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Potential for a pluripotent adult stem cell treatment for acute radiation sickness

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World Journal of experimental Medicine 2012年第3期2卷 37-44页

作者： Denis O Rodgerson bruce e Reidenberg Alan G Harris Andrew L Pecora Ne-oS tem Inc. New York NY 10170 United States Department of Pharmacology Weill Medical College of Cornell University The Cancer Center Hackensack University Medical Center

Accidental radiation exposure and the threat of deliberate radiation exposure have been in the news and are a public health concern. experience with acute radiation sickness has been gathered from atomic blast survivors of Hiroshima and Nagasaki and from civilian nuclear accidents as well as experience gained during the development of radiation therapy for cancer. This paper reviews the medical treatment reports relevant to acute radiation sickness among the survivors of atomic weapons at Hiroshima and Nagasaki, among the victims of Chernobyl, and the two cases described so far from the Fukushima Dai-Ichi disaster. The data supporting the use of hematopoietic stem cell transplantation and the new efforts to expand stem cell populations ex vivo for infusion to treat bone marrow failure are reviewed. Hematopoietic stem cells derived from bone marrow or blood have a broad ability to repair and replace radiation induced damaged blood and immune cell production and may promote blood vessel formation and tissue repair. Additionally, a constituent of bone marrow-derived, adult pluripotent stem cells, very small embryonic like stem cells, are highly resistant to ioniz-ing radiation and appear capable of regenerating radiation damaged tissue including skin, gut and lung.

关键词： Nuclear accident Acute radiation syndrome Radiological casualties Stem cell transplantation Cellular therapy emergency response Ionizing radiation injury Hematopoietic rescue Pluripotent stem cells Induced pluripotent stem cells Mesenchymal stem cells Very small embryonic-like stem cells Mobilizing agents

A Standard Model Approach to Inflation

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Journal of Modern Physics 2022年第2期13卷 113-121页

作者： Robert bruce Hayes Nuclear engineering Department North Carolina State University Raleigh NC USA

By assuming the cosmological principle includes the Pauli exclusion Principle (PeP) and that the initial singularity existed within Planck time and length scales, a model for inflationary expansion is argued using only standard model physics without any changes to general relativity. All Fermionic matter is forced by the PeP to make a quantum transition to minimally orthogonal states in sequential Planck time intervals. This results in an initial inflation effect due to nearest neighbor quantum transitions which is then exacerbated by matter and antimatter creation effects due to collisions giving rise to the observational effects of universal inflation. The model provides a mechanistic explanation for primordial expansion using only physics from the standard model, specifically utilizing the PeP as a repulsion force between indistinguishable fermions. The present theory offers the benefit of not requiring any particles or fields outside of the standard model nor utilizing changes to general relativity. More succinctly, this theory goes beyond simply offering a mathematical representation (or fit) of the functional dependence but rather offers a mechanistic model to drive inflation using only standard model physics.

关键词： Inflation Cosmological expansion Standard Model Pauli exclusion Principle Genesis

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烧结-硬化钢的尺寸精度

粉末冶金技术 2009年第6期27卷 468-470页

作者： bruce Lindsley Thomas Murphy Hoeganaes Corporation 1001 Taylors Lane CinnaminsonNJ 08077 USA

尺寸精度是铁基粉末冶金零件生产工艺的关键参数。除了和标准粉末冶金低合金钢的压制与烧结相关的尺寸变化外,烧结-硬化合金还会产生从奥氏体转变为马氏体的相变。马氏体是钢中密度最低的相,因此,冷却时马氏体的形成会导致零件显著胀大... 详细信息

尺寸精度是铁基粉末冶金零件生产工艺的关键参数。除了和标准粉末冶金低合金钢的压制与烧结相关的尺寸变化外,烧结-硬化合金还会产生从奥氏体转变为马氏体的相变。马氏体是钢中密度最低的相,因此,冷却时马氏体的形成会导致零件显著胀大。当马氏体转变为密度较高的铁素体与碳化物显微组织时,回火的淬硬钢发生收缩。这两种相变对零件的尺寸变化都有很大影响。另外,在Cu与C含量高的马氏体区可能有大量残余奥氏体存在。奥氏体相密度最高,所以残余奥氏体会导致压坯胀大较小。除回火处理外,马氏体与残余奥氏体的存在都会影响零件的最终尺寸。本文考察了两个烧结-硬化钢牌号,同时通过不同的后烧结热处理,研究了这两个牌号钢的尺寸变化和显微组织变化。

关键词：尺寸控制烧结-硬化膨胀仪测定法回火

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粉末冶金锰钢研究新进展

粉末冶金技术 2012年第1期30卷 63-73页

作者： bruce Lindsley Brian James Hoeganaes公司 CinnaminsonNJ08077美国

铁基粉末冶金产业在继续开发与扩大使用非传统粉末冶金合金化元素。Mo、Ni与Cu的价格、环境与可回收性一直在推动这种扩大使用。Mn是铸锻钢的价格比较低廉且有效的合金化元素;不过,过去氧的敏感性限制了Mn在粉末冶金钢中的应用,现在氧... 详细信息

铁基粉末冶金产业在继续开发与扩大使用非传统粉末冶金合金化元素。Mo、Ni与Cu的价格、环境与可回收性一直在推动这种扩大使用。Mn是铸锻钢的价格比较低廉且有效的合金化元素;不过,过去氧的敏感性限制了Mn在粉末冶金钢中的应用,现在氧分压低的氮-氢烧结气氛可允许使用Mn。Mn与适量Mo的组合可使粉末冶金钢合金的力学性能接近FD-0405的水平。同样重要的是,这些合金可在常用的工业烧结条件下进行处理。在较高碳含量下,这些锰钢可用作贫合金烧结硬化钢牌号。笔者将讨论含Mn铁基粉末冶金材料的这些优势。

关键词： Mn 铁基粉末冶金钢力学性能

Approaching democracy / Larry Berman, bruce Allen Murphy. 5th ed.

