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Anticancer effect of Psidium guajava(Guava) leaf extracts against colorectal cancer through inhibition of angiogenesis

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Asian Pacific Journal of Tropical Biomedicine 2020年第7期10卷 293-307页

作者： bronwyn lok Doblin Sandai Hussein M.Baharetha Mansoureh Nazari V Muhammad Asif Chu Shan Tan AMS Abdul Majid EMAN Laboratory Discipline of PharmacologySchool of Pharmaceutical SciencesUniversiti Sains MalaysiaPenangMalaysia Infectomics Cluster Advance Medical and Dental InstituteUniversiti Sains MalaysiaPenangMalaysia Department of Pharmacy College of Medicine and Health SciencesHadhramout UniversityHadhramoutYemen Department of Pharmacology Faculty of Pharmaceutical SciencesGovernment College University FaisalabadFaisalabadPakistan Discipline of Pharmacology School of Pharmaceutical SciencesUniversiti Sains MalaysiaPenangMalaysia ACRF Department of Cancer Biology and Therapeutics John Curtin School of Medical ResearchAustralian National UniversityCanberraAustralia

Objective:To evaluate the anti-angiogenic and anticancer activities of Psidium guajava leaf extracts against angiogenesis-dependent colorectal ***:Three extracts were produced using distilled water,ethanol,and n-hexane as *** extracts were physically characterised through gas chromatography–mass spectrometry,ultraviolet–visible spectroscopy,and Fourier transform infrared *** antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl,total phenolic content,and total flavonoid content *** assess their anti-angiogenic activity,cell viability and rat aortic ring assays were conducted,while cell migration,tube formation,colony formation,and VEGF ELISA assays were conducted to elucidate their effects on different aspects of *** docking was used to assess the antiangiogenic potential of some possible compounds in the *** spheroid assay was used to assess the extracts’potential as a treatment for colorectal ***:The ethanol extract showed the best antioxidant *** distilled water and ethanol extracts exhibited more inhibitory activity against ***926 cell viability and aortic ring microvessel *** addition,the ethanol extract performed significantly better than the distilled water extract against cell migration and colony formation,and VEGF expression of the cells was suppressed by the ethanol *** the distilled water and ethanol extracts showed significant inhibitory effect on ***926 tube formation and tumour spheroids consisting of ***926 and HCT116 *** ethanol extract containedβ-caryophyllene andβ-elemene by phytochemical analysis and subsequent docking studies,which may contribute to its anti-angiogenic ***:The ethanol extract of Psidium guajava has potential in the treatment of colorectal cancer through the inhibition of angiogenesis.

关键词： Angiogenesis Antioxidant Colorectal cancer Psidium guajava VEGF

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Adenosine triphosphate induced cell death: Mechanisms and implications in cancer biology and therapy

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World Journal of Clinical Oncology 2023年第12期14卷 549-569页

作者： Hao-Ling Zhang Doblin Sandai Zhong-Wen Zhang Zhi-Jing Song Dinesh Babu Yasser Tabana Sabbar Saad Dahham Mowaffaq Adam Ahmed Adam Yong Wang Wei Wang Hao-Long Zhang Rui Zhao Khaled Barakat Mohammad Syamsul Reza Harun Siti Nurfatimah Mohd Shapudin bronwyn lok Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia School of Public Health Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Clinical College of Chinese Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Faculty of Pharmacy and Pharmaceutical Sciences University of AlbertaEdmonton AB T6G 2E1Canada Department of Science University of Technology and Applied Sciences RustaqRustaq 10 P.C.329Oman Department of Chemistry and Biochemistry San Diego State UniversitySan DiegoCA 92182United States Pathology Center Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina College of Acupuncture-Moxibustion and Tuina Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina

Adenosine triphosphate(ATP)induced cell death(AICD)is a critical cellular process that has garnered substantial scientific interest for its profound relevance to cancer biology and to therapeutic *** comprehensive review unveils the intricate web of AICD mechanisms and their intricate connections with cancer *** review offers a comprehensive framework for comprehending the multifaceted role of AICD in the context of *** is achieved by elucidating the dynamic interplay between systemic and cellular ATP homeostasis,deciphering the intricate mechanisms governing AICD,elucidating its intricate involvement in cancer signaling pathways,and scrutinizing validated key ***,the exploration of AICD as a potential avenue for cancer treatment underscores its essential role in shaping the future landscape of cancer therapeutics.

关键词： Adenosine triphosphate induced cell death Adenosine triphosphate homeostasis Mechanism Cancer signaling pathways Prognosis and clinical values Cancer treatment

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