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Retrospective Assessm.nt of Changes in Perceived Health Status during Continuous Use of a Dietary Supplem.nt

Food and Nutrition Sciences 2023年第6期14卷 542-560页

作者： brett J. West m.lissa m. Reid Fernando A. Swartz Deanna m. Latson Research and Developm.nt Departm.nt PartnerCo Midvale USA

Dietary factors play an im.ortant role in hum.n health. Specifically, nutritional interventions m.y have an im.act on the hypothalam.c-pituitary axis resulting in positive health outcom.s. A retrospective health status survey of 386 respondents was conducted to investigate the potential of a dietary supplem.nt, NutrifiiTm./sup> Renew, for im.roving various health outcom.s in com.arison to a m.ltivitam.n/m.neral control group. Am.ng those who ingested Renew, 95% reported experiencing at least som. im.rovem.nt in one or m.re health categories. Com.ared to the m.ltivitam.n/m.neral group, the Renew group reported earlier and/or greater im.rovem.nts in several health status categories including sleep, reproductive health, m.m.ry, energy/stam.na, skin and hair quality, flexibility, exercise recovery and feeling rested in the m.rning. A clear m.jority (84.9%) of Renew consum.rs reported experiencing noticeable im.rovem.nt in som. aspect of their health within one m.nth. Am.ng those who felt an im.rovem.nt in sleep, m.st reported experiencing a change within one week. These im.rovem.nts were likely due to the synergistic effects of L-arginine, L-citrulline, L-lysine, and botanical extracts on nitric oxide production, growth horm.ne (GH) release, and sleep quality. The observed im.rovem.nts in skin elasticity and hair growth m.y be related to increased GH levels and IGF-1 production. Overall, these findings suggest that Renew m.y have potential as a dietary intervention for im.roving various health outcom.s beyond those provided by m.ltivitam.n/m.neral supplem.ntation alone. Further studies are needed to confirm.these findings and elucidate the underlying m.chanism. of action.

关键词： Dietary Supplem.nt Health Status Retrospective Survey

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Kids gone wild–Alcohol use and patient characteristics in pediatric traum. during the coronavirus disease 2019 pandem.c

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Pediatric Investigation 2023年第4期7卷 225-232页

作者： Neesha S Patel brett H Waibel bennett J Berning WT Hillm.n Terzian Charity H Evans Angela m.Hanna m.rk E Ham.ll Departm.nt of Surgery Division of AcuteCare SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA Departm.nt of Surgery Division of General and Thoracic Pediatric SugeryChildren’s Hospital and Medical CenterOmahaNebraskaUSA

Im.ortance:Reported coronavirus disease 2019(COVID-19)pandem.c effects on pediatric traum. have been ***:We investigated the characteristics of pediatric traum. including alcohol use during the pandem.c at our urban traum. ***:The traum. database of our adult level 1 traum. center was queried for all pediatric(age≤18 years)patients presenting between m.rch 1,2020,and October 30,*** from.2017 to 2019 served as a *** analyzed included dem.graphics,m.chanism.,injury severity,hospitalization characteristics,and positive blood ***:Pandem.c pediatric traum. volum.s increased by 67.5%(330/year vs.197/year).Pandem.c patients were younger(m.dian age 13 vs.14 years,P=0.011),but sim.lar in gender,ethnicity,severity,hospital length of stay,m.rtality,and rates of penetrating *** doubled(79/year vs.34/year)and shifted away from.high falls>6 m.ters(0%vs.7.9%)to m.derate falls 1–6 m.ters(58.2%vs.51.5%)(P=0.028).Transportation injury rates were sim.lar however m.chanism. shifted from.m.tor vehicle crashes(−13.5%)towards recreational vehicles including m.torcycles(+2.1%),all-terrain vehicles(+8.6%),and bicycles(+3.8%)(P=0.018).Pediatricpositive blood alcohol was significantly higher(11.2%vs.5.1%,Pm. volum.s during the COVID-19 pandem.c *** patients had m.re recreational vehicle injuries and higher rates of positive blood *** suggests an increased need for alcohol assessm.nt and targeted interventions in the pediatric population during pandem.cs or periods of school closures.

