检索结果-南通市图书馆

Emerging role of galectin 3 in neuroinflammation and neurodegeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第9期19卷 2004-2009页

作者： brian m.Lozinski Khanh Ta Yifei Dong Department of Clinical Neuroscience University of CalgaryCalgaryABCanada Deparment of Biochemistry Microbiology&ImmunologyUniversity of SaskatchewanSaskatoonSKCanada

Neuroinflammation and neurodegeneration are key processes that mediate the development and progression of neurological ***,the mechanisms modulating these processes in different diseases remain incompletely *** in single cell based multi-omic analyses have helped to identify distinct molecular signatures such as Lgals3 that is associated with neuroinflammation and neurodegeneration in the central nervous system(CNS).Lgals3 encodes galectin-3(Gal3),aβ-galactoside and glycan binding glycoprotein that is frequently upregulated by reactive microglia/macrophages in the CNS during various neurological *** Gal3 has previously been associated with non-CNS inflammatory and fibrotic diseases,recent studies highlight Gal3 as a prominent regulator of inflammation and neuroaxonal damage in the CNS during diseases such as multiple sclerosis,Alzheimer’s disease,and Parkinson’s *** this review,we summarize the pleiotropic functions of Gal3 and discuss evidence that demonstrates its detrimental role in neuroinflammation and neurodegeneration during different neurological *** also consider the challenges of translating preclinical observations into targeting Gal3 in the human CNS.

关键词： Alzheimer’s disease Galectin 3 microglia multiple sclerosis neurodegeneration neuroinflammation Parkinson’s disease therapeutics

Kinetics of glyphosate and aminomethylphosphonic acid sorption onto montmorillonite clays in soil and their translocation to genetically modified corn

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第1期135卷 669-680页

作者： meichen Wang Kelly J Rivenbark Timothy D phillips Veterinary Physiology and Pharmacology College of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityTX 77845USA

The co-occurrence of glyphosate(GLP)and aminomethylphosphonic acid(AmPA)in contaminated water,soil,sediment and plants is a cause for concern due to potential threats to the ecosystem and human health.A major route of exposure is through contact with contaminated soil and consumption of crops containing GLP and AmPA ***,clay-based sorption strategies for mixtures of GLP and AmPA in soil,plants and garden produce have been very *** this study,in vitro soil and in vivo genetically modified corn models were used to establish the proof of concept that the inclusion of clay sorbents in contaminated soils will reduce the bioavailability of GLP and AmPA in soils and their adverse effects on plant *** of chemical concentration(1–10 mg/kg),sorbent dose(0.5%-3%in soil and 0.5%-1%in plants)and duration(up to 28 days)on sorption kinetics were *** time course results showed a continuous GLP degradation to *** inclusion of calcium montmorillonite(Cm)and acid processed montmorillonite(APm)clays at all doses significantly and consistently reduced the bioavailability of both chemicals from soils to plant roots and leaves in a dose-and time-dependent manner without detectable *** treated with 0.5%and 1%APm inclusion showed the highest growth rate(p≤0.05)and lowest chemical bioavailability with up to 76%reduction in roots and57%reduction in *** indicated that montmorillonite clays could be added as soil supplements to reduce hazardous mixtures of GLP and AmPA in soils and plants.

关键词： Glyphosate AmPA Adsorption Soil remediation Plant Hydroponic system

The influence of resistance exercise training prescription variables on skeletal muscle mass,strength,and physical function in healthy adults:An umbrella review

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第1期13卷 47-60页

作者： Jonathan C.mcleod Brad S.Currier Caroline V.Lowisz Stuart m.phillips Department of Kinesiology Faculty of ScienceMcMaster UniversityHamilton L8S4L8Canada

Purpose:The aim of this umbrella review was to determine the impact of resistance training(RT)and individual RT prescription variables on muscle mass,strength,and physical function in healthy ***:Following Preferred Reporting Items for Systematic Reviews and meta-Analyses(PRISmA)guidelines,we systematically searched and screened eligible systematic reviews reporting the effects of differing RT prescription variables on muscle mass(or its proxies),strength,and/or physical function in healthy adults aged>18 ***:We identified 44 systematic reviews that met our inclusion *** methodological quality of these reviews was assessed using A measurement Tool to Assess Systematic Reviews;standardized effectiveness statements were *** found that RT was consistently a potent stimulus for increasing skeletal muscle mass(4/4 reviews provide some or sufficient evidence),strength(4/6 reviews provided some or sufficient evidence),and physical function(1/1 review provided some evidence).RT load(6/8 reviews provided some or sufficient evidence),weekly frequency(2/4 reviews provided some or sufficient evidence),volume(3/7 reviews provided some or sufficient evidence),and exercise order(1/1 review provided some evidence)impacted RT-induced increases in muscular *** discovered that 2/3 reviews provided some or sufficient evidence that RT volume and contraction velocity influenced skeletal muscle mass,while 4/7 reviews provided insufficient evidence in favor of RT load impacting skeletal muscle *** was insufficient evidence to conclude that time of day,periodization,inter-set rest,set configuration,set end point,contraction velocity/time under tension,or exercise order(only pertaining to hypertrophy)influenced skeletal muscle adaptations.A paucity of data limited insights into the impact of RT prescription variables on physical ***:Overall,RT increased muscle mass,strength,and physical function compared to no ***

