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2008北京国际生理科学学术大会

作者： MiLLeRSHiP Joanne bruce jason i e DeVOR Daniel C FeARON ian M Life Sciences the University of ManchesterManchester M13 9NTUK Department of Cell Biology and Physiology School of MedicineUniversity of PittsburghPittsburghPA 15261USA

Potassium channels regulate proliferation of a number of cell *** the potassium channel family, K3.1(iK1/SK4),is involved in the proliferation of endothelial cells(eC),T lymphocytes and several cancer cell *** respect to endothelial cells,these cells express a wide variety of ion channel types and subtypes,and the patterns of expression differ due to differences in vascular beds from which cells were isolated,passage number and culture *** this reason,it is difficult to dissect,and examine in isolation,the functional role of a specific potassium channel in eC ***,to investigate the mechanisms underlying the role of K3.1 in cell proliferation in isolation,we performed proliferation assays in HeK293 cells expressing recombinant hK3.1 *** cells stably expressing this channel,selective inhibition of hK3.1 with 10μmol/L TRAM-34 reduced proliferation,while transient expression of hK3.1 in WT HeK293 cells increased *** mechanism by which hK3.1 stimulates cell proliferation is thought to be mediated by cell hyperpolarisation(via K efflux),which increases[Ca] by driving Ca influx through non-selective cation ***,when WT HeK293 cells were transiently transfected with a mutant(GYG/AAA)hK3.1 channel,which neither conducts K ions nor promotes Ca entry,proliferation was increased relative to control(mock-transfected)***,when WT HeK293 cells were transiently transfected with a trafficking mutant(L18A/L25A)hK3.1 channel,which is not expressed at the cell surface,proliferation was also increased relative to control ***,both K efflux and Ca influx are not necessary for hK 3.1-induced proliferation in HeK293 cells,and nor does hK 3.1 need to be expressed at the cell *** propose that hK 3.1-induced cell proliferation is independent of electrophysiological function and arises potentially due to direct regulation of intracellular signalling *** support of this hypothesis,in cells

关键词： KCa3.1 endothelial cells proliferation MAP kinase

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Handwriting Analysis Based on Belief of Targeted individual Supporting insider Threat Detection

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Journal of information Security 2024年第3期15卷 308-319页

作者： jason Slaughter Carole e. Chaski Kellep Charles Center for Cybersecurity Research and Analysis (CCRA) Capitol Technology University Laurel United States

The Unintentional insider Threat (UiT) concept highlights that insider threats might not always stem from malicious intent and can occur across various domains. This research examines how individuals with medical or psychological issues might unintentionally become insider threats due to their perception of being targeted. insights from the survey A Survey of Unintentional Medical insider Threat Category indicate that such perceptions can be linked to underlying health conditions. The study emotion Analysis Based on Belief of Targeted individual Supporting insider Threat Detection reveals that anger is a common emotion among these individuals. The findings suggest that UiTs are often linked to medical or psychological issues, with anger being prevalent. To mitigate these risks, it is recommended that insider Threat programs integrate expertise from medicine, psychology, and cybersecurity. Additionally, handwriting analysis is proposed as a potential tool for detecting insider threats, reflecting the evolving nature of threat assessment methodologies.

关键词： insider Threat Detection Targeted Medical

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The new kid on the block in insect pest management:sprayable RNAi goes commercial

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Science China(Life Sciences) 2024年第8期67卷 1766-1768页

作者： Junjie Yan Ralf Nauen Stuart Reitz Andrei Alyokhin Jiang Zhang David Mota-Sanchez Yonggyun Kim Subba Reddy Palli Silvia i.Rondon Brian A.Nault Juan Luis Jurat-Fuentes Michael S.Crossley William e.Snyder Angharad M.R.Gatehouse Myron P.Zalucki bruce e.Tabashnik Yulin Gao State Key Laboratory for Biology of Plant Disease and insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Bayer AG Crop Science DivisionR&DPest ControlMonheim 40789Germany Department of Crop and Soil Science Oregon State UniversityOntario 97914USA School of Biology and ecology University of MaineOrono 04469USA Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China Department of entomology Michigan State UniversityEast Lansing 48864USA Department of Plant Medicals Andong National UniversityAndong 36729Republic of Korea Department of entomology University of KentuckyLexington 40503USA Oregon State University Oregon Integrated Pest Management CenterCorvallis 97838USA Department of entomology Cornell UniversityCornell AgriTechGeneva 14456USA Department of entomology and Plant Pathology University of TennesseeKnoxville 37996USA Department of entomology and Wildlife ecology University of DelawareNewark 19716USA Department of entomology University of GeorgiaAthensGeorgia 30602USA School of Natural and environmental Sciences Newcastle UniversityNewcastle upon TyneNE17RUUK School of the environment University of QueenslandBrisbane 4072Australia Shandong engineering Research Center for environment-Friendly Agricultural Pest Management College of Plant Health and MedicineQingdao Agricultural UniversityQingdao 266109China Department of entomology University of ArizonaTucson 85721USA National Center of excellence for Tuber and Root Crop Research Chinese Academy of Agricultural SciencesBeijing 100081China

