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养猪 2012年第3期 32-32页

作者： Miriam Goerke brenda de Rodas 石文标

仔猪断奶早期的饲粮采食是必不可少的，它会影响猪整个肥育期的生产性能表现，这一点近年来已得到公认。随着科技的进步，除了代乳品、哺乳仔猪干料和开食料，另一种新型的仔猪饲料现在正进入市场：凝胶饲料。

关键词：仔猪营养饲料饲喂凝胶断奶早期生产性能哺乳仔猪仔猪饲料肥育期

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50岁之后的健身管理

50岁之后的健身管理

Boceprevir early-access for advanced-fibrosis/cirrhosis in Asia-pacific hepatitis C virus genotype 1 non-responders/relapsers

作者： (英)沃尔特·H.艾丁格(Walter H. Ettinger)，(英)布伦达·S.莱特(brenda S. Wright)，(英)史蒂芬·N.布莱尔(Steven N. Blair)

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World Journal of Gastroenterology 2015年第28期21卷 8660-8669页

作者： Wattana Sukeepaisarnjaroen Tri Pham Tewesak Tanwandee Saroja Nazareth Sam Galhenage Lindsay Mollison Leanne Totten Alan Wigg Rosalie Altus Anton Colman brenda Morales Sue Mason Tracey Jones Nadine Leembruggen Vince Fragomelli Cheryl Sendall Richard Guan Dede Sutedja Soek Siam Tan Yock Young Dan Yin Mei Lee Widjaja Luman Eng kiong Teo Yin Min Than Teerha Piratvisuth Seng Gee Lim Srinagarind Hospital Cabramatta Practice Siriraj Hospital Bangkok Royal Perth Hospital Fremantle Hospital Flinders Medical Centre Royal Adelaide Hospital Austin Hospital Royal Prince Alfred Hospital John Hunter Hospital Nepean Hospital Cairns Base Hospital Mount Elizabeth Medical Centre Gleneagles Hospital Selayang Hospital National University Health System Yong Loo Lin School of Medicine National University of Singapore Changi General Hospital NkC Institute of Gastroenterology and Hepatology Prince of Songkla University

AIM:To examined the efficacy and safety of treatment with boceprevir,PEGylated-interferon and ribavirin(PR)in hepatitis C virus genotype 1(HCVGT1) PR treatmentfailures in ***:The Boceprevir Named-Patient Program provided boceprevir to HCVGT1 PR *** physicians were invited to contribute data from their patients:baseline characteristics,ontreatment responses,sustained virological response at week 12(SVR12),and safety were collected and *** analysis was performed to determine predictors of ***:150 patients were enrolled from Australia,Malaysia,Singapore and Thailand(Asians = 86,Caucasians = 63).Overall SVR12 was 61%(Asians= 59.3%,Caucasians = 63.5%).SVR12 was higher in relapsers(78%) compared with non-responders(34%).On-treatment responses predicted SVR,with undetectable HCVRNA at week 4,8 and 12 leading to SVR12 s of 100%,87%,and 82%respectively,and detectable HCVRNA at week 4,8 and 12,leading to SVR12 s of 58%,22%and 6%*** patients were similar to Caucasian patients with regards to on-treatment *** with cirrhosis(n= 69) also behaved in the same manner with regards to on-treatment *** with the IL28 B CC genotype(80%) had higher SVRs than those with the CT/TT(56%) genotype(P = 0.010).Multivariate analysis showed that TW8 and TW12 responses were independent predictors of *** adverse events occurred in 18.6%:sepsis(2%),decompensation(2.7%) and blood transfusion(14%).Discontinuations occurred in 30.7%,with 18.6%fulfilling stopping ***:Boceprevir can be used successfully in PR treatment failures with a SVR12 > 80%if they have good on-treatment responses;however,discontinuations occurred in 30%because of virological failure or adverse events.

关键词： Chronic hepatitis C Treatment failure Rapid virological response Lead-in Null response Partial response Relapse Cirrhosis Response guidedtherapy

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低剂量苯暴露与接苯工人精子非整倍体相关

低剂量苯暴露与接苯工人精子非整倍体相关

中国毒理学会第三届中青年学者科技论坛暨2011年全国前列腺药理毒理学研讨会

作者：邢彩虹 Marchetti Francesco 李桂兰 Weldon Rosana H kurtovich Elaine Young Suzanne Schmid Thomas E 张罗平 Rappaport Stephen Waidyanatha Suramya Wyrobek Andrew J Eskenazi brenda 中国疾病预防控制中心职业卫生与中毒控制美国劳伦斯伯克利国家实验室美国加利福尼亚大学公共卫生学院美国南加利福尼亚大学

背景:苯是广泛存在的工业化学物,高浓度的苯暴露(>10ppm)可引起白血病和其他血液疾病,以及人外周血及精子非整倍体。近期报道,小于1ppm的苯暴露浓度可

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Cochrane脑卒中组简介

中国循证医学杂志 2005年第2期5卷 177-178页

作者： Hazel Fraser brenda Thomas Peter Sandercock 曾亚莉 Department of Clinical Neurosciences Western General HospitalCrewe RoadEdinburghUK

