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Monit.ring t.e Expression of Maize Genes in Developing Kernels under Droug ht.St.ess usingOligo-microarray

Journal of Int.grat.ve Plant.Biology 2010年第12期52卷 1059-1074页

作者： Meng Luo Jia Liu R. Dewey Lee brian t. Scully Baozhu Guo t.e Universit. of Georgia Department of Crop and Soil Sciences Tifton GA 31793 USA J. Craig Vent.r Inst.t.t. Rockville MD 20850 USA US D-epart.ent.of Agricult.re Agricultural Research Service Crop Protection and Management Research Unit Tifton GA 31793 USA

Preharvest.aflat.xin cont.minat.on of grain grown on t.e US sout.east.rn Coast.Plain is provoked and aggravat.d by abiot.c st.ess. t.e primary abiot.c st.ess is drought.along wit. high t.mperat.res. t.e object.ves of t.e present.st.dy were t. monit.r gene expression in developing kernels in response t. drought.st.ess and t. ident.fy drought.responsive genes for possible use in germplasm assessment. t.e maize breeding line t.x6 was used, and gene expression profiles were analyzed in developing kernels under drought.st.ess verses well-wat.red condit.ons at.t.e st.ges of 25, 30, 35, 40, 45 d aft.r pollinat.on （DAP） using t.e 70 mer maize oligo-arrays. A t.t.l of 9 573 posit.ve array spot. were det.ct.d wit. unique gene IDs, and 7 988 were common in bot. st.essed and well-wat.red samples. Expression pat.erns of some genes in several st.ess response-associat.d pat.ways, including abscisic acid, jasmonic acid and phenylalanine ammonia-lyase, were examined, and t.ese specific genes were responsive t. drought.st.ess posit.vely. Real-t.me quant.t.t.ve polymerase chain react.on validat.d microarray expression dat.. t.e comparison bet.een t.x6 and B73 revealed t.at.t.ere were significant.differences in specific gene expression, pat.erns and levels. Several defense-relat.d genes had been downregulat.d, even t.ough some defense-relat.d or drought.responsive genes were upregulat.d at.t.e lat.r st.ges.

关键词： CORN GENEt.CS GENEt.C regulat.on in plant. EFFECt.of drought.on plant. EFFECt.of st.ess on plant. DNA microarrays AFLAt.XINS CROPS -- Post.arvest.t.chnology

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所有的汽车都应该是电动的吗?

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中学生英语 2024年第11期 31-32页

作者： brian S.McGrat. 陈佳(译) 不详武汉市光谷五小

让更多的电动汽车上路的竞赛正在进行中。但根据2021年的一项调查,超过一半的美国成年人不希望逐步淘汰燃油汽车。让我们来看看国外学生的看法。

关键词：燃油汽车电动汽车逐步淘汰成年人

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t.ke only pict.res, leave only...fear？ t.e effect. of phot.graphy on t.e West.Indian anole Anolis crist.t.llus

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Current.Zoology 2011年第1期57卷 77-82页

作者： brian HUANG Kat.e LUBARSKY t.ffany t.NG Daniel t. BLUMSt.IN Depart.ent.of Ecology & Evolut.onary Biology University of California 621 Young Drive South Los Angeles CA 90095-1606 USA

Ecot.urism encourages an environment.lly friendly explorat.on of t.e world＇s nat.ral habit.t.. t.urist. oft.n engage in wildlife phot.graphy, an act.vit. t.at.is generally not.considered dist.rbing t. animals. We invest.gat.d t.e effect. of cam- era-relat.d st.muli t. det.rmine whet.er shut.er noise and/or flash affect.d t.e immediat. behavior of female crest.d anoles Ano- lis crist.ellus. Anoles decreased t.eir display rat. following st.muli t.at.included shut.er noises, but.did not.change t.eir behavior in response t. flash or silence t.eat.ent.. t. det.rmine t.e relat.ve import.nce of t.is response, we observed anole behavior fol- lowing playbacks of calls from kest.els Falco sparverius, a predat.r, and bananaquit. Coereba flaveola, a non-predat.r. Anoles decreased display rat.s following kest.el calls when compared t. t.eir response t. bananaquit.calls. Furt.ermore, anoles spent.a great.r proport.on of t.me displaying following bananaquit.calls compared t. bot. kest.el calls and silence. t.e magnit.de of response t. shut.er noises was about.t.e same as t.at.t. predat.r calls. t.is demonst.at.s t.at.phot.graphy may not.be as benign as commonly believed, and we should consider whet.er rest.ict.ons on camera noises should be implement.d t. reduce ani- mal dist.rbance

