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Local immunotherapy with interleuk in-2 delivered from biodegradable p olymer microspheres combined with interstitial chemotherapy:a novel treatme nt for experimental malignant glioma

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癌症 2003年第7期22卷 752-752页

作者： Rhines LD DiMeco F Lawson hC Tyler BM hanes J Olivi A brem h

OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradable polymers prolon gs survival against experimental brain ***,paracrine administration of inte rleukin-2(IL-2)has been shown to elicit a potent antitumor immune response and to improve survival in animal brain tumor *** r eport the use of a novel polymeric mic rosphere delivery vehicle to release *** demonstr ate both in vitro release of cytokine from the microspheres and histological evidence of the inflammatory response elicited by I L-2released from the microspheres i n the rat *** microspheres a re used to deliver IL-2,and biodegradable polymer wafers are used to deliver BCNU,directly at the site of an intracranially implanted glioma in the *** two agents administered locally show a s ynergistic ***:Fischer 344rats challenged intracranially with 9L gliosarcoma received an intracranial implant of either empty microspheres or microspheres containing IL-2(IL-2MS ).Five days later,animals in each group were randomized to receiv e polymer implants loaded with 0,3.8,or 10%BCNU at the tumor ***:Animals that received the combination of IL-2MS a nd 3.8%BCNU polymer(median survival,28.5d )or IL-2MS and 10%BCNU polymer(median survival,45.5d )showed significantly improved surv ival compared with animals that rece ived monotherapy with IL-2microsph eres(median survival,24d ),3.8%BCNU polymer(median survival,24d ),or 10%BCNU polymer(median survival,32.5d ).Control animals had a median survival of *** combination of either 3.8or 10%BCNU polymer with IL-2MS resulted in 7and 25%long-term survivors,***:By showing synergy of IL-2and BCNU in an animal glioma model and using a reproducible synthetic delivery sy stem for each agent (i.e.,one that did not rely on genetic ally engineered cells or viruses),we hope that the combination of local immunotherapy and chemotherapy can take an important step closer to clinical applic ation in patients with

关键词：实验性神经胶质瘤 IL-2 腔内化疗

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心脏MRI评估优秀铁人三项运动员心脏房室功能和结构适应能力

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国际医学放射学杂志 2010年第6期 571-572页

作者： M.Scharf M.h.brem M.Wilhelm U.J.Schoepf M.Uder M.M.Lell 何珍 Departments of Radiology University of Erlangen NurembergMaximiliansplatz 191054 ErlangenGermany

目的使用MRI评估运动员心脏形态和机能的适应性,并且与休养对照组进行比较。材料与方法本研究经机构审查委员会同意,所有参与者均签署知情同意书。26名男

关键词： MRI 心脏形态右室左室铁人三项心脏运动员体育工作者功能

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Local immunotherapy with interleukin - 2 delivered from biodegradable polymer microspheres combined with interstitial chemotherapy: a novel treatment for experimental malignant glioma.

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中国神经肿瘤杂志 2003年第2期1卷 81-81页

作者： Rhines LD DiMeco F Lawson hC Tyler BM hanes J Olivi A brem h Department of Neurosurgery University of Texas M. D.Anderson Cancer CenterHoustonTexas.

OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradablepolymers prolongs survival against experi-mental brain ***,paracrine administration of interleukin-2(IL-2)has been shown to elicit apotent antitumor immune response and to improve survival in animal brain tumor *** report the use of anovel polymeric microsphere delivery vehicle to release *** demonstrate both in vitro release of cytokinefrom the microspheres and histological evidence of the inflammatory response elicited by IL-2 released from themicrospheres in the rat *** microspheres are used to deliver IL-2,and biodegradable polymer wafers

关键词： BCNU Local immunotherapy with interleukin from delivered from biodegradable polymer microspheres combined with interstitial chemotherapy a novel treatment for experimental malignant glioma for with

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An Energy Analysis on Gasification of Sewage Sludge by a Direct Injection in Supercritical Water

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American Journal of Analytical Chemistry 2017年第12期8卷 753-773页

作者： Riza Yukananto Alexander C. Louwes Eddy A. Bramer Gerrit brem Thermal Engineering Group Faculty of Engineering Technology University of Twente Enschede The Netherlands

Supercritical Water Gasification is an efficient technology in converting wet biomass into h2 and Ch4 in comparison to other conventional thermochemical processes. Coke deposition, however, remains as a major challenge in this technology. Coke formation is the result of polymerization reactions that take place at sub-critical conditions. Directly injecting the relatively unheated wet biomass feed into supercritical water increases the heating rate and reduces the residence time of the feed in the sub-critical condition. This leads to a minimized coke formation in the process. however, a non-isothermal mixing takes place during this direct injection that is less energy-efficient. In addition, the biomass feedstream experiences less pre-heating that means less heat recovery from the product gas. These two aspects might reduce the overall process performance. Parametric studies of key operating parameters, such as operating temperature, dry matter content, bypass water ratio and heat exchanger effectiveness, are carried out to investigate the influence of direct injection to the thermal efficiency of the system. Subsequently, optimization using pinch analysis is conducted to the system with direct injection. Finally, an operating window for optimum performance of the optimized direct injection gasification system is proposed.

