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不同金瓷面积比对瓷修补树脂粘结强度的影响

口腔医学研究 2008年第4期24卷 440-442页

作者：黄海蓉王革 bruce A.Mati 陈珍俊武汉大学口腔医学院修复科湖北武汉430079 美国印地安那大学牙学院黄石市第一医院口腔科

目的:比较树脂与不同比例金属暴露的瓷面的粘结剪切强度。方法:按常规烤瓷方法分别制作总面积8mm×8mm,金瓷比例分别为1∶3(组1),1∶1(组2),3∶1(组3),8∶0(组4,作为对照)的试样各10个,瓷厚度为1mm,金瓷结合处为钝角,以避免内应力的产生... 详细信息

目的:比较树脂与不同比例金属暴露的瓷面的粘结剪切强度。方法:按常规烤瓷方法分别制作总面积8mm×8mm,金瓷比例分别为1∶3(组1),1∶1(组2),3∶1(组3),8∶0(组4,作为对照)的试样各10个,瓷厚度为1mm,金瓷结合处为钝角,以避免内应力的产生,将各组试样表面按照瓷修补套装的产品说明书处理各试样的1/2的面积,粘结8mm×4mm×2mm的树脂材料。用Instron力学测试仪,进行剪切强度测试。结果:组1,组2的剪切强度显著性高于组3,组4。结论:使用Ultradent修补套装对部分金属暴露的崩瓷进行修补时,金瓷面积比<1时的粘结力明显较大,修补效果较好。

关键词：瓷修补剪切粘结强度崩瓷树脂

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Visualization of Percolation Threshold Phenomena in an Agent-Based Model

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通讯和计算机（中英文版） 2013年第9期10卷 1190-1195页

作者： bruce Paizen Jay Kraut Marcia R. Friesen Robert (Bob) d. McLeod department of Electrical and Computer Engineering University of Manitoba Winnipeg R3T 5 V6 Canada

A modified percolation theory model was developed to incorporate agent mobility on the model grid. In this ABM (agent-based model), the impact of agent density was found to significantly influence agent mobility. The visual representation software tool developed provides an intuitive understanding of the ABM simulation dynamics and mechanisms. The software tool visually illustrates that there is a relationship between mobility and density that would have to be taken into account for research into connectedness or connectivity (i. e., epizootic modeling) involving percolation models. Visualization is a common method that is often employed in many percolation models and studies as it helps in narrowing down regions of interest that can be followed up on in a more systematic manner.

关键词：网格模型移动代理可视化渗流阈值软件工具渗流模型流行病模型渗流理论

Optical detection of distal Lung Enzyme Activity in Human Inflammatory Lung disease

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Biomedical Engineering Frontiers 2021年第1期2卷 44-54页

作者： Alicia Megia-Fernandez Adam Marshall Ahsan R.Akram Bethany Mills Sunay V.Chankeshwara Emma Scholefield Amy Miele bruce C.McGorum Chesney Michaels Nathan Knighton Tom Vercauteren Francois Lacombe Veronique dentan Annya M.bruce Joanne Mair Robert Hitchcock Nik Hirani Chris Haslett Mark Bradley Kevin dhaliwal EaStCHEM The University of Edinburgh School of ChemistryJoseph Black BuildingWest Mains RoadEdinburghUK EH93FJ Translational Healthcare Technologies Group Centre for Inflammation ResearchQueen’s Medical Research InstituteUniversity of Edinburgh47 Little France CrescentEdinburgh BioQuarterEdinburghUK EH164TJ The Roslin Institute and Royal(dick)School of Veterinary Studies University of EdinburghEaster BushMidlothianUK EH259RG department of Biomedical Engineering University of Utah36 S Wasatch DrSalt Lake CityUT 84112USA School of Biomedical Engineering&Imaging Sciences King’s College LondonLondonUK SE17EH Mauna Kea Technologies 9Rue d’EnghienParisFrance 75010

Objective and Impact *** is a need to develop platforms delineating inflammatory biology of the distal human *** describe a platform technology approach to detect in situ enzyme activity and observe drug inhibition in the distal human lung using a combination of matrix metalloproteinase(MMP)optical reporters,fibered confocal fluorescence microscopy(FCFM),and a bespoke delivery *** development of new therapeutic agents is hindered by the lack of in vivo in situ experimental methodologies that can rapidly evaluate the biological activity or drug-target engagement in *** optimised a novel highly quenched optical molecular reporter of enzyme activity(FIB One)and developed a translational pathway for in-human *** demonstrate the specificity for matrix metalloproteases(MMPs)2,9,and 13 and probe dequenching within physiological levels of MMPs and feasibility of imaging within whole lung models in preclinical ***,in a first-in-human exploratory experimental medicine study of patients with fibroproliferative lung disease,we demonstrate,through FCFM,the MMP activity in the alveolar space measured through FIB One fluorescence increase(with pharmacological inhibition).*** translational in situ approach enables a new methodology to demonstrate active drug target effects of the distal lung and consequently may inform therapeutic drug development pathways.