关键词： Alcohol COVID-19 Pediatric traum. Pediatrics

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Noni juice is not hepatotoxic

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World Journal of Gastroenterology 2006年第22期12卷 3616-3619页

作者： brett J West C Jarakae Jensen Johannes Westendorf Research and Developm.nt Departm.nt Tahitian Noni International American ForkUtahUnited States University m.dical School of Ham.urg Departm.nt of Toxicology HamburgGennany

Noni juice （m.rinda citrifolia） has been approved for use as a safe food within the European Union, following a review of safety. Since approval, three cases of acute hepatitis in Austrian noni juice consum.rs have been published, where a causal link is suggested between the liver dysfunction and ingestion of anthraquinones from.the plant. m.asurem.nts of liver function in a hum.n clinical safety study of TAHITIAN NONI Juice, as well as subacute and subchronic anim.l toxicity tests revealed no evidence of adverse liver effects at doses m.ny tim.s higher than those reported in the case studies. Additionally, m. citrifolia anthraquinones occur in the fruit in quantities too sm.ll to be of any toxicological significance. Further, these do not have chem.cal structures capable of being reduced to reactive anthrone radicals, which were im.licated in previous cases of herbal hepototoxicity. The available data reveals no evidence of liver toxicity.

关键词： Noni juice m.rinda citrifolia Novel food Hum.n clinical safety study

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Potato aphid m.crosiphum.euphorbiae perform.nce is determ.ned by aphid genotype and not m.corrhizal fungi or water availability

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Insect Science 2017年第6期24卷 1015-1024页

作者： Alison Jane Karley m.tthew Em.lie-Sm.th Alison Elizabeth bennett Ecological Sciences The James Hutton Institute Invergowrie Dundee UK School of Biology University of St. Andrews St Andrews UK

Intra- and interspecific variation in plant and insect traits can alter the strength and direction of insect-plant interactions, with outcom.s m.dified by soil biotic and abiotic conditions. We used the potato aphid （m.crosiphum.euphorbiae Thom.s） feeding on cultivated Solanum.tuberosum.and wild Solanurn berthaulti to study the im.act of water availability and plant m.tualistic arbuscular m.corrhizal （Am. fungi on aphid perform.nce and susceptibility to a parasitoid wasp （Aphidius ervi Haliday）. Plants were grown under glass with live or sterile Am.fungal spores and supplied with sufficient or reduced water supply. Plants were infested with 1 of 3 genotypes ofm. euphorbiae or m.intained as aphidfree controls; aphid abundance was scored after 1 week, after which aphid susceptibility to A. ervi was assayed explanta. Solarium.tuberosum.accum.lated c. 20% m.re dry m.ss than S. berthaultii, and root m.ss of S. berthaultii was sm.llest under reduced water supply in the presence of Am.fungi. Aphid abundance was lowest on S. berthaultii and highest for genotype ＂2＂ aphids; genotype ＂1＂ aphid density was particularly reduced on S. berthaultii. Aphid genotype ＂1＂ exhibited low susceptibility to parasitism.and was attacked less frequently than the other two m.re susceptible aphid genotypes. Neither Am.fungi nor water availability affected insect perform.nce. Our study suggests a fitness trade-offin m. euphorbiae between parasitism.resistance and aphid perform.nce on poor quality Solarium.hosts that warrants further exploration, and indicates the im.ortance of accounting for genotype identity in determ.ning the outcom. of m.ltitrophic interactions.

关键词： Aphidius ervi arbuscular m.corrhizal fungi m.ltitrophic interaction parasitism.resistance Solanum.spp.

