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女性求职100问(二)

人才开发 1996年第7期 42-43页

作者： brigitte 魏丽萍德

●如何才能达到较好的咨询效果? 任何人作任何选择时,都想征求一下别人的看法,如果你是位女学生,想要报考一个合适的学校和专业,为了在决定之前能达到良好的咨询效果,则需要你做两件事: 第一,寻找一个声誉较好的咨询师和咨询机构。第二... 详细信息

●如何才能达到较好的咨询效果? 任何人作任何选择时,都想征求一下别人的看法,如果你是位女学生,想要报考一个合适的学校和专业,为了在决定之前能达到良好的咨询效果,则需要你做两件事: 第一,寻找一个声誉较好的咨询师和咨询机构。第二,作好咨询前的自我准备。无论你面对的是怎样的咨询师,你总能得到不同程度的帮助;但是,这种帮助是建立在对客体,也就是对你自己的了解基础上实施的。因此,你提供的情况越全面,越真实,咨询就越有个体的针对性,就对你越有帮助,因此,作好自我准备是收到良好咨询效果的关键。

关键词：职业培训企业企业管理咨询效果终止合同女性大学毕业生

Pulsatile gonadotropin-releasing hormone therapy is associated with earlier spermatogenesis compared to combined gonadotropin therapy in patients with congenital hypogonadotropic hypogonadism

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Asian Journal of Andrology 2017年第6期19卷 680-685页

作者： Jiang-Feng Mao Zhao-Xiang Liu Min Nie Xi Wang Hong-Li Xu Bing-Kun Huang Jun-Jie Zheng Le Min Ursula brigitte Kaiser Xue-Yan Wu Department of Endocrinology Peking Union Medical College Hospital Key Laboratory of Endocrinology Ministry of Health Beijing 100730 China Internal Department Division of Endocrinology Diabetes and Hypertension Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA.

Both pulsatile gonadotropin-releasing hormone （GnRH） infusion and combined gonadotropin therapy （human chorionic gonadotropin and human menopausal gonadotropin [HCG/HMG]） are effective to induce spermatogenesis in male patients with congenital hypogonadotropic hypogonadism （CH H）. However, evidence is lacking as to which treatment strategy is better. This retrospective cohort study included 202 patients with CHH： twenty had received pulsatile GnRH and 182 had received HCG/HMG. Patients had received therapy for at least 12 months. The total follow-up time was 15.6 ± 5.0 months （range： 12-27 months） for the GnRH group and 28.7 ± 13.0 months （range： 12-66 months） for the HCG/HMG group. The median time to first sperm appearance was 6 months （95% confidence interval [CI]： 1.6-10.4） in the GnRH group versus 18 months （95% Ch 16.4-20.0） in the HCG/HMG group （P〈 0.001）. The median time to achieve sperm concentrations 〉5 x 106 m1-1 was 14 months （95% Ch 5.8-22.2） in the GnRH group versus 27 months （95% Ch 18.9-35.1） in the HCG/HMG group （P 〈 0.001）, and the median time to concentrations 〉10 x 106 m1-1 was 18 months （95% Ch 10.0-26.0） in the GnRH group versus 39 months （95% CI unknown） in the HCG/HMG group. Compared to the GnRH group, the HCG/HMG group required longer treatment periods to achieve testicular sizes of 〉4 ml, 〉8 ml, 〉12 ml, and 〉16 ml. Sperm motility （a ＋ b ＋ c percentage） evaluated in semen samples with concentrations 〉1 × 106 ml-1 was 43.7% ± 20.4% （16 samples） in the GnRH group versus 43.2% ± 18.1% （153 samples） in the HCG/HMG group （P= 0.921）. Notably, during follow-up, the GnRH group had lower serum testosterone levels than the HCG/HMG group （8.3 ±4.6 vs 16.2 ± 8.2 nmol 1-1, P 〈 0.001）. Our study found that pulsatile GnRH therapy was associated with earlier spermatogenesis and larger testicular size compared to combined gonadotropin therapy. Additional prospective randomized studies would be required to confirm these findings.

