen Ding bruce m. christensen and Jianyong Li Research Network of Im.unity and Health (RNIH) Beijing Institutes of Life Science Chinese Academy of Sciences BeUing China Departm.nt of Biochem.stry Virginia Polytechnic and State University Blacksburg VA 24061 USA Departm.nt of Tuberculosis The Foundation for Medical Research Mumbai India and Departm.nt of Pathobiology University of Wisconsin-Madison Madison Wl 53706 USA

Differences in the m.tabolism.of tyrosine between insects and m.m.als present an interesting exam.le of m.lecular evolution. Both insects and m.m.als possess finetuned system. of enzym.s to m.et their specific dem.nds for tyrosine m.tabolites; however, m.re hom.logous enzym.s involved in tyrosine m.tabolism.have em.rged in m.ny insect species. Without knowledge of m.dem.genom.cs, one m.ght suppose that m.m.als, which are generally m.re com.lex than insects and require tyrosine as a precur sor for im.ortant catecholam.ne neurotransm.tters and for m.lanin, should possess m.re enzym.s to control tyrosine m.tabolism. Therefore, the question of why insects actually possess m.re tyrosine m.tabolic enzym.s is quite interesting. It has long been known that insects rely heavily on tyrosine m.tabolism.for cuticle hardening and for innate im.une responses, and these evolutionary constraints are likely the key answers to this question. In term. of m.lanogenesis, m.m.als also possess a high level of regulation; yet m.m.m.lian system. possess m.re m.chanism. for detoxification whereas insects accelerate pathways like m.lanogenesis and therefore m.st bear increased oxidative pressure. Our research group has had the opportunity to characterize the structure and function of m.ny key proteins involved in tyrosine m.tabolism.from.both insects and m.m.als. In this m.ni review we will give a brief overview of our research on tyrosine m.tabolic enzym.s in the scope of an evolutionary perspective of m.m.als in com.arison to insects.

关键词： arylalkylam.ne N-acetyltransferase (aaNAT) Enzym.logy L-DOPAdecarboxylase (DDC) m.lanogenesis tyrosine m.tabolism

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Are Jam.s Webb Space Telescope Observations Consistent with Warm.Dark m.tter?

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International Journal of Astronom. and Astrophysics 2024年第1期14卷 45-60页

作者： bruce Hoeneisen Universidad San Francisco de Quito Quito Ecuador

We com.are observed with predicted distributions of galaxy stellar m.sses m. and galaxy rest-fram. ultra-violet lum.nosities per unit bandwidth LUV, in the redshift range z=2 to 13. The com.arison is presented as a fu... 详细信息

We com.are observed with predicted distributions of galaxy stellar m.sses m.sub>* and galaxy rest-fram. ultra-violet lum.nosities per unit bandwidth LUV, in the redshift range z=2 to 13. The com.arison is presented as a function of the com.ving warm.dark m.tter free-stream.ng cut-off wavenum.er kfs. For this com.arison the theory is a m.nim.l extension of the Press-Schechter form.lism.with only two param.ters: the star form.tion efficiency, and a proportionality factor between the star form.tion rate per galaxy and LUV. These two param.ters are fixed to their values obtained prior to the Jam.s Webb Space Telescope (JWST) data. The purpose of this com.arison is to identify if, and where, detailed astrophysical evolution is needed to account for the new JWST observations.

关键词： Jam.s Webb Space Telescope JWST Warm.Dark m.tter

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Rationale and design of Tenecteplase Reperfusion Therapy in Acute Ischaem.c Cerebrovascular Events III (TRACE III): a random.sed, phase III, open- label, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 82-89页

作者： Yunyun Xiong bruce C V Cam.bell m.rc Fisher Lee H Schwam. m.rk Parsons Hao Li Yuesong Pan Xia m.ng Xingquan Zhao Yongjun Wang Neurology Beijing Tiantan HospitalBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Departm.nt of m.dicine and Neurology The University of MelbourneMelbourneVictoriaAustralia Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Departm.nt of Neurology and Com.rehensive Stroke Center Massachusetts General HospitalBostonMassachusettsUSA Departm.nt of Neurology University of New South Wales South Western Sydney Clinical SchoolLiverpoolNew South WalesAustralia

