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A Prospective, Open-Label, 12 Week Trial of S-adenosylmethionine in the Symptomatic Treatment of Alzheimer’s disease

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Neuroscience & Medicine 2011年第3期2卷 222-225页

作者： Maja L. Rudolph Michael Rabinoff bruce L. Kagan UCLA Neuropsychiatric Institute and Hospital

Objective: To determine if treatment with S-adenosylmethionine (SAM-e) might lead to cognitive and behavioral improvement in patients with Alzheimer’s disease (Ad). Interventions: We conducted a prospective, open-label study of six subjects who were given oral SAM-e over 12 weeks and measured the effects on cognition and behavior. Outcome measures: Outcome measures of cognition and behavior included the Alzheimer’s disease Assessment Scale-Cognitive subscale (AdAS-Cog), Mini-Mental State Examination (MMSE), Behave-Ad, Clinical Global Impression Scale (CGI), Hamilton Rating Scale for depression (HAM-d), informant version, Blessed dementia Scale to assess activities of daily living (AdL), the Physical Self-Maintainance Scale (PSMS), and the Lawton-Brody IAdL Scale to measure instrumental activities of daily living. Results: At study completion, two subjects were “moderately improved” and 4 were “minimally improved” on the CGI. Five subjects improved on the AdAS-Cog by an average of 20%. No significant side effects were reported. Conclusions: In this small open label study, SAM-e appeared to have a beneficial effect in patients with Ad, but the small subject number didn’t provide enough power to show statistical significance. Controlled trials with adequate statistical power to investigate its utility in Ad are warranted.

关键词： S-adenosylmethionine Treatment Alzheimer’s disease

石油和天然气工业装置中耐腐蚀合金钢的选用准则

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化肥设计 2010年第2期48卷 59-62页

作者： bruce d. Craig 刘道芬(译) 姚佩贤(校核) 不详湖北楚冠实业股份有限公司

对于生产和运输石油及天然气的工业装置,如何选用耐腐蚀合金钢可能是一个复杂的程序,因为如果处理不当,会导致因选材错误而误解耐腐蚀合金在特定使用环境下的抗腐蚀性能.

关键词：耐腐蚀合金工业装置合金钢天然气选用准则石油抗腐蚀性能使用环境

Comparison of point detection and area detection for point-scanning structured illumination microscopy

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创新光学健康科学杂志(英文) 2023年第4期16卷 134-149页

作者： Wenshuai Wu Jiajie Chen Meiting Wang Lei Wang Xiaomin Zheng Jia Li Junle Qu bruce Zhi Gao Yonghong Shao College of Physics and Optoelectronic Engineering Key Laboratory of Optoelectronic devices and Systems of Ministry of Education and Guangdong Province Shenzhen University Shenzhen 518060GuangdongP.R.China department of Bioengineering and COMSET Clemson University ClemsonSC 29634 USA

Structured illumination microscopy(SIM)is suitable for biological samples because of its relatively low-peak illumination intensity requirement and high imaging *** system resolution is affected by two typical detection modes:Point detection and area ***,a systematic analysis of the imaging performance of the different detection modes of the system has rarely been *** this study,we compared laser point scanning point detection(PS-Pd)and point scanning area detection(PS-Ad)imaging in nonconfocal microscopy through theoretical analysis and simulated *** results revealed that the imaging resolutions of PSPd and PS-Ad depend on excitation and emission point spread functions(PSFs),***,we combined the second harmonic generation(SHG)of point detection(P-SHG)and area detection(A-SHG)with SIM to realize a nonlinear SIM-imaging technique that improves the imaging ***,we analytically and experimentally compared the nonlinear SIM performance of P-SHG with that of A-SHG.

关键词： Super-resolution structured illumination microscopy second harmonic generation

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可溶性环氧水解酶抑制剂的设计合成

可溶性环氧水解酶抑制剂的设计合成

Approaching democracy / Larry Berman, bruce Allen Murphy. 5th ed.

