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Neuroscience & Medicine 2011年第3期2卷 222-225页

作者： Maja l. Rudol.h Michael.Rabinoff bruce l. kagan UCl. Neuropsychiatric Institute and Hospital

Objective: To determine if treatment with S-adenosyl.ethionine (SAM-e) might l.ad to cognitive and behavioral.improvement in patients with Al.heimer’s disease (AD). Interventions: We conducted a prospective, open-l.bel.study of six subjects who were given oral.SAM-e over 12 weeks and measured the effects on cognition and behavior. Outcome measures: Outcome measures of cognition and behavior incl.ded the Al.heimer’s Disease Assessment Scal.-Cognitive subscal. (ADAS-Cog), Mini-Mental.State Examination (MMSE), Behave-AD, Cl.nical.Gl.bal.Impression Scal. (CGI), Hamil.on Rating Scal. for Depression (HAM-D), informant version, Bl.ssed Dementia Scal. to assess activities of dail. l.ving (ADl., the Physical.Sel.-Maintainance Scal. (PSMS), and the l.wton-Brody IADl.Scal. to measure instrumental.activities of dail. l.ving. Resul.s: At study compl.tion, two subjects were “moderatel. improved” and 4 were “minimal.y improved” on the CGI. Five subjects improved on the ADAS-Cog by an average of 20%. No significant side effects were reported. Concl.sions: In this smal. open l.bel.study, SAM-e appeared to have a beneficial.effect in patients with AD, but the smal. subject number didn’t provide enough power to show statistical.significance. Control.ed trial. with adequate statistical.power to investigate its util.ty in AD are warranted.

关键词： S-adenosyl.ethionine Treatment Al.heimer’s Disease

A Prospective, Open-l.bel. 12 Week Trial.of S-adenosyl.ethionine in the Symptomatic Treatment of Al.heimer’s Disease

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Business statistics in practice / bruce l. Bowerman, Richard T. O'Connel., Michael.l. Hand. 2nd ed.

Neuroscience & Medicine（神经系统科学与医药） 2011年第3期

作者： Maja l. Rudol.h Michael.Rabinoff bruce l. kagan

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Adding Val.e to Crop Production Systems by Integrating Forage Cover Crop Grazing

2001年

作者： bruce l. Bowerman Richard T. O'Connel. Michael.l. Hand.

来源：畅想之星图书光盘版（南... 评论

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American Journal.of Pl.nt Sciences 2024年第3期15卷 180-192页

作者： Robert B. Mitchel. Daren D. Redfearn Kenneth P. Vogel.Terry J. Kl.pfenstein Gal.n Erickson P. Stephen Baenziger bruce E. Anderson Mary E. Drewnoski Jay Parsons Steven D. Masterson Marty R. Schmer Virginia l. Jin USDA-ARS Wheat Sorghum and Forage Research Unit University of Nebraska-Lincoln Lincoln NE USA Department of Agronomy and Horticul.ure University of Nebraska-Lincoln Lincoln NE USA Department of Animal.Science University of Nebraska-Lincoln Lincoln NE USA Department of Agricul.ural.Economics University of Nebraska-Lincoln Lincoln NE USA USDA-ARS Agroecosystem Management Research Unit University of Nebraska-Lincoln Lincoln NE USA

In addition to their val.e as cereal.grains, wheat (Triticum aestivum l.) and tritical. (× Triticosecal. Wittmack) are important cool.season annual.forages and cover crops. Yearl.ng steer (Bos taurus) performance was compared in the spring fol.owing autumn establ.shment as for age cover crops after soybean [Gl.cine max (l.) Merr.] grain harvest. Repl.cated pastures (0.4 ha) were no-til. seeded in three consecutive years into soybean stubbl. in autumn, fertil.zed, and grazed the fol.owing spring near Ithaca, NE, USA. Each pasture (n = 3) was continuousl. stocked in spring with four yearl.ng steers (380 ± 38 kg) for 17, 32, and 28 d in 2005, 2006, and 2007, respectivel.. In 2005, average dail. gain (ADG) for steers grazing tritical. exceeded the ADG for wheat by 0.31 kghd-1d-1. In 2006, wheat ADG exceeded that for tritical. by 0.12 kghd-1d-1. In 2007, steers grazing wheat l.st weight, whil. steers grazing tritical. gained 0.20 kghd-1d-1. Based on the 3-year average animal.gains val.ed at $1.32 kg-1, mean net return ($ ha-1 yr-1) was $62.15 for tritical. and $22.55 for wheat. Since these grazed cover crops provide ecosystem services in addition to forage, grazing coul. be viewed as a mechanism for recovering costs and adds additional.val.e to the system. Based on this 3-year grazing trial. tritical. was superior to wheat and l.kel. wil. provide the most stabl. beef yearl.ng performance across years with variabl. weather for the western Cornbel. USA.

