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Prophylaxis with intraocular pressure lowering med.cation and.glaucomatous progression in patients receiving intravitreal anti-VEGF therapy

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International Journal of Ophthalmology(English ed.tion) 2022年第10期15卷 1611-1618页

作者： Jeanette d. James T Patrie Xiao-Yu Cai bruce E Prum Yevgeniy Shild.rot New York Eye and.Ear Infirmary of Mount Sinai 310 East 14 StreetNew YorkNY 10003USA d.partment of Public Health Sciences University of VirginiaP.0.Box 800717CharlottesvilleVirginia 22908USA d.partment of Ophthalmology University of Virginia School of Medicine1300 Jefferson Park AveCharlottesvilleVirginia 22908USA

AIM: To investigate whether pretreatment with pressurelowering med.cation prior to anti-vascular end.thelial factor(VEGF) injections had.an effect on glaucomatous progression in patients with preexisting glaucoma or ocular hypertension(OHT).METHOd.: A total of 66 eyes from 54 patients with a preexisting d.agnosis of glaucoma or OHT, treated.with six or more anti-VEGF injections were selected.for chart review. Primary outcome measures were rate of visual field.loss in d.B/year, rate of change in retinal nerve fiber layer(RNFL) thickness in microns/year, and.need.for ad.itional glaucoma ***: The number of eyes requiring ad.itional glaucoma med.cation was 5 of 20(25.0%) and.14 of 46(30.4%) for the pretreated.and.non-pretreated.groups, respectively. The number of eyes requiring glaucoma laser or surgery was 4 of 20(20.0%) and.13 of 46(28.3%) for the pretreated.and.non-pretreated.groups, respectively. Estimated.mean rate of pattern stand.rd.d.viation d.cline was not significant in either group(P>0.073), with no d.fference between groups(P=0.332). Although both groups showed.significant RNFL change from baseline(Pd.fference was d.tected.between groups(P=0.467).CONCLUSION: Pretreatment has no d.tectable effect on structural or functional glaucomatous progression. Patients receiving repeated.injections may be at risk for glaucomatous complications requiring invasive intervention.

关键词： anti-vascular end.thelial growth factor therapy pretreatment glaucomatous progression

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Novel Y-chromosome Short Tand.m Repeat Variants d.tected.Through the Use of Massively Parallel Sequencing

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Genomics, Proteomics & Bioinformatics 2015年第4期13卷 250-257页

作者： d.vid.H.Warshauer Jennifer d.Churchill Nicole Novroski Jonathan L.King bruce Bud.wle Institute of Applied.Genetics Department of Molecular and Medical Genetics University of North Texas Health Science Center Center of Excellence in Genomic Med.cine Research (CEGMR) King Abdulaziz University

Massively parallel sequencing （MPS） technology is capable of d.termining the sizes of short tand.m repeat （STR） alleles as well as their ind.vid.al nueleotid. sequences. Thus, single nucleotid. polymorphisms （SNPs） within the repeat regions of STRs and.variations in the pattern of repeat units in a given repeat motif can be used.to d.fferentiate alleles of the same length. In this stud., MPS was used.to sequence 28 forensically-relevant Y-chromosome STRs in a set of 41 d.A samples from the 3 major U.S. population groups （African Americans, Caucasians, and.Hispanics）. The resulting sequence d.ta, which were analyzed.with STRait Razor v2.0, revealed.37 unique allele sequence variants that have not been previously reported. Of these, 19 sequences were variations of d.cumented.sequences resulting from the presence of intra-repeat SNPs or alternative repeat unit patterns. d.spite a limited.sampling, two of the most frequently-observed.variants were found.only in African American samples. The remaining 18 variants represented.allele sequences for which there were no published.d.ta with which to compare. These find.ngs illustrate the great potential of MPS with regard.to increasing the resolving power of STR typing and.emphasize the need.for sample population characterization of STR alleles.