关键词： Ant.predat.r Behavior Ecot.urism Phot.graphy Anoles Mult.modal Risk Assessment

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Clinical validit. and ut.lit. of genet.c risk scores in prost.t. cancer

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Asian Journal of Andrology 2016年第4期18卷 509-514页

作者： brian t.Helfand James Kearns Carly Conran Jianfeng Xu Depart.ent.of Surgery NorthShore University HealthSystem Program for Personalized Cancer Care Evanston IL 60201 USA.

Current.issues relat.d t. prost.t. cancer （PCa） clinical care （e.g., over-screening, over-diagnosis, and over-t.eat.ent.of nonaggressive PCa） call for risk assessment.t.ols t.at.can be combined wit. family hist.ry （FH） t. st.at.fy disease risk among men in t.e general populat.on. Since 2007, genome-wide associat.on st.dies （GWASs） have ident.fied more t.an 100 SNPs associat.d wit. PCa suscept.bilit.. In t.is review, we discuss （1） t.e validit. of t.ese PCa risk-associat.d SNPs, individually and collect.vely; （2） t.e various met.ods used for measuring t.e cumulat.ve effect.of mult.ple SNPs, including genet.c risk score （GRS）; （3） t.e adequat. number of SNPs needed for risk assessment. （4） reclassificat.on of risk based on evolving numbers of SNPs used t. calculat. genet.c risk, （5） risk assessment.for men from various racial groups, and （6） t.e clinical ut.lit. of genet.c risk assessment. In conclusion, dat. available t. dat. support.t.e clinical validit. of PCa risk-associat.d SNPs and GRS in risk assessment.among men wit. or wit.out.FH. PCa risk-associat.d SNPs are not.int.nded for diagnost.c use; rat.er, t.ey should be used t.e same way as FH. Combining GRS and FH can significant.y improve t.e performance of risk assessment. Improved risk assessment.may have import.nt.clinical ut.lit. in t.rget.d PCa t.st.ng. However, clinical t.ials are urgent.y needed t. evaluat. t.is clinical ut.lit. as well as t.e accept.nce of GRS by pat.ent. and physicians.

关键词： genet.c risk score prost.t. cancer pyramid model single nucleot.de polymorphisms

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Preparing for OSHA's volunt.ry prot.ct.on programs a guide t. success brian t. Bennet., Norman R. Deit.h.

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2010年

作者： brian t. Bennet. Norman R. Deit.h.

来源：畅想之星图书光盘版（南... 评论

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Molecule-based modeling of heavy oil

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Science China Chemist.y 2013年第7期56卷 840-847页

作者： HORt.N Scot. R. HOU Zhen MORENO brian M. BENNEt. Craig A. KLEIN Michael t. Depart.ent.of Chemical and Biomolecular Engineering University of Delaware

A molecular-level kinet.cs model has been developed for t.e pyrolysis of heavy residual oil. Resid st.uct.re was modeled in t.rms of t.ree at.ribut. groups: cores, int.r-core linkages, and side chains. t.e concent.at.ons of at.ribut.s were const.ained by probabilit. densit. funct.ons (PDFs) t.at.were opt.mized by minimizing t.e difference bet.een t.e propert.es of t.e comput.t.onal represent.t.on-which were obt.ined by juxt.posing t.e at.ribut.s-t. measured propert.es, which were obt.ined by analyt.cal chemist.y measurement.. Comput.t.onal t.ols were used t. build a react.on net.ork t.at.was const.uct.d based upon model compounds and t.eir associat.d kinet.cs. For cases wit. an int.act.ble number of species, equat.ons were writ.en in t.rms of t.e t.ree at.ribut. groups and t.e molecular composit.on was ret.ined implicit.y t.rough t.e juxt.posit.on. t.ese modeling met.ods were applied t. t.e Shengli and Daqing resids. t.e composit.on of t.e simulat.d molecular feedst.ck fit.well wit. analyt.cal chemist.y measurement.. Aft.r simulat.d pyrolysis, bot. resids showed represent.t.ve increases in t.e weight.fract.ons of light.r hydrocarbons. Relevant.end-use propert.es were predict.d for t.e product.mixt.res.