insect pest damage to crops is a threat to global food security(Tilman et al.,2011).Climate change,the evolution of insecticide resistance,and the phasing out of insecticides due to environmental and safety concerns exacerbate this *** urgently need safe and effective crop protection tools to sustainably generate yields that meet ever-increasing global demand.

关键词： crops damage pest

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Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

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Light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman jason Lynch Christopher e.Stevens Christopher Munley Chentao Li Jin Hou Hao Zhang Andrew Torma Thomas Darlington Francis Coen Kevin Li Arka Majumdar PJames Schuck Aditya Mohite Hayk Harutyunyan Joshua R.Hendrickson Deep Jariwala Department of electrical and Systems engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR inc. BeavercreekOH45431USA Air Force Research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical engineering Columbia UniversityNew YorkNY10027USA Department of electrical and Computer engineering University of WashingtonSeattleWA98195USA

excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOiPs)are capable of forming hybrid light-matter states known as exciton-polaritons(e–Ps)when the excitonic medium is confined in an optical *** the case of 2D HOiPs,they can self-hybridize into e–Ps at specific thicknesses of the HOiP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized e–Ps in 2D HOiPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOiP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized e–P *** e–Ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy e–Ps to lower energy e–***,we also demonstrate that e–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in e–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

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Systematic Radio Telescope Alignment Using Portable Fringe Projection Profilometry

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Nanomanufacturing and Metrology 2024年第1期7卷 75-85页

作者： Joel Berkson Justin Hyatt Nathan Julicher Byeongjoon Jeong isaac Pimienta Rachel Ball Wyatt ellis jason Voris Diego Torres‑Barajas Daewook Kim James C.Wyant College of Optical Sciences University of Arizona1630 E.University Blvd.TucsonAZ 85721USA Department of Astronomy at Steward Observatory University of Arizona933 N Cherry Ave.TucsonAZ 85721USA

in 2019,the event Horizon Telescope(eHT)released the first-ever image of a black hole event *** are now aiming for higher angular resolutions of distant targets,like black holes,to understand more about the fundamental laws of gravity that govern our *** achieve this higher resolution and increased sensitivity,larger radio telescopes are needed to operate at higher frequencies and in larger *** like the next-generation Very Large Array(ngVLA)and the Square-Kilometer Array(SKA)require building hundreds of telescopes with diameters greater than 10 ms over the next *** has a twofold *** telescope surfaces need to be more accurate to operate at higher frequencies,and the logistics involved in maintaining a radio telescope need to be simplified to support them properly in large *** of these problems can be solved with improved methods for surface metrology that are faster and more accurate with a higher *** leads to faster and more accurate panel alignment and,therefore,a more productive *** this paper,we present the use of binocular fringe projection profilometry as a solution to this problem and demonstrate it by aligning two panels on a 3-m radio telescope *** measurement takes only 10 min and directly delivers feedback on the tip,tilt,and piston of each panel to create the ideal reflector shape.

关键词： Metrology Fringe projection profilometry Off-axis alignment Radio astronomy Radio antenna

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Degradation and resynthesis of chlorophyll during increased oxidative stress and prolonged darkness differ between annual and perennial flax(Linum L.)