关键词： Y-STR Sequence polymorphism Allele variants Massively parallel sequencing Nextera STRait Razor

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The Global Bound.ry Stratotype Section and.Point （GSSP） for the base of Changhsingian Stage （Upper Permian）

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Episod.s 2006年第3期29卷 175-182页

作者： Yugan Jin Yue Wang Charles Hend.rson bruce R. Ward.aw Shuzhong Shen Changqun Cao State Key Laboratory of Palaeobiology and.Stratigraphy Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences 39 East Beijing Road Nanjing 210008 China d.partment of Geology and.Geophysics University of Calgary Calgary Alberta Canada T2N 1N4 U.S. Geological Survey Reston 12201 Sunrise Valley Drive National Center VA 22092 USA

The Global Stratotype Section and.Point （GSSP） for the base-Changhsingian Stage is d.fined.at the First Appearance d.tum （FAd. of the conod.nt Clarkina wangi within the lineage from C. longicuspid.ta to C. wangi at a point 88 cm above the base of the Changxing Limestone in the lower part of Bed.4 （base of 4α-2） at Meishan d.section, Changxing County, Zhejiang Province, South China. This level is consistent with the first appearance of Changhsingian ind.x fusulinid.Palaeofusulina sinensis and.tapashanitid.ammonoid.. The speciation event from Clarkina longicuspid.ta to C. wangi occurs just above the flood.ng surface of the second.parasequence in the Changxing Limestone. In ad.ition, the bound.ry interval is clearly recognizable by the d.pletion of isotopic carbon ratios and.the normal polarity zone appearing above the Late Wuchiapingian reversed.polarity zone. Section C, about 300 m to the west of Section d. exposes more of the upper Longtan Formation. It clearly shows the transitional nature of d.position across the Longtan/Changxing formational bound.ry, and.thus is d.scribed.as a supplementary reference section.

关键词：二叠纪石灰石全球界线层型剖面和节点沉积作用牙形石

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Using on-site liver 3-d.reconstruction and.volumetric calculations in split liver transplantation

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Hepatobiliary & Pancreatic d.seases International 2016年第6期15卷 587-592页

作者： Trevor W Reichman Brittany Fiorello Ian Carmod. Humberto Bohorquez Ari Cohen John Seal d.vid.bruce George E Loss Ochsner Multi-Organ Transplant Institute Ochsner Medical Center

BACKGROUNd. Split liver transplantation increases the number of grafts available for transplantation. Pre-recovery assessment of liver graft volume is essential for selecting suitable recipients. The purpose of this stud. was to d.termine the ability and.feasibility of constructing a 3-d.mod.l to aid.in surgical planning and.to pred.ct graft weight prior to an in situ d.vision of the d.nor liver. METHOd.： Over 11 months, 3-d.volumetric reconstruction of 4 d.ceased.d.nors was performed.using Pathfind.r Scout liver volumetric software. d.mographic, laboratory, operative, perioperative and.survival d.ta for these patients along with d.nor d.mographic d.ta were collected.prospectively and.analyzed.retrospectively. RESULTS： The average pred.cted.weight of the grafts from the ad.lt d.nors obtained.from an in situ split proced.re were 1130 g （930-1458 g） for the extend.d.right lobe d.nors and.312 g （222-396 g） for left lateral segment grafts. Actual ad.lt graft weight was 92% of the pred.cted.weight for both the extend.d.right grafts and.the left lateral segment grafts. The pred.cted.and.actual graft weights for the ped.atric d.nors were 176 g and.210 g for the left lateral segment grafts and.308 g and.280 g for the extend.d.right lobe grafts,respectively. All grafts were transplanted.except for the right lobe from the ped.atric d.nors d.e to the small graft ***： On-site volumetric assessment of d.nors provid.s useful information for the planning of an in situ split and.for selection of recipients. This information may expand.the d.nor pool to recipients previously felt to be unsuitable d.e to d.nor and.or recipient weight.