关键词： combined gonadotropin therapy congenital hypogonadotropic hypogonadism pulsatile GnRH therapy spermatogenesis

A novel post-transcriptional splicing form of the acute T cell leukemia proto-oncogene Lmo2

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Science China(Life Sciences) 2001年第6期44卷 561-569页

作者：朱天慧秦刚 brigitte Roye r-Pokora

Lmo2 is a T cell leukemia-related proto-oncogene, which belongs to the LIM protein family. Previous work has established its key role in yolk sac erythropoiesis and adult hematopoiesis, and it is also necessary for regulating angiogenesis. It has been demonstrated that this gene encodes a protein of 158 amino acids, consisting of two tandem cysteine-rich LIM domains, but the detailed mechanism of its transcriptional regulation remains to be elucidated. To further investigate the mechanism of transcriptional regulation of Lmo2, we combined SMART PCR technology with 5′RACE and found a novel post-transcriptional splicing form of Lmo2 in adult human kidney. This alternative transcript contains only two exons, encoding a smaller protein of 151 amino acids. Interestingly, it shares the same reading frame as the original Lmo2, but differs in 7 amino acids at the N-terminus. A genomic DNA fragment (from ?294 nts to +180 nts) containing the putative promoter region has been inserted into the luciferase reporter gene vector pGL3-basic and showed stable promoter activity when transfected into COS7. RT-PCR analysis revealed that this variant transcript was expressed widely in human tissues and cell lines, suggesting its potential basic functional importance.

关键词： Lmo2 transcript splicing form promoter activity RT-PCR.

Mitigating the Impact of Climate Change by Reducing Evaporation Losses: Sediment Removal from the High Aswan Dam Reservoir

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American Journal of Climate Change 2017年第2期6卷 230-246页

作者： Emad Elba brigitte Urban Bernd Ettmer Dalia Farghaly Faculty of Sustainability Sciences Institute of Ecology Landscape Change Division LEUPHANA University of Lüneburg Lüneburg Germany Department of Water and Waste Management: University of Applied Sciences Magdeburg-Stendal Magdeburg Germany

Scientists in Egypt are particularly interested in the sustainable management of water and land resources. Global climate change will have a dramatic impact on the Egyptian water and land resources as well as its coastline and agriculture. Egypt is likely to become one of the most vulnerable countries in the world in the next several decades. Many climate scenarios predict that climate change will severely affect rainfall in the Nile basin and the flow of the Nile River in general and the High Aswan Dam Reservoir (HADR) in particular. Global warming and the higher temperatures will lead to higher evaporation rates, which, in turn, will result in less water availability at the HADR. Egypt’s Ministry of Water Resources and Irrigation predicts that the evaporation losses will, compared to the mean annual evaporation rates for the last 30 years, be approximately 3% to 10% higher by the year 2100. Since the construction of the High Aswan Dam fifty years ago, high sediment loads are a tremendous problem. 6.6 Billion Cubic Meter (km3) of sediments were deposited in the HADR during this period. The sediment has raised the lakebed level as well as the water level and caused a larger surface area. These developments have decreased the storage capacity of HADR and have increased the evaporation rate. The presented paper investigates the impact of lowering the lakebed by removing sediments from the HADR with a distinct emphasis on evaporation losses. A digital elevation model for the HADR was developed to describe the hydrological characteristics and to assess the consequences of removing sediment deposits. The results show that the removal of sediments will reduce evaporation losses by about 1.1 km3 projected for 2100, which represents 6.5% of the total projected evaporation losses.

关键词： Bathymetric Survey Climate Change DEM Evaporation Losses GIS Sediments

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细粒棘球绦虫抗原5决定簇基因的分子克隆

地方病译丛 1992年第5期13卷 38-41页

作者： F.brigitte 牛新玲

包虫病或单房棘球蚴病是由细粒棘球绦虫幼虫期引起,该病广泛分布于世界各地并造成严重的经济和公共健康问题。细粒棘球绦虫相继在终未宿主(狗)和中间宿主(羊、人)中发育,这在兽医学和医学方面具有双重意义。如果动物诊断试验仍然颇受限制,

