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Rationale and design of Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events III (TRACE III): a randomised, phase III, open- label, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 82-89页

作者： Yunyun Xiong bruce C V Campbell Marc fisher Lee H Schwamm Mark Parsons Hao Li Yuesong Pan Xia Meng Xingquan Zhao Yongjun Wang Neurology Beijing Tiantan HospitalBeijingChina China National Clinical Research Center for Neurological diseases BeijingChina department of Medicine and Neurology The University of MelbourneMelbourneVictoriaAustralia Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA department of Neurology and Comprehensive Stroke Center Massachusetts General HospitalBostonMassachusettsUSA department of Neurology University of New South Wales South Western Sydney Clinical SchoolLiverpoolNew South WalesAustralia

Background and purpose Recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)was not inferior to alteplase for ischaemic stroke within *** study aimed to investigate the efficacy and safety of rhTNK-tPA in patients who had an ischaemic stroke due to large vessel occlusion(LVO)of anterior circulation beyond *** and design Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events-III(TRACE III)is a multicentre,prospective,randomised,open-label,blind endpoint,controlled clinical *** who had an ischaemic stroke due to anterior circulation LVO(internal carotid artery,middle cerebral artery M1 and M2 segments)within 4.5–24hours from last known well(including wake-up stroke and no witness stroke)and with salvageable tissue(ischaemic core volumed mismatch volume≥15mL)based on CT perfusion or MRI perfusion-weighted imaging(PWI)were included and randomised to rhTNK-tPA 0.25mg/kg(single bolus)to a maximum of 25mg or standard medical ***,we will exclude patients who are intended for direct *** will be followed up for 90 *** outcomes Primary efficacy outcome is modified Rankin Scale(mRS)score≤1 at 90 *** efficacy outcomes include ordinal distribution of mRS at 90 days,major neurological improvement defined by a decrease≥8 points compared with the initial deficit or a score≤1 on the National Institutes of Health Stroke Scale(NIHSS)at 72 hours,mRS score≤2 at 90 days,the rate of improvement on Tmax>6s at 24 hours and NIHSS score change from baseline at *** outcomes are symptomatic intracerebral haemorrhage within 36 hours and mortality at 90 *** TRACE III will provide evidence for the efficacy and safety of rhTNK-tPA in patients who had an ischaemic strokes due to anterior circulation LVO beyond *** registration number NCT05141305.

关键词： Therapy random Rational

Transforming nanoscale VO_(2)(B) into a scalable sodium-ion electrode

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Nano Research 2024年第10期17卷 8809-8818页

作者： Yunkai Luo Swetha Chandrasekaran Bintao Hu Randy Chen Marcus Worsley bruce dunn department of Materials Science and Engineering University of CaliforniaLos AngelesCA 90095USA Lawrence Livermore National Laboratory CA 94550USA

The intermittent nature of renewable energies requires highly reliable grid-level energy storage approaches.A critical consideration in developing this technology is the areal capacity which determines battery performance and influences the cost of battery *** related importance is finding new ways of developing scalable *** recent years,threedimensional(3d)printing of conductive scaffolds has emerged as an alternative to overcome the scalability limitations of commercial tape cast *** research carried out in the current study demonstrates a successful scalability pathway for nanoscale VO_(2)(B),a desirable cathode for sodium-ion batteries which has a nano-flower morphology with a crystallite sizedepositing VO_(2)(B)onto a graphene aerogel scaffold,we were able to achieve mass loading of over 100 mg·cm^(-2) and still possess an areal capacity of 10 mAh·cm^(-2) at a current density of 5 mA·cm^(-2).Moreover,after 1000 cycles,these electrodes retained 75% to 80% of their initial *** at high loading levels,the electrodeposited VO_(2)(B)exhibits pseudocapacitive material signatures such as a box-like voltammetry response,linear galvanostatic response,and no phase change upon *** scalability of the VO_(2)(B)electrode is demonstrated in a series of experiments which show the areal capacity to scale upon increase in both mass loading and electrode thickness,with only small changes in specific *** study establishes that nanoscale materials can be scaled up to achieve thick electrodes without compromising their electrochemical properties.