关键词： Hypertrophy Resistance training Resistance training prescription variables Strength Umbrella review

mesenchymal stem cell-based TRAIL delivery inhibits the metastatic state of clinical therapy-resistant progressive neuroblastoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第3期20卷 287-293页

作者： Dinesh Babu Somasundaram Andrew maher Sheeja Aravindan Zhongxin Yu brian mBesch Natarajan Aravindan Department of Radiation Oncology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Stephenson Cancer Center Oklahoma CityOKUSA Department of Pathology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Radiation Biology Laboratory University of Oklahoma Health Sciences CenterBSEB 302F941 Stanton L.Young BoulevardOklahoma CityOK 73104USA

Progressive neuroblastomas(pNBs)that defy current intensive multimodal clinical therapy(ImCT)are a significant contributor to overall childhood cancer deaths[l].Neuroblastomas(NBs)that survive first-line ImCT actively evolve to acquire genetic and molecular rearrangements and display unparalleled plasticity and evolution,which causes frequent relapses in a rapidly accelerating timeline[2-4].

关键词： neuroblastoma clinical evolve

New Opportunities for Neutrons in Environmental and Biological Sciences

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2024年第7期18卷 179-186页

作者： Alexander Johs Shuo Qian Leighton Coates brian H.Davison James G.Elkins Xin Gu Jennifer morrell-Falvey Hugh O'Neill Jeffrey m.Warren Eric m.Pierce Kenneth Herwig Oak Ridge National Laboratory Oak RidgeTN37831USA

The use of neutron methods in environmental and biological sciences is rapidly emerging and accelerating with the development of new instruments at neutron user *** article,based on a workshop held at Oak Ridge National Laboratory(ORNL),offers insights into the application of neutron techniques in environmental and biological *** highlight recent advances and identify key challenges and potential future research *** include soil and rhizosphere processes,root water dynamics,plant-microbe interactions,structure and dynamics of biological systems,applications in synthetic biology and enzyme engineering,next-generation bioproducts,biomaterials and bioenergy,nanoscale structure,and fluid dynamics of porous materials in *** provide an outlook on emerging opportunities with an emphasis on new capabilities that will be enabled at the Spallation Neutron Source Second Target Station currently under design at *** mission of scientific neutron user facilities worldwide is to enable science using state-of-the-art neutron *** aim to encourage researchers in the environmental and biological research community to explore the unique capability afforded by neutrons at these facilities.

关键词： Neutrons Environment Biology Neutron imaging Neutron scattering Second Target Station(STS)

聚乳酸无纺布环保PDA类阻燃剂的制备与研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

聚乳酸无纺布环保PDA类阻燃剂的制备与研究

作者： brian Branch 北京化工大学

学位级别：硕士

石油基聚合物的降解以及其火安全性能是当今世界面临的关键挑战。这是由于石油基聚合物应用广泛,在使用后难以降解,会导致严重的环境污染问题。此外,石油基聚合物大多易燃,易引发火灾对人类的生命安全造成威胁。因此解决这些问题显得相... 详细信息

石油基聚合物的降解以及其火安全性能是当今世界面临的关键挑战。这是由于石油基聚合物应用广泛,在使用后难以降解,会导致严重的环境污染问题。此外,石油基聚合物大多易燃,易引发火灾对人类的生命安全造成威胁。因此解决这些问题显得相当紧迫,需要我们提出能够同时平衡材料环保与阻燃性能的创新解决方案。对于聚合物的降解问题,一种潜在的解决方案是利用和开发同时具有生物安全性和可生物降解的生物基聚合物。然而,相较于石油基聚合物,这些替代品往往在某些方面有性能缺陷（如力学性能et al）。因此,对这些生物基聚合物的研究需要同时兼顾其环境友好的优点并改善其对应性能的缺陷。而在阻燃性能方面,传统的阻燃剂（如含卤阻燃剂）,已被证明具有良好的阻燃效果,但由于其会产生毒副产物,存在环境与健康隐患,因此将开发新型安全无卤的磷系阻燃剂以代替传统的卤系阻燃剂。本研究通过将聚多巴胺（PDA）和磷系阻燃剂应用在聚乳酸（PLA）无纺布,为解决上述问题做出了一定贡献。通过实验发现,PDA涂层与磷系化合物的同时应用可显著提高PLA织物的阻燃性能,且涂层同样具有较高的生物安全性且对环境影响较小。此外,这项工作还凸现了PDA涂层可在PLA中快速高效应用的潜力。主要成果如下:本论文的第一部分是聚多巴胺和磷基化合物THPO作为关键阻燃剂的应用。通过喷雾共沉积方法将THPO引入到聚多巴胺基质中。这种方法显著增强了涂层织物的耐火性。极限氧指数（LOI）从对照织物的18%增加到27.5%。此外,UL-94测试的损坏长度从9.5厘米减少到7.5厘米。值得注意的是,熔体滴落性能得到增强,在测试过程中没有观察到火焰滴落。此外,热重分析显示THPO促进了适度的炭形成。仅存在聚多巴胺涂层时,样品的总烟雾产生量和烟雾产生速率均显着降低,导致Fig RA值从22.2 k W/m2s降低至14.7 k W/m2s;进一步凸显了该方法的有效性。抗紫外线测试显示,20小时内涂层样品的质量平均损失1.5%,而对照PLA织物的质量损失超过15%。本研究的第二部分重点是使用聚多巴胺作为功能涂层和聚磷酸铵（APP）作为磷基阻燃剂,在PLA织物表面形成称为PDA-Cu-APP的金属络合物。这种创新方法证明了进一步增强了织物的耐火性能,熔体滴落性能得到改善,在UL-94垂直燃烧测试中未观察到熔滴。极限氧指数（LOI）从对照PLA的18%显着增加至29.2%。此外,热重分析表明,炭残留物从对照PLA织物的1.5%增加到9.0%。Fig RA值从22.2 k W/m2s降低至14.7 k W/m2s,降低了33%。涂层中的PDA组分显着提高了抗紫外线性能,降低了质量损失率,紫外老化后涂层织物的拉伸强度是对照PLA织物的4倍。总之,本研究将生物基聚多巴胺涂层与磷基阻燃剂相结合以增强PLA织物的防火安全性,保持了环境可持续性目标的可行性。这些发现为未来开发生物基聚合物材料阻燃解决方案的研究提供了有效的途径。