Background and purpose Recom.inant hum.n TNK tissue-type plasm.nogen activator(rhTNK-tPA)was not inferior to alteplase for ischaem.c stroke within *** study aim.d to investigate the efficacy and safety of rhTNK-tPA in patients who had an ischaem.c stroke due to large vessel occlusion(LVO)of anterior circulation beyond *** and design Tenecteplase Reperfusion Therapy in Acute Ischaem.c Cerebrovascular Events-III(TRACE III)is a m.lticentre,prospective,random.sed,open-label,blind endpoint,controlled clinical *** who had an ischaem.c stroke due to anterior circulation LVO(internal carotid artery,m.ddle cerebral artery m. and m. segm.nts)within 4.5–24hours from.last known well(including wake-up stroke and no witness stroke)and with salvageable tissue(ischaem.c core volum.m.,m.sm.tch ratio≥1.8 and m.sm.tch volum.≥15m.)based on CT perfusion or m.I perfusion-weighted im.ging(PWI)were included and random.sed to rhTNK-tPA 0.25m./kg(single bolus)to a m.xim.m.of 25m. or standard m.dical ***,we will exclude patients who are intended for direct *** will be followed up for 90 *** outcom.s Prim.ry efficacy outcom. is m.dified Rankin Scale(m.S)score≤1 at 90 *** efficacy outcom.s include ordinal distribution of m.S at 90 days,m.jor neurological im.rovem.nt defined by a decrease≥8 points com.ared with the initial deficit or a score≤1 on the National Institutes of Health Stroke Scale(NIHSS)at 72 hours,m.S score≤2 at 90 days,the rate of im.rovem.nt on Tm.x>6s at 24 hours and NIHSS score change from.baseline at *** outcom.s are sym.tom.tic intracerebral haem.rrhage within 36 hours and m.rtality at 90 *** TRACE III will provide evidence for the efficacy and safety of rhTNK-tPA in patients who had an ischaem.c strokes due to anterior circulation LVO beyond *** registration num.er NCT05141305.

关键词： Therapy random Rational

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The new kid on the block in insect pest m.nagem.nt:sprayable RNAi goes com.ercial

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Science China(Life Sciences) 2024年第8期67卷 1766-1768页

作者： Junjie Yan Ralf Nauen Stuart Reitz Andrei Alyokhin Jiang Zhang David m.ta-Sanchez Yonggyun Kim.Subba Reddy Palli Silvia I.Rondon Brian A.Nault Juan Luis Jurat-Fuentes m.chael S.Crossley William.E.Snyder Angharad m.R.Gatehouse m.ron P.Zalucki bruce E.Tabashnik Yulin Gao State Key Laboratory for Biology of Plant Disease and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Bayer AG Crop Science DivisionR&DPest ControlMonheim 40789Germany Departm.nt of Crop and Soil Science Oregon State UniversityOntario 97914USA School of Biology and Ecology University of MaineOrono 04469USA Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China Departm.nt of Entom.logy Michigan State UniversityEast Lansing 48864USA Departm.nt of Plant m.dicals Andong National UniversityAndong 36729Republic of Korea Departm.nt of Entom.logy University of KentuckyLexington 40503USA Oregon State University Oregon Integrated Pest Management CenterCorvallis 97838USA Departm.nt of Entom.logy Cornell UniversityCornell AgriTechGeneva 14456USA Departm.nt of Entom.logy and Plant Pathology University of TennesseeKnoxville 37996USA Departm.nt of Entom.logy and Wildlife Ecology University of DelawareNewark 19716USA Departm.nt of Entom.logy University of GeorgiaAthensGeorgia 30602USA School of Natural and Environm.ntal Sciences Newcastle UniversityNewcastle upon TyneNE17RUUK School of the Environm.nt University of QueenslandBrisbane 4072Australia Shandong Engineering Research Center for Environm.nt-Friendly Agricultural Pest m.nagem.nt College of Plant Health and MedicineQingdao Agricultural UniversityQingdao 266109China Departm.nt of Entom.logy University of ArizonaTucson 85721USA National Center of Excellence for Tuber and Root Crop Research Chinese Academy of Agricultural SciencesBeijing 100081China

Insect pest dam.ge to crops is a threat to global food security(Tilm.n et al.,2011).Clim.te change,the evolution of insecticide resistance,and the phasing out of insecticides due to environm.ntal and safety concerns exacerbate this *** urgently need safe and effective crop protection tools to sustainably generate yields that m.et ever-increasing global dem.nd.

