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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a maj.r contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Continental velocity through Precambrian times:The link to magmatism,crustal accretion and episodes of global cooling

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Geoscience Frontiers 2013年第1期4卷 7-36页

作者： j.D.A.piper Geomagnetism Laboratory Geology and GeophysicsSchool of Environmental SciencesUniversity of Liverpool.Liverpool L69 7ZEUK

Quasi-integrity of continental crust between Mid-Archaean and Ediacaran times is demonstrated by conformity of palaeomagnetic poles to near-static positions between -2.7-2.2 Ga, -1.5-1.2 Ga and -0.75-0.6 Ga. Intervening data accord to coherent APW loops turning at ＂hairpins＂ focused near a continental-centric location. Although peripheral adj.stments occurred during Early Proterozoic （-2.2 Ga） and Grenville （- 1.1 Ga） times, the crust retained a low order symmetrical crescent-shaped form constrained to a single global hemisphere until break-up in Ediacaran times. Conformity of palaeomagnetic data to specific Eulerian parameters enables definition of a master Precambrian APW path used to estimate the root mean square velocity （VRMS） of continental crust between 2.8 and 0.6 Ga. A long interval of little polar movement between -2.7 and 2.2 Ga correlates with global magmatic shutdown between -2.45 and 2.2 Ga, whilst this interval and later slowdown at -0.75-0.6 Ga to velocities of 〈2 cm/year correlate with episodes of widespread glaciation implying that these prolonged climatic anomalies had an internal origin; the reduced input of volcanically-derived atmospheric greenhouse gases is inferred to have permitted freeze-over conditions with active ice sheets extending into equatorial latitudes as established by low magnetic inclinations in glaciogenic deposits. VRMS vari- ations through Precambrian times correspond to the distribution of U-Pb ages in orogenic granitoids and detrital zircons and demonstrate that mobility of continental crust has been closely related to crustal tectonism and incrementation. Both periods of near-stillstand were followed by rapid VRMS recording massive heat release from beneath the continental lid at -2.2 and 0.6 Ga. The first coincided with the Lomagundi-j.tuli isotopic event and led to prolonged orogenesis accompanied by continental flooding and reconfiguration of the crust on the Earth＇s surface; the second led to continental break-up and i

关键词： Continental velocity Precambrian Palaeopangaea Palaeomagnetism Magmatism Tectonics

Dominant Lid Tectonics behaviour of continental lithosphere in Precambrian times:Palaeomagnetism confirms prolonged quasi-integrity and absence of supercontinent cycles

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Geoscience Frontiers 2018年第1期9卷 61-89页

作者： j.D.A.piper Geomagnetism Laboratory Department of Earth and Ocean Sciences University of Liverpool

Although Plate Tectonics cannot be effectively tested by palaeomagnetism in the Precambrian aeon due to the paucity of high precision poles spanning such a long time period,the possibility of Lid Tectonics is eminently testable because it seeks accordance of the wider dataset over prolonged intervals of time;deficiencies and complexities in the data merely contribute to *** of palaeomagnetic poles across a quasi-integral continental crust for time periods of up to thousands of millions of years,together with recognition of very long intervals characterised by minimal polar motions(～2.6-2.0,～1.5-1.25 and～0.75-0.6 Ga)has been used to demonstrate that Lid Tectonics dominated this *** new PALEOMAGIA database is used to refine a model for the Precambrian lid incorporating a large quasiintegral crescentric core running from South-Central Africa through Laurentia to Siberia with peripheral cratons subj.ct to reorganisation at～2.1,～1.6 and～1.1 *** model explains low levels of tidal friction,reduced heat balance,unique petrologic and isotopic signatures,and the prolonged crustal stability of Earth's"Middle Age",whilst density concentrations of the palaeomagnetic poles show that the centre of the continental lid was persistently focussed near Earth's rotation axis from～2.8 to 0.6 *** exception was the～2.7-2.2 Ga interval defined by～90°polar movements which translated the periphery of the lid to the rotation pole for this quasi-static period,a time characterised by glaciation and low levels of magmatic activity;the～2.7 Ga shift correlates with key interval of mid-Archaean crustal growth to some 60-70%of the present volume and REE signatures whilst the～2.2 Ga shift correlates with the Lomagundiδ～(13)C and Great Oxygenation *** palaeomagnetic signature of breakup of the lid at～0.6 Ga is recorded by the world-wide Ediacaran development of passive margins and associated environmental signatures of new ocean *** event defined the end of a