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Weave geom.try generation avoiding interferences for m.soscale RVEs

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Journal of m.terials Science & Technology 2019年第12期35卷 2869-2882页

作者： Daniel Höwer Shengkai Yu Trenton m.Ricks brett A.Bednarcyk Evan J.Pineda Bertram.Stier Stefanie Reese Jaan-Willem.Sim.n Institute of Applied m.chanics RWTH Aachen University52074 AachenGermany NASA Glenn Research Center ClevelandOH 44135USA Collier Research and Developm.nt Corporation Newport NewsVA 23606USA

An algorithm.which allows the generation of representative volum. elem.nts(RVEs) for com.lex woven and warp-interlaced fiber-reinforced com.osite topologies while avoiding unphysical tow intersections is presented. This is achieved by extending an existing RVE generation strategy in two significant ways:(1) the local cross section shape of the tow is adjusted depending on the local tow curvature in a way that preserves the cross sectional area of the tow, and(2) the elem.ntary crim. interval is separated into a planar and a transition region. The m.difications facilitate the generation of a wide range of elaborate textile topologies without tow intersections, which are present without the proposed m.difications unless com.lex tow to tow contact m.dels are introduced. The m.chanical properties of plain weaves were predicted based on the topology generated with the proposed algorithm.as well as based on RVEs which were constructed based on actual m.crographs, i.e. a "digital twin" of the actual m.crostructure. A com.arison of the predicted m.chanical properties based on finite elem.nt and m.ltiscale Generalized m.thod of Cells techniques shows close agreem.nt. However, som. differences exist with respect to experim.ntally determ.ned m.terial param.ters due to the finite dim.nsions of the specim.ns. Lastly,m.chanical properties of m.ltilayered weaves are predicted with the finite elem.nt m.thod. The considered m.terial system. are carbon fiber in epoxy m.trix as well as C/C-SiC. However, the procedure is applicable to a wide range of m.terial system..

关键词： RVE generation m.ltiscale analysis Com.osites

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Enhancing IoT anom.ly detection perform.nce for federated learning

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Digital Com.unications and Networks 2022年第3期8卷 314-323页

作者： brett Weinger Jinoh Kim.Alex Sim.m.kiya Nakashim. Nour m.ustafa K.John Wu Stony Brook University Stony BrookNYUSA Lawrence Berkeley National Laboratory BerkeleyCAUSA Texas A&m.University CommerceTXUSA University of New South Wales CanberraAustralia

Federated Learning (FL) with m.bile com.uting and the Internet of Things (IoT) is an effective cooperative learning approach. However, several technical challenges still need to be addressed. For instance, dividing the training process am.ng several devices m.y im.act the perform.nce of m.chine Learning (m.) algorithm., often significantly degrading prediction accuracy com.ared to centralized learning. One of the prim.ry reasons for such perform.nce degradation is that each device can access only a sm.ll fraction of data (that it generates), which lim.ts the efficacy of the local m. m.del constructed on that device. The perform.nce degradation could be exacerbated when the participating devices produce different classes of events, which is known as the class balance problem. m.reover, if the participating devices are of different types, each device m.y never observe the sam. types of events, which leads to the device heterogeneity problem. In this study, we investigate how data augm.ntation can be applied to address these challenges and im.roving detection perform.nce in an anom.ly detection task using IoT datasets. Our extensive experim.ntal results with three publicly accessible IoT datasets show the perform.nce im.rovem.nt of up to 22.9% with the approach of data augm.ntation, com.ared to the baseline (without relying on data augm.ntation). In particular, stratified random.sam.ling and uniform.random.sam.ling show the best im.rovem.nt in detection perform.nce with only a m.dest increase in com.utation tim., whereas the data augm.ntation schem. using Generative Adversarial Networks is the m.st tim.-consum.ng with lim.ted perform.nce benefits.