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Oil Crop Science 2024年第2期9卷 121-130页

作者： Kenyon J. Nisbett Abida Alokozai Su Hyun elizabeth Ko G. Adam Mott jason C.L. Browna Department of Biological Sciences University of Toronto ScarboroughTorontoONCanada Department of Cell&Systems Biology University of TorontoTorontoONCanada Centre for the Analysis of Genome evolution&Function University of TorontoTorontoONCanada

Among plants,there is considerable variation in lifespan:annuals live less than one year,whereas perennials live for several years,with the longest-living perennial having survived 43,600 *** proposed by the Disposable Soma Theory,this lifespan variation among plants likely reflects differential investment of limited energy and nutrient resources,with perennials investing more energy and nutrients into biomolecular maintenance compared to annuals in order to ensure persistence over multiple *** differential investment may be particularly important during periods of exogenous stress,which are known to accelerate biomolecular *** present study evaluated this hypothesis using annual and perennial flax(Linum L.)subjected to two exogenous stressors—increased oxidative stress(i.e.,foliar H2O2spraying)and complete prolonged *** chlorophyll has been shown to exhibit degradation in response to changes in environmental conditions,we utilized changes in chlorophyll levels during and after periods of exogenous stress to evaluate our *** predicted that i)perennials would exhibit a slower rate of chlorophyll degradation during exposure to exogenous stressors compared to annuals,and ii)perennials would exhibit a faster rate of chlorophyll resynthesis following such exposure compared to *** levels before,during,and after exposure to both exogenous stressors were measured in two separate trails,once using image colour analysis and once using *** chlorophyll degradation rates in response to oxidative stress did not differ between annuals and perennials,contrary to our predictions,chlorophyll resynthesis rates following such exposure were significantly higher in perennials,as *** plants were subjected to complete prolonged darkness,chlorophyll degradation rates were significantly lower in perennials than annuals,as predicted;however,when plants were subsequently reintroduced to natural photoperiod,ch

关键词： Ageing Life history Maximum lifespan Oxidative stress Somatic maintenance

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Multinuclear MR and MRi study of lithium-ion cells using a variable field magnet and a fixed frequency RF probe

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Magnetic Resonance Letters 2024年第1期4卷 10-20页

作者： Andrés Ramírez Aguilera Florin Marica Kevin J.Sanders Md Al Raihan C.Adam Dyker Gillian R.Goward bruce *** UNB MRi Centre Department of PhysicsUniversity of New BrunswickFrederictonNew BrunswickE3B 5A3Canada Department of Chemistry McMaster UniversityHamiltonOntarioL8S 4L8Canada Department of Chemistry University of New BrunswickFrederictonNew BrunswickE3B 5A3Canada

An exploratory multinuclear magnetic resonance(MR)and magnetic resonance imaging(MRi)study was performed on lithium-ion battery cells with ^(7)Li,^(19)F,and ^(1)H measurements.A variable field superconducting magnet with a fixed frequency parallel-plate radiofrequency(RF)probe was employed in the *** magnetic field was changed to set the resonance frequency of each nucleus to the fixed RF probe frequency of 33.7 *** cartridge-like lithium-ion cells,with graphite anodes and LiNi_(0.5)Mn_(0.3)Co_(0.2)O_(2)(NMC)cathodes,were *** cell was pristine,and one was charged to a cell voltage of 4.2 *** results presented demonstrate the great potential of the variable field magnet approach in multinuclear measurement of lithium-ion *** methods open the door for developing faster and simpler methods for detecting,quantifying,and interpreting MR and MRi data from lithium-ion and other batteries.

关键词： Multinuclear MR/MRi Variable field magnet Lithium-ion battery Parallel-plate rf probe

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in memory of Perry L. McCarty, seminal founder of environmental Biotechnology

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Frontiers of environmental Science & engineering 2023年第10期17卷 171-173页

作者： bruce e.Rittmann Biodesign Swette Center for environmental Biotechnology Arizona State UniversityTempeAZ 85287-5701USA

Perry *** passed away on June 4,at the age of *** was a revered leader in environmental engineering and *** *** passed away peacefully and with his family on June 4,*** was a world leader in environmental engineering,with special emphasis on environmental Biotechnology,in which we form partnerships with microbial communities that provide services to make human society more sustainable.i was one of Perry’s ***,and we worked together on research,service,and publishing throughout my career.i have deep and personal knowledge of how Perry and his students developed the fundamental principles that have allowed environmental Biotechnology to flourish and advance humans’sustainability.