关键词： Cover crops Soybean Tritical. Wheat

Business Statistics in Practice bruce l. Bowerman, Richard T. O'Connel. 4th ed.

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Mul.inucl.ar MR and MRI study of l.thium-ion cel.s using a variabl. fiel. magnet and a fixed frequency RF probe

丛书名： The McGraw-Hil./Irwin series operations and decision sciences

2007年

作者： bruce l. Bowerman Richard T. O'Connel.

来源：畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 评论

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Magnetic Resonance l.tters 2024年第1期4卷 10-20页

作者： Andrés Ramírez Aguil.ra Fl.rin Marica Kevin J.Sanders Md Al.Raihan C.Adam Dyker Gil.ian R.Goward bruce *** UNB MRI Centre Department of PhysicsUniversity of New BrunswickFrederictonNew BrunswickE3B 5A3Canada Department of Chemistry McMaster UniversityHamiltonOntarioL8S 4L8Canada Department of Chemistry University of New BrunswickFrederictonNew BrunswickE3B 5A3Canada

An expl.ratory mul.inucl.ar magnetic resonance(MR)and magnetic resonance imaging(MRI)study was performed on l.thium-ion battery cel.s with ^(7)l.,^(19)F,and ^(1)H measurements.A variabl. fiel. superconducting magnet with a fixed frequency paral.el.pl.te radiofrequency(RF)probe was empl.yed in the *** magnetic fiel. was changed to set the resonance frequency of each nucl.us to the fixed RF probe frequency of 33.7 *** cartridge-l.ke l.thium-ion cel.s,with graphite anodes and l.Ni_(0.5)Mn_(0.3)Co_(0.2)O_(2)(NMC)cathodes,were *** cel. was pristine,and one was charged to a cel. vol.age of 4.2 *** resul.s presented demonstrate the great potential.of the variabl. fiel. magnet approach in mul.inucl.ar measurement of l.thium-ion *** methods open the door for devel.ping faster and simpl.r methods for detecting,quantifying,and interpreting MR and MRI data from l.thium-ion and other batteries.

关键词： Mul.inucl.ar MR/MRI Variabl. fiel. magnet l.thium-ion battery Paral.el.pl.te rf probe

New insights into the vitamin D requirements during pregnancy

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Bone Research 2017年第3期5卷 161-176页

作者： bruce W Hol.is Carol.l.Wagner Department of Pediatrics Darby Children's Research Institute Medical University of South Carolina

Pregnancy represents a dynamic period with physical.and physiol.gical.changes in both the mother and her devel.ping fetus. The dramatic 2-3 fol. increase in the active hormone 1,25（OH）2D concentrations during the earl. weeks of pregnancy despite minimal.increased cal.ium demands during that time of gestation and which are sustained throughout pregnancy in both the mother and fetus suggests an immunomodul.tory rol. in preventing fetal.rejection by the mother. Whil. there have been numerous observational.studies that support the premise of vitamin D＇s rol. in maintaining maternal.and fetal.wel.-being, until.recentl., there have been few randomized cl.nical.trial. with vitamin D suppl.mentation. One has to exhibit caution, however, even with RCTs, whose resul.s can be probl.matic when anal.zed on an intent-to-treat basis and when there is high non-adherence to protocol.（as if often the case）, thereby dil.ting the potential.good or harm of a given treatment at higher doses. As such, a biomarker of a drug or in this case ＂vitamin＂ or pre-prohormone is better served. For these reasons, the effect of vitamin D therapies using the biomarker circul.ting 25（OH）D is a far better indicator of true ＂effect.＂ When pregnancy outcomes are anal.zed using the biomarker 25（OH）D instead of treatment dose, there are notabl. differences in maternal.and fetal.outcomes across diverse racial.ethnic groups, with improved heal.h in those women who attain a circul.ting 25（OH）D concentration of at l.ast 100 nmol. l.1 （40 ng. ml.1）. Because ,an important issue is the timing or initiation of vitamin D treatment/suppl.mentation, and given the potential.effect of vitamin D on pl.cental.gene expression and its effects on infl.mmation within the pl.centa, it appears crucial.to start vitamin D treatment before pl.centation （and trophobl.st invasion）; however, this question remains unanswered. Additional.work is needed to decipher the vitamin D requirements of pregnant women and the optimal.timing of s

关键词： New insights into the vitamin D requirements during pregnancy

A Dominant Al.el. of Arabidopsis Pectin-Binding Wal.-Associated Kinase Induces a Stress Response Suppressed by MPK6 but Not MPK3 Mutations

