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2008北京国际生理科学学术大会

作者： MiLLeRSHiP Joanne bruce jason i e DeVOR Daniel C FeARON ian M Life Sciences the University of ManchesterManchester M13 9NTUK Department of Cell Biology and Physiology School of MedicineUniversity of PittsburghPittsburghPA 15261USA

Potassium channels regulate proliferation of a number of cell *** the potassium channel family, K3.1(iK1/SK4),is involved in the proliferation of endothelial cells(eC),T lymphocytes and several cancer cell *** respect to endothelial cells,these cells express a wide variety of ion channel types and subtypes,and the patterns of expression differ due to differences in vascular beds from which cells were isolated,passage number and culture *** this reason,it is difficult to dissect,and examine in isolation,the functional role of a specific potassium channel in eC ***,to investigate the mechanisms underlying the role of K3.1 in cell proliferation in isolation,we performed proliferation assays in HeK293 cells expressing recombinant hK3.1 *** cells stably expressing this channel,selective inhibition of hK3.1 with 10μmol/L TRAM-34 reduced proliferation,while transient expression of hK3.1 in WT HeK293 cells increased *** mechanism by which hK3.1 stimulates cell proliferation is thought to be mediated by cell hyperpolarisation(via K efflux),which increases[Ca] by driving Ca influx through non-selective cation ***,when WT HeK293 cells were transiently transfected with a mutant(GYG/AAA)hK3.1 channel,which neither conducts K ions nor promotes Ca entry,proliferation was increased relative to control(mock-transfected)***,when WT HeK293 cells were transiently transfected with a trafficking mutant(L18A/L25A)hK3.1 channel,which is not expressed at the cell surface,proliferation was also increased relative to control ***,both K efflux and Ca influx are not necessary for hK 3.1-induced proliferation in HeK293 cells,and nor does hK 3.1 need to be expressed at the cell *** propose that hK 3.1-induced cell proliferation is independent of electrophysiological function and arises potentially due to direct regulation of intracellular signalling *** support of this hypothesis,in cells

关键词： KCa3.1 endothelial cells proliferation MAP kinase

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Lactate-mediated medium-chain fatty acid production from expired dairy and beverage waste

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environmental Science and ecotechnology 2024年第5期21卷 278-286页

作者： Bin Bian Wenxiang Zhang Najiaowa Yu Wei Yang Jiajie Xu bruce e.Logan Pascal e.Saikaly Water Desalination and Reuse Center(WDRC) King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia environmental Science and engineering Program Biological and Environmental Science and Engineering(BESE)DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia Department of Civil and environmental engineering The Pennsylvania State UniversityUniversity ParkPA16802USA Research Centre of ecology&environment for Coastal Area and Deep Sea Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)Guangzhou511458China School of Marine Science Ningbo UniversityNingbo315211China

Fruits,vegetables,and dairy products are typically the primary sources of household food ***,anaerobic digestion is the most used bioprocess for the treatment of food waste with concomitant generation of ***,to achieve a circular carbon economy,the organics in food waste should be converted to new chemicals with higher value than *** we demonstrate the feasibility of medium-chain carboxylic acid(MCCA)production from expired dairy and beverage waste via a chain elongation platform mediated by *** a two-stage fermentation process,the first stage with optimized operational conditions,including varying temperatures and organic loading rates,transformed expired dairy and beverage waste into lactate at a concentration higher than 900 mM C at 43℃.This lactate was then used to produce>500 mM C caproate and>300 mM C butyrate via microbial chain ***,lactate-producing microbes such as Lactobacillus and Lacticaseibacillus were regulated by temperature and could be highly enriched under mesophilic conditions in the firststage *** the second-stage chain elongation reactor,the dominating microbes were primarily from the genera Megasphaera and Caproiciproducens,shaped by varying feed and inoculum *** network analysis revealed positive correlations among species from the genera Caproiciproducens,Ruminococcus,and CAG-352,as well as Megasphaera,Bacteroides,and Solobacterium,indicating strong microbial interactions that enhance caproate *** findings suggest that producing MCCAs from expired dairy and beverage waste via lactate-mediated chain elongation is a viable method for sustainable waste management and could serve as a chemical production platform in the context of building a circular bioeconomy.