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Developing aptamers into tumor diagnostics and therapeutics

2007年

作者： Larry Berman bruce Allen Murphy.

来源：畅想之星图书光盘版（南... 评论

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中国肿瘤生物治疗杂志 2008年第4期15卷 301-304页

作者： Jing Mi bruce A. Sullenger Bryan M. Clary Departments of Surgery Duke University Medical Center DurhamNC 27710 USA

Aptamers are small single-stranded nucleic acid molecules that bind a target protein with high affinity and *** to their stability,low toxicity and immunogenicity,as well as improved safety,aptamers are attractive alternatives to antibody and are therefore suitable for in vivo *** are typically isolated,through a process termed SeLeX(systematic evolution of ligands by exponential enrichment),from combinatorial libraries with desired *** the present review,the recent non-conventional aptamer selection process will be discussed together with an overview on the aptamer application in cancer diagnosis and therapy.

关键词：肿瘤诊断方法治疗方法蛋白质

Prohibitin regulates mTOR pathway via interaction with FKBP8

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Frontiers of Medicine 2021年第3期15卷 448-459页

作者： Jiahui Zhang Yanan Yin Jiahui Wang Jingjing Zhang Hua Liu Weiwei Feng Wen Yang bruce Zetter Yingjie Xu Department of Biochemistry and Molecular and Cell Biology Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Obstetrics and Gynecology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Vascular Biology Program Boston Children’s HospitalHarvard Medical SchoolBostonMA 02115USA

The ability of tumor cells to sustain continuous proliferation is one of the major characteristics of *** activation of oncogenes and the mutation or inactivation of tumor suppressor genes ensure the rapid proliferation of tumor *** PI3K-Akt-mTOR axis is one of the most frequently modified signaling pathways whose activation sustains cancer ***,it is also one of the most commonly attempted targets for cancer ***506 binding protein 8(FKBP8)is an intrinsic inhibitor of mTOR kinase that also exerts an anti-apoptotic *** aimed to explain these contradictory aspects of FKBP8 in cancer by identifying a“switch”type *** identified through immunoprecipitation--mass spectrometry-based proteomic analysis that the mitochondrial protein prohibitin 1(PHB1)specifically interacts with ***,the downregulation of PHB1 inhibited the proliferation of ovarian cancer cells and the mTOR signaling pathway,whereas the FKBP8 level in the mitochondria was substantially ***,concomitant with these changes,the interaction between FKBP8 and mTOR substantially increased in the absence of ***,our finding highlights PHB1 as a potential regulator of FKBP8 because of its subcellular localization and mTOR regulating role.

关键词： prohibitin 1 FKBP8 mTOR cell proliferation cancer

Differences between amorphous indium oxide thin films

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Progress in Natural Science:Materials International 2013年第05期23卷 475-480页

作者： D.bruce Buchholz Li Zeng Michael J.Bedzyk Robert P.H.Chang Department of Materials Science and engineering Northwestern University

A series of 60~nm thick indium oxide thin-films,all amorphous as determined by x-ray diffraction,were found to have physical and electrical properties that depended on the temperature of *** carrier mobility and flm conductivity decreased with decreasing deposition temperature;the best electrical properties of high mobility and conductivity were observed at a deposition temperature just below the temperature at which crystalline films *** density of the flm also decreased with deposition temperature from 7.2g/cm3 at+50℃ to 5.3g/cm3 at 100℃.

关键词： Transparent conducting oxide Semiconductor Oxide Amorphous Deposition temperature

Neuroendocrine tumors of the gastrointestinal tract: Case reports and literature review

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World Journal of Gastrointestinal Oncology 2014年第8期6卷 301-310页

作者： William J Salyers Kenneth J Vega Juan Carlos Munoz bruce W Trotman Silvio S Tanev Division of Gastroenterology University of Florida College of Medicine/Jacksonville Jacksonville FL 32207 United States Division of Digestive Diseases and Nutrition University of Oklahoma Health Sciences Center Oklahoma City OK 73104 United States Department of Medicine University of Maryland School of Medicine Baltimore MD 21201 United States Department of Pathology Manatee Memorial Hospital Bradenton FL 34208 United States

Neuroendocrine tumors(NeT)previously called carcinoid tumors are neoplasms of enterochromaffin/neuroendocrine cell origin which display neurosecretory capacity that may result in the carcinoid *** annual incidence of patients with NeT is 8.4 per 100000;yet many NeT remain asymptomatic and clinically undetected.A majority of NeT follows a benign course;however,some will display malignant *** most commonly occur in the gastrointestinal tract(67%)and bronchopulmonary system(25%).Gastrointestinal NeT occur within the stomach,small intestine,liver,and *** report a retrospective study of 11 subjects:eight with benign carcinoid tumors:duodenal bulb(n=2),terminal ileum(n=1),sigmoid colon(n=2),and rectum(n=3);three with malignant carcinoid:liver(n=1)and intra-abdominal site(n=2).The diagnosis,endoscopic images,outcome,treatment and review of the literature are presented.

关键词： Neuroendocrine Carcinoid Gastrointestinal Tumors