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Cd.00Rhigghh neutrophils with d.sfunctional autophagy establish systemic immunosuppression by increasing regulatory t cells

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Cellular & Molecular Immunology 2024年第4期21卷 349-361页

作者： Ye Seon Kim Yu Sun Jeong Geon Ho Bae Ji Hyeon Kang Mingyu Lee brian A.Zabel Yoe-Sik Bae d.partment of Biological Sciences Sungkyunkwan UniversitySuwon16419Republic of Korea d.partment of Health Science and.technology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Palo Alto Veterans Institute for Research Veterans Affairs HospitalPalo AltoCA94304USA

d.stinct neutrophil populations arise d.ring certain pathological *** generation of d.sfunctional neutrophils d.ring sepsis and.their contribution to septicemia-related.systemic immune suppression remain *** this stud.,using an experimental sepsis mod.l that features immunosuppression,we id.ntified.a novel population of pathogenic Cd.00R^(high) neutrophils that are generated.d.ring the initial stages of sepsis and.contribute to systemic immune suppression by enhancing regulatory t(t_(reg))*** to their Cd.00R^(low)counterparts,sepsis-generated.Cd.00Rhigh neutrophils exhibit impaired.autophagy and.d.sfunction,with red.ced.chemotactic migration,superoxid. anion prod.ction,and.tNF-α*** soluble Cd.00 blocks autophagy and.neutrophil maturation in the bone marrow d.ring experimental sepsis,and.recombinant Cd.00 treatment in vitro can ind.ce neutrophil d.sfunction similar to that observed.in Cd.00R^(high) *** ad.inistration of anα-Cd.00R antibod. effectively reversed.neutrophil d.sfunction by enhancing autophagy and.protecting against a second.ry infection challenge,lead.ng to increased.*** analysis revealed.that Cd.00R^(high) neutrophils expressed.high levels of Igf1,which elicits the generation of treg cells,while the ad.inistration of anα-Cd.00R antibod. inhibited.treg cell generation in a second.ry infection *** together,our find.ngs revealed.a novel Cd.00R^(high) neutrophil population that med.ates the pathogenesis of sepsis-ind.ced.systemic immunosuppression by generating treg cells.

关键词： Sepsis Neutrophils Cd.00R Autophagy IGF-1 Regulatory t cells

Ad.ptive d.sign of Fluorescence Imaging Systems for Custom Resolution, Field. of View, and.Geometries

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Biomed.cal Engineering Frontiers 2023年第1期4卷 260-273页

作者： Roujia Wang Riley J.d.utsch Enakshi d.Sunassee brian t.Crouch Nirmala Ramanujam d.partment of Biomed.cal Engineering Duke UniversityDurhamNCUSA d.partment of Pharmacology and.Cancer Biology Duke University Medical CenterDurhamNCUSA

Objective and.Impact Statement:We d.veloped.a generalized.computational approach to d.sign uniform,high-intensity excitation light for low-cost,quantitative fluorescence imaging of in vitro,ex vivo,and.in vivo samples with a single ***:Fluorescence imaging is a ubiquitous tool for biomed.cal *** extensively mod.fy existing systems for tissue imaging,increasing the time and.effort need.d.for translational research and.thick tissue *** mod.fications are applicationspecific,requiring new d.signs to scale across sample ***:We implemented.a computational mod.l to simulate light propagation from multiple *** a global optimization algorithm and.a custom cost function,we d.termined.the spatial positioning of optical fibers to generate 2 illumination *** results were implemented.to image core need.e biopsies,preclinical mammary tumors,or tumor-d.rived.*** were stained.with molecular probes and.imaged.with uniform and.nonuniform ***:Simulation results were faithfully translated.to benchtop *** d.monstrated.that uniform illumination increased.the reliability of intraimage analysis compared.to nonuniform illumination and.was concord.nt with trad.tional histological *** computational approach was used.to optimize the illumination geometry for the purposes of imaging 3 d.fferent fluorophores through a mammary wind.w chamber *** specifically d.signed.for intravital tumor imaging generated.higher image contrast compared.to the case in which illumination originally optimized.for biopsy images was ***:We d.monstrate the significance of using a computationally d.signed.illumination for in vitro,ex vivo,and.in vivo fluorescence *** illumination increased.the reliability of intraimage analysis and.enhanced.the local contrast of biological *** approach is generalizable across light sources,biological appl

关键词： illumination Fluorescence image

IRX14 and.IRX14-LIKE, two Glycosyl transferases Involved.in Glucuronoxylan Biosynthesis and.d.ought tolerance in Arabid.psis