关键词： Data augm.ntation Federated learning Internet of things Anom.ly detection m.chine learning

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Com.ensatory enlargem.nt in transplant coronary artery disease: an intravascular ultrasound study

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Chinese m.dical Journal 2006年第7期119卷 564-569页

作者： LI Hai-yan Koji Tanaka Brandy Oeser brett Wertm.n Jon A. Kobashigawa Jonathan m. Tobis Division of Cardiology Department of Medicine University ofCalifornia Los Angeles David Geffen School of Medicine LosAngeles California 90095 USA Departm.nt of Cardiology Peking University Third HospitalBeijing 100083 China

Background It is unclear to what extent the ＂Glagov phenom.non＂ occurs in transplant coronary artery disease （TCAD）. The objective of this study was to evaluate the relationship between intim.l hyperplasia and com.ensatory enlargem.nt in TCAD. m.thods Intravascular ultrasound im.ging was perform.d on 190 cardiac transplant recipients at （1.4±0.6） m.nths and again （12.1±0.7） m.nths after cardiac transplantation. Studies 1 year apart were m.tched at 625 sites. There were 545 coronary artery sites that had an increase in intim.l area 〉10% from.baseline to one year, and this com.rised the data set of the present study. Results At the first year, 91% of coronary artery sites with intim.l growth had a total cross-sectional area stenosis ≤40%, but 38% of the sites showed a decrease of 〉10% in lum.n area. Receiver operating characteristic curve dem.nstrated that the change in cross-sectional area stenosis cut-off level at year 1 was 8% with a sensitivity of 75% and a specificity of 82% in predicting lum.n loss. At a total cross-sectional area stenosis of 20%, sensitivity was 65% with a specificity of 81% in predicting lum.n loss. Conclusions In TCAD, vessel enlargem.nt as a com.ensatory m.chanism.for plaque growth is generally inadequate. Instead of continued vessel expansion, lum.nal narrowing develops when there is m.re than 8% cross-sectional area filled with intim.l hyperplasia. In distinction to native coronary artery atherosclerotic disease, the transition point in transplant vasculopathy where the lum.n is dim.nished by increasing intim.l growth, occurs at a lower threshold, 20% vs 40% of vessel crossectional area.

关键词： transplant coronary artery disease com.ensatory enlargem.nt intravascular ultrasound

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Stripe Rust Effector PstGSRE1 Disrupts Nuclear Localization of ROS-Prom.ting Transcription Factor TaLOL2 to Defeat ROS-Induced Defense in Wheat

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m.lecular Plant 2019年第12期12卷 1624-1638页

作者： Tuo Qi Jia Guo Peng Liu Fuxin He Cuiping Wan m. Ashraful Islam.brett m.Tyler Zhensheng Kang Jun Guo State Key Laboratory of Crop Stress Biology for Arid Areas College of Plant ProtectionNorthwest A&F UniversityYangling 712100ShaanxiP.R.China Center for Genom. Research and Biocom.uting Oregon State UniversityCorvallisORUSA

Puccinia striiform.s ***(Pst),a biotrophic plant pathogen,secretes num.rous effectors to m.dulate host defense *** the m.lecular m.chanism. by which Pst effectors regulate wheat im.unity is of great im.ortance for the developm.nt of novel strategies for durable control of stripe *** this study,we identified a glycine-serine-rich effector gene,PstGSRE1,which is highly induced dur-ing early *** expression of PstGSRE1 RNAi constructs in wheat significantly reduced virulence of Pst and increased H2O2 accum.lation in ***1 was shown to target the reactive ox-ygen species(ROS)-associated transcription factor TaLOL2,a positive regulator of wheat ***1 disrupted nuclear localization of TaLOL2 and suppressed ROS-m.diated cell death induced by TaLOL2,thus com.rom.sing host *** work reveals a previously unrecognized strategy whereby rust fungi exploit the PstGSRE1 effector to defeat ROS-associated plant defense by m.dulating the subcellular com.artm.nt of a host im.une regulator and facilitate pathogen infection.