关键词：阻燃剂聚多巴胺聚乳酸聚磷酸铵三(羟甲基)膦氧化物无纺布

Advancements in endoscopic hemostasis for non-variceal upper gastrointestinal bleeding

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2024年第7期16卷 376-384页

作者： Xue Jing Li brian m Fung Department of Gastroenterology and Hepatology Banner-University Medical Center PhoenixPhoenixAZ 85006United States

Non-variceal upper gastrointestinal(GI)bleeding is a significant cause of morbidity and ***,through-the-scope(TTS)clips,thermal therapy,and injection therapies are used to treat GI *** this review,we provide an overview of novel endoscopic treatments that can be used to achieve ***,we discuss the efficacy and applicability of over-thescope clips,hemostatic agents,TTS doppler ultrasound,and endoscopic ultrasound,each of which offer an effective method of reducing rates of GI rebleeding.

关键词： Doppler probe Endoscopic ultrasound Endoscopy techniques Gastrointestinal bleeding Hemospray Hemostasis Hemostatic agents Over-the-scope clips Ovesco

Finding the magnetopause location using soft X-ray observations and a statistical inverse method

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2024年第1期8卷 184-203页

作者： Gonzalo Cucho-Padin Hyunju Connor Jaewoong Jung brian Walsh David G.Sibeck Space Weather Laboratory NASA Goddard Space Flight CenterGreenbeltMDUSA Department of Physics The Catholic University of AmericaWashingtonDCUSA Geospace Physics Laboratory NASA Goddard Space Flight CenterGreenbeltMDUSA Astronomy Department University of Maryland College ParkCollege ParkMDUSA Center for Space Physics Department of Mechanical EngineeringBoston UniversityBostonMAUSA

Variability in the location and shape of the dayside magnetopause is attributed to magnetic reconnection,a fundamental process that enables the transfer of mass,energy,and momentum from the solar wind into the *** spatial and temporal properties of the magnetopause,under varying solar and magnetospheric conditions,remain largely unknown because empirical studies using in-situ observations are challenging to *** wide field-of-view(FOV)imaging is the only means to simultaneously observe the spatial distribution of the plasma properties over the vast dayside magnetospheric region and,subsequently,quantify the energy transport from the interplanetary medium into the terrestrial *** upcoming missions,ESA/CAS SmILE and NASA’s LEXI will provide wide-field imagery of the dayside magnetosheath in soft X-rays,an emission generated by charge exchange interactions between high charge-state heavy ions of solar wind origin and exospheric neutral ***-cadence two-dimensional observations of the magnetosheath will allow the estimation of dynamic properties of its inner boundary,the magnetopause,and enable studies of its response to changes in the solar wind dynamic pressure and interplanetary magnetic field *** work introduces a statistically-based estimation approach based on inverse theory to estimate the spatial distribution of magnetosheath soft X-ray emissivities and,with this,identify the location of the magnetopause over the Sun−Earth *** do so,we simulate the magnetosheath structure using the mHD-based OpenGGCm model and generate synthetic soft X-ray images using LEXI’s orbit and attitude *** results show that 3-D estimations using the described statistically-based technique are robust against Poisson-distributed shot noise inherent to soft X-ray ***,our proposed methodology shows that the accuracy of both three-dimensional(3-D)estimation and the magnetopause standoff distance calculation hi

关键词： magnetopause soft X-ray tomography

在线全文

学校读者我要写书评

暂无评论

采用Kalman滤波器的实时混合试验方法

采用Kalman滤波器的实时混合试验方法