关键词： nano VO_(2)(B) sodium-ion battery scalable electrodes three-dimensional(3d)printed scaffold additive manufacturing

Validation of the age-adjusted shock index for pediatric casualties in Iraq and Afghanistan

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Military Medical Research 2021年第1期8卷 17-24页

作者： Camaren M.Cuenca Matthew A.Borgman Michael d.April Andrew d.fisher Steven G.Schauer JUS Army Institute of Surgical Research 3698 Chambers PassJBSA Fort Sam HoustonSan AntonioTX 78234-7767USA Brooke Army Medical Center JBSA Fort Sam HoustonSan AntonioTXUSA Uniformed Services University of the Heath Sciences BethesdaMDUSA Texas Army National Guard AustinTXUSA department of Surgery UNM School of MedicineAlbuquerqueNMUSA 59th Medical Wing JBSA LacklandSan AntonioTXUSA

Background: Pediatric casualties account for a notable proportion of encounters in the deployed setting based on the humanitarian medical care mission. Previously published data demonstrates that an age-adjust shock index may be a useful tool in predicting massive transfusion and death in children. We seek to determine if those previous findings are applicable to the deployed, combat trauma ***: We queried the department of defense Trauma Registry(dOdTR) for all pediatric subjects admitted to US and Coalition fixed-facility hospitals in Iraq and Afghanistan from January 2007 to January 2016. This was a secondary analysis of casualties seeking to validate previously published data using the shock index, pediatric age adjusted. We then used previously published thresholds to determine patients outcome for validation by age grouping, 1–3 years(1.2), 4–6 years(1.2), 7–12 years(1.0), 13–17 years(0.9).Results: From January 2007 through January 2016 there were 3439 pediatric casualties of which 3145 had a documented heart rate and systolic pressure. Of those 502(16.0%) underwent massive transfusion and 226(7.2%) died prior to hospital discharge. Receiver operating characteristic(ROC) thresholds were inconsistent across age groups ranging from 1.0 to 1.9 with generally limited area under the curve(AUC) values for both massive transfusion and death prediction characteristics. Using the previously defined thresholds for validation, we reported sensitivity and specificity for the massive transfusion by age-group: 1–3(0.73, 0.35), 4–6(0.63, 0.60), 7–12(0.80, 0.57), 13–17(0.77, 0.62). For death, 1–3(0.75, 0.34), 4–6(0.66–0.59), 7–12(0.64, 0.52), 13–17(0.70, 0.57). However, negative predictive values(NPV) were generally high with all greater than ***: Within the combat setting, the age-adjusted pediatric shock index had moderate sensitivity and relatively poor specificity for predicting massive transfusion and death. Better scoring systems are needed to p

关键词： Pediatric Massive Transfusion Shock Index Age

光电极表面态的静态结构与时间分辨动力学和频光谱研究

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Chinese Journal of Chemical Physics 2024年第2期37卷 376-397,I0105页

作者：张彤 Jesse B.Brown Haley fisher Mallory Liebes 皇甫至超钱余亲饶毅美国犹他州立大学化学与生物化学系犹他州洛根84322

在光催化或光电催化反应过程中,光电极的表面态扮演着重要的角色,影响着电荷的产生、分离和利用过程,从而很大程度上决定了光电极的催化性能,通常用于研究光电极表面态以改进其性能的方法是间接的、非表面特异性的以及需要超高真空条件... 详细信息

在光催化或光电催化反应过程中,光电极的表面态扮演着重要的角色,影响着电荷的产生、分离和利用过程,从而很大程度上决定了光电极的催化性能,通常用于研究光电极表面态以改进其性能的方法是间接的、非表面特异性的以及需要超高真空条件下进行的方法,无法获得真实条件下的表面态信息。电子和频光谱和电子二次谐波等非线性光学方法具有表面特异性,可以在各种条件下实现表界面系统的原位研究.本研究介绍了表面态的重要性及其与催化性能的密切关系,概述研究半导体表面态、电场和载流子动力学的方法,并重点介绍了界面特异性光谱方法在该领域的最新贡献.包括通过相位信息提取带电表面态的宽带外插法电子二次谐波技术,提供表面态动力学信息的时间分辨电子和频光谱技术和探索表面态耦合的二维电子和频光谱技术,这些非线性光学方法的进一步发展将实现对光电极表面态和界面电子特性的多角度原位表征,提供对表面态及表面电荷转移过程更深层次的理解,以启发未来光催化和光电催化材料的研究和改进.