关键词： Lid Tectonics Plate tectonics Archaean Proterozoic Palaeomagnetism PALEOMAGIA

Effect of Air Plasma Processing on the Adsorption Behaviour of Bovine Serum Albumin on Spin-Coated PMMA Surfaces

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j.urnal of Bionic Engineering 2008年第3期5卷 204-214页

作者： Chaozong Liu brian j. Meenan Advanced Materials and Biomaterials Research Centre School of Engineering The Robert Gordon University Aberdeen ABIO 1FR UK Northern ireland Bioengineering Centre University of Ulster Newtownabbey BT37 OQB Northern Ireland UK

This paper reports the adsorption of Bovine Serum Albumin （BSA） onto Dielectric Barrier Discharge （DBD） processed Poly（methyl methacrylate）（PMMA） surfaces by a Quartz Crystal Microbalance with Dissipation monitoring （QCM-D） technique. The purpose is to study the influence of DBD processing on the nature and scale of BSA adsorption on PMMA surface in vitro. It was observed that DBD processing improves the surface wettability of PMMA film, a fact attributable to the changes in surface chemistry and topography. Exposure of the PMMA to Phosphate Buffed Saline （PBS） solution in the QCM-D system resulted in surface adsorption which reaches an equilibrium after about 30 minutes for pristine PMMA, and 90 minutes for processed PMMA surface. Subsequent inj.ction of BSA in PBS indicated that the protein is immediately adsorbed onto the PMMA surface. It was revealed that adsorption behaviour of BSA on pristine PMMA differs from that on processed PMMA surface. A slower adsorption kinetics was observed for pristine PMMA surface, whilst a quick adsorption kinetics for processed PMMA. Moreover, the dissipation shift of protein adsorption suggested that BSA forms a more rigid structure on pristine PMMA surface that on processed surface. These data suggest that changes in wettability and attendant chemical properties and surface texture of the PMMA surface may play a significant role in BSA adsorption process.

关键词： in vitro test protein adsorption surface modification polymethylmethacrylate QCM-D

Crystalline compounds for remediation of rare-earth fission products:A review

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j.urnal of Rare Earths 2022年第3期40卷 365-380,I0001页

作者： Saehwa Chong brian j.Riley Zayne j.Nelson Pacific Northwest National Laboratory RichlandWA99352USA

Rare earth(RE)-containing crystals have been investigated as media for the immobilization of RE fission products from nuclear waste *** reprocessing of spent nuclear fuel,fission products including REs,alkalis,and alkaline earths released from the *** viable option to immobilize the RE fission products is to incorporate them into chemically durable crystalline phases in specific waste *** study summarizes the crystal structures and synthesis methods of six RE-containing compounds that have applications in remediation of RE fission *** compounds include oxyapatite(AE_(2)RE_(8)(SiO_(4))_(6)O_(2)),oxychloride(REOCl),borosilicate(RE_(3)BSi_(2)O_(10)),pyrochlore(RE_(2)M_(2)O_(7)),monazite(REPO_(4)),and perovskite(REMO_(3))where AE denotes alkaline earth metals and M denotes transition *** review provides an overview of literature on the usage of these six compounds for immobilizing RE fission products and summarizes different synthesis methods for producing these *** of structural parameters with different REs in each compound are also discussed.

关键词： Rare-earth compounds Nuclear waste forms Crystal structures Synthesis of rare-earth compounds

Trees are rarely most abundant where they grow best

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j.urnal of Plant Ecology 2012年第1期5卷 46-51页

作者： brian j.McGill School of Biology and Ecology and Sustainability Solutions Initiative 303 Deering HallUniversity of MaineOronoME 04469USA

Aims A common assumption in ecology is that where a species is found to be most abundant must correspond to the environmental context in which the species performs the best(*** niche space).This assumption is central to common conservation and management tools such as habitat suitability assessment and species distribution modeling.I test this *** I use the US Forest Inventory Assessment data for the abundance of trees across eastern North America.I use the FORAST tree-ring dataset for ontogenetic growth rate(tree-ring increment),a measure of niche performance and correlated with intrinsic rate of increase,*** Findings I find that across 15 species,there are significantly more negative correlations than expected by *** negative correlation between abundance and performance across space contradicts common assumptions but is consistent with an inclusive niche structuring of the community.