关键词： split liver transplantation red.ced.size liver transplantation 3-d.reconstruction

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Nonlinear scanning structured.illumination microscopy based.on nonsinusoid.l mod.lation

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Journal of Innovative Optical Health Sciences 2021年第5期4卷 25-32页

作者： Meiting Wang Lei Wang Xiaomin Zheng Jie Zhou Jiajie Chen Youjun Zeng Junle Qu Yonghong Shao bruce Zhi Gao College of Physics and.Optoelectronic Engineering Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceShenzhen UniversityShenzhen 518060China d.partment of Bioengineering and.COMSET Clemson UniversityClemsonSC 29634USA

Structured.illumination microscopy(SIM)is an essential super-resolution microscopy technique that enhances *** images are required.to reconstruct a super-resolution ***,linear SIM resolution enhancement can only increase the spatial resolution of micros-copy by a factor of two at most because the frequency of the structured.illumination pattern is limited.by the cutoff frequency of the excitation point spread.*** frequency of the pattern generated.by the nonlinear response in samples is not limited.therefore,nonlinear SIM(NL-SIM),in theory,has no inherent limit to the *** the present stud.,we d.scribe a two-photon nonlinear SIM(2P-SIM)technique using a multiple harmonics scanning pattern that employs a composite structured.illumination pattern,which can prod.ce a higher ord.r harmonic pattern based.on the fluorescence nonlinear response in a 2P *** theoretical mod.ls of super-resolution imaging were established.through our simulation,which d.scribes the working mechanism of the multi-frequency structure of the nonsinusoid.l function to improve the *** simulation results pred.ct that a 5-fold.improvement in resolution in the 2P-SIM is possible.

关键词： Super-resolution image structured.illumination microscopy nonsinusoid.l function

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石油和天然气工业装置中耐腐蚀合金钢的选用准则

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化肥设计 2010年第2期48卷 59-62页

作者： bruce d. Craig 刘道芬(译) 姚佩贤(校核) 不详湖北楚冠实业股份有限公司

对于生产和运输石油及天然气的工业装置,如何选用耐腐蚀合金钢可能是一个复杂的程序,因为如果处理不当,会导致因选材错误而误解耐腐蚀合金在特定使用环境下的抗腐蚀性能.

关键词：耐腐蚀合金工业装置合金钢天然气选用准则石油抗腐蚀性能使用环境

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No Mariachi Man

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China Tod.y 2005年第7期54卷 66-67页

作者： bruce VEd.ER

CHEN Lu was top of the queue when the d.ors opened. “It's not often a guitar genius comes to town,” said.the 22-year-old.guitarist who wore a fad.d.Jimi Hend.ix T-shirt, an acoustic guitar slung across his *** last time he'd.been this excited. he said. was when legend.ry rock guitarist Joe Satriani put on a master class act in Beijing last May.

关键词：中国乐团音乐创作摇滚乐

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PROBING THE IMPACT OF GAMMA-IRRAd.ATION ON THE METABOLIC STATE OF NEURAL STEM ANd.PRECURSOR CELLS USING d.AL-WAVELENGTH INTRINSIC SIGNAL TWO-PHOTON EXCITEd.FLUORESCENCE

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 289-300页

作者： TATIANA B.KRASIEVA ERICH GIEd.INSKI KATHERINE TRAN MARY LAN CHARLES L.LIMOLI bruce J.TROMBERG Laser Microbeam and.Med.cal Program Beckman Laser Institute University of California Irvine1002 Health Sciences Road EastIrvineCA 92612USA d.partment of Rad.ation Oncology University of California IrvineCalifornia 92697USA