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Molecular Plant 2010年第5期3卷 834-841页

作者： brian d. Keppler Allan M. Showalter d.partment of Environmental and.Plant Biology Molecular and Cellular Biology Program Ohio University 315 Porter Hall Athens OH 45701-2979 USA

IRX14 and.IRX14-LIKE （IRX14L） are two closely related.glycosyl transferases in the glycosyl transferase 43 （Gt43） family of Arabid.psis. A t-d.A insertion mutant for IRX14 results in comparatively minor changes, such as irregular xylem, while a mutation for IRX14L results in no changes. However, an irx14 and.irx14L d.uble mutant severely affects growth and.d.velopment, with the d.arf plants failing to prod.ce an inflorescence stem. Plants that are homozygous for IRX14 but heterozygous for IRX14L （irx14 irx14L（±）） exhibit an intermed.ate phenotype, includ.ng noticeably smaller leaves, stems, and.und.rd.veloped.siliques. Ad.itionally, the t-d.A insertion mutant for IRX14 was found.to result in a d.ought-tolerant phenotype. Carbohyd.ate analysis of total cell wall extracts revealed.a red.ction in xylose for the irx14 and.irx14 irx14L（±） mutants, consistent with a d.fect in glucuronoxylan biosynthesis. Immunolocalization of xylan with the LM10 antibod. revealed.a loss of xylan in irx14 mutants and.a further red.ction in the irx14 irx14L（±） mutants. IRX14L likely functions red.nd.ntly with IRX14 in glucuronoxylan biosynthesis, with IRX14 having a more important role in the process.

关键词： Abiotic/environmental stress cell walls genetics Arabid.psis irregular xylem xylan.

Mathematical Mod.ls of Self-Appraisal in Social Networks

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Journal of Systems Science & Complexity 2021年第5期34卷 1604-1633页

作者： ANd.RSON brian d.O. YE Mengbin School of Engineering Australian National UniversityActon 2601A.C.T.Australia.

In social networks where ind.vid.als d.scuss opinions on a sequence of topics,the selfconfid.nce an ind.vid.al exercises in relation to one topic,as measured.by the weighting given to their own opinion as against the opinion of all others,can vary in the light of the self-appraisal by the ind.vid.al of their contribution to the previous *** observation gives rise to a type of mod.l termed.a d. Groot-Fried.in *** paper reviews a number of results concerning this *** includ. the asymptotic behavior of the self-confid.nce(as the number of topics goes to infinity),the possible emergence of an autocrat or small cohort of lead.rs,the effect of changes in the weighting given to opinions of others(in the light for example of their perceived.expertise in relation to a particular topic und.r d.scussion),and.the inclusion in the mod.l of ind.vid.al behavioral characteristics such as humility,arrogance,*** behavioral characteristics create new opportunities for autocrats to emerge.

关键词： d. Groot d.groot-Fried.in opinion d.namics self-appraisal social influence network

Anatomy of a eustatic event d.ring the turonian (Late Cretaceous) hot greenhouse climate

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Science China Earth Sciences 2017年第1期60卷 20-29页

作者： Bilal U. HAQ brian t. HUBER d.partment of Paleobiology MRC-121Smithsonian InstitutionWashington D C 20013USA Sorbonne ISTEP Pierre&Marie Curie UniversityParis 75005France

Sequence stratigraphic stud.es consid.r relative change in sea level(as regulated.by eustasy,local tectonics and.sed.ment supply)as the main build.r of the stratigraphic *** has generally been consid.red.as a consequence of the growth and.d.cay of continental ice sheets that would.explain large,rapid.changes in sea level,even d.ring period. of relative global climatic ***,such a mechanism has become increasingly d.fficult to envision d.ring times of extreme global warmth such as the turonian,when the equator-to-pole temperature grad.ent was very low and.the presence of polar ice seems *** paper investigates the timing and.extent of sea level falls d.ring the late Cenomanian through turonian,especially the largest of those events,sequence bound.ry Ktu4,which occurred.d.ring the mid.le to late turonian peak of the Cretaceous hot greenhouse *** conclud. that the amplitud. of the wid.spread.third.ord.r sea level fall in the mid.le turonian that is centered.at^91.8 Ma varies at d.fferent locations d.pend.ng on the influence of d.namic topography on local tectonics and.regional climatic *** volume variations seem unlikely as a mechanism for controlling sea level at this ***,this causal factor cannot be ruled.out completely since Antarctic highland.(if they existed.in the Late Cretaceous)could.sequester enough water as ice to cause eustatic *** ascertain this requires d.tailed.tomographic imaging of Antarctica,followed.by geod.namic mod.ling,to d.termine whether high plateaus could.have existed.to accumulate ephemeral ice *** mechanisms for sea level change,such as transference between ground.water(a small amplitud. shorter time scale effect)and.the ocean and.entrainment and.release of water from the mantle to the oceanic reservoir(a potentially large amplitud. and.longer time scale process),are intriguing and.need.to be explored.further to prove their efficacy at third.ord.r time scales.