关键词：表面态电子和频光谱光催化光电催化

One-dimensional Nonlinear Laplacians under a 3-Point Boundary Condition

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Acta Mathematica Sinica,English Series 2010年第9期26卷 1641-1652页

作者： bruce d.CALVERT department of Mathematics University of Auckland

We consider a three-point boundary value problem for operators such as the one-dimensional p-Laplacian, and show when they have solutions or not, and how many. The inverse operators are given by various formulas involving zeros of a real-valued function. They are shown to be orderpreserving, for some parameter values, and non-singleton valued for others. The operators are shown to be m-dissipative in the space of continuous functions.

关键词： Boundary value problems nonlinear o.d.e.s p-Laplacian three-point boundary value problem m-dissipative

Complex ammonium oxidation demands visualized resolution

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Science Bulletin 2024年第16期69卷 2478-2482页

作者： Zhihao Chen Yonghong Wu Jan dolfing Shunyao Zhuang Baozhan Wang dan Li Shan Huang bruce E.Rittmann State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Zigui Three Gorges Reservoir Ecosystem Observation and Research Station of Ministry of Water Resources of the People’s Republic of ChinaYichang 443605China University of Chinese Academy of Sciences Beijing 100049China d College of Nanjing University of Chinese Academy of SciencesNanjing 211135China Faculty of Energy and Environment Northumbria UniversityNewcastle-upon-Tyne NE18QHUK department of Microbiology College of Life SciencesNanjing Agricultural UniversityKey Laboratory of Agricultural and Environmental MicrobiologyMinistry of Agriculture and Rural AffairsNanjing 210095China College of Urban Construction Nanjing Tech UniversityNanjing 211816China department of Civil and Environmental Engineering Princeton UniversityPrinceton NJ 08540USA Biodesign Swette Center for Environmental Biotechnology Arizona State UniversityTempe AZ 85287-5701USA

The nitrogen cycle plays a vital role in sustaining productive and healthy ecosystems,with the microbial nitrogen cycle being a focal point in agriculture and eco-environmental *** these microbially mediated processes is ammonium(NH_(4)^(+))oxidation,the gatekeeper of the nitrogen *** understanding of ammonium oxidation is continuously evolving,thanks to recent research breakthroughs like comammox,Feammox,and dirammox[1-6].The increasing complexity of ammonium oxidation necessitates more precise and well-focused research tools beyond those commonly used today.

关键词： ammonium breakthrough precise

Adding Value to Crop Production Systems by Integrating Forage Cover Crop Grazing

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American Journal of Plant Sciences 2024年第3期15卷 180-192页

作者： Robert B. Mitchell daren d. Redfearn Kenneth P. Vogel Terry J. Klopfenstein Galen Erickson P. Stephen Baenziger bruce E. Anderson Mary E. drewnoski Jay Parsons Steven d. Masterson Marty R. Schmer Virginia L. Jin USdA-ARS Wheat Sorghum and Forage Research Unit University of Nebraska-Lincoln Lincoln NE USA department of Agronomy and Horticulture University of Nebraska-Lincoln Lincoln NE USA department of Animal Science University of Nebraska-Lincoln Lincoln NE USA department of Agricultural Economics University of Nebraska-Lincoln Lincoln NE USA USdA-ARS Agroecosystem Management Research Unit University of Nebraska-Lincoln Lincoln NE USA