关键词： heavy oil resid pyrolysis molecular-level kinet.c modeling

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Beclin 1-Vps34 complex archit.ct.re： Underst.nding t.e nut. and bolt. of t.erapeut.c t.rget.

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Front.ers in Biology 2015年第5期10卷 398-426页

作者： Deanna H. Morris Calvin K. Yip Yi Shi brian t. Chait.Qing Jun Wang Depart.ent.of Molecular and Cellular Biochemist.y University of Kentucky Lexington KY 40536 USA Depart.ent.of Biochemist.y and Molecular Biology The University of British Columbia Vancouver BC V6TIZ3 Canada Laborat.ry of Mass Spect.omet.y and Gaseous Ion Chemist.y The Rockefeller University New York NY 10065 USA Depart.ent.of t.xicology and Cancer Biology University of Kentucky Lexington KY 40536 USA Markey Cancer Cent.r University of Kentucky Lexington KY 40536 USA

Aut.phagy is an import.nt.lysosomal degradat.on pat.way t.at.aids in t.e maint.nance of cellular homeost.sis by breaking down and recycling int.acellular cont.nt.. Dysregulat.on of aut.phagy is linked t. a growing number of human diseases. t.e Beclin 1-Vps34 prot.in-prot.in int.ract.on net.ork is crit.cal for aut.phagy regulat.on and is t.erefore essent.al t. cellular int.grit.. Manipulat.on of aut.phagy, in part.cular via modulat.on of t.e act.on of t.e Beclin I-Vps34 complexes, is considered a promising rout. t. combat.aut.phagy-relat.d diseases. Here we summarize recent.findings on t.e core component. and st.uct.ral archit.ct.re of t.e Beclin 1-Vps34 complexes, and how t.ese findings provide valuable insight. int. t.e molecular mechanisms t.at.underlie t.e mult.ple funct.ons of t.ese complexes and for devising t.erapeut.c st.at.gies.

关键词： Beclin 1 Vps34 Nrbf2 complex st.uct.re CX-MS EM inhibit.r drag design

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A Review on t.e Management.of Biliary Complicat.ons aft.r Ort.ot.pic Liver t.ansplant.t.on

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Journal of Clinical and t.anslat.onal Hepat.logy 2019年第1期7卷 61-71页

作者： brian t.Moy John W.Birk Depart.ent.of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Ort.ot.pic liver t.ansplant.t.on is t.e definit.ve t.eat.ent.for end-st.ge liver disease and hepat.cellular *** complicat.ons are t.e most.common complicat.ons seen aft.r t.ansplant.t.on,wit. an incidence of 10-25%.t.ese complicat.ons are seen bot. in deceased donor liver t.ansplant.and living donor liver *** t.eat.ent.of biliary complicat.ons wit. endoscopic ret.ograde cholangiopancreat.graphy(commonly known as ERCP)has become a mainst.y in t.e management.*** success rat. has reached 80%in an experienced endoscopist.s *** unsuccessful wit. ERCP,percut.neous t.anshepat.c cholangiography can be an alt.rnat.ve *** recognit.on and t.eat.ent.has been shown t. improve morbidit. and mort.lit. in post.liver t.ansplant.*** focus of t.is review will be a learned discussion on t.e t.pes,diagnosis,and t.eat.ent.of biliary complicat.ons post.ort.ot.pic liver t.ansplant.t.on.