中国化学会第四届有机化学学术会议

作者：李慧媛 HAMMOCK,bruce d．龙亚秋中国科学院上海药物研究所 department of Entomology University of CaliforniaOne shields AvenueDavisCA 95616 中国科学院上海药物研究所

＜正＞环氧水解酶与花生四烯酸、亚油酸和其它脂肪酸环氧化物代谢有关,是调节血压和炎症重要的内源性化学物质,现已成为抗高血压和抗炎药物设计的新靶点． 1,3-二取代脲类化合物在体内外均有较好的环氧水解酶抑制活性,但是这类化合物在...

＜正＞环氧水解酶与花生四烯酸、亚油酸和其它脂肪酸环氧化物代谢有关,是调节血压和炎症重要的内源性化学物质,现已成为抗高血压和抗炎药物设计的新靶点． 1,3-二取代脲类化合物在体内外均有较好的环氧水解酶抑制活性,但是这类化合物在水中和有机溶剂中的溶解度低使其体内有效性降低,而且难以做成合适的剂型．为了改善这类化合物的理化性质,提高溶解性,可在脲类化合物的烷基侧链引入极性基团．我们设计了一类新结构的分子,如通式1所示,既含有金刚烷关键结构片段,

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Case Series of 10 drug-Refractory IBS Patients Who Respond to Oral Serum-derived Bovine Immunoglobulin/Protein Isolate (SBI)

2007年

作者： Larry Berman bruce Allen Murphy.

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Open Journal of Gastroenterology 2014年第10期4卷 321-328页

作者： Raouf Hilal Patricia Mitchell Ernesto Guerra Jr. bruce P. Burnett Center for Advanced Gastroenterology Maitland USA San Antonio Gastroenterology Associates San Antonio USA department of Medical Affairs Entera Health Inc. Cary USA

Aim: The responses of 10 patients with long-standing, symptomatic, intractable drug-refractory histories of irritable bowel syndrome with diarrhea (IBS-d) and with abdominal pain, gas/bloating and distention, termed IBS undefined (IBS-U), were evaluated when administering a medical food product containing serum-derived bovine immunoglobulin/protein isolate (SBI). Methods: Patients in this case series were chosen based on their lack of satisfactory response to a variety of drugs, including antidiarrheal and antispasmodic medications, serotonin 5-HT3 receptor antagonists, selective serotonin re-uptake inhibitors (SSRIs), proton pump inhibitors (PPIs), antibiotics, and antidepressive drugs. Patients met Rome III criteria and were administered 5 g/day of SBI as standard-of-care nutritional support. A scale of 0% - 25%, 25% - 50%, 50% - 75%, 75% - 100% response to SBI was used for patient-reported improvement in overall IBS symptoms following administration for one month. Exact methods for calculating confidence intervals and p-values were used to assess complete management of symptoms and response to therapy. Adverse events were also monitored for this nutritional product. Results: The onset of gastrointestinal (GI) symptom reduction utilizing nutritional management with SBI occurred within an average time of 2-4 weeks with improved or near complete management in all 10 patients who were refractory to previous drug therapies by 4 weeks. When prompted, patients reported significant IBS symptom improvement which averaged between 50% - 100% (p = 0.002) with an average for complete management in all patients of 69%. No side effects were reported after SBI administration even when taken for up to 28 weeks. Conclusion: Based on the safety profile and reported outcomes in this case report, SBI should be considered as a nutritional option for management in IBS-d and IBS-U.