关键词： tree rings biogeography inclusive niche climate change

Learning from Taiyuan: Chinese cities as urban sustainability laboratories

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Geography and Sustainability 2020年第2期1卷 118-126页

作者： piper Gaubatz Dean Hanink Department of Geosciences University of Massachusetts AmherstAmherstMA 01003United States Department of Geography University of ConnecticutStorrsCT 06209United States

China and the United States are the two most significant nations in the contemporary global food and agricultural *** addition,they are two of the most important innovators with respect to the development of new crop varieties,agro-technologies,farm products,markets and consumer issues,such as consumer resistance to genetically modified foods,among *** the face of an ever-complex web of interactions,technologies and products among producers and consumers in both nations,there are far more structural similarities than differences in the food and agriculture sectors of these two *** essay,adopting some of the themes of the Sino-American Symposium on Future Issues Affecting Quality of Life,presents a limited but representative comparative assessment of three of the most important shared challenges impacting the agricultural sectors of China and the United States for the period from 2000 to the present including 1)environmental challenges related to agricultural water supply,2)declines in farm labor and rural population,and 3)growing food-related concerns and *** both nations,excessive and unsustainable groundwater consumption has lowered water tables and limited crop *** populations and farm workforces in both nations are also declining,leading to labor challenges in both ***,concerns regarding food safety are also very similar with maj.r challenges to the farm sector associated with consumer resistance to genetically modified food crops and sanitation issues linked to lengthening supply *** of these issues threaten the development of sustainable agricultural production systems.

关键词： Agriculture Food safety China United States Sino-US comparative study

The impact of seasonality on multi-scale feature extraction techniques

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International j.urnal of Digital Earth 2020年第1期13卷 9-21页

作者： brian Moore j.cob j.McKee Geographic Information Science and Technology Group Computational Sciences and Engineering DivisionOak Ridge National LaboratoryOak RidgeTNUSA

A key component in constructing a broad-scale,gridded population dataset is fine resolution geospatial data accurately depicting the extent of human *** datasets are often developed using a wide range of methods and classification techniques,including the use of spatial features,spectral features,or the coupling of both to identify the presence of man-made structures from high-resolution satellite *** using spatial and textural-based descriptors to generate highresolution settlement layers for two dissimilar regions at the peak of seasonal disparity,this study attempts to quantify the influence of seasonality on the accuracy of a supervised,multi-scale,feature extraction framework for automated delineation of human *** generated by numerous models are evaluated against a reference dataset allowing for assessment of seasonal and feature differences in the context of *** or regional mapping of human settlement requires the assemblage of high-resolution satellite images with variegated acquisition characteristics(season,sun elevation,off-nadir,etc.)to produce a cloud-free composite image from which features are *** of this study suggest an emphasis on imagery criteria,in particular acquisition date,could improve classification accuracy when mapping human settlement at scale.

关键词： Remote sensing highresolution imagery image processing human settlement accuracy

The endogenous progenitor response following traumatic brain inj.ry:a target for cell therapy paradigms

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Neural Regeneration Research 2022年第11期17卷 2351-2354页

作者： Anna Badner brian j.Cummings Department of Psychiatry and Behavioral Sciences Stanford UniversityPalo AltoCAUSA Sue and Bill Gross Stem Cell Center University of California-IrvineIrvineCAUSA Institute for Memory Impairments and Neurological Disorders University of California-IrvineIrvineCAUSA Physical Medicine and Rehabilitation University of California-IrvineIrvineCAUSA Department of Anatomy and Neurobiology University of California-IrvineIrvineCAUSA

Although there is ample evidence that central nervous system progenitor pools respond to traumatic brain inj.ry,the reported effects are variable and likely contribute to both recovery as well as *** a better understanding of the diverse progenitor populations in the adult brain and their niche-specific reactions to traumatic insult,treatments can be tailo red to enhance the benefits and dampen the deleterious effects of this *** review provides an overview of endogenous precursors,the associated effects on cognitive recovery,and the potential of exogenous cell therapeutics to modulate these endogenous repair *** the hippocampal dentate gyrus and subventricular zone of the lateral ventricles,more recently identified sites of adult neurogenesis,the meninges,as well as circumventricular organs,are also discussed as targets for endogenous ***,this review highlights that progenitor prolife ration alone is no longer a meaningful outcome and studies must strive to better chara cterize precursor spatial localization,transcriptional profile,morphology,and functional synaptic *** improved insight and a more targeted approach,the stimulation of endogenous neurogenesis remains a promising strategy for recovery following traumatic brain inj.ry.

关键词： cell therapy endogenous repair neurogenic niche progenitors traumatic brain inj.ry