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2011年ASA／ACCF／AHA／AANN／AANS／ACR／ASNR／CNS／SAIP／SCAI/SIR/SNIS／SVM/SVS颅外颈动脉和椎动脉疾病患者处理指南（续前）

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国际脑血管病杂志 2013年第10期21卷 721-758页

作者： Thomas G. Brott Jonathan L. Halperin Suhny Abbara J. Michael Bacharach John d. Barr Ruth L. Bush Christopher U. Cates Mark A. Creager Susan B. Fowler Gary Friday Vicki S. Hertzberg E. bruce Mclff Wesley S. Moore Peter d. Panagos Thomas S. Riles Robert H. Rosenwasser Allen J. Taylor 曲东锋陈兴洲(译) 不详南京脑血管疾病分册杂志社 211135

7血运重建术7．1关于颈动脉血运重建术患者选择的推荐意见I级推荐1对于在6个月内有过非致残性缺血性卒中或TIA症状（包括半球事件或一过性黑噱）且手术风险中等或较低的患者，

关键词：颅外颈动脉椎动脉疾病患者 CNS ACR AHA ASA 血运重建术

Visualization of Percolation Threshold Phenomena in an Agent-Based Model

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通讯和计算机（中英文版） 2013年第9期10卷 1190-1195页

作者： bruce Paizen Jay Kraut Marcia R. Friesen Robert (Bob) d. McLeod department of Electrical and Computer Engineering University of Manitoba Winnipeg R3T 5 V6 Canada

A modified percolation theory model was developed to incorporate agent mobility on the model grid. In this ABM (agent-based model), the impact of agent density was found to significantly influence agent mobility. The visual representation software tool developed provides an intuitive understanding of the ABM simulation dynamics and mechanisms. The software tool visually illustrates that there is a relationship between mobility and density that would have to be taken into account for research into connectedness or connectivity (i. e., epizootic modeling) involving percolation models. Visualization is a common method that is often employed in many percolation models and studies as it helps in narrowing down regions of interest that can be followed up on in a more systematic manner.

关键词：网格模型移动代理可视化渗流阈值软件工具渗流模型流行病模型渗流理论

Optical detection of distal Lung Enzyme Activity in Human Inflammatory Lung disease

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Biomedical Engineering Frontiers 2021年第1期2卷 44-54页

作者： Alicia Megia-Fernandez Adam Marshall Ahsan R.Akram Bethany Mills Sunay V.Chankeshwara Emma Scholefield Amy Miele bruce C.McGorum Chesney Michaels Nathan Knighton Tom Vercauteren Francois Lacombe Veronique dentan Annya M.bruce Joanne Mair Robert Hitchcock Nik Hirani Chris Haslett Mark Bradley Kevin dhaliwal EaStCHEM The University of Edinburgh School of ChemistryJoseph Black BuildingWest Mains RoadEdinburghUK EH93FJ Translational Healthcare Technologies Group Centre for Inflammation ResearchQueen’s Medical Research InstituteUniversity of Edinburgh47 Little France CrescentEdinburgh BioQuarterEdinburghUK EH164TJ The Roslin Institute and Royal(dick)School of Veterinary Studies University of EdinburghEaster BushMidlothianUK EH259RG department of Biomedical Engineering University of Utah36 S Wasatch DrSalt Lake CityUT 84112USA School of Biomedical Engineering&Imaging Sciences King’s College LondonLondonUK SE17EH Mauna Kea Technologies 9Rue d’EnghienParisFrance 75010

Objective and Impact *** is a need to develop platforms delineating inflammatory biology of the distal human *** describe a platform technology approach to detect in situ enzyme activity and observe drug inhibition in the distal human lung using a combination of matrix metalloproteinase(MMP)optical reporters,fibered confocal fluorescence microscopy(FCFM),and a bespoke delivery *** development of new therapeutic agents is hindered by the lack of in vivo in situ experimental methodologies that can rapidly evaluate the biological activity or drug-target engagement in *** optimised a novel highly quenched optical molecular reporter of enzyme activity(FIB One)and developed a translational pathway for in-human *** demonstrate the specificity for matrix metalloproteases(MMPs)2,9,and 13 and probe dequenching within physiological levels of MMPs and feasibility of imaging within whole lung models in preclinical ***,in a first-in-human exploratory experimental medicine study of patients with fibroproliferative lung disease,we demonstrate,through FCFM,the MMP activity in the alveolar space measured through FIB One fluorescence increase(with pharmacological inhibition).*** translational in situ approach enables a new methodology to demonstrate active drug target effects of the distal lung and consequently may inform therapeutic drug development pathways.