1 Cochrane脑卒中组于1993年8月注册的Cochrane脑卒中组是Cochrane协作网50个系统评价组之一,其编辑部设在英国爱丁堡西区综合医院的爱丁堡大学临床神经科学系.……

关键词： Cochrane脑卒中组卒中

遭受攻击情况下Ad hoc网络生存能力预测

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通信对抗 2013年第3期32卷 50-55页

作者： Jaime C.Acosta brenda G. Medina 杨红娃(翻译) U.S. Army Research LaboratoryWhite Sands Missile Range NM 88002-5513 不详

网络生存能力分析主要研究在攻击等意外事件中网络实体正常运行的能力。目前,为搞清某种攻击对网络的影响,通常需要在数千种配置情况下运行数千种场景来测试Ad hoc网络的生存能力。然而,此方法的效果并不能令人信服:配置方式是人为选择... 详细信息

网络生存能力分析主要研究在攻击等意外事件中网络实体正常运行的能力。目前,为搞清某种攻击对网络的影响,通常需要在数千种配置情况下运行数千种场景来测试Ad hoc网络的生存能力。然而,此方法的效果并不能令人信服:配置方式是人为选择或随机的,测试结论不能推广到其它场景。针对这些问题,提出了一种提高生存能力分析效率的新方法,该方法使用机器学习和以攻击者为中心的网络表示法。收集了一个数据集并用其构造了一个分类器,该分类器准确(正确率大于97%)预测了网络欺骗和数据转发攻击造成的数据流损失。

关键词： Adhoc网络网络生存攻击者能力预测正常运行网络实体意外事件

Erratum to “BME 2.0: Engineering the Future of Medicine”

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Biomedical Engineering Frontiers 2023年第1期4卷 29-29页

作者： Michael I.Miller Andrew O.Brightman Frederick H.Epstein k.Jane Grande-Allen Jordan J.Green Eileen Haase Cato T.Laurencin Elizabeth Logsdon Feilim Mac Gabhann brenda Ogle Chun Wang George R.Wodicka Raimond L.Winslow Department of Biomedical Engineering Johns Hopkins UniversityBaltimoreMDUSA Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteINUSA Biomedical Engineering University of VirginiaCharlottesvilleVAUSA Department of Bioengineering Rice UniversityHoustonTXUSA Department of Biomolecular Engineering and Department of Orthopaedic Surgery University of ConnecticuttStorrsCTUSA Department of Biomedical Engineering University of Minnesota-Twin CitiesMinneapolisMNUSA

In the article“BME 2.0:Engineering the Future of Medicine”[1],the competing interests statement was inadvertently omitted by the publisher from the published version of the *** has now been corrected in the PDF and ... 详细信息

关键词： HTML BME text

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产前和产后双酚A暴露和童年体质指数

环境与职业医学 2013年第7期30卷 554-554页

作者： kim G.Harley Raul Aguilar Schall Jonathan Chevrier kristin Tyler Helen Aguirre Asa Bradman Nina T.Holland Robert H.Lustig Antonia M.Calafat brenda Eskenazi

[背景]双酚A(BPA)是一种广泛使用的内分泌干扰化学物,与啮齿类动物体重增加和脂肪沉积有关联。[目的]在CHAMACOS纵向队列的9岁儿童组(n=311)中,研究产前和产后尿BPA浓度与体质指数(BMI)、腰围、体脂肪率和肥胖间的关联。[方法]采集母亲... 详细信息

[背景]双酚A(BPA)是一种广泛使用的内分泌干扰化学物,与啮齿类动物体重增加和脂肪沉积有关联。[目的]在CHAMACOS纵向队列的9岁儿童组(n=311)中,研究产前和产后尿BPA浓度与体质指数(BMI)、腰围、体脂肪率和肥胖间的关联。[方法]采集母亲怀孕期间现场收集的两次尿样以及5岁和9岁儿童的尿样,测量BPA浓度。[结果]产前尿BPA浓度与9岁女孩BMI降低有关联,但在男孩中无此关联。在女孩中,位于产前BPA浓度最高的三分位数与BMI z分值降低(β=-0.47,95%CI:-0.87～-0.07)和体脂肪率降低(β=-4.36,95%CI:-8.37～-0.34)有关联;与位于最低三分位数组的女孩相比,超重/肥胖的风险下降[比值比(OR)=0.37,95%CI:0.16～0.91]。这些发现在青春期前期的女孩中最强。5岁时的尿BPA浓度与5岁或9岁时任何人体测量学参数没有相关性,在9岁时的BPA浓度与男孩和女孩9岁时的BMI、腰围、脂肪量、超重/肥胖呈正相关。[结论]本研究的发现与其他横断面研究相一致,9岁时尿BPA浓度较高与9岁时肥胖增加相关联。然而,母亲怀孕期间BPA浓度增加与他们的女儿9岁时BMI、体内脂肪和超重/肥胖降低有关联。