关键词：棘球蚴病抗原基因克隆

Design,synthesis,and biological evaluation of multiple targeting antimalarials

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2900-2913页

作者： Yiqing Yang Tongke Tang Xiaolu Li Thomas Michel Liqin Ling Zhenghui Huang Maruthi Mulaka Yue Wu Hongying Gao Liguo Wang Jing Zhou brigitte Meunier Hangjun Ke Lubin Jiang Yu Rao MOE Key Laboratory of Protein Sciences School of Pharmaceutical SciencesMOE Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical BiologyTsinghua UniversityBeijing 100084China Unit of Human Parasite Molecular and Cell Biology Key Laboratory of Molecular Virology and ImmunologyInstitut Pasteur of ShanghaiUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Biochemistry and Molecular Biology State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100005China Institute for Integrative Biology of the Cell(I2BC) CEACNRSUniversite´Paris-SaclayGif-sur-Yvette 91198France Center for Molecular Parasitology Department of Microbiology and ImmunologyDrexel University College of MedicinePhiladelphiaPA 19129USA Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041China The Nanjing Unicorn Academy of Innovation Institut Pasteur of ShanghaiChinese Academy of SciencesNanjing 211135China

Malaria still threatens global health seriously *** the current discoveries of antimalarials are almost totally focused on single mode-of-action inhibitors,multi-targeting inhibitors are highly desired to overcome the increasingly serious drug ***,we performed a structure-based drug design on mitochondrial respiratory chain of Plasmodium falciparum and identified an extremely potent molecule,RYL-581,which binds to multiple protein binding sites of *** simultaneously(allosteric site of type Ⅱ NADH dehydrogenase,Q_(o) and Q_(i) sites of cytochrome bc_(1)).Antimalarials with such multiple targeting mechanism of action have never been reported ***-581 kills various drug-resistant strains in vitro and shows good solubility as well as in vivo *** structurebased strategy for designing RYL-581 from starting compound may be helpful for other medicinal chemistry projects in the future,especially for drug discovery on membrane-associated targets.

关键词： Drug design Multiple targeting compounds Antimalarial inhibitors Mechanism of action Membrane proteins

Determination of Coke,Pitch and Pores/Cracks in Green Anode by Image Analysis

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Journal of Surface Engineered Materials and Advanced Technology 2013年第3期3卷 1-6页

作者： Dipankar Bhattacharyay Duygu Kocaefe Yasar Kocaefe brigitte Morais University Research Center on Aluminum(CURAL) University of Quebec at ChicoutimiChicoutimiCanada Aluminerie Alouette Inc. Sept-IlesCanada

Carbon anodes are an essential part of the primary aluminum production. They are made of coal tar pitch, calcined petroleum coke, recycled anodes and butts. As pitch acts as a binder for the anode, its proper distribution in a green anode has a great impact on the properties of the baked anode. Information on cracks in anodes is important for the quality of the baked anode. There is presently no reliable method available to analyze and quantify the amount of coke, pitch and pores/cracks in a green anode sample. In this article, an image analysis technique has been described, that can analyze as well as quantify the area percentage of pores/cracks and weight percentages of pitch and coke. The novelty of the method is its capacity to differentiate the different components of anode.

关键词： Image Analysis Carbon Anode Coke Pitch Pore Crack

Species-specific,pan-European diameter increment models based on data of 2.3 million trees

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Forest Ecosystems 2018年第3期5卷 277-295页

作者： Mart-Jan Schelhaas Geerten M Hengeveld Nanny Heidema Esther Thurig brigitte Rohner Giorgio Vacchiano Jordi Vayreda John Redmond Jaroslaw Socha Jonas Fridman Stein Tomter Heino Polley Susana Barreiro Gert-Jan Nabuurs Wageningen University and Research Wageningen Environmental Research(WENR)Droevendaalsesteeg 36708PB WageningenThe Netherlands Wageningen University and Research BiometrisDroevendaalsesteeg 16708PB WageningenThe Netherlands Wageningen University and Research Forest and Nature Conservation Policy GroupDroevendaalsesteeg 36708PB WageningenThe Netherlands Swiss Federal Institute for Forest Snow and Landscape Research WSLResource AnalysisZuercherstrasse 111CH-8903 BirmensdorfSwitzerland European Commission Joint Research CentreDirectorate DSustainable Resources-Bio-Economy UnitIspraItaly CREAF 08193 Cerdanyola del VallesSpain Univ Autonoma Barcelona 08193 Cerdanyola del VallesSpain Forest Service Department of AgricultureFood and the MarineJohnstown Castle EstateCo.WexfordIreland Department of Biometry and Forest Productivity Institute of Forest Resources ManagementFaculty of ForestryUniversity of Agriculture in KrakowAI.29Listopada 4631-425CracowPoland Swedish University of Agricultural Sciences (SLU) 90183 UmeaSweden Norwegian Institute of Bioeconomy Research P.O.Box 115N-143 1AsNorway Thunen Institute Institute of Forest EcosystemsAlfred-Mo1ler-Strabe 1Haus41/4216225 EberswaldeGermany Forest Research Centre (CEF) Instituto Superior de AgronomiaUniversidade de LisboaTapada da Ajuda1349-017Lisbon.Portugal Wageningen University and Research Forest Ecology and Forest Management GroupDroevendaalsesteeg 36708PBWageningenThe Netherlands