关键词： Supercritical Water Gasification System Model Sewage Sludge Coke Formation Pinch Analysis

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转基因家畜

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国外畜牧学（草食家畜） 1992年第4期 1-6页

作者： G.brem h-G.Wagner 张富春张居农马纪

1980年,首次报道了用DNA显微注射法成功地获得转基因鼠的实验(Gordon等,1980),从此建立了单一离体基因转移的方法。利用70年代发展起来的分子生物学技术,对有利育种的基因可以进行分离、测序以及同调控结构重组,并在体内和体外检测其表... 详细信息

1980年,首次报道了用DNA显微注射法成功地获得转基因鼠的实验(Gordon等,1980),从此建立了单一离体基因转移的方法。利用70年代发展起来的分子生物学技术,对有利育种的基因可以进行分离、测序以及同调控结构重组,并在体内和体外检测其表达能力。虽然这一基础方法在动物育种领域刚刚起步,但未来前景广阔。本文综述了已建立的基因转移技术和家畜基因转移现状。基因转移技术基因转移是指将体外重组基因结构导入动物体的技术。

关键词：家畜基因转移

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Investigation of the Influence of Free Convection on the heat Transfer of Cylinders with Different Aspect Ratios

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Journal of Thermal Science 2001年第1期10卷 58-63页

作者： C.henselowsky h.C.Kuhlmann 等 ZARMUniversityofbremen AmFallturmD－28359BremenGermany ZARMUniversityofbremen AmFallturmD－28359Brem

The heat transfer from an electrically heated cylinder (wire) of finite length to the surrounding fluid can be divided into heat radiation, conduction and convection. A technical application of these cylinders with typical dimensions of 1-2 mm length and a few micrometers diameter is the *** systematic study should clarify the influence of the convection to three dimensional heat transfer of cylinders. For this aim it is planned to investigate Reynolds numbers below Re = 1 (creeping flow). For this reason measurements should be done under 1g in the earth laboratory and also under microgravity (μg) conditions. Comparisons of these measurements under otherwise same conditions allows to distinguish between the pure convection heat transfer and the contributions due to conduction and other effects. For measarements under μg the Drop Tower bremen can be used as research facility. Due to the fast response of convection to changes in the gravity conditions the Drop Tower is an ideal and cost efficient experimental tool. The experimental setup is build to operate at velocity range of 0-l m/s which includes the whole range of convection from pure free convection at 0 m/s over mixed convection up to pure forced convection at velocities above about 0.15 m/s. This velocity region corresponds to a range of the Reynolds number of Re = 0 - 0.18 for a cylinder of 5 μ m diameter at Tf= 140℃ in air at an ambient temperature of about 21℃.

关键词： thermal anemometry hot-wire microgravity free convection hat transfer.

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采用3TMRI与DSA对一侧颅内硬脑膜动静脉瘘进行评估与临床治疗方案的制定:对时间分辨对比剂动态成像(TRICKS)与对比增强MR血管成像的详细分析

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国际医学放射学杂志 2017年第1期 110-110页

作者： L.Ertl h.Brückmann M.Kunz M.Patzig C.brem R.Forbrig 柴超 Department of Neuroradiology Institute of Clinical Radiology Ludwig-Maximilians-University Grosshadern Campus

摘要目的目前诊断一侧颅内硬脑膜动静脉瘘(LDAVF)的金标准是数字减影血管造影(DSA)。然而,MRI是评估这类疾病的一种无创性的工具。本研究的目的是将

关键词：硬脑膜动静脉瘘 MRI 治疗方案 DSA TRICKS 对比增强颅内血管成像 MR 对比剂时间分辨

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江西稻苞虫(Parnara guttata brem.)的研究

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昆虫学报 1954年第2期 139-148页

作者：张斌徐劲帆林振华江西省农业科学研究所

稻苞虫Parnara guttata brem.是我国水稻区域的主要害虫之一,发生普遍而且为害亦严重。1950年江西省发生稻苞虫达34县之多,被害面积,据江西省病虫害防治所调查31县所得,共有2,179,156亩,损失稻谷产量达35％,可见

关键词：雌雄性化蛹姬蜂 Parnara guttata brem 卵期游草菱白江西

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