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Facile synthesis of intra-nanogap enhanced Raman tags with different shapes

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Nano Research 2024年第9期17卷 8415-8423页

作者： Sanjun Fan brian t.Scarpitti Zhewen Luo Abigail E.Smith Jian Ye Zachary D.Schultz Department of Chemistry and Biochemistry The Ohio State UniversityColumbusOhio 43210USA School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200030China

Hot spot engineering in plasmonic nanostructures plays a significant role in surface-enhanced Raman scattering(SERS)for bioanalysis and cell ***,creating stable,reproducible,and strong SERS signals remains challenging due to the potential interference from surrounding chemicals and locating SERS-active analytes into hot-spot ***,we developed a straightforward approach to synthesize intra-gap nanoparticles encapsulating 4-nitrobenzenethiol(4-NBt)as a reporter molecule within these gaps to avoid outside *** made three kinds of intra-gap nanoparticles using nanorods,bipyramids,and nanospheres as cores,in which the nanorods based intra-gap nanoparticles exhibit the highest SERS *** advantage of our method is the ease of preparation of high-yield and stable intra-gap nanoparticles characterized by a short incubation time(10 min)with 4-NBt and quick synthesis without requiring an additional step to centrifuge for the purification of core *** intense localized field in the synthesized hot spots of these plasmonic gap nanostructures holds great promise as a SERS substrate for a broad range of quantitative optical applications.

关键词： hot spot engineering surface enhanced Raman scattering intra-gap nanoparticles 4-nitrobenzenethiol

Shoaling Internal Solitary Waves and the Formation of Boluses

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Open Journal of Fluid Dynamics 2024年第2期14卷 65-82页

作者： Hooman Enayati brian t. Helenbrook Department of Mechanical Engineering Lafayette College Easton PA USA Department of Mechanical & Aerospace Engineering Clarkson University Potsdam NY USA

An internal solitary wave of elevation in a two-layer density stratified system of an incompressible, viscous and homogeneous fluid was studied. the run-up of a wave of elevation encountering different slopes was investigated numerically based on solving the continuity, Navier-Stokes and convective-diffusion equations within the Boussinesq approximation. the commercial software COMSOL Multiphysics was used to conduct the numerical simulations. For gradual shoals, a bolus formed that transported dense fluid up the shoal. the bolus disappeared when it reached its maximum height on the slope due to the draining of the dense fluid. Various shoal angles were simulated to detect the critical angle above which a bolus does not form. An angle of 30 or less resulted in the formation of a bolus. In addition, the simulations demonstrated that the size of the bolus induced by shallower slopes was larger and that the vertical height traveled by the bolus was insensitive to the slope of the shoal.

关键词： Internal Solitary Waves COMSOL Multiphysics Wave Breaking

Why and how to use the SeqCode

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mLife 2024年第1期3卷 1-13页

作者： Wiliam B.Whitman Maria Chuvochina brian P.Hedlund Konstantinos t.Konstantinidis Marike Palmer Luis M.Rodriguez-R lain Sutcliffe Fengping Wang Deparment of Microbioogy University of GeorgiaAthensGeorgiaUAA Schoolof Chemistry and Molecular Biosciences Australian CentreforEogenomicsThe Universty of QueenslandSt LuciaAustralia University of Nevada Las Vegas Las VegasNevadaUSA Schol of Civil and Environmental Engineering and School of Biological SciencesGeorgia Institute of TechnologyAtlantaGeorgiaUSA Department of Microbiology University of ManitobaWinnipegManitobaCanada School of Life Sciences University of Nevada Las VegasLas VegasNevadaUSA Department of Microbiology and Digital Science Center(DiSC) University of InnsbruckInnsbruckAustria Faculty of Health&Life Sciences Northumbria UniversityNewcastle upon TyneUK School of Oceanography International Center for Deep Life InvestigationShanghai Jiao Tong UniversityShanghaiChina