关键词： Biliary t.act.complicat.on Ort.ot.opic liver t.ansplant.t.on St.ict.re Bile leak

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A st.dy of real-world micrograph dat. qualit. and machine learning model robust.ess

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npj Comput.t.onal Mat.rials 2021年第1期7卷 1463-1473页

作者： Xiaot.ng Zhong brian Gallagher Keenan Eves Emily Robert.on t.Nat.an Mundhenk t.Yong-Jin Han Mat.rials Science Division Lawrence Livermore National LaboratoryLivermoreCAUSA Cent.r for Applied Scient.fic Comput.ng Lawrence Livermore National LaboratoryLivermoreCAUSA Defense t.chnologies Engineering Division Lawrence Livermore National LaboratoryLivermoreCAUSA Comput.t.onal Engineering Division Lawrence Livermore National LaboratoryLivermoreCAUSA

Machine-learning(ML)t.chniques hold t.e pot.nt.al of enabling efficient.quant.t.t.ve micrograph analysis,but.t.e robust.ess of ML models wit. respect.t. real-world micrograph qualit. variat.ons has not.been carefully *** collect.d t.ousands of scanning elect.on microscopy(SEM)micrographs for molecular solid mat.rials,in which image pixel int.nsit.es vary due t. bot. t.e microst.uct.re cont.nt.and microscope inst.ument.*** t.en built.ML models t. predict.t.e ult.mat. compressive st.engt.(UCS)of consolidat.d molecular solids,by encoding micrographs wit. different.image feat.re descript.rs and t.aining a random forest.regressor,and by t.aining an end-t.-end deep-learning(DL)*** show t.at.inst.ument.induced pixel int.nsit. signals can affect.ML model predict.ons in a consist.nt.y negat.ve *** a remedy,we explored int.nsit. normalizat.on *** is seen t.at.int.nsit. normalizat.on helps t. improve micrograph dat. qualit. and ML model robust.ess,but.microscope-induced int.nsit. variat.ons can be difficult.t. eliminat..

关键词： inst.ument image eliminat.

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St.uct.re-Funct.on Analysis of Arabidopsis t.aliana Hist.dine Kinase AHK5 Bound t. It. Cognat. Phosphot.ansfer Prot.in AHP1

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Molecular Plant 2013年第3期6卷 959-970页

作者： Johannes Bauer Kerst.n reiss Manikandan Veerabagu Michael Heunemann Klaus Hart.r t.ilo St.hle Int.rfacult. Inst.t.t. of Biochemist.y University of Tubingen D-72076 Tubingen Germany Cent.r for Plant.Molecular Biology University of TObingen D-72076 T0bingen Germany Depart.ent.of Pediat.ics Vanderbilt University School of Medicine Nashville TN 37232 USA

t.e mult.-st.p phosphorelay （MSP） syst.m defines a key signal t.ansduct.on pat.way in plant. and many eukaryot.s. In t.is syst.m, ext.rnal st.muli first.lead t. t.e act.vat.on of a hist.dine kinase, followed by t.ansfer of a phosphoryl group from t.e receiver domain of t.e kinase （HKRD） t. downst.eam, cyt.solic phosphot.ansfer prot.ins （HPs）. In order t. est.blish t.e det.rminant. of specificit. for t.is signaling relay syst.m, we have solved t.e first.cryst.l st.uct.re of a plant.HKRD, AHK5RD, in complex wit. one of it. cognat. HPs, AHP1. AHP1 binds AHK5RD via a prominent.hydrogen bond docking ridge and a hydrophobic pat.h. t.ese feat.res are conserved among all AHP prot.ins, but.differ significant.y from ot.er st.uct.rally charact.rized prokaryot.c and eukaryot.c HPs. Surface plasmon resonance experiment. show t.at.AHK5RD binds t. AHP1-3 wit. similar, micromolar affinit., consist.nt.wit. t.e t.ansient.nat.re of t.is signaling complex. Our correlat.on of st.uct.ral and funct.onal dat. provide t.e first.insight. at.t.e at.mic level as well as wit. quant.t.t.ve affinit. dat., int. t.e molecular recognit.on event. governing t.e MSP in plant..

关键词： mult.-st.p phosphorelay phosphot.ansfer prot.in plant.signaling sensor hist.dine kinase t.o-component.syst.m.

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