关键词： Lung lung specificity

Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level

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Light(Science & Applications) 2013年第1期2卷 154-162页

作者： Zhen Ma Qiuying Liu Huaxiao Yang Raymond B Runyan Carol A Eisenberg Meifeng Xu Thomas K Borg Roger Markwald Yifei Wang bruce Z Gao department of Bioengineering and COMSET Clemson UniversityClemsonSC 29634USA department of Bioengineering University of CaliforniaBerkeleyBerkeleyCAUSA Biomedical R&d Center Jinan UniversityGuangzhouChina department of Cellular and Molecular Medicine University of ArizonaTucsonAZ 85724USA New York Medical College/Westchester Medical Center Stem Cell Laboratory New York Medical CollegeValhallaNew YorkUSA department of Pathology and Laboratory Medicine University of Cincinnati Medical CenterCincinnatiOHUSA department of Regenerative Medicine and Cell Biology Medical University of South CarolinaCharlestonSCUSA

Mesenchymal stem cells(MSCs)have been cited as contributors to heart repair through cardiogenic differentiation and multiple cellular interactions,including the paracrine effect,cell fusion,and mechanical and electrical *** to heart–muscle complexity,progress in the development of knowledge concerning the role of MSCs in cardiac repair is heavily based on MSC–cardiomyocyte *** conventional coculture systems,however,the in vivo cardiac muscle structure,in which rod-shaped cells are connected end-to-end,is not sustained;instead,irregularly shaped cells spread randomly,resulting in randomly distributed cell ***,contact-mediated cell–cell interactions(e.g.,the electrical triggering signal and the mechanical contraction wave that propagate through MSC–cardiomyocyte junctions)occur ***,the data generated on the beneficial effects of MSCs may be irrelevant to in vivo biological *** this study,we explored whether cardiomyocyte alignment,the most important phenotype,is relevant to stem cell cardiogenic ***,we report(i)the construction of a laser-patterned,biochip-based,stem cell–cardiomyocyte coculture model with controlled cell alignment;and(ii)single-cell-level data on stem cell cardiogenic differentiation under in vivo-like cardiomyocyte alignment conditions.

关键词： cardiogenic differentiation mesenchymal stem cells microenvironment optical force single-cell analysis

Preliminary evaluation of the VIsion PERformance(VIPER) simulator

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Military Medical Research 2020年第3期7卷 312-323页

作者： denise S.Ryan Rose K.Sia Jennifer B.Eaddy Lorie A.Logan Jide O.Familoni Hind Beydoun Samantha B.Rodgers bruce A.Rivers Warfighter Refractive Eye Surgery Program and Research Center Fort Belvoir Community HospitalFort BelvoirVA 22060USA Night Vision and Electronic Sensors directorate Fort BelvoirVA 22060USA department of Research Programs Fort Belvoir Community HospitalFort BelvoirVA 22060USA

Background:This study evaluated the VIsion PERformance(VIPER)simulator’s ability to assess the functional visual performance in warfighters conducting civilian and military ***:Thirty service members,aged 25–35 years old with a best corrected distance visual acuity(VA)better than or equal to 20/20 or logarithm of the minimum angle of resolution(logMAR)0.00,were randomized to locate and identify road signs and mock improvised explosive devices(IEds)under either daytime conditions or with infrared imagery,with(cc)and without(sc)wearing their habitual *** also underwent binocular uncorrected(UdVA)and corrected(CdVA)visual assessment,refraction,contrast sensitivity testing and wavefront ***:The mean age was 28.47 *** manifest spherical equivalent was–3.16±1.75 diopters(d),the UdVA in both eyes(OU)was logMAR 0.83±0.47,and the CdVA OU was–0.11±*** VIPER,the mean difference in the detection distance(dd)for road signs ccdd *** was(76.7±52.8)m(Pdifference in identification distance(Id)ccId *** was(13.9±6.3)m(Pd 27.9%for cc and sc,respectively(Pdicated that a 1.6 m change in the distance accounts for a 1%change in the accuracy(P=0.002).Without correction,a 4.1 m change accounts for a 1%change in the accuracy(Pd ccdd was(29.9±8.2)m,and that for scdd was(13.2±13.6)m(Pd ccId was(32.2±6.2)m and that for the scId was(7.4±10.3)m(Pd identification accuracy was 46.7 and 11.4%for cc and sc,respectively(Pdetecting and identifying signs and ***,VIPER is able to detect performance changes with and without correction.