关键词： Microbial chain elongation Medium chain carboxylic acids Food waste Fermentation

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Handwriting Analysis Based on Belief of Targeted individual Supporting insider Threat Detection

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Journal of information Security 2024年第3期15卷 308-319页

作者： jason Slaughter Carole e. Chaski Kellep Charles Center for Cybersecurity Research and Analysis (CCRA) Capitol Technology University Laurel United States

The Unintentional insider Threat (UiT) concept highlights that insider threats might not always stem from malicious intent and can occur across various domains. This research examines how individuals with medical or psychological issues might unintentionally become insider threats due to their perception of being targeted. insights from the survey A Survey of Unintentional Medical insider Threat Category indicate that such perceptions can be linked to underlying health conditions. The study emotion Analysis Based on Belief of Targeted individual Supporting insider Threat Detection reveals that anger is a common emotion among these individuals. The findings suggest that UiTs are often linked to medical or psychological issues, with anger being prevalent. To mitigate these risks, it is recommended that insider Threat programs integrate expertise from medicine, psychology, and cybersecurity. Additionally, handwriting analysis is proposed as a potential tool for detecting insider threats, reflecting the evolving nature of threat assessment methodologies.

关键词： insider Threat Detection Targeted Medical

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The new kid on the block in insect pest management:sprayable RNAi goes commercial

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Science China(Life Sciences) 2024年第8期67卷 1766-1768页

作者： Junjie Yan Ralf Nauen Stuart Reitz Andrei Alyokhin Jiang Zhang David Mota-Sanchez Yonggyun Kim Subba Reddy Palli Silvia i.Rondon Brian A.Nault Juan Luis Jurat-Fuentes Michael S.Crossley William e.Snyder Angharad M.R.Gatehouse Myron P.Zalucki bruce e.Tabashnik Yulin Gao State Key Laboratory for Biology of Plant Disease and insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Bayer AG Crop Science DivisionR&DPest ControlMonheim 40789Germany Department of Crop and Soil Science Oregon State UniversityOntario 97914USA School of Biology and ecology University of MaineOrono 04469USA Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China Department of entomology Michigan State UniversityEast Lansing 48864USA Department of Plant Medicals Andong National UniversityAndong 36729Republic of Korea Department of entomology University of KentuckyLexington 40503USA Oregon State University Oregon Integrated Pest Management CenterCorvallis 97838USA Department of entomology Cornell UniversityCornell AgriTechGeneva 14456USA Department of entomology and Plant Pathology University of TennesseeKnoxville 37996USA Department of entomology and Wildlife ecology University of DelawareNewark 19716USA Department of entomology University of GeorgiaAthensGeorgia 30602USA School of Natural and environmental Sciences Newcastle UniversityNewcastle upon TyneNE17RUUK School of the environment University of QueenslandBrisbane 4072Australia Shandong engineering Research Center for environment-Friendly Agricultural Pest Management College of Plant Health and MedicineQingdao Agricultural UniversityQingdao 266109China Department of entomology University of ArizonaTucson 85721USA National Center of excellence for Tuber and Root Crop Research Chinese Academy of Agricultural SciencesBeijing 100081China

insect pest damage to crops is a threat to global food security(Tilman et al.,2011).Climate change,the evolution of insecticide resistance,and the phasing out of insecticides due to environmental and safety concerns exacerbate this *** urgently need safe and effective crop protection tools to sustainably generate yields that meet ever-increasing global demand.

关键词： crops damage pest

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Blockchain-based refurbishment certification system for enhancing the circular economy

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Blockchain(Research and Applications) 2024年第1期5卷 85-96页

作者： Cristina Regueiro Aitor Gómez-Goiri Nuno Pedrosa Christos Semertzidis eider iturbe jason Mansell TeCNALiA Research&innovation Basque Research and Technology Alliance(BRTA)Parque Científico y Tecnológico de Bizkaia48160Derio BizkaiaSpain Projecto Desenvolvimento Manutenção Formação e Consultadoria Rua Fradesso da Silveira n.41B1300-609LisbonPortugal

As the global population continues to grow,the enormous stress on our environment and resources is becoming impossible to ignore.A focus on producing and consuming as cheaply as possible has created an economy in which objects are briefly used and then discarded as waste,featuring a linear lifecycle that creates an enormous amount of *** alternative to the linear economy“take-make-waste”is called the“circular economy”.Under this paradigm,materials are recycled to build new products or components that are designed and built to promote their reuse and *** assures the continuous(re-)exploitation of existing resources,reducing the extraction of new raw ***,customers often reject these reused or refurbished products under the suspicion that they do not meet the same usability,safety,or performance levels of new *** this sense,trustworthy records of historical details of refurbished products could increase consumers’confidence in products and components of the“circular economy”,prioritizing trustworthiness,reliability,and *** work presents a new certification tool based on blockchain technology to guarantee trusted,accurate,transparent,and traceable lifecycle information of products and their components and to generate trustworthy certificates to probe refurbished product historical *** tool aims to enhance refurbished product visibility by creating the basis for making the circular economy a reality in any domain.