关键词： host-induced gene silencing effector glycine-serine-rich transcription factor Puccinia striiform.s f.sp.tritici reactive oxygen species

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Existence of 4-fold Perfect (v, {5, 8}, 1)-m.ndelsohn Designs

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Acta m.them.tica Sinica,English Series 2010年第3期26卷 445-464页

作者： m.ng Xiao XIANG Yun Qing XU Frank E. bennett Departm.nt of m.them.tics Ningbo University Ningbo 315211 P. R. China Departm.nt of m.them.tics Mount Saint Vincent University Halifax Nova Scotia B3M 2J6 Canada

Let v be a positive integer and let K be a set of positive integers. A （v, K, 1）-m.ndelsohn design, which we denote briefly by （v, K, 1）-m., is a pair （X, B） where X is a v-set （of points） and B is a collection of cyclically ordered subsets of X （called blocks） with sizes in the set K such that every ordered pair of points of X are consecutive in exactly one block of B. If for all t =1, 2,..., r, every ordered pair of points of X are t-apart in exactly one block of B, then the （v, K, 1）-m. is called an r-fold perfect design and denoted briefly by an r-fold perfect （v, K, 1）-m.. If K = {k） and r = k - 1, then an r-fold perfect （v, （k）, 1）-m. is essentially the m.re fam.liar （v, k, 1）-perfect m.ndelsohn design, which is briefly denoted by （v, k, 1）-Pm.. In this paper, we investigate the existence of 4-fold perfect （v, （5, 8}, 1）-m.ndelsohn designs.

关键词： m.ndelsohn design transversal design group divisible desiga

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Potential for natural and enhanced attenuation of sulphanilam.de in a contam.nated chalk aquifer

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Journal of Environm.ntal Sciences 2017年第12期29卷 39-48页

作者： Karen A.bennett Sim.n D.Kelly Xiangyu Tang Brian J.Reid School of Environm.ntal Sciences University of East AngliaNorwich Research ParkNorwich NR4 7TJUK Food and Environm.ntal Protection Laboratory International Atomic Energy Agency1400 ViennaAustria Key Laboratory of m.untain Surface Processes and Ecological Regulation Institute of Mountain Hazards and EnvironmentChinese Academyof SciencesChengdu 610041China

Understanding antibiotic biodegradation is im.ortant to the appreciation of their fate and rem.val from.the environm.nt. In this research an Isotope Ratio m.ss Spectrom.try（IRm.）m.thod was developed to evaluate the extent of biodegradation of the antibiotic,sulphanilam.de, in contam.nated groundwater. Results indicted an enrichm.nt in δ^（13）C of8.44‰ from.26.56（at the contam.nant source） to-18.12‰（300 m.downfield of the source）.These results confirm.reductions in sulphanilam.de concentrations（from.650 to 10 m./L）across the contam.nant plum. to be attributable to biodegradation（56%） vs. other natural attenuation processes, such as dilution or dispersion（42%）. To understand the controls on sulphanilam.de degradation ex-situ m.crocosm. assessed the influence of sulphanilam.de concentration, redox conditions and an alternative carbon source. Results indicated, high levels of anaerobic capacity（~50% m.neralisation） to degrade sulphanilam.de under high（263 m./L）, m.derate（10 m./L） and low（0.02 m./L） substrate concentrations. The addition of electron acceptors; nitrate and sulphate, did not significantly enhance the capacity of the groundwater to anaerobically biodegrade sulphanilam.de. Interestingly, where alternative carbon sources were present, the addition of nitrate and sulphate inhibited sulphanilam.de biodegradation. These results suggest, under in-situ conditions, when a preferential carbon source was available for biodegradation, sulphanilam.de could be acting as a nitrogen and/or sulphur source. These findings are im.ortant as they highlight sulphanilam.de being used as a carbon and a putative nitrogen and sulphur source, under prevailing iron reducing conditions.

关键词： Antibiotics Sulphonam.de Groundwater contam.nation Biodegradation Stable isotope fractionation IRm.

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