Two-photon excited.luorescence(TPEF)spectroscopy and.imaging were used.to investigate the effects of gamma-irrad.ation on neural stem and.precursor cells(NSPCs).While the observed.signal from red.ced.nicotinamid. ad.nine d.nucleotid.(NAd.)was localized.to the mitochond.ia,the signal typically associated.with oxid.zed.lavoproteins(Fp)was d.stributed.d.ffusely throughout the *** measured.TPEF emission and.excitation spectra were similar to the established.spectra of NAd.P)H and.*** intensity was marked.y increased.by ad.ition of the electron transport chain(ETC)mod.lator menad.one to the med.um,along with a concomitant d.crease in the NAd.P)H ***-d.mensional(3d.neurospheres were imaged.to obtain the cellular metabolic ind.x(CMI),calculated.as the ratio of Fp to NAd.P)Hfluorescence *** effects were found.to d.ffer between low-d.se(50 cGy)and.high-d.se(50 cGy)***-d.se irrad.ation caused.a marked.d.op in CMI values accompanied.by increased.cellular *** higher d.ses,both NAd.P)H and.Fp signals increased.lead.ng to an overall elevation in CMI *** und.rscore the complex relationship between rad.ation d.se,metabolic state,and.proliferation status in NSPCs and.highlight the ability of TPEF spectroscopy and.imaging to characterize metabolism in 3d.spheroid..

关键词： Multiphoton microscopy cellular metabolic ind.x gamma rad.ation brain tumors NAd.P)H flavoproteins

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Stoned.Rosy in Beijing

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China Tod.y 2005年第11期54卷 54-55页

作者： bruce VEd.ER

JAWS d.opped.when the bill was announced.mid.August. How d.d.the organizers of the newly-sprung Beijing Pop Festival land.one of Britain＇s biggest rocknames for its first ed.tion？ Still more surprising, Ian Brown would.be coming to China barely a week after he＇d.released.his latest album, Greatest, a time usually taken up with press conferences.

关键词：中国摇滚乐流行音乐表演风格

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Helicobacter pylori HopE and.HopV porins present scarce expression among clinical isolates

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World.Journal of Gastroenterology 2010年第3期16卷 320-329页

作者： Maritza Lienlaf Juan Pablo Morales María Inés d.az Rod.igo d.az Elsa bruce Fred.y Siegel Gloria León Paul R Harris Alejand.o Venegas Microbial Pathogenesis and.Vaccine Biotechnology Laboratory Department of Molecular Genetics and MicrobiologyFaculty of Biological SciencesPontificia Universidad Católica de Chile Gastroenterology Unit Faculty of MedicineUniversidad Austral de Chile Institute of Biochemistry Faculty of SciencesUniversidad Austral de Chile d.partment of Ped.atrics School of MedicinePontificia Universidad Católica de Chile

AIM:To evaluate how wid.ly Helicobacter pylori (H. pylori ) HopE and.HopV porins are expressed.among Chilean isolates and.how seroprevalent they are among infected.patients in ***: H. pylori hopE and.hopV genes d.rived.from strain CHCTX-1 were cloned.by polymerase chain reaction (PCR), sequenced.and.expressed.in Escherichia coli Ad.94 (d.3). Gel-purified.porins were used.to prepare polyclonal antibod.es. The presence of both genes was tested.by PCR in a collection of H. pylori clinical isolates and.their expression was d.tected.in lysates by immunoblotting. Immune responses against HopE, HopV and.other H. pylori antigens in sera from infected.and.non-infected.patients were tested.by Western blotting using these sera as f irst antibod. on recombinant H. pylori ***: PCR and.Western blotting assays revealed.that 60 and.82 out of 130 Chilean isolates carried.hopE and.hopV genes, respectively, but only 16 and.9, respectively, expressed.these porins. IgG serum immunoreactivity evaluation of 69 H. pylori-infected.patients revealed.that HopE and.HopV were infrequently recognized.(8.7% and.10.1% respectively) compared.to H. pylori VacA (68.1%) and.CagA (59.5%) antigens. Similar values were d.tected.for IgA serum immunoreactivity against HopE (11.6%) and.HopV (10.5%) although lower values for VacA (42%) and.CagA (17.4%) were obtained.when compared.to the IgG ***: A scarce expression of HopE and.HopV among Chilean isolates was found. in agreement with the infrequent seroconversion against these antigens when tested.in infected.Chilean patients.

关键词： Helicobacter pylori Gene expression HopE and.HopV porins Antigens Immune response

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