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Association between admission haematocrit and mortality among men with acute ischaemic stroke

Stroke & Vascular Neurology 2018年第3期3卷 160-168页

作者： jason j Sico Laura j Myers brenda j fenton john Concato Linda S Williams Dawn M Bravata Neurology Service VA Connecticut Healthcare SystemWest HavenConnecticutUSA Department of Neurology Center for NeuroEpidemiological and Clinical Neurological ResearchYale University School of MedicineNew HavenConnecticutUSA Department of Internal Medicine Yale University School of MedicineNew HavenConnecticutUSA Clinical Epidemiology Research Center(CERC) VA Connecticut Healthcare SystemWest HavenConnecticutUSA Pain Research InformaticsMultimorbidities and Education(PRIME)Center of InnovationVA Connecticut Healthcare SystemWest HavenConnecticutUSA Communication and the HSR&D Stroke Quality Enhancement Research Initiative(QUERI) Richard L Roudebush VA Medical CenterIndianapolisIndianaUSA VA Health Services Research and Development(HSR&D) Center for Healthcare InformaticsRichard L Roudebush VA Medical CenterIndianapolisIndianaUSA Division of Chronic Disease Epidemiology Yale School of Public HealthWest HavenConnecticutUSA Medical Service VA Connecticut Healthcare SystemWest HavenConnecticutUSA Regenstrief Institute IndianapolisIndianaUSA Department of Neurology Indiana University School of MedicineIndianapolisIndianaUSA Department of Internal Medicine Indiana University School of MedicineIndianapolisIndianaUSA

Objective Anaemia is associated with higher mortality among patients with non-stroke cardiovascular conditions;less is known regarding the relationship between anaemia and mortality among patients with acute ischaemic *** Medical records were abstracted for n=3965 veterans from 131 Veterans Health Administration facilities who were admitted with ischaemic stroke in fiscal year *** values within 24 hours of admission were classified as≤27%,28%-32%,33%-37%,38%-42%,43%-47% or≥48%.Multivariate logistic regression was used to examine the relationship between anaemia and in-hospital,30-day,6-month and 1-year mortality,adjusting for age,medical comorbidities,modified Acute Physiology and Chronic Health Evaluation-III and stroke *** factors were calculated to standardise comparisons between haematocrit tier and other *** Among n=3750 patients included in the analysis,the haematocrit values were≤27%in 2.1%(n=78),28%-32% in 6.2%(n=234),33%-37%in 17.9%(n=670),38%-42% in 36.4%(n=1366),43%-47% in 28.2%(n=1059)and≥48% in 9.1%(n=343).Patients with haematocrit≤27%,compared with patients in the 38%-42% range,were more likely to have died across all follow-up intervals,with statistically significant adjusted ORs(aORs)ranging from 2.5 to *** with polycythaemia(ie,haematocrit≥48%)were at increased risk of in-hospital mortality(aOR=2.9;95%CI 1.4 to 6.0),compared with patients with mid-range admission *** differences between patients receiving and not receiving blood transfusion limited our ability to perform a propensity *** factors in the 1-year mortality model were 0.46(severe anaemia),0.06(cancer)and 0.018(heart disease).Conclusions Anaemia is independently associated with an increased risk of death throughout the first year post stroke;high haematocrit is associated with early poststroke *** anaemia is associated with 1-year mortality to a greater degree than cancer or heart dise

关键词： mortality admitted transfusion

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Forecasting the development of boreal paludified forests in response to climate change: a case study using Ontario ecosite classification

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Forest Ecosystems 2015年第1期2卷 45-55页

作者： Benoit Lafleur Nicole j fenton Yves Bergeron Institut de recherche sur les forêts Université du Québec en Abitibi-Témiscamingue 445 boul. de l’Université Rouyn-Noranda QC J9X 5E4 Canada Centre d’étude de la forêt Université du Québec à Montréal 141 Avenue du Président-Kennedy Montréal QC H2X 1Y4 Canada