关键词：双酚A BMI CHAMACOS 儿童肥胖

SARS-CoV-2 productively infects primary human immune system cells in vitro and in CoviD-19 patients

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Journal of Molecular Cell Biology 2022年第4期14卷 51-64页

作者： Marjorie C.Pontelli italo A.Castro Ronaldo B.Martins Leonardo La Serra Flavio P.Veras Daniele C.Nascimento Camila M.Silva Ricardo S.Cardoso Roberta Rosales Rogério Gomes Thais M.Lima Juliano P.Souza brenda C.Vitti Diego B.Caetite Mikhael H.F.de Lima Spencer D.Stumpf Cassandra E.Thompson Louis-Marie Bloyet Juliana E Toller-kawahisa Marcela C.Giannini Leticia P.Bonjorno Marial.F.Lopes Sabrina S.Batah Li Siyuan Rodrigo Luppino-Assad Sergio C.L.Almeida Fabiola R.Oliveira Maira N.Benatti Lorena L.F.Pontes Rodrigo C.Santana Fernando C.Vilar Maria Auxiliadora-Martins Pei-Yong Shi Thiago M.Cunha Rodrigo T.Calado JoséC.Alves-Filho Dario S.Zamboni Alexandre T.Fabro Paulo Louzada-Junior Rene D.R.Oliveira Sean P.J.Whelan Fernando Q.Cunha Eurico Arruda Virology Research Center Ribeirao Preto Medical SchoolUniversity of Sao Pauloibeirao PretoSao Paulo 14049-900.Brazil Center of Research in Inflammatory Diseases Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Celland Molecular Biology Ribeirao Preto Medical SchoolUniversityof Sao PauloRibeirao PretoSao Paulo 14049-900 Brazil Regional Blood Centerof Ribeirao Preto Ribeirao Preto Medical ScholUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Biochemistry&Molecular Biology the University of Texas Medical BranchGalvestonTX7755USA Divisions of Clinical lmmunology Infectious Diseases and Intensive Care UnitRibeirao Preto Medical Schooniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Pathology Ribeirao Preto Medical Scholniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Molecular Microbiology.Washington University in St.Louis Saint LouisMO 63110USA

The severe acute respiratory syndrome coronavirus 2(SARS-CovV-2)infection is associated with a hyperinflammatory state and lymphocytopenia,a hallmark that appears as both signature and prognosis of disease severity *** cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion,it is still unclear whether direct SARS-Cov-2 infection of immune cells could also play a role in this scenario by harboring viral *** found that monocytes,as well as both B and T lymphocytes,were susceptible to SARS-Cov-2 infection in vitro,accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell *** addition,flow cytometry and immunofluorescence analysis revealed that SARS-Cov-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019(CoVID-19)*** rates of SARS-Cov-2-infected monocytes in peripheral blood mononuclear cells from CoVID-19 patients increased over time from symptom onset,with SARS-CoV-2-positive monocytes,B cells,and CD4+T lymphocytes also detected in postmortem lung *** results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in covID-19 patients might have important implications for disease pathogenesis and progression,immune dysfunction,and virus spread within the host.

关键词： SARS-CoV-2 CoVID-19 lymphocytopenia peripheral blood mononuclear cell(PBMC) lymphocytes monocytes apoptosis

Study of the Addition Effect of Glycerin Originated from Biodiesel Production at Compressive Strengh of Concrete

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Journal of Environmental Science and Engineering(A) 2020年第3期9卷 113-118页

作者： Matheus Alves Lima daSilva Alan Carlos de Almeida brenda Fernandes deFreitas Pedro Luís Millen Penedo Sandro Pereira Ribeiro GustavoJoséda CostaGomes Mayara Lisboa Santos Adriana Lau da Silva Martins Cristiane de Souza Siqueira Pereira Universidade de Vassouras VassourasRio de Janeiro 27700-000Brazil Institute of Technical Culture Volta RedondaRio de Janeiro 27251-220Brazil Department of Engineering University Center Geraldo Di BiaseBarra do PiraíRio de Janeiro 27600-000Brazil

The residues generated by big industries are directly and gradually impacting the environment,and some of these have not been fully tapped in a proper ***,some researches and studies about minimalizing the residue’s disposal become *** biodiesel industries have been producing increasingly glycerin as the main *** on that,it is considered as a good option of the reutilization of this material,for example,the merging at the concrete’s *** this argument,the addition’s effects of glycerin were evaluated as well as the influence of its adding at the compressive *** proof-bodies were formulated according to the trace in proportion of 1:1:2(cement,sand and gravel,respectively)and 0.4 L of glycerin added at the final *** the bases of the survey results,it was verified that the proof-bodies without the addition of glycerin presented average mechanical resistance of 12.2±1.95 MPa after twenty eight(28)days of curing,and mechanical resistance of the proof-bodies with the addition achieved resistance of 26.2±1.62 MPa,suggesting influence on the hydration kinetics of the concrete.

关键词： Glycerin cement biodiesel