关键词： Blockchain Traceability Lifecycle Product lifecycle management(PLM) Refurbishment Certification Circular economy

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Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

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Light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman jason Lynch Christopher e.Stevens Christopher Munley Chentao Li Jin Hou Hao Zhang Andrew Torma Thomas Darlington Francis Coen Kevin Li Arka Majumdar PJames Schuck Aditya Mohite Hayk Harutyunyan Joshua R.Hendrickson Deep Jariwala Department of electrical and Systems engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR inc. BeavercreekOH45431USA Air Force Research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical engineering Columbia UniversityNew YorkNY10027USA Department of electrical and Computer engineering University of WashingtonSeattleWA98195USA

excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOiPs)are capable of forming hybrid light-matter states known as exciton-polaritons(e–Ps)when the excitonic medium is confined in an optical *** the case of 2D HOiPs,they can self-hybridize into e–Ps at specific thicknesses of the HOiP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized e–Ps in 2D HOiPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOiP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized e–P *** e–Ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy e–Ps to lower energy e–***,we also demonstrate that e–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in e–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

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Complex ammonium oxidation demands visualized resolution

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Science Bulletin 2024年第16期69卷 2478-2482页

作者： Zhihao Chen Yonghong Wu Jan Dolfing Shunyao Zhuang Baozhan Wang Dan Li Shan Huang bruce e.Rittmann State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Zigui Three Gorges Reservoir ecosystem Observation and Research Station of Ministry of Water Resources of the People’s Republic of ChinaYichang 443605China University of Chinese Academy of Sciences Beijing 100049China d College of Nanjing University of Chinese Academy of SciencesNanjing 211135China Faculty of energy and environment Northumbria UniversityNewcastle-upon-Tyne NE18QHUK Department of Microbiology College of Life SciencesNanjing Agricultural UniversityKey Laboratory of Agricultural and Environmental MicrobiologyMinistry of Agriculture and Rural AffairsNanjing 210095China College of Urban Construction Nanjing Tech UniversityNanjing 211816China Department of Civil and environmental engineering Princeton UniversityPrinceton NJ 08540USA Biodesign Swette Center for environmental Biotechnology Arizona State UniversityTempe AZ 85287-5701USA

The nitrogen cycle plays a vital role in sustaining productive and healthy ecosystems,with the microbial nitrogen cycle being a focal point in agriculture and eco-environmental *** these microbially mediated processes is ammonium(NH_(4)^(+))oxidation,the gatekeeper of the nitrogen *** understanding of ammonium oxidation is continuously evolving,thanks to recent research breakthroughs like comammox,Feammox,and dirammox[1-6].The increasing complexity of ammonium oxidation necessitates more precise and well-focused research tools beyond those commonly used today.

关键词： ammonium breakthrough precise

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Systematic Radio Telescope Alignment Using Portable Fringe Projection Profilometry

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Nanomanufacturing and Metrology 2024年第1期7卷 75-85页

作者： Joel Berkson Justin Hyatt Nathan Julicher Byeongjoon Jeong isaac Pimienta Rachel Ball Wyatt ellis jason Voris Diego Torres‑Barajas Daewook Kim James C.Wyant College of Optical Sciences University of Arizona1630 E.University Blvd.TucsonAZ 85721USA Department of Astronomy at Steward Observatory University of Arizona933 N Cherry Ave.TucsonAZ 85721USA

in 2019,the event Horizon Telescope(eHT)released the first-ever image of a black hole event *** are now aiming for higher angular resolutions of distant targets,like black holes,to understand more about the fundamental laws of gravity that govern our *** achieve this higher resolution and increased sensitivity,larger radio telescopes are needed to operate at higher frequencies and in larger *** like the next-generation Very Large Array(ngVLA)and the Square-Kilometer Array(SKA)require building hundreds of telescopes with diameters greater than 10 ms over the next *** has a twofold *** telescope surfaces need to be more accurate to operate at higher frequencies,and the logistics involved in maintaining a radio telescope need to be simplified to support them properly in large *** of these problems can be solved with improved methods for surface metrology that are faster and more accurate with a higher *** leads to faster and more accurate panel alignment and,therefore,a more productive *** this paper,we present the use of binocular fringe projection profilometry as a solution to this problem and demonstrate it by aligning two panels on a 3-m radio telescope *** measurement takes only 10 min and directly delivers feedback on the tip,tilt,and piston of each panel to create the ideal reflector shape.