Background：Successional paludification,a dynamic process that leads to the formation of peatlands,is influenced by climatic factors and site features such as surficial deposits and soil *** boreal regions,projected climate change and corresponding modifications in natural fire regimes are expected to influence the paludification process and forest *** objective of this study was to forecast the development of boreal paludified forests in northeastern North America in relation to climate change and modifications in the natural fire regime for the period 2011–***：A paludification index was built using static（*** deposits and soil texture）and dynamic（*** regime and soil organic layer thickness）stand scale factors available from forest *** index considered the effects of three temperature increase scenarios（i.e.＋1°C,＋3°C and＋6°C）and progressively decreasing fire cycle（from 300 years for 2011–2041,to 200 years for 2071–2100）on peat accumulation rate and soil organic layer（SOL）thickness at the stand level,and paludification at the landscape ***：Our index show that in the context where in the absence of fire the landscape continues to paludify,the negative effect of climate change on peat accumulation resulted in little modification to SOL thickness at the stand level,and no change in the paludification level of the study area between 2011 and ***,including decreasing fire cycle to the index resulted in declines in paludified ***,the index predicts a slight to moderate decrease in the area covered by paludified forests in 2100,with slower rates of ***：Slower paludification rates imply greater forest productivity and a greater potential for forest harvest,but also a gradual loss of open paludified stands,which could impact the carbon balance in paludified ***,as the thick Sphagnum layer typical of paludified forests may protect soil organic layer from dr

关键词： Boreal forest Canada Carbon sequestration Paludification Peat forests Forest harvest

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Differential effects of energy balance on experimentally-induced colitis

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World journal of Gastroenterology 2012年第7期18卷 627-636页

作者： Sarah j McCaskey Elizabeth A Rondini Ingeborg M Langohr jenifer I fenton Department of Food Science and Human Nutrition Michigan State UniversityEast LansingMI 48824United States Department of Pathobiology and Diagnostic Investigation Michigan State UniversityEast LansingMI 48824United States College of Osteopathic Medicine Michigan State UniversityEast LansingMI 48824United States

AIM： To characterize the influence of diet-induced changes in body fat on colitis severity in SlVlAD3-/- mice.METHODS： SMAD3-/- mice （6-8 wk of age） were ran- domly assigned to receive a calorie restricted （30% of control; CR）, control （CON）, or high fat （HF） diet for 20 wk and were gavaged with sterile broth or with Helicobacter hepaticus （H. hepaticus） to induce colitis. Four weeks after infection, mice were sacrificed and the cecum and colons were processed for histological evaluation.RESULTS： Dietary treatment significantly influenced body composition prior to infection （P 〈 0.05）, with CR mice having less （14%±2%） and HF-fed mice more body fat （32% ± 7%） compared to controls （22%±4%）. Differences in body composition were associated with alterations in plasma levels of leptin （HF 〉 CON 〉 CR） and adiponectin （CON 〉 HF 〉/ CR）（P 〈 0.05）. There were no significant differences in colitis scores between CON and HF-fed mice 4 wk post-infection. Consistent with this, differences in proliferation and in- flammation markers （COX-2, iNOS）, and infiltrating cell types （CD3^＋ T lymphocytes, macrophages） were not observed. Unexpectedly, only 40% of CR mice survived infection with H. hepaticus, with mortality observed as early as I wk following induction of colitis.CONCLUSION： Increased adiposity does not influence colitis severity in SMAD3-/- mice. Importantly, caloric restriction negatively impacts survival following pathogen challenge, potentially due to an impaired immune response.

关键词： SMAD3 Colitis Adipokine Obesity Calorierestriction

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Iron regulatory protein 1: the deadly switch of ferroptosis

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Neural Regeneration Research 2024年第3期19卷 477-478页

作者： Daniel A.Bórquez Pamela j.Urrutia Center for Biomedical Research Faculty of MedicineUniversidad Diego PortalesSantiagoChile Institute of Nutrition&Food Technology(INTA) Universidad de ChileSantiagoChile Geroscience Center for Brain Health and Metabolism SantiagoChile

Ferroptosis,an iron-dependent cell death:Ferroptosis is a type of regulated necrosis,characterized by redox-active iron accumulation and increased free radical production derived by fenton chemistry,that triggers oxidation of polyunsaturated fatty acids in phospholipids,loss of cellular membranes integrity,and leakage of intracellular contents.

关键词： integrity switch Iron

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3D printing of ABS *** of processing and effects of multi-wall and single-wall carbon nanotubes on thermal,mechanical and electrical properties

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journal of Materials Science & Technology 2022年第26期121卷 52-66页

作者： Sithiprumnea Dul brenda j.Alonso Gutierrez Alessandro Pegoretti jaime Alvarez-Quintana Luca Fambri Department of Industrial Engineering and INSTM Research Unit University of TrentoTrento 38123Italy Centro de Investigación en Materiales Avanzados S.C.Unidad MonterreyApodaca 66600Mexico Facultad de Ingeniería Mecánica y Eléctrica Universidad Autónoma de Nuevo LeónAvenida Universidad s/nCiudad UniversitariaSan Nicolás de los Garza 66451México