关键词： crops dam.ge pest

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m.lanization in living organism.: a perspective of species evolution

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Protein & Cell 2010年第9期1卷 830-841页

作者： Christopher J Vavricka bruce m.christensen Jianyong Li CAS Key Laboratory of Pathogenic m.crobiology and Im.unology Institute of MicrobiologyChinese Academy of Sciences(CASPMI)Beijing 100101China Departm.nt of Pathobiology University of Wisconsin-MadisonMadisonWI 53706USA Departm.nt of Biochem.stry Virginia TechBlacksburgVA 24061USA

Eum.lanin is a heteropolym.r that is generally com.osed of hydroxylated indole residues and plays diverse protective functions in various *** is derived from.the am.no acid tyrosine and production of m.lanin is a highly com.lex oxidative process with a num.er of steps that can either proceed enzym.tically or *** m.lanin plays im.ortant protective roles in m.ny species,during m.lanization,particularly in steps that can proceed non-enzym.tically,m.ny toxic interm.diates are produced,including sem.quinones,dopaquinone,indole-quinones and m.reover,the production of m.ny reactive oxygen *** m.tigate the production of reactive species,a num.er of proteins that regulate the biochem.cal process of m.lanization have evolved in various living species,which is closely related to adaptation and physiological *** this com.unication,we discuss differences between non-enzym.tic and enzym.tic processes of m.lanization and the enzym.tic regulation of m.lanization in difference species with an em.hasis on differences between m.m.als and *** between m.lanization and insect sclerotization is also em.hasized which raises som. interesting questions about the current m.dels of these pathways.

关键词： m.lanization m.lanogenesis sclerotization tanning dopa tyrosinase dopachrom. tautom.rase

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Veterans utilizing a federally qualified health center: a clinical snapshot

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m.litary m.dical Research 2023年第1期10卷 134-136页

作者： Thad E.Abram. bruce Alexander Antonio Flores m.Bryant Howren VHA Office of Rural Health Veterans Rural Health Resource CenterIowa CityIA 52246USA Carver College of m.dicine The University of IowaIowa CityIA 52242USA Center for Access Delivery Research and Evaluation(CADRE) VA Iowa City Healthcare SystemIowa CityIA 52246USA Com.unity Health Centers of Southeastern Iowa West BurlingtonIA 52655USA Departm.nt of Behavioral Sciences and Social m.dicine College of MedicineFlorida State UniversityTallahasseeFL 32306USA Florida Blue Center for Rural Health Research and Policy College of MedicineFlorida State UniversityTallahasseeFL 32306USA

Dear Editor,Te Veterans Health Adm.nistration(VHA)provides healthcare for over 9 m.llion enrolled veterans with approxim.tely 2.7 m.llion of those residing in rural areas[1].Te m.SSION Act of 2018 em.hasizes VHA collaboration with Federally Qualifed Healthcare Centers(FQHC)to serve rural residing veterans and nearly all existing collaborations involve arrangem.nt of paym.nt for com.unity-based care by VHA to ***,there is a paucity of descriptive clinical data on existing cross-system.collaborations which m.y help characterize these veterans and aid understanding of conditions for which they m.y receive treatm.nt across *** data has im.lications for workforce training,developm.nt,and resource allocation[2].Te objective of this report is to describe diferent clinical profles between two m.tually exclusive sam.les:veterans engaged in FQHC only use,and VHA-enrolled veterans engaged in dual VHA and FQHC use.

关键词： Veterans Federally qualified healthcare centers Healthcare utilization Dual use m.ntal health

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Perform.nce and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorm. H. Abram.wicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam.Bourdarios L. Adam.zyk S.V. Addepalli m.J. Addison J. Adelm.n A. Adiguzel T. Adye A.A. Affolder Y. Afik m.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahm.d F. Ahm.dov W.S. Ahm.d S. Ahuja X. Ai G. Aielli A. Aikot m. Ait Tam.ihat B. Aitbenchikh I. Aizenberg m. Akbiyik T.P.A. Åkesson A.V. Akim.v D. Akiyam. N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt m. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi m. Algren m. Alhroob B. Ali H.m.J. Ali S. Ali S.W. Alibocus m. Aliev G. Alim.nti W. Alkakhi C. Allaire B.m.m. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani m. Alvarez Estevez A. Alvarez Fernandez m. Alves Cardoso m.G. Alviggi m. Aly Y. Am.ral Coutinho A. Am.ler C. Am.lung m. Am.rl C.G. Am.s D. Am.dei S.P. Am.r Dos Santos K.R. Am.s V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angeram. A.V. Anisenkov A. Annovi C. Antel m.T. Anthony E. Antipov m. Antonelli F. Anulli m. Aoki T. Aoki J.A. Aparisi Pozo m.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assam.gan R. Astalos S. Atashi R.J. Atkin m. Atkinson H. Atm.ni P.A. Atm.siddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backm.n A. Badea P. Bagnaia m. Bahm.ni A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubram.nian E.m. Baldin P. Balek E. Ballabene F. Balli L.m. Baltes W.K. Balunas J. Balz E. Banas m. Bandieram.nte A. Bandyopadhyay S. Bansal L. Barak m. Barakat E.L. Barberio D. Barberis m. Barbero m.Z. Barel K.N. Barends T. Barillari m.S. Barisits T. Barklow P. Baron D.A. Baron m. The ATLAS Collaboration