关键词： Irritable Bowel Syndrome diarrhea Gas Bloating distention Serum-derived Bovine Immunoglobulins

HIV-1附属蛋白特异性细胞毒性T细胞应答研究

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中国病毒学 2006年第6期21卷 529-535页

作者：黄德东孙永涛翟嵩赵曙光王少扬庄严李新红康文臻余旭 Marcus Altfeld bruce d.Walker 第四军医大学唐都医院全军感染病诊疗中心 Partners AIdS Research Center Massachusetts General HospitalHarvard Medical SchoolBostonMA02129USA

人类免疫缺陷病毒(Humanimmunodeficiencyvirus,HIV)附属蛋白Nef、Vpu、Vpr和Vif在病毒复制中起着关键作用,并能被细胞毒性T细胞(CytotoxicTLymphocyte,CTL)识别。然而,对我国HIV感染者体内附属蛋白特异性的CTL应答研究比较少。本研究... 详细信息

人类免疫缺陷病毒(Humanimmunodeficiencyvirus,HIV)附属蛋白Nef、Vpu、Vpr和Vif在病毒复制中起着关键作用,并能被细胞毒性T细胞(CytotoxicTLymphocyte,CTL)识别。然而,对我国HIV感染者体内附属蛋白特异性的CTL应答研究比较少。本研究应用覆盖HIV-1B、C亚型附属蛋白(Nef、Vpu、Vpr和Vif)的142个肽段作为抗原,通过酶联免疫斑点实验(Enzyme-LinkedImmunospot,ELISPOT)检测61例中国HIV/AIdS患者和10例HIV-1血清阴性对照的HIV-1附属蛋白特异性CTL应答。无论对HIV-1B亚型还是HIV-1C亚型附属蛋白都能产生特异性CTL应答,特别是Nef区蛋白的反应频率和累积应答强度都较高(P0.05),其免疫优势区也大致相同。附属蛋白特异性的累积CTL应答强度将近达到总应答的21%。这些结果表明尽管HIV-1附属蛋白的体积小,但它们在诱导特异性的CTL应答中发挥了重要作用,对评价HIV-1免疫应答的幅度和特异性以及研发针对中国人群的HIV疫苗有重要的意义。

关键词：人类免疫缺陷病毒1型细胞毒性T细胞酶联免疫斑点实验

Genetic diversity Analysis of Jatropha Species from Costa Rica Using AFLP Markers

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American Journal of Plant Sciences 2015年第14期6卷 2426-2438页

作者： Roberto Avendano Elmer García díaz Marta Valdez-Melara Nefertiti Chaves Solano Aníbal Mora Villalobos Francisco Aguilar Cascante bruce Williamson Benavides Laura Y.Solís-Ramos Center for Biotechnological Innovations(CENIBiot) CeNAT-CONARESan JoséCosta Rica School of Biology University of Costa RicaSan JoséCosta Rica

The genetic diversity from species of the genus Jatropha collected from Costa Rica was analyzed by AFLP (amplified fragments length polymorphism). The study consisted of 114 accessions from 15 populations of 4 different species: J. curcas, J. costaricensis, J. gossypifolia and J. stevensii. These were collected from different locations in Costa Rica. Three different primers were used, resulting in 428 loci, and they were classified in three categories: unique and double bands (UBd), rare bands (RB) and shared bands (SB). The UBd were excluded for a total of 339 polymorphic loci used for the UPGMA dendrogram and principal component analysis (PCA). The species that obtained the highest average of polymorphic loci was J. curcas, which obtained the highest percentage of polymorphic loci (80.24%), followed by J. gossypifolia (79.35%), J. costaricensis (78.76%), and finally J. stevensii (40.71%). The average for the polymorphic loci was of 69.76%. Thus, the phylogeny of the Jatropha species in Costa Rica was elucidated, showing J. curcas more related to J. stevensii and this one with J. costaricensis, and J. gossypifolia as the most distant member of the genus. For the best of our knowledge this is the first report of a genetic analysis of J. costaricensis and J. stevensii. The obtained molecular evidence showed high levels of polymorphisms in the present study compared with reports from Africa, India, and China. The molecular diversity estimated in our analysis, together with agronomical or morphological data, can be very useful for plant breeding programs, given the importance of Jatropha species in oil production. Interestingly, Central American Jatropha material can be used to increase the genetic base of J. curcas populations localized in Asia and Africa, where reduced genetic diversity has been reported.

关键词： Jatropha spp. AFLP Molecular Markers Polymorphism Genetic diversity