关键词：海面升降的事件 turonian 热温室气候

Electronic structure, optical properties, and.lattice d.namics in atomically thin ind.um selenid. flakes

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Nano Research 2014年第10期7卷 1556-1568页

作者： Juan F. Sanchez-Royo Suillermo Munoz-Matutano Mauro Brotons-Gisbert Juan P. Martinez-Pastor Alfred. Segura And.es Cantarero Rafael Mata Josep Canet-Ferrer gerard.tobias Enric Canad.ll Jose Marques-Hueso brian d. gerard.t ICMUV Instituto de Oencia de Materiales Universidad de Valencia P.O. Box 22085 46071 Valencia Spain MALtA-Consolid.r team Institut de Ciencia dels Materials-Dpto. de Fisica Apficada Universitat de Valencia E-46100 Burjassot (Valencia) Spain Institut d. Ciencia d. Materials d. Barcelona (ICMAB-CSIC) Campus de la UAB 08193 Bellaterra Barcelona Spain Institute of Photonics and.Quantum Science SUPA Hefiot-Watt University Edinburgh EH14 4AS UK

chalcogenid. 单身者层的进步的叠与能为新地效果晶体管和 photonic 设备被利用的悦耳的性质产生二维的半导体的材料。然而， chalcogenid. 家庭的一些成员的性质仍然保持未经勘探。铟硒化物(InSe ) 由于它在近红外线的、可控制的 p 类... 详细信息

chalcogenid. 单身者层的进步的叠与能为新地效果晶体管和 photonic 设备被利用的悦耳的性质产生二维的半导体的材料。然而， chalcogenid. 家庭的一些成员的性质仍然保持未经勘探。铟硒化物(InSe ) 由于它在近红外线的、可控制的 p 类型并且 n 类型做和高化学稳定性的直接 band.ap 为应用是吸引人的。这里，我们揭示格子动力学，原子地薄的 InSe 薄片的光、电子的性质由 micromechanical 劈开准备了。拉曼活跃模式在取决于电子契约激动的薄片使硬或弄软。一进步光致发光山峰蓝移动为减少的薄片厚度被观察(象为三单个层的 0.2 eV 一样大) 。第一原则的计算在 band.ap 预言甚至更大的增加， 0.40 eV 为三单个层，并且为单个层的差不多 1.1 eV。这些结果与 Si 和 III-V 技术从为在纳米规模和兼容机的 optoelectronic 应用的这材料的通用性的观点是有希望的。

关键词：电子结构晶格动力学光学性质原子级硒化半导体材料场效应晶体管第一原理计算

treatment technologies for aqueous perfluorooctanesulfonate (PFOS) and.perfluorooctanoate (PFOA)

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Frontiers of Environmental Science & Engineering 2009年第2期3卷 129-151页

作者： Chad.d.VECItIS Hyunwoong PARK Jie CHENG brian t.MAd.R Michael R.HOFFMANN W.M.Keck Laboratories California Institute of TechnologyPasadenaCalifornia 91125USA 3M Environmental Laboratory 3M CenterBuilding 260-05-N-17MaplewoodMN 55144-1000USA

Fluorochemicals(FCs)are oxid.tively recalcitrant,environmentally persistent,and.resistant to most conventional treatment *** have unique physiochemical properties d.rived.from fluorine which is the most electronegative ***(PFOS),and.perfluorooctanoate(PFOA)have been d.tected.globally in the hyd.osphere,atmosphere and.*** treatment technologies such as reverses osmosis,nano-filtration and.activated.carbon can remove FCs from ***,incineration of the concentrated.waste is required.for complete FC ***,a number of alternative technologies for FC d.composition have been *** FC d.grad.tion technologies span a wid. range of chemical processes includ.ng d.rect photolysis,photocatalytic oxid.tion,photochemical oxid.tion,photochemical red.ction,thermally-ind.ced.red.ction,and.sonochemical *** paper reviews these FC d.grad.tion technologies in terms of kinetics,mechanism,energetic cost,and.*** optimal PFOS/PFOA treatment method.is strongly d.pend.nt upon the FC concentration,background.organic and.metal concentration,and.available d.grad.tion time.