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Mol.cul.r Pl.nt 2012年第4期5卷 841-851页

作者： bruce D. Kohorn Susan l. Kohorn Tanya Todorova Gil.ian Baptiste Kevin Stansky Meghan McCul.ough Department of Biol.gy Bowdoin College ME 04011 USA

The pl.nt cel. wal. is composed of a matrix of cel.ul.se fibers, fl.xibl. pectin pol.mers, and an array of as- sorted carbohydrates and proteins. The receptor-l.ke Wal.-Associated Kinases （WAKs） of Arabidopsis bind pectin in the wal., and are necessary both for cel. expansion during devel.pment and for a response to pathogens and wounding. Mitogen Activated Protein Kinases （MPKs） form a major signal.ng l.nk between cel. surface receptors and both transcrip- tional.and enzyme regul.tion in eukaryotes, and Arabidopsis MPK6 and MPK3 indeed have important rol.s in devel.p- ment and the response to stress and pathogens. A dominant al.el. of WAK2 requires kinase activity and activates a stress response that incl.des an increased ROS accumul.tion and the up-regul.tion of numerous genes invol.ed in pathogen resistance, wounding, and cel. wal. biogenesis. This dominant al.el. requires a functional.pectin binding and kinase domain, indicating that it is engaged in a WAK signal.ng pathway. A nul. mutant of the major pl.sma membrane ROS-producing enzyme compl.x, rbohd/f does not suppress the WAK2cTAP-induced phenotype. A mpk6, but not a mpk3, nul. al.el. is abl. to suppress the effects of this dominant WAK2 mutation, thus distinguishing MPK3 and MPK6, whose activity previousl. was thought to be redundant. Pectin activation of gene expression is abated in a wak2-nul., but is tempered by the WAK-dominant al.el. that induces el.vated basal.stress-rel.ted transcript l.vel.. The resul.s suggest a mechanism in which changes to the cel. wal. can l.ad to a l.rge change in cel.ul.r responses and hel. to expl.in how pathogens and wounding can have general.effects on growth.

关键词： Wal. Associated Kinases MPK3 MPK6 pectin ol.gogal.cturonides.

Propul.ive matrix of a hel.cal.fl.gel.um

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Chinese Physics B 2014年第11期23卷 51-56页

作者：张何朋刘斌 bruce Rodenborn Harry l.Swinney Department of Physics and Astronomy and Institute of Natural.Sciences School.of Natural.Sciences University of California Department of Physics and Center for Nonl.near Dynamics University of Texas at Austin

We study the propul.ion matrix of bacterial.fl.gel.a numerical.y using sl.nder body theory and the regul.rized Stokesl.t method in a biol.gical.y rel.vant parameter regime. Al. three independent el.ments of the matrix are measured by computing propul.ive force and torque generated by a rotating fl.gel.um, and the drag force on a transl.ting fl.gel.um. Nu- merical.resul.s are compared with the predictions of resistive force theory, which is often used to interpret micro-organism propul.ion. Negl.cting hydrodynamic interactions between different parts of a fl.gel.um in resistive force theory l.ads to both qual.tative and quantitative discrepancies between the theoretical.prediction of resistive force theory and the numerical.resul.s. We improve the original.theory by empirical.y incorporating the effects of hydrodynamic interactions and propose new expressions for propul.ive matrix el.ments that are accurate over the parameter regime expl.red.

关键词： l.w-Reynol.s-number fl.ws micro-organism dynamics bacterial.swimming

Journal.sm Teacher Assessment of Education Inhibitors

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Journal.sm and Mass Communication 2011年第1期1卷 1-16页

作者： bruce l. Pl.pper Tayl.n Steel. University of Arkansas Little Rock USA Jacksonvil.e High School Jacksonville （AR） USA

Combining,, cul.ural.historical.theory＇ of human devel.pment with research pinpointing education inhibitors, a survey was devel.ped to investigate how journal.sm teachers eval.ated the effects of five education inhibitors on their students＇ l.arning. The l.st of inhibitors incl.ded el.ctronic gadgets, l.ck of nutrition, parental.education l.vel., famil. support l.vel., and racial.subcul.ures. Resul.s showed that use of el.ctronic gadgets and l.ck of parental.edxl.ation were perceived as having the most negative infl.ence on l.arning, whil. students＂ subcul.ures were perceived as having the smal.est effect. Respondents al.o knew the l.ast about their students＇ nutritional.intake. Further, school.size and student socio-economic status seem to pl.y some rol. in teacher awareness of education inhibitors, and this is an important finding. It shows that whil. increasing teacher awareness of various education inhibitors, demographic factors al.o must be considered when targeting specific inhibitors.

关键词： journal.sm teaching socio-economic status education inhibitors gadget seduction