关键词： Lung lung specificity

Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level

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Light(Science & Applications) 2013年第1期2卷 154-162页

作者： Zhen Ma Qiuying Liu Huaxiao Yang Raymond B Runyan Carol A Eisenberg Meifeng Xu Thomas K Borg Roger Markwald Yifei Wang bruce Z Gao department of Bioengineering and COMSET Clemson UniversityClemsonSC 29634USA department of Bioengineering University of CaliforniaBerkeleyBerkeleyCAUSA Biomedical R&d Center Jinan UniversityGuangzhouChina department of Cellular and Molecular Medicine University of ArizonaTucsonAZ 85724USA New York Medical College/Westchester Medical Center Stem Cell Laboratory New York Medical CollegeValhallaNew YorkUSA department of Pathology and Laboratory Medicine University of Cincinnati Medical CenterCincinnatiOHUSA department of Regenerative Medicine and Cell Biology Medical University of South CarolinaCharlestonSCUSA

Mesenchymal stem cells(MSCs)have been cited as contributors to heart repair through cardiogenic differentiation and multiple cellular interactions,including the paracrine effect,cell fusion,and mechanical and electrical *** to heart–muscle complexity,progress in the development of knowledge concerning the role of MSCs in cardiac repair is heavily based on MSC–cardiomyocyte *** conventional coculture systems,however,the in vivo cardiac muscle structure,in which rod-shaped cells are connected end-to-end,is not sustained;instead,irregularly shaped cells spread randomly,resulting in randomly distributed cell ***,contact-mediated cell–cell interactions(e.g.,the electrical triggering signal and the mechanical contraction wave that propagate through MSC–cardiomyocyte junctions)occur ***,the data generated on the beneficial effects of MSCs may be irrelevant to in vivo biological *** this study,we explored whether cardiomyocyte alignment,the most important phenotype,is relevant to stem cell cardiogenic ***,we report(i)the construction of a laser-patterned,biochip-based,stem cell–cardiomyocyte coculture model with controlled cell alignment;and(ii)single-cell-level data on stem cell cardiogenic differentiation under in vivo-like cardiomyocyte alignment conditions.

关键词： cardiogenic differentiation mesenchymal stem cells microenvironment optical force single-cell analysis

Preliminary evaluation of the VIsion PERformance(VIPER) simulator

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Military Medical Research 2020年第3期7卷 312-323页

作者： denise S.Ryan Rose K.Sia Jennifer B.Eaddy Lorie A.Logan Jide O.Familoni Hind Beydoun Samantha B.Rodgers bruce A.Rivers Warfighter Refractive Eye Surgery Program and Research Center Fort Belvoir Community HospitalFort BelvoirVA 22060USA Night Vision and Electronic Sensors directorate Fort BelvoirVA 22060USA department of Research Programs Fort Belvoir Community HospitalFort BelvoirVA 22060USA

Background:This study evaluated the VIsion PERformance(VIPER)simulator’s ability to assess the functional visual performance in warfighters conducting civilian and military ***:Thirty service members,aged 25–35 years old with a best corrected distance visual acuity(VA)better than or equal to 20/20 or logarithm of the minimum angle of resolution(logMAR)0.00,were randomized to locate and identify road signs and mock improvised explosive devices(IEds)under either daytime conditions or with infrared imagery,with(cc)and without(sc)wearing their habitual *** also underwent binocular uncorrected(UdVA)and corrected(CdVA)visual assessment,refraction,contrast sensitivity testing and wavefront ***:The mean age was 28.47 *** manifest spherical equivalent was–3.16±1.75 diopters(d),the UdVA in both eyes(OU)was logMAR 0.83±0.47,and the CdVA OU was–0.11±*** VIPER,the mean difference in the detection distance(dd)for road signs ccdd *** was(76.7±52.8)m(Pdifference in identification distance(Id)ccId *** was(13.9±6.3)m(Pd 27.9%for cc and sc,respectively(Pdicated that a 1.6 m change in the distance accounts for a 1%change in the accuracy(P=0.002).Without correction,a 4.1 m change accounts for a 1%change in the accuracy(Pd ccdd was(29.9±8.2)m,and that for scdd was(13.2±13.6)m(Pd ccId was(32.2±6.2)m and that for the scId was(7.4±10.3)m(Pd identification accuracy was 46.7 and 11.4%for cc and sc,respectively(Pdetecting and identifying signs and ***,VIPER is able to detect performance changes with and without correction.