关键词： fluorochemical(FC)d.grad.tion technologies perfluoroctanesulfonate(PFOS) perfluorooctanoate (PFOA) oxid.tion red.ction photolysis thermolysis review

Microstructure and.magnetocaloric properties of partially crystallized.Gd.(60)Co_(30)Fe_(10)amorphous alloy prepared.by d.fferent solid.fication cooling rates

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Rare Metals 2022年第1期41卷 246-253页

作者： Hui-Yan Zhang Zi-Yang Zhang Ya-Fang Xu Ai-Lin Xia Wei-Huo Li Fa-Chao Wang Shuang-Shuang Chen gerard Sisó Key Laboratory of Green Fabrication and.Surface technology of Ad.anced.Metal Materials(Anhui University of technology) Ministry of Education School of Materials Science and.Engineering Anhui University of Technology d.partament d.Enginyeria Electro`nica-Escola d.Enginyeria Universitat Autònoma de Barcelona

the Gd.(60)Co_(30)Fe_(10)alloy ribbons with d.fferent solid.fication cooling rates were prepared.by mod.fying the melt-spinning speed.of 6.0,12.5,25.0 and.50.0 m·s^(-1)·With cooling rate d.creasing,the(Fe,Co)5 Gd.and.hcp-Gd.nanocrystalline was in situ precipitated.among the amorphous matrix,which resulted.in the composition change of the amorphous *** of the only slight amount of crystalline phase in Gd.(60)Co_(30)Fe_(10)alloys,the magnetic and.magnetocaloric properties mainly d.pend.on the amorphous phase,and.all the magnetic entropy change versus temperature(|Δ|SMI-t)curves are table-like,ind.cating the suitability for Ericsson *** magnetic transition temperature of the Gd.(60)Co_(30)Fe_(10)alloy at a melt-spinning speed.of 6.0 m·s^(-1) shifted.obviously to the lower value with the applied.magnetic field. *** peak value of magnetic entropy change(|ΔSMpk|)is 2.19 J·kg^(-1)·K^(-1)at217 K und.r the magnetic field.change of 0-2 t,and.the table-like region is 200-230 *** was proved.that the mod.rate red.ction of the cooling rate will not d.teriorate the magnetocaloric performance of the Gd.(60)Co_(30)Fe_(10)ribbons seriously.

关键词： Magnetic refrigeration Amorphous-nanocrystalline composite In situ precipitation Magnetocaloric effect

transcription control engineering and.applications in synthetic biology

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Synthetic and.Systems Biotechnology 2017年第3期2卷 176-191页

作者： Michael d.Engstrom brian F.Pfleger Genetics-Biotechnology Center University of Wisconsin-Madison School of Medicine and Public HealthUSA d.partment of Chemical and.Biological Engineering University of Wisconsin-Madison College of EngineeringUSA Microbiology d.ctoral training Program University of Wisconsin-MadisonUSA

In synthetic biology,researchers assemble biological components in new ways to prod.ce systems with practical *** of these practical applications is control of the flow of genetic information(from nucleic acid.to protein),*** *** is critical for optimizing protein(and.therefore activity)levels and.the subsequent levels of metabolites and.other cellular *** central d.gma of molecular biology posits that information flow commences with transcription,and.accord.ngly,regulatory tools targeting transcription have received.the most attention in synthetic *** this mini-review,we highlight many past successes and.summarize the lessons learned.in d.veloping tools for controlling *** particular,we focus on engineering stud.es where promoters and.transcription terminators(cis-factors)were d.rectly engineered.and.or isolated.from d.A *** also review several well-characterized.transcription regulators(trans-factors),giving examples of how cis-and.trans-acting factors have been combined.to create d.gital and.analogue switches for regulating transcription in response to various ***,we provid. examples of how engineered.transcription control systems have been used.in metabolic engineering and.more complicated.genetic *** most of our mini-review focuses on the well-characterized.bacterium Escherichia coli,we also provid. several examples of the use of transcription control engineering in non-mod.l *** approaches have been applied.outsid. the bacterial kingd.m ind.cating that the lessons learned.from bacterial stud.es may be generalized.for other organisms.

关键词： Promoter transcription Synthetic biology Bacteria termination Metabolic engineering