关键词： Metrology Fringe projection profilometry Off-axis alignment Radio astronomy Radio antenna

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Degradation and resynthesis of chlorophyll during increased oxidative stress and prolonged darkness differ between annual and perennial flax(Linum L.)

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Oil Crop Science 2024年第2期9卷 121-130页

作者： Kenyon J. Nisbett Abida Alokozai Su Hyun elizabeth Ko G. Adam Mott jason C.L. Browna Department of Biological Sciences University of Toronto ScarboroughTorontoONCanada Department of Cell&Systems Biology University of TorontoTorontoONCanada Centre for the Analysis of Genome evolution&Function University of TorontoTorontoONCanada

Among plants,there is considerable variation in lifespan:annuals live less than one year,whereas perennials live for several years,with the longest-living perennial having survived 43,600 *** proposed by the Disposable Soma Theory,this lifespan variation among plants likely reflects differential investment of limited energy and nutrient resources,with perennials investing more energy and nutrients into biomolecular maintenance compared to annuals in order to ensure persistence over multiple *** differential investment may be particularly important during periods of exogenous stress,which are known to accelerate biomolecular *** present study evaluated this hypothesis using annual and perennial flax(Linum L.)subjected to two exogenous stressors—increased oxidative stress(i.e.,foliar H2O2spraying)and complete prolonged *** chlorophyll has been shown to exhibit degradation in response to changes in environmental conditions,we utilized changes in chlorophyll levels during and after periods of exogenous stress to evaluate our *** predicted that i)perennials would exhibit a slower rate of chlorophyll degradation during exposure to exogenous stressors compared to annuals,and ii)perennials would exhibit a faster rate of chlorophyll resynthesis following such exposure compared to *** levels before,during,and after exposure to both exogenous stressors were measured in two separate trails,once using image colour analysis and once using *** chlorophyll degradation rates in response to oxidative stress did not differ between annuals and perennials,contrary to our predictions,chlorophyll resynthesis rates following such exposure were significantly higher in perennials,as *** plants were subjected to complete prolonged darkness,chlorophyll degradation rates were significantly lower in perennials than annuals,as predicted;however,when plants were subsequently reintroduced to natural photoperiod,ch

关键词： Ageing Life history Maximum lifespan Oxidative stress Somatic maintenance

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Machine Learning Analysis of impact of Western US Fires on Central US Hailstorms

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Advances in Atmospheric Sciences 2024年第7期41卷 1450-1462页

作者： Xinming LiN Jiwen FAN Yuwei ZHANG Zjason HOU Pacific Northwest National Laboratory RichlandWA 99354USA Argonne National Laboratory LemontIL 60439USA

Fires,including wildfires,harm air quality and essential public services like transportation,communication,and *** fires can also influence atmospheric conditions,including temperature and aerosols,potentially affecting severe convective ***,we investigate the remote impacts of fires in the western United States(WUS)on the occurrence of large hail(size:≥2.54 cm)in the central US(CUS)over the 20-year period of 2001–20 using the machine learning(ML),Random Forest(RF),and extreme Gradient Boosting(XGB)*** developed RF and XGB models demonstrate high accuracy(>90%)and F1 scores of up to 0.78 in predicting large hail occurrences when WUS fires and CUS hailstorms coincide,particularly in four states(Wyoming,South Dakota,Nebraska,and Kansas).The key contributing variables identified from both ML models include the meteorological variables in the fire region(temperature and moisture),the westerly wind over the plume transport path,and the fire features(i.e.,the maximum fire power and burned area).The results confirm a linkage between WUS fires and severe weather in the CUS,corroborating the findings of our previous modeling study conducted on case simulations with a detailed physics model.

关键词： wildfire severe convective storm hailstorm machine learning

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