关键词： peace allowed passed

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Adding Value to Crop Production Systems by integrating Forage Cover Crop Grazing

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American Journal of Plant Sciences 2024年第3期15卷 180-192页

作者： Robert B. Mitchell Daren D. Redfearn Kenneth P. Vogel Terry J. Klopfenstein Galen erickson P. Stephen Baenziger bruce e. Anderson Mary e. Drewnoski Jay Parsons Steven D. Masterson Marty R. Schmer Virginia L. Jin USDA-ARS Wheat Sorghum and Forage Research Unit University of Nebraska-Lincoln Lincoln NE USA Department of Agronomy and Horticulture University of Nebraska-Lincoln Lincoln NE USA Department of Animal Science University of Nebraska-Lincoln Lincoln NE USA Department of Agricultural economics University of Nebraska-Lincoln Lincoln NE USA USDA-ARS Agroecosystem Management Research Unit University of Nebraska-Lincoln Lincoln NE USA

in addition to their value as cereal grains, wheat (Triticum aestivum L.) and triticale (× Triticosecale Wittmack) are important cool-season annual forages and cover crops. Yearling steer (Bos taurus) performance was compared in the spring following autumn establishment as for age cover crops after soybean [Glycine max (L.) Merr.] grain harvest. Replicated pastures (0.4 ha) were no-till seeded in three consecutive years into soybean stubble in autumn, fertilized, and grazed the following spring near ithaca, Ne, USA. each pasture (n = 3) was continuously stocked in spring with four yearling steers (380 ± 38 kg) for 17, 32, and 28 d in 2005, 2006, and 2007, respectively. in 2005, average daily gain (ADG) for steers grazing triticale exceeded the ADG for wheat by 0.31 kghd-1d-1. in 2006, wheat ADG exceeded that for triticale by 0.12 kghd-1d-1. in 2007, steers grazing wheat lost weight, while steers grazing triticale gained 0.20 kghd-1d-1. Based on the 3-year average animal gains valued at $1.32 kg-1, mean net return ($ ha-1 yr-1) was $62.15 for triticale and $22.55 for wheat. Since these grazed cover crops provide ecosystem services in addition to forage, grazing could be viewed as a mechanism for recovering costs and adds additional value to the system. Based on this 3-year grazing trial, triticale was superior to wheat and likely will provide the most stable beef yearling performance across years with variable weather for the western Cornbelt USA.

关键词： Cover crops Soybean Triticale Wheat

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innovations in otorhinolaryngology in the age of COViD-19: A systematic literature review

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第3期8卷 224-238页

作者： e.Berryhill McCarty Liuba Soldatova jason A.Brant jason G.Newman Perelman School of Medicine at the Universityof Pennsylvania PhiladelphiaPAUSA Department of Otorhinolaryngology-Head and Neck Surgery Universityof Pennsylvania Health SystemPhiladelphiaPennsylvaniaPAUSA

Objective: Otolaryngologists are at increased occupational risk of Coronavirus Disease 2019 (COViD-19) infection due to exposure from respiratory droplets and aerosols generated during otologic, nasal, and oropharyngeal examinations and procedures. There have been a variety of guidelines and precautions developed to help mitigate this risk. While many reviews have focused on the personal protective equipment (PPe) and preparation guidelines for surgery in the COViD-19 era, none have focused on the more creative and unusual solutions designed to limit viral transmission. This review aims to fill that *** Sources: PubMed, Ovid/Medline, and ScopusMethods: A comprehensive review of literature was performed on September 28, 2020 using PubMed, Ovid/Medline, and Scopus databases. All english-language studies were included if they proposed or assessed novel interventions developed for Otolaryngology practice during the COViD-19 pandemic. The Preferred Reporting items for Systematic Reviews and Meta-Analyses (PRiSMA) guidelines were ***: A total of 41 papers met inclusion criteria and were organized into 5 categories ("General Recommendations for Otolaryngologic Surgery’, "equipment Shortage Solutions’, "Airway Procedures’, "Nasal endoscopy and Skull Base Procedures’, and "Otologic Procedures’). Articles were summarized, highlighting the innovations created and evaluated during the COViD-19 pandemic. Creative solutions such as application of topical viricidal agents, make-shift mask filters, three-dimensional (3-D) printable adapters for headlights, aerosol containing separation boxes, and a variety of new draping techniques have been developed to limit the risk of COViD-19 ***: Persistent risk of COViD-19 exposure remains high. Thus, there is an increased need for solutions that mitigate the risk of viral transmission during office procedures and surgeries, especially given that most COViD-19 positive patients present asymptomatically

关键词： COViD-19 innovations inventions Literature Review Otolaryngology

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