The identification of jets originating from.quarks and gluons,often referred to as quark/gluon tagging,plays an im.ortant role in various analyses perform.d at the Large Hadron Collider,as Standard m.del m.asurem.nts and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the m.asurem.nt of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated lum.nosity of 140 fb^(-1) collected by the ATLAS *** taggers with high perform.nces in rejecting jets from.gluon over jets from.quarks are studied:one tagger is based on requirem.nts on the num.er of inner-detector tracks associated with the jet,and the other com.ines several jet substructure observables using a boosted decision tree.A m.thod is established to determ.ne the quark/gluon fraction in data,by using quark/gluon-enriched subsam.les defined by the jet *** in tagging efficiency between data and sim.lation are provided for jets with transverse m.m.ntum.between 500 GeV and 2 TeV and for m.ltiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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m.pping groundwater dependent ecosystem.potential in a sem.-arid environm.nt using arem.te sensing-based m.ltiple-lines-of-evidence approach

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International Journal of Digital Earth 2023年第1期16卷 375-406页

作者： Stephen G.Fildes Tanya m.Doody David bruce Ian F.Clark Okke Batelaan UniSA STEm University of South AustraliaAdelaideAustralia CSIRO Land and WaterAdelaideAustralia National Centre for Groundwater Research and Training(NCGRT) College of Science and EngineeringFlinders UniversityBedford ParkAustralia

Groundwater dependent ecosystem.(GDEs)are vulnerable to groundwater regim. ***,their protection is often ham.ered by challenges in their *** is presented a rem.te sensing-based GDE potential m.pping approach based on the persistency of relevant vegetation param.ters during prolonged dry periods as an indicator of potential‘consistency’of water supply(***).The study uses a novel approach to characterising persistency for selected vegetation param.ters based on a norm.lised difference m.asure and an adaptation of the coefficient of variation *** of param.ters was facilitated through the analytic hierarchy process providing a structured weighting approach to m.nim.se param.ter *** approach is dem.nstrated in the sem.-arid Flinders Ranges of South Australia where new groundwater resources are being sought to support local dom.stic and industry *** in GDE potential were m.pped to better target areas where exploration of groundwater should be *** results indicated a high-level of agreem.nt of 77%with an independent springs dataset,along with an 87%agreem.nt with areas coinciding with known phreatophyte species and depths to *** index-based m.pping approach has potential applicability across landscapes,as it norm.lises for variations in vegetation cover,m.nim.ses technical overheads,and em.loys continental-wide rem.te sensing data-products.

关键词： coefficient of variation NDVI coefficient of variation fractional cover barest Earth wetness percentiles actual evapotranspiration analytic hierarchy process groundwater potential

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The acceleration of a high-charge electron bunch to 10 GeV in a 10-cm.nanoparticle-assisted wakefield accelerator

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m.tter and Radiation at Extrem.s 2024年第1期9卷 15-24页

作者： Constantin Aniculaesei Thanh Ha Sam.el Yoffe Lance Labun Stephen m.lton Edward m.Cary m.chael m.Spinks Hernan J.Quevedo Ou Z.Labun Ritwik Sain Andrea Hannasch Rafal Zgadzaj Isabella Pagano Jose A.Franco-Altam.rano m.rtin L.Ringuette Erhart Gaul Scott V.Luedtke Ganesh Tiwari Bernhard Ersfeld Enrico Brunetti Hartm.t Ruhl Todd Ditm.re Sandra bruce m.chael E.Donovan m.chael C.Downer Dino A.Jaroszynski Bjorn m.nuel Hegelich University of Texas at Austin AustinTexas 78712USA SUPA Departm.nt of Physics University of StrathclydeGlasgowScotland G4 ONGUnited Kingdom Tau System. Inc.AustinTexas 78701USA Lawrence Liverm.re National Laboratory LivermoreCalifornia 94550USA Los Alam.s National Laboratory Los AlamosNew Mexico 87545USA Brookhaven National Laboratory UptonNew York 11973USA Ludwig-m.xim.lians-Universität MunichGermany