The following paper reports on a comparative study of the effects of two types of carbon nanotubes,namely multiwall(MWCNT)and single-wall(SWCNT)carbon nanotube,on the properties of 3D-printed parts produced with acrylonitrile-butadiene-styrene(ABS)nanocomposites with various CNT loadings of5-10 wt.%.Quasi-static tensile properties and Vicat softening temperature of 3D-printed parts were enhanced with the increasing CNT *** highest enhancement in tensile properties was observed for the ABS/CNT nanocomposites at 10 wt.%filler loading.3D-printed ABS/SWCNT composites showed higher tensile modulus,better creep stability and higher Vicat ***,the strength of ABS/SWCNT 3D samples is relatively lower than that of ABS/*** addition,3D-printed parts exhibited anisotropic electrical conductive behaviour,which has a conductivity of through-layer of about2-3 orders of magnitude higher than *** highest conductivity of 3D-printed samples reached25.2 S/m,and 9.3 S/m for ABS/MWCNT and ABS/SWCNT composites at 10 wt.%,*** results obtained,*** successful fuse filament fabrication and the consequent electromechanical properties,confirm that these 3D printable nanocomposite could be properly utilized for the production,and application up to about 90°C,of thermoelectric devices and/or resistors for flexible circuits.

关键词： Fuse filament fabrication Conductive polymers Nanocomposites Mechanical properties Creep behavior Resistivity

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Ecosystem management in paludified boreal forests:enhancing wood production,biodiversity,and carbon sequestration at the landscape level

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Forest Ecosystems 2018年第4期5卷 376-389页

作者： Benoit Lafleur Nicole j.fenton Martin Simard Alain Leduc David Paré Osvaldo Valeria Yves Bergeron NSERC-UQAT-UQAM Industrial Chair in Sustainable Forest Management and Institut de recherche sur les forêts Université du Québec en Abitibi-Témiscamingue445boul.de I'UniversiteRouyn-NorandaQC J9X 5E4Canada Department of Geography Laval UniversityQuebecQC GIV 0A6Canada Centre d'etude de la foret Universite du Quebec a Montreal141 Avenue du President-KennedyMontrealQC H2X IY4Canada Ressources Naturelles Canada Service canadien des forets Centre de foresterie des Laurentides1055du P.E P S.P.O.13ox 3800QuebecQC GIV 4C7Canada

Canada’s boreal forest represents an important contributor of the world’s wood supply industry. However,maintaining or increasing productivity of the boreal forest may be challenging in areas dominated by forested peatlands. Moreover, sustainable management of these forests must also consider other important aspects of the forest ecosystem such as biodiversity and carbon sequestration. To address these concerns, ecosystem-based management has been implemented in some Canadian jurisdictions, such as in regions where a large portion of the boreal forest is dominated by forested peatlands. The objectives of this paper are(1) to summarize our current understanding of how natural disturbances influence stand dynamics and biodiversity in forested peatlands, and(2) to review the main differences between natural and managed forest stands with respect to soil properties, stand productivity, understory plant communities. We also discuss how even-age management regime succeeds or fails to preserve old forests and how this loss affects both forest structure and habitat diversity at the landscape *** conclude by showing how, in boreal forested peatlands, forest management could contribute to carbon sequestration and mitigate projected climate change.

关键词： Clearcutting Fire Forest dynamics Partial cutting Soil properties Stand productivity Understory plant

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Increased presence of effector lymphocytes during Helicobacter hepaticus-induced colitis

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World journal of Gastroenterology 2012年第13期18卷 1459-1469页

作者： Sarah j McCaskey Elizabeth A Rondini jonathan F Clinthorne Ingeborg M Langohr Elizabeth M Gardner jenifer I fenton Department of Food Science and Human Nutrition College of Osteopathic MedicineMichigan State UniversityEast LansingMI 48824United States Department of Food Science Human Nutrition Michigan State UniversityEast LansingMI 48824United States Department of Pathobiology and Diagnostic Investigation Michigan State UniversityEast Lansing MI 48824United States