the SeqCode,formally called the Code of Nomenclature of Prokaryotes Described from Sequence Data,is a new code of nomenclature in which genome sequences are the nomenclatural types for the names of prokaryotic *** similar to the International Code of Nomenclature of Prokaryotes(ICNP)in structure and rules of priority,it does not require the deposition of type strains in international culture ***,it allows for the formation of permanent names for uncultured prokaryotes whose nearly complete genome sequences have been obtained directly from environmental DNA as well as other prokaryotes that cannot be deposited in culture *** the diversity of uncultured prokaryotes greatly exceeds that of readily culturable prokaryotes,the SeqCode is the only code suitable for naming the majority of prokaryotic *** start date of the SeqCode was January 1,2022,and the online Registry(https://***)was created to ensure valid publication of *** SeqCode recognizes all names validly published under the ICNP before *** that date,names validly published under the SeqCode compete with ICNP names for *** a result,species can have only one name,either from the SeqCode or ICNP,enabling effective communication and the creation of unified taxonomies of uncultured and cultured *** SeqCode is administered by the SeqCode Committee,which is comprised of the SeqCode Community and elected administrative *** with an interest in the systematics of prokaryotes is encouraged to join the SeqCode Community and participate in the development of this resource.

关键词： genome sequences metagenome-assembled genomes nomenclature SeqCode

CD200Rhigghh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory t cells

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Cellular & Molecular Immunology 2024年第4期21卷 349-361页

作者： Ye Seon Kim Yu Sun Jeong Geon Ho Bae Ji Hyeon Kang Mingyu Lee brian A.Zabel Yoe-Sik Bae Department of Biological Sciences Sungkyunkwan UniversitySuwon16419Republic of Korea Department of Health Science and technology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Palo Alto Veterans Institute for Research Veterans Affairs HospitalPalo AltoCA94304USA

Distinct neutrophil populations arise during certain pathological *** generation of dysfunctional neutrophils during sepsis and their contribution to septicemia-related systemic immune suppression remain *** this study,using an experimental sepsis model that features immunosuppression,we identified a novel population of pathogenic CD200R^(high) neutrophils that are generated during the initial stages of sepsis and contribute to systemic immune suppression by enhancing regulatory t(t_(reg))*** to their CD200R^(low)counterparts,sepsis-generated CD200Rhigh neutrophils exhibit impaired autophagy and dysfunction,with reduced chemotactic migration,superoxide anion production,and tNF-α*** soluble CD200 blocks autophagy and neutrophil maturation in the bone marrow during experimental sepsis,and recombinant CD200 treatment in vitro can induce neutrophil dysfunction similar to that observed in CD200R^(high) *** administration of anα-CD200R antibody effectively reversed neutrophil dysfunction by enhancing autophagy and protecting against a secondary infection challenge,leading to increased *** analysis revealed that CD200R^(high) neutrophils expressed high levels of Igf1,which elicits the generation of treg cells,while the administration of anα-CD200R antibody inhibited treg cell generation in a secondary infection *** together,our findings revealed a novel CD200R^(high) neutrophil population that mediates the pathogenesis of sepsis-induced systemic immunosuppression by generating treg cells.

关键词： Sepsis Neutrophils CD200R Autophagy IGF-1 Regulatory t cells

Cardiovascular health awareness,risk perception,behavioural intention and INtERHEARt risk stratification among middle-aged adults in Malaysia

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Asian Pacific Journal of tropical Medicine 2024年第2期17卷 61-70页

作者： Siew-Keah Lee Ang-Lim Chua Clement Heng Yew Fong Ban Hao brian Cong Wen Ling Ng Jing Feng Kong Yik-Ling Chew Kai Bin Liew Yang Shao M.Kandiah Faculty of Medicine and Health Sciences Universiti Tunku Abdul RahmanMalaysia Faculty of Medicine Universiti Teknologi MARAMalaysia Faculty of Pharmaceutical Sciences UCSI UniversityMalaysia Faculty of Pharmacy University of CyberjayaMalaysia the First Affiliated Hospital of Hainan Medical University China

Objective:to investigate the interrelationship between cardiovascular health awareness,risk perception,behavioural intention,and INtERHEARt risk stratification in a middle-aged adult population in ***:A cross-sectional survey with convenience sampling was conducted during November 2022 and January *** completed validated questionnaires assessing cardiovascular health awareness,risk perception of cardiovascular diseases,behavioural intention towards adopting healthy habits,and INtERHEARt risk stratification score(IHRS)based on established risk factors.A total of 602 respondents were included in the final *** were analysed with independent t-test/one-way ANOVA or Mann-Whitney/Kruskal-Wallis to test the differences,Pearson correlation or linear regression test to analyze the association of independent and dependent ***:there was a significant positive correlation between medical knowledge related to cardiovascular disease(CVD)and knowledge related to CVD risk prevention,risk perception,behavioural intention and IHRS(Ption).Notably,individuals with higher IHRS tended to have lower knowledge related to CVD and CVD risk prevention,risk perception,and behavioural ***,laborers,active/former smokers,individuals with lower household income and educational levels,those involved in occupations not related to the healthcare sector,and those who did not receive the CVD health brochure or are unaware of health self-assessment tools are likely to have lower levels of knowledge,risk perception,and poorer behavioural intention regarding cardiovascular health(Ptional level,smoking status,awareness about CVD poster,self-assessment tools were repeatedly significantly associated with knowledge related to CVD and CVD risk prevention,risk perception,behavioral intention and/or IHRS(Pthese findings underscore the importance of promoting car