Background: Over the last decades, many forest simulators have been developed for the forests of individual European countries. The underlying growth models are usually based on national datasets of varying size, obtained from National Forest Inventories or from long-term research plots. Many of these models include country-and location-specific predictors, such as site quality indices that may aggregate climate, soil properties and topography effects. Consequently, it is not sensible to compare such models among countries, and it is often impossible to apply models outside the region or country they were developed for. However, there is a clear need for more generically applicable but still locally accurate and climate sensitive simulators at the European scale, which requires the development of models that are applicable across the European continent. The purpose of this study is to develop tree diameter increment models that are applicable at the European scale, but still locally accurate. We compiled and used a dataset of diameter increment observations of over 2.3 million trees from 10 National Forest Inventories in Europe and a set of 99 potential explanatory variables covering forest structure, weather, climate, soil and nutrient ***: Diameter increment models are presented for 20 species/species groups. Selection of explanatory variables was done using a combination of forward and backward selection methods. The explained variance ranged from10% to 53% depending on the species. Variables related to forest structure(basal area of the stand and relative size of the tree) contributed most to the explained variance, but environmental variables were important to account for spatial patterns. The type of environmental variables included differed greatly among ***: The presented diameter increment models are the first of their kind that are applicable at the European scale. This is an important step towards the development of a new ge

关键词： European forests Diameter increment model Climate change Growth modelling National forest inventory

Obesity leads to higher risk of sperm DNA damage in infertile patients

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Asian Journal of Andrology 2013年第5期15卷 622-625页

作者： Charlotte Dupont Celine Fauret Nathalie Sermondade Marouane Boubaya Florence Eustache Patrice Clement Pascal Briot Isabelle Berthaut Vincent Levy Isabelle Cedrin-Durnerin brigitte Benzacken Pascale Chavatte-Palmer Rachel Levy AP-H P Jean Verdier hospital Reproductive Biology unit-CECOS F-93140 Bondy France paris 13 University Sorbonne Paris Cite Nutritional epidemiology unit (UREN U M R U557 Inserm Ul125 Inra Cnam CRNH IdF) F-93017 Bobigny France INRA UMR1198 Biologie du Developpement et Reproduction (Biology of Reproductive and development unit) F-78352 Jouy en Josas France ENVA veterinary school F-94704 Maisons-Alfort France AP-HP Avicenne hospital Clinical research unit F-93000 Bobigny France Clement laboratory Laboratoire Clement F-93150 Le Blanc Mesnil France American hospital of Paris Reproductive Biology unit F-92200 Neuilly sur seine France AP-HP Tenon hospital Reproductive Biology unit-CECOS F-75020 Paris France AP-HP Jean Verdier hospital Reproductive medicine unit Paris 13 University F-93140 Bondv. France

There has been a growing interest over the past few years in the impact of male nutrition on fertility. Infertility has been linked to male overweight or obesity, and conventional semen parameter values seem to be altered in case of high body mass index （BMI）. A few studies assessing the impact of BMI on sperm DNA integrity have been published, but they did not lead to a strong consensus. Our objective was to explore further the relationship between sperm DNA integrity and BMI, through a 3-year multicentre study. Three hundred and thirty male partners in subfertile couples were included. Using the terminal uridine nick-end labelling （TUNEL） assay, we observed an increased rate of sDerm DNA damage in obese men （odds ratio （95% confidence interval）： 2.5 （1.2-5.1））.

关键词： male infertility obesity overweight sperm sperm DNA fragmentation