AIM： To identify and characterize drosophila mothers against decapentaplegic （SMAD）3-dependent changes in immune cell populations following infection with He- Iicobacter hepaticus （H. hepaticus）. METHODS： SMAD3/ （n = L9） and colitis-resistant SMAD3＋/ （n = 24） mice （8-10 wk of age） were in- fected with/-/, hepaticus and changes in immune cell populations [T lymphocytes, natural killer （NK） cells, T regulatory cells] were measured in the spleen and mesenteric lymph nodes （MsLNs） at 0 d, 3 d, 7 d and 28 d post-infection using flow cytometry. Genotype-dependent changes in T lymphocytes and granzyme B＋ cells were also assessed after 28 d in proximal colon tissue using immunohistochemistry. RESULTS： As previously observed, SMAD3＋, but not SMAD3＋/- mice, developed colitis, peaking at 4 wk post-infection. No significant changes in T cell subsets were observed in the spleen or in the MsLNs between genotypes at any time point. However, CD4＋ and CD8＋/ CD62L＋＋ cells, an effector T lymphocyte population, as well as NK cells （NKp46/DX5＋） were significantly higher in the MsLNs of SMAD3/ mice at 7 d and 28 d post-in- fection. In the colon, a higher number of CD3＋ cells were present in SMAD3＋ compared to SMAD3＋/- mice at base- line, which did not significantly change during infection. However, the number of granzyme B＋ cells, a marker of cytolytic lymphoo/tes, significantly increased in SMAD3＋ mice 28 d post-infection compared to both SMAD3＋/- mice and to baseline values. This was consistent with more severe colitis development in these animals. CONCLUSION： Data suggest that defects in SMAD3 signaling increase susceptibility to H. hepaticus-induced colitis through aberrant activation and/or dysregulation of effector lymphoo/tes.

关键词： Transforming growth factor-j3 Colitis Dro-sophila mothers against decapentaplegic Colon cancer T lymphocytes

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Evolving Values and How They Have Shaped the United States National Park System

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Built Heritage 2018年第3期2卷 27-38页

作者： Cari Goetcheus Nora j.Mitchell brenda Barrett College of Environment and Design University of GeorgiaAthensUnited States Historic Preservation Program History DepartmentUniversity of VermontWoodstockUnited States Living Landscape Observer HarrisburgUnited States

As one of the oldest and best-known park systems,the US National Park System continues to influence park systems around the ***,the origins and wide diversity of US national parks are often not fully understood as there is a long-lived misconception that the large western parks represent the entirety of the US National Park *** fact,the establishment of the first US national parks was heavily influenced by large 19th-century picturesque urban parks that provided benefits to the public and *** foundational concept of national parks serving a public purpose has never changed,however,the types of landscapes selected as national parks have changed as societal values have evolved and now the system provides public benefits beyond those originally *** paper examines the development of the US National Park System,emphasising the evolution of landscape *** emergence of the cultural landscape concept illustrates the evolution of landscape values from their early antecedents in the late 19th century to their contributions to innovative conservation strategies *** the development of the US National Park System,international exchange has and continues to play a pivotal role,advancing the inter-linkages of culture and nature for the most effective conservation.

关键词： US National Park Service US National Park System cultural landscape landscape values interlinkages of culture-nature

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Mate-recognition and species boundaries in the ascomycetes

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Fungal Diversity 2013年第1期58卷 1-12页

作者： Simon H.Martin Emma T.Steenkamp Michael j.Wingfield brenda D.Wingfield Department of Genetics Forestry and Agricultural Biotechnology InstituteUniversity of PretoriaPretoria 0002South Africa Department of Microbiology and Plant Pathology Forestry and Agricultural Biotechnology InstituteUniversity of PretoriaPretoria 0002South Africa

Reproductive gene evolution is commonly invoked as a source of reproductive isolation during *** possibility has not been adequately explored in the Ascomycota,the most species-rich fungal *** mechanisms of mate-recognition in this group are relatively simple:a“mating type”locus determines reproductive mode and sexual compatibility,and two pheromone/receptor pairs control sexual ***,ascomycete reproductive genes can experience unique and interesting evolutionary forces,which could lead to rapid *** this review,we examine the mechanisms of sexual interaction in ascomycetes and explore current evidence as to whether these mechanisms allow for species-specificity in *** discuss the evolutionary forces that can drive reproductive gene divergence,how these may apply in the world of ascomycetes,and their possible consequences for speciation.

关键词： Ascomycota Speciation Mating type Pheromone Receptor

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环境、性能和质量控制的测试技术

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汽车与新动力 1995年第6期 57-61页

作者： fenton j 王树英

英国皇家运输及环境保护委员会最近提交了一份报告,其焦点是汽车制造商对降低其产品对环境影响的需求。为满足这一要求,需要先进的噪声、排气污染和安全性的测试技术。

关键词：测试技术发动机诊断参数动态扭矩热试车气缸压力故障检测故障探测故障诊断火花塞点火电嘴点火装置机油耗诊断系统柴油机压燃发动机油耗测量仪气体色谱质量

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