关键词： Functional visual performance Military task performance

Study on little active and sedentary women: Comparison between protocols and prospects for admission in physical activity program

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Open Journal of Preventive Medicine 2013年第6期3卷 413-419页

作者： A.d.P.Bankoff postural assessment laboratory faculdade de educacao fisica(fef)unicampcampinasbrazil department of cardiology hospital de clinicas(hc)unicampcampinasbrazil 3policy research groupinstitute of mathematicsstatistics and scientific computationunicampcampinasbrazil

The aim of this work was to study little active and sedentary women through physical assessments using anthropometric measurements and exercise testing using the Naughton and bruce protocols. Approximately 53 women were evaluated: Group 1—comprised of 17 completely sedentary women, aged 25-58 years, mean age 44.4 years, and Group 2—comprised of 36 women who answered doing physical activities once or twice a week (low active), aged 28-54 years, mean age 39.5 years. The results Group 1— high weight, body mass index showing overweight, heart rate above the target areas of your training, i.e., above 85% effort. Systolic blood pressure reached a high level in the seventh stage with 21 minutes of effort (177.3) and diastolic (92.7). Group 2—normal weight, body mass index recorded is considered thin, heart rate heart zones above the target of your training, i.e., above 85% effort also. Systolic blood pressure reached the highest level in phase 1 recovery (156.75). diastolic blood pressure recorded pressure levels considered normal for the type of work done by the group. The values reported for the double product are considered normal for the type of effort made by both groups. Conclusion: The participants from group 1 are able to join physical activity programs from the results presented, specifically due to weight, BMI, heart rate and blood pressure. The participants from group 2 require more days of practice of physical activities and longer hours to improve the levels of heart rate and blood pressure.

关键词： Sedentary Lifestyle double Product Heart Rate Blood Pressure

接受64层心脏CT评估胸痛综合征的零或低钙评分患者中阻塞性冠状动脉疾病的患病率和严重程度

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世界核心医学期刊文摘（心脏病学分册） 2007年第7期3卷 19-20页

作者： Rubinshtein R. Gaspar T. Halon d.A. B.S. Lewis 黄欣 department of Cardiovascular Medicine Lady Davis Carmel Medical Center Ruth and Bruce Rappaport School of Medicine Haifa Israel Dr.

检测了拟行胸痛综合征评估的零或低冠状动脉钙评分（CS）患者中64层对比增强CT检查所示冠状动脉疾病（CAd）的程度。在连续668例行心脏多层CT的胸痛综合征患者（39％具有急性临床表现，61％具有长期临床表现）中，评定了231例具有零（n=... 详细信息

检测了拟行胸痛综合征评估的零或低冠状动脉钙评分（CS）患者中64层对比增强CT检查所示冠状动脉疾病（CAd）的程度。在连续668例行心脏多层CT的胸痛综合征患者（39％具有急性临床表现，61％具有长期临床表现）中，评定了231例具有零（n=125）或低冠状动脉CS（n=106）的患者（54±12岁，女性占45％）中冠状动脉狭窄（至少1支冠状动脉狭窄〉150％）的患病率和严重程度。231例患者中27例存在阻塞性（〉150％病变）CAd，其中125例零CS患者中有9例（7％），106例低CS患者中有18例（17％），具有急性临床表现的90例患者中有14例（16％），具有长期临床表现的141例患者中有13例（9％）（P值无显著性）。

关键词：冠状动脉疾病 CT评估综合征患病率阻塞性钙评分胸痛心脏

Nanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor immunotherapy

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Nanobody-based chimeric antigen receptor T cells designed by...

Radiation Use Efficiency of Cotton in Contrasting Environments

第十四届全国免疫学学术大会

作者： Fengzhen Mo Siliang duan Xiaobing Jiang Xiaomei Yang Xiaoqiong Hou Wei Shi Cueva Jumbo Juan Carlos Aiqun Liu Shihua Yin Wu Wang Hua Yao Zihang Yu Zhuoran Tang Shenxia Xie Ziqiang ding Xinyue Zhao bruce d.Hammock Xiaoling Lu Guangxi Medical University 华中科技大学同济医学院附属协和医院 University of California davis

Chimeric antigen receptor-based T cell immunotherapy is a promising strategy for treatment of hematological malignant tumors,however its efficacy towards solid cancer remains *** therefore focused on developing nanobody-based CAR T cells that treat the solid ***105 expression is up-regulated on neoangiogenic endothelial and cancer ***105 has been developed as a drug *** we show the generation of a Cd105-specific nanobody,an anti-human Cd105 CAR-T cells by inserting the sequences for anti-Cd105 nanobody-linked standard cassette genes into AAVS1 site using CRISPR/Cas9 ***-culture with Cd105+target cells led to the activation of anti-Cd105 CAR-T cells that displayed the typically activated cytotoxic T cell characters,ability to proliferate,the production of pro-inflammatory cytokines,and the specific killing efficacy against Cd105+target cells in *** in vivo treatment with anti-Cd105 CAR-T cells significantly inhibited the growth of implanted Cd105+tumors,reduced tumor weight and prolonged the survival time of tumor-bearing NOd/SCId ***-based CAR-T cells can therefore function as an anti-tumor agent in human tumor xenograft *** findings determined that the strategy of nanobody-based CAR-T cells engineered by CRISPR/Cas9 system has a certain potential to treat solid tumor through targeting Cd105 antigen.

关键词： Nanobody chimeric antigen receptor T cells CRISPR/Cas9 tumor immunotherapy

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