关键词： Cardiovascular risk Knowledge Risk perception Behavioural intention INtERHEARt Middle-aged Lifestyle Physical activity Psychosocial stress

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所有的汽车都应该是电动的吗?

中学生英语 2024年第11期 31-32页

作者： brian S.McGrath 陈佳(译) 不详武汉市光谷五小

让更多的电动汽车上路的竞赛正在进行中。但根据2021年的一项调查,超过一半的美国成年人不希望逐步淘汰燃油汽车。让我们来看看国外学生的看法。

关键词：燃油汽车电动汽车逐步淘汰成年人

Explainable machine learning in materials science

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npj Computational Materials 2022年第1期8卷 1951-1969页

作者： Xiaoting Zhong brian Gallagher Shusen Liu Bhavya Kailkhura Anna Hiszpanski t.Yong-Jin Han Materials Science Division Lawrence Livermore National LaboratoryLivermoreCAUSA Center for Applied Scientific Computing Lawrence Livermore National LaboratoryLivermoreCAUSA

Machine learning models are increasingly used in materials studies because of their exceptional ***,the most accurate machine learning models are usually difficult to *** to this problem lie in explainable artificial intelligence(XAI),an emerging research field that addresses the explainability of complicated machine learning models like deep neural networks(DNNs).this article attempts to provide an entry point to XAI for materials *** are defined to clarify what explain means in the context of materials *** works are reviewed to show how XAI helps materials science *** and opportunities are also discussed.

关键词： explain learning plain

Preparing for OSHA's voluntary protection programs a guide to success brian t. Bennett, Norman R. Deitch.

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Changes in Lipoprotein Lipase in the Heart Following Diabetes Onset

2010年

作者： brian t. Bennett Norman R. Deitch.

来源：畅想之星图书光盘版（南... 评论

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Engineering 2023年第1期20卷 19-25页

作者： Chae Syng Lee Yajie Zhai brian Rodrigues Faculty of Pharmaceutical Sciences University of British ColumbiaVancouverBC V6T 1Z3Canada

Due to its constant pumping and contraction, the heart requires a substantial amount of energy, with fatty acids (FAs) providing a major part of its adenosine triphosphate (AtP). However, the heart is incapable of making this substrate and attains its FAs from multiple sources, including the action of lipoprotein lipase (LPL). LPL is produced in cardiomyocytes and subsequently secreted to its heparan sulfate proteoglycan (HSPG) binding sites on the plasma membrane. to then move LPL to the endothelial cell (EC) lumen, glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) attaches to interstitial LPL and transfers it to the vascular lumen, where the LPL is ready to perform its function of breaking down circulating triglycerides (tG) into FAs. the endo-β-glucuronidase heparanase (Hpa) is unique in that it is the only known mammalian enzyme to cleave heparan sulfate (HS), thereby promoting the abovementioned release of LPL from the cardiomyocyte HSPG. In diabetes, it has been suggested that changes in how the heart generates energy are responsible for the development of diabetic cardiomyopathy (DCM). Following moderate diabetes, with the reduction in glucose utilization, the heart increases its LPL activity at the vascular lumen due to an increase in Hpa action. Although this adaptation might be beneficial to compensate for the underutilization of glucose by the heart, it is toxic over the long term, as harmful lipid metabolite accumulation, along with augmented FA oxidation and thus oxidative stress, leads to cell death. this coincides with the loss of a cardioprotective growth factor—namely, vascular endothelial growth factor B (VEGFB). this review discusses interconnections between Hpa, LPL, and VEGFB and their potential implications in DCM. Given that mechanism-based therapeutic care for DCM is unavailable, understanding the pathology of this cardiomyopathy, along with the contribution of LPL, will help us advance its clinical ma

关键词： Cardiac metabolism Lipopr otein lipase Heparanase Vascular endothelial growth factor Diabetic car diomyopathy