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世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 21-22页

作者： brocard a. Ba.ba.ot S. Milpied B. Sta.der J.-F. 周少娜 Clinique Derma.ologique CHU Htel-Dieu1place Alexis Ricordeau 44093 Nantes

Introduction. Tha.idomide is the second line trea.ment of chronic lupus erythema.osus. The effica.y of this trea.ment, the minima. effective doses a.d tolera.ce a.e poorly documented in the litera.ure. Pa.ients a.d methods. We present the da.a.of a.single-center retrospective studied a.ong 18 pa.ients with chronic lupus erythema.osus, trea.ed with tha.idomide from 1998 to 2003. Inclusion criteria.were: the presence of clinica. lesions evoking the disea.e, confirmed by histologica. exa.ina.ion a.d direct immunofluorescence a.d trea.mentwith tha.idomide for more tha. 2 months. Results. Mea. a.e on dia.nosis wa. of 35.8 yea.s. Tha.idomide ha. been initia.ed a.mea. of 10.6 yea.s a.ter dia.nosis of chronic lupus erythema.osus. In 13 out of 18 pa.ients, tha.idomide ha. been prescribed beca.se of fa.lure with prior trea.ments. Fifteen pa.ients were improved by tha.idomide (83.3 p. 100), with 11 (61 p. 100)- complete a.d 4 (22 p. 100) pa.tia. remissions. Two (11 p. 100) pa.ients were sta.ilized a.d trea.ment fa.led in one. The mea. initia. dose wa. of 100 mg/d (50- 150), a.d ma.ntena.ce dose wa. of a.ound 50 mg/d (56 mg/d). The mea. follow-up with tha.idomide wa. of 19.4 months. Only one withdra.a. due to side effects wa. reported. The most frequent side effects were: a.thenia.(33 p. 100), pa.esthesia.(22 p. 100) a.d weight ga.n (16.6 p. 100). No side effects were reported in 10 out of 18 pa.ients. Discussion. This study confirms the effica.y of low dose tha.idomide in the trea.ment of chronic lupus erythema.osus. In our experience, tolera.ce to this trea.ment is good, the most frequent side effect wa. a.thenia. but usua.ly mild. No significa.t periphera. neuropa.hy wa. noted. The fea. of side effects, nota.ly neurologica., should not dela. initia.ion of tha.idomide in the ca.e of fa.lure with current trea.ments.

关键词：慢性盘状红斑狼疮沙利度胺前治疗红斑狼疮患者直接免疫荧光检查完全缓解组织学检查二线药物纳入标准耐受量

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The SlSHN2 tra.scription fa.tor contributes to cuticle forma.ion a.d epiderma. pa.terning in toma.o fruit

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Molecula. Horticulture 2022年第1期2卷 186-205页

作者： Cecile Bres Joha.n Petit Nicola. Reynoud Lysia.e brocard Didier Ma.ion Ma.c La.a.e Benedicte Ba.a. Christophe Rotha. UMR 1332 BFP INRAEUniversite de Bordeaux33140 Villenave d’OrnonFrance Unite Biopolymeres InteractionsAssemblagesINRAEBP7162744316 Nantes Cedex 3France Univ.Bordea.x CNRSINSERMBordeaux Imaging CenterBICUMS 3420US 433000 BordeauxFrance INRA UMR1332 Biologie du Fruit Et Pathologie71 Av Edouard Bourlaux33140 Villenave d’OrnonFrance

Toma.o(Sola.um lycopersicum)is a. esta.lished model for studying pla.t cuticle beca.se of its thick cuticle covering a.d embedding the epiderma. cells of the *** this study,we screened a. EMS muta.t collection of the minia.ure toma.o cultiva. Micro-Tom for fruit cra.king muta.ts a.d found a.muta.t displa.ing a.glossy fruit *** using a. esta.lished ma.ping-by-sequencing stra.egy,we identified the ca.sa. muta.ion in the SlSHN2 tra.scription fa.tor tha. is specifica.ly expressed in outer epidermis of growing *** point muta.ion in the shn2 muta.t intro-duces a.K to N a.ino a.id cha.ge in the highly conserved‘mm’doma.n of SHN *** cuticle from shn2 fruit showed a.fivefold reduction in cutin while a.unda.ce a.d composition of wa.es were ba.ely *** a.dition to a.tera.ions in cuticle thickness a.d properties,epiderma. pa.terning a.d polysa.cha.ide composition of the cuticle were *** a.a.ysis further highlighted the a.tered expression of hundreds of genes in the fruit exoca.p of shn2,including genes a.socia.ed with cuticle a.d cell wa.l forma.ion,hormone signa.ing a.d response,a.d tra.scrip-tiona. *** conclusion,we showed tha. a.point muta.ion in the tra.scriptiona. regula.or SlSHN2 ca.ses ma.or cha.ges in fruit cuticle forma.ion a.d its coordina.ion with epiderma. pa.terning.

关键词： Muta.t SHINE Cuticle Epidermis Cell wa.l Ethylene

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一项关于妊娠期血红蛋白浓度与围生儿死亡率的伦敦队列研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第11期1卷 12-12页

作者： Little M.P. brocard P. Elliott P. Steer P.J. 朱晓明 Depa.tment of Epidemiology a.d Public Hea.th Imperial College Faculty of Medicine St. Mary' s Campus Norfolk Place London W2 1PG United Kingdom Dr.

Objective: Fa.lure of feta. growth during pregna.cy, a.d preterm birth, a.e the ma.or ca.ses of stillbirth a.d ea.ly neona.a. dea.h. The objective of the study wa. to determine the a.socia.ion between ma.erna. hemoglobin concentra.ion during pregna.cy a.d perina.a. morta.ity. Study design: The design wa. prospective, using da.a.on 222,614 first singleton pregna.cies in the St Ma.y’ s Ma.ernity Informa.ion System da.a.a.e in the Northwest Tha.es region of London. Results: The a.socia.ion of perina.a. morta.ity with ma.erna. hemoglobin a. first a.tena.a. check wa. not sta.istica.ly significa.t (P >.10), but a.sta.istica.ly significa.t (P a.ed pa.tern wa. found with lowest recorded ma.erna. hemoglobin concentra.ion. Both ea.ly neona.a. morta.ity a.d stillbirth ra.es were sta.istica.ly significa.tly (P a.socia.ed with lowest ma.erna. hemoglobin concentra.ion. The rela.ionship of lowest hemoglobin with ea.ly neona.a. morta.ity wa. la.gely media.ed by the effect of preterm birth, a.d tha. between lowest hemoglobin a.d stillbirth by feta. growth restriction. The lowest perina.a. morta.ity wa. a.socia.ed with a.lowest recorded ma.erna. hemoglobin concentra.ion of between 9-11 g/dL. Conclusion: There is a. optima. ra.ge of lowest hemoglobin concentra.ion in pregna.cy, a.d on either side of this perina.a. morta.ity is increa.ed. The effect of lowest hemoglobin is la.gely media.ed through a.socia.ions with preterm birth a.d feta. growth restriction.

关键词：围生儿死亡率血红蛋白浓度队列研究单胎妊娠早期新生儿新生儿死亡率最低死亡率信息系统数据库曲线模型早期死亡率

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