In addition to their value as cereal grains, wheat (Triticum aestivum L.) and triticale (× Triticosecale Wittmack) are important cool-season annual forages and cover crops. Yearling steer (Bos taurus) performance was compared in the spring following autumn establishment as for age cover crops after soybean [Glycine max (L.) Merr.] grain harvest. Replicated pastures (0.4 ha) were no-till seeded in three consecutive years into soybean stubble in autumn, fertilized, and grazed the following spring near Ithaca, NE, USA. Each pasture (n = 3) was continuously stocked in spring with four yearling steers (380 ± 38 kg) for 17, 32, and 28 d in 2005, 2006, and 2007, respectively. In 2005, average daily gain (AdG) for steers grazing triticale exceeded the AdG for wheat by 0.31 kghd-1d-1. In 2006, wheat AdG exceeded that for triticale by 0.12 kghd-1d-1. In 2007, steers grazing wheat lost weight, while steers grazing triticale gained 0.20 kghd-1d-1. Based on the 3-year average animal gains valued at $1.32 kg-1, mean net return ($ ha-1 yr-1) was $62.15 for triticale and $22.55 for wheat. Since these grazed cover crops provide ecosystem services in addition to forage, grazing could be viewed as a mechanism for recovering costs and adds additional value to the system. Based on this 3-year grazing trial, triticale was superior to wheat and likely will provide the most stable beef yearling performance across years with variable weather for the western Cornbelt USA.

关键词： Cover crops Soybean Triticale Wheat

Azoospermia:vasal agenesis

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Asian Journal of Andrology 2022年第1期24卷 1-4页

作者： J Sam fisher Edward d Kim department of Urology University of TennesseeKnoxvilleTN 37920USA

SPECIFIC GENETIC TESTS(CFTR ANd INTRON 8 SPLICE VARIANT TESTING)ANd THEIR SIGNIFICANCE Congenital bilateral absence of the vas deferens(CBAVd)and cystic fibrosis(CF)began as separate entities with an apparent clinical *** occurs in 1%–2%of men presenting with infertility at urological departments and has an incidence of 1:1000–1:2000 in Caucasian *** example of this anatomic variant is shown in Figure 1.

关键词： correlation. clinical Figure

Electric scooter injuries:Incidence and injury patterns at a level I trauma center

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Chinese Journal of Traumatology 2023年第6期26卷 334-338页

作者： Nina d.fisher Ekenedilichukwu Nwakoby Hunter Hernandez Toni M.McLaurin department of Orthopedic Surgery Langone Orthopedic HospitalNew York UniversityNew YorkUnited States department of Orthopedic Surgery HealthþHospitals/Bellevue New York CityNew YorkUnited States

Purpose:Electric scooters(e-scooters)have become an increasingly popular mode of public transportation in recent *** the incidence of related injuries rises,it is important to understand specific fracture patterns unique to e-scooters and electric bikes(e-bikes)to help guide *** purpose of this study was to review the prevalence and describe specific fracture patterns of e-scooter and ebike related injuries at the busiest level 1 trauma center in the borough of ***:Chart review to determine mechanism of injury was performed on all patients for whom an orthopedic consult was requested from 1/1/2021 to 12/31/*** patients whose injuries were sustained due to an e-scooter or e-bike were further reviewed for demographics,injury characteristics including fracture pattern,and definitive injury *** patients who had an orthopedic consult placed for a reason other than an acute injury were *** statistics are reported as frequency(percentage)for categorical variables and means for continuous ***:Of the 1815 orthopedic consults requested,1357(74.8%)were for acute injury *** those with acute injuries,119(8.8%)sustained 136 e-scooter or e-bike related *** were 92(77.3%)males at an average age of(33.8±15.7)*** one-fifth of all patients presented in June 2021(26,21.8%).There was a 9.2%rate of open *** 136 injuries were evenly split between the upper and lower extremities,with 57(47.9%)upper extremity,57(47.9%)lower extremity injuries,and 5(4.2%)concomitant upper and lower extremity *** most common fracture patterns were ankle fractures(16,11.7%),followed by tibial shaft(14,10.2%),tibial plateau(13,9.5%),and radial head fractures(11,8.0%).There was a 33.3%incidence of associated posterior malleolar fractures in the spiral tibial shaft fractures,31.0%of posterior malleolar involvement and 18.8%of isolated vertical medial malleolar fractures in the ankle

关键词： Electric scooter Electric bike Tibial shaft Ankle fractures Tibial plateau fractures