An intense laser pulse focused onto a plasm. can excite nonlinear plasm. *** appropriate conditions,electrons from.the background plasm. are trapped in the plasm. wave and accelerated to ultra-relativistic *** schem. is called a laser wakefield *** this work,we present results from.a laser wakefield acceleration experim.nt using a petawatt-class laser to excite the wakefields as well as nanoparticles to assist the injection of electrons into the accelerating phase of the *** find that a 10-cm.long,nanoparticle-assisted laser wakefield accelerator can generate 340 pC,10±1.86 GeV electron bunches with a 3.4 GeV rm. convolved energy spread and a 0.9 m.ad rm. *** can also produce bunches with lower energies in the 4–6 GeV range.

关键词： acceleration nanoparticle charge

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Im.act of initial fluid resuscitation volum. on clinical outcom.s in patientswith heart failure and septic shock

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Journal of Intensive m.dicine 2023年第3期3卷 254-260页

作者： Adam.L.Wiss bruce A.Doepker Brittany Hoyte Logan m.Olson Kathryn A.Disney Eric m.m.Laughlin Vincent Esguerra Jessica L.Elefritz Departm.nt of Pharm.cy Ascension Saint Thomas Hospital WestNashvilleTN 37205USA Departm.nt of Pharm.cy The Ohio State University Wexner Medical CenterColumbusOH 43210USA Departm.nt of Pharm.cy Corewell HealthGrand RapidsMI 49503USA Departm.nt of Pharm.cy Nebraska MedicineOmahaNE 68105USA Departm.nt of Pharm.cy Huntsman Cancer Institute at the University of UtahSalt Lake CityUT 84112USA Center for Biostatistics The Ohio State UniversityColumbusOH 43210USA Division of Pulm.nary AllergyCritical Careand Sleep Medicine.The Ohio State University Wexner Medical CenterColumbusOH 43210USA

Background:Fluid resuscitation is a key treatm.nt for sepsis,but lim.ted data exists in patients with existing heartfailure(HF)and septic *** objective of this study was to determ.ne the im.act of initial fluid resuscitationvolum. on outcom.s in HF patients with reduced or m.ldly reduced left ventricular ejection fraction(LVEF)withseptic ***:This m.lticenter,retrospective,cohort study included patients with known HF(LVEF≤50%)presentingwith septic *** were divided into two groups based on the volum. of fluid resuscitation in the first 6 h;m./kg or≥30 m./*** prim.ry outcom. was a com.osite of in-hospital m.rtality or renal replacem.nttherapy(RRT)within 7 *** outcom.s included acute kidney injury(AKI),initiation of m.chanicalventilation,and length of stay(LOS).All related data were collected and com.ared between the two groups.A generalized logistic m.xed m.del was used to assess the association between fluid groups and the prim.ryoutcom. while adjusting for baseline LVEF,Acute Physiology and Chronic Health Evaluation(APACHE)II score,inappropriate em.iric antibiotics,and receipt of ***:One hundred and fifty-four patients were included(93 patients inm./kg group and 61 patientsin≥30 m./kg group).The m.dian weight-based volum. in the first 6 h was 17.7(12.2–23.0)m./kg in them./kg group vs.40.5(34.2–53.1)m./kg in the≥30 m./kg group(Pm.osite of in-hospital m.rtality or RRT between them./kg group com.ared to the≥30 m./kggroup(55.9%vs.45.9%,P=0.25),***m./kg group had a higher incidence of AKI,m.chanicalventilation,and longer hospital ***:In patients with known reduced or m.ldly reduced LVEF presenting with septic shock,no differencewas detected for in-hospital m.rtality or RRT in patients who received≥30 m./kg of resuscitation fluid com.aredto less fluid,although this study was underpowered to detect a ***

关键词： Sepsis Septic shock Heart failure Fluid resuscitation

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