关键词： Functional visual performance Military task performance

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Study on little active and sedentary women: Comparison between protocols and prospects for admission in physical activity program

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Open Journal of Preventive Medicine 2013年第6期3卷 413-419页

作者： A.d.P.Bankoff postural assessment laboratory faculdade de educacao fisica(fef)unicampcampinasbrazil department of cardiology hospital de clinicas(hc)unicampcampinasbrazil 3policy research groupinstitute of mathematicsstatistics and scientific computationunicampcampinasbrazil

The aim of this work was to study little active and sedentary women through physical assessments using anthropometric measurements and exercise testing using the Naughton and bruce protocols. Approximately 53 women were evaluated: Group 1—comprised of 17 completely sedentary women, aged 25-58 years, mean age 44.4 years, and Group 2—comprised of 36 women who answered doing physical activities once or twice a week (low active), aged 28-54 years, mean age 39.5 years. The results Group 1— high weight, body mass index showing overweight, heart rate above the target areas of your training, i.e., above 85% effort. Systolic blood pressure reached a high level in the seventh stage with 21 minutes of effort (177.3) and diastolic (92.7). Group 2—normal weight, body mass index recorded is considered thin, heart rate heart zones above the target of your training, i.e., above 85% effort also. Systolic blood pressure reached the highest level in phase 1 recovery (156.75). diastolic blood pressure recorded pressure levels considered normal for the type of work done by the group. The values reported for the double product are considered normal for the type of effort made by both groups. Conclusion: The participants from group 1 are able to join physical activity programs from the results presented, specifically due to weight, BMI, heart rate and blood pressure. The participants from group 2 require more days of practice of physical activities and longer hours to improve the levels of heart rate and blood pressure.

关键词： Sedentary Lifestyle double Product Heart Rate Blood Pressure

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创业者的白金思维法

科技创业月刊 2002年第4期 33-33页

作者： bruce d.Henderson

任何一个复杂的问题都是近乎无数的事实和关系的组合。商业行为尤其受到方方面面的影响,包括过去的、非逻辑的和不可知的事物的影响。这种复杂性又因目标不同与服务于各种各样的顾客的需要而更加盘根错节,而顾客的许多目标不得不经过权... 详细信息

任何一个复杂的问题都是近乎无数的事实和关系的组合。商业行为尤其受到方方面面的影响,包括过去的、非逻辑的和不可知的事物的影响。这种复杂性又因目标不同与服务于各种各样的顾客的需要而更加盘根错节,而顾客的许多目标不得不经过权衡后放弃。在这样复杂的条件下解决问题需要井井有条的、系统的方法以试图优化最后的决定。

关键词：定义顾客概念思维形式洞察力自知力

卒中和短暂性脑缺血发作患者的卒中预防指南美国心脏协会/美国卒中协会为医疗卫生专业人员制定的指南

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国际脑血管病杂志 2014年第11期22卷 805-841页

作者： Walter N.Kernan bruce Ovbiagele Henry R.Black dawn M.Bravata Marc I.Chimowitz Michael d.Ezekowitz Margaret C.Fang Marc Fisher Karen L.Furie 洪道俊黄招君李小兵周美鸿吴成斯王博卢艺吴裕臣代表美国心脏协会卒中委员会、心血管和卒中护理委员会、临床心脏病学委员会以及周围血管病委员会南昌大学第一附属医院神经内科 330006

本更新版指南旨在为缺血性卒中或短暂性脑缺血发作存活者的卒中预防提供全面和及时的循证推荐.本指南适用于所有为上述患者提供二级预防的临床医生.这些循证推荐包括危险因素的控制、血管闭塞的干预、心源性栓塞的抗栓治疗以及非心源性... 详细信息

本更新版指南旨在为缺血性卒中或短暂性脑缺血发作存活者的卒中预防提供全面和及时的循证推荐.本指南适用于所有为上述患者提供二级预防的临床医生.这些循证推荐包括危险因素的控制、血管闭塞的干预、心源性栓塞的抗栓治疗以及非心源性栓塞性卒中的抗血小板治疗.还对各种特殊情况下复发性卒中的预防提供了推荐意见,包括主动脉弓粥样硬化、动脉夹层分离、卵圆孔未闭、高同型半胱氨酸血症、高凝状态、抗心磷脂抗体综合征、镰状细胞病、脑静脉窦血栓形成以及妊娠.此外,还有专门的章节对颅内出血后抗栓和抗凝治疗的应用以及指南的实施进行了讨论.

关键词：美国心脏协会声明心房颤动颈动脉狭窄高血压缺血短暂性脑缺血发作预防卒中

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Nanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor immunotherapy

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Nanobody-based chimeric antigen receptor T cells designed by...