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RNA m^(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

Genes & Diseases 2024年第1期11卷 382-396页

作者： Zheng Zhang Keren Zhou Li Han Andrew Small Jianhuang Xue Huilin Huang Hengyou Weng Rui Su brandon Tan chao Shen Wei Li Zhicong Zhao Ying Qing Xi Qin Kitty Wang Keith Leung Mark Boldin chun-Wei chen David Ann Zhijian Qian Xiaolan Deng Jianjun chen Zhenhua chen Department of Systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA Irell and Manella Graduate School of Biological Sciences Beckman Research Institute of City of HopeDuarteCA 91010USA Gehr Family center for Leukemia Research City of HopeDuarteCA 91010USA Sun Yat-sen University cancer center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060China Guangzhou Laboratory GuangzhouGuangdong 510005China Bioland Laboratory GuangzhouGuangdong 51005China Department of Liver Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Diabetes complications and Metabolism Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Biochemistry and Molecular Biology University of FloridaGainesvilleFL 32603USA Tongji Hospital Affiliated to Tongji University Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China School of Pharmacy China Medical UniversityShenyangLiaoning 110001China

As the most common internal modification of mRNA,Ne-methyladenosine(m^(6)A)and its regulators modulate gene expression and play critical roles in various biological and patholog-ical processes including *** was reported previously that m^(6)A methyltransferase(writer),methyltransferase-like 3(METTL3)adds m^(6)A in primary microRNAs(pri-miRNAs)and fa-cilitates its processing into precursor miRNAs(pre-miRNAs).However,it is unknown whether m^(6)A modification also plays a role in the maturation process of pre-miRNAs and(if so)whether such a function contributes to ***,we found that YTHDF2 is aberrantly overexpressed in acute myeloid leukemia(AML)patients,especially in relapsed patients,and plays an onco-genic role in ***,YTHDF2 promotes expression of miR-126-3p(also known as miR-126,as it is the main product of precursor miR-126(pre-miR-126)),a miRNA that was reported as an oncomiRNA in AML,through facilitating the processing of pre-miR-126 into mature ***,YTHDF2 recognizes m^(6)A modification in pre-miR-126 and recruits AGO2,a regulator of pre-miRNA processing,to promote the maturation of ***2 posi-tively and negatively correlates with miR-126 and miR-126's downstream target genes,respec-tively,in AML patients,and forced expression of miR-126 could largely rescue YTHDF2/Ythdf2 depletion-mediated suppression on AML cell growth/proliferation and leukemogenesis,indi-cating that miR-126 is a functionally important target of YTHDF2 in ***,our studies not only reveal a previously unappreciated YTHDF2/miR-126 axis in AML and highlight the ther-apeutic potential of targeting this axis for AML treatment,but also suggest that m^(6)A plays a role in pre-miRNA processing that contributes to tumorigenesis.

关键词： AML miR-126 N^(6)-methyladenosine Pre-miRNA maturation YTHDF2

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新的非镇静性抗组胺药将代替老药吗

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国外医药.合成药.生化药.制剂分册 1986年第5期 264-265页

作者： brandon ML 王正吕松风罗信兴

近十年来,人们对抗组胺药及其作用的兴趣重新增加。这是由于开发了特非那定、阿司咪唑和其它可能无镇静作用的抗组胺药如美喹他嗪、BW825c(一种类似安太乐和美克洛嗪的药物)和UcB—PO71(一种新的赛克利嗪类化合物)。另外正在评价一些无... 详细信息

近十年来,人们对抗组胺药及其作用的兴趣重新增加。这是由于开发了特非那定、阿司咪唑和其它可能无镇静作用的抗组胺药如美喹他嗪、BW825c(一种类似安太乐和美克洛嗪的药物)和UcB—PO71(一种新的赛克利嗪类化合物)。另外正在评价一些无镇静作用抗组胺药,其中有SK&F 3944,它正试用于变应性鼻炎。 1.新老非镇静性抗组胺药的活性差别上述各药在常用量时,均不易通过血脑屏障,比较起来,大多数老药由于脂溶性很强,容易透过血脑屏障。理想的纯粹的H_—

关键词：抗组胺药老药特非那定抗胆碱能组织胺H1受体阻断药敏必治镇静作用过敏性鼻炎变应性鼻炎

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利用地震体波方法约束地幔过渡带中不连续面的三维起伏结构

利用地震体波方法约束地幔过渡带中不连续面的三维起伏结构

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2019年中国地球科学联合学术年会

作者：张涵 brandon Schmandt 倪四道储日升新墨西哥大学地球与行星科学学院测量与地球物理研究所大地测量与地球动力学国家重点实验室

由于地幔过渡带的地震学观测结果与矿物物理在橄榄石多相系统的高温高压实验展示了良好的相关性,以及其在地球内部物质循环中可能扮演到的重要过滤作用,这一位于地下410公里到660公里之间的层状区域在近些年被多种地球学科广泛研究。在... 详细信息

由于地幔过渡带的地震学观测结果与矿物物理在橄榄石多相系统的高温高压实验展示了良好的相关性,以及其在地球内部物质循环中可能扮演到的重要过滤作用,这一位于地下410公里到660公里之间的层状区域在近些年被多种地球学科广泛研究。在众多的研究焦点之中,地幔过渡带中的不连续面(上界面410公里不连续面,中部520公里不连续面,下边界660公里不连续面)的三维起伏结构

关键词：地幔过渡带前驱波地幔结构

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剖析注水诱发地震：以美国Raton Basin为例

剖析注水诱发地震：以美国Raton Basin为例

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作者：王蕊嘉 brandon Schmandt Margaret Glasgow 张淼

诱发地震的研究已有几十年历史。随着非常规油气开采的发展、密集台阵的普及,以及地震监测技术的提高,学界对于诱发地震本质的探讨也逐步深入。其中,注水活动相关的地震具有较高的代表性和关注度,其研究尺度(～10-100千米)、时间跨度(月... 详细信息

诱发地震的研究已有几十年历史。随着非常规油气开采的发展、密集台阵的普及,以及地震监测技术的提高,学界对于诱发地震本质的探讨也逐步深入。其中,注水活动相关的地震具有较高的代表性和关注度,其研究尺度(～10-100千米)、时间跨度(月-年)介于传统构造地震和压裂微震之间。因此,对于此类地震的观测和分析,成为理解、剖析中小(天然或诱发)地震的一个契机。

关键词： Raton Basin 中小尺度

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Rh催化的烯烃/炔烃对邻二酮α-位烷基化/烯基化的研究

Rh催化的烯烃/炔烃对邻二酮α-位烷基化/烯基化的研究

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中国化学会全国第十一届有机合成化学学术研讨会

作者：王智谦 brandon J.Reinus Guangbin Dong Department of chemistry and Biochemistry University of Texasat Austin AustinTexas 78712United States 北京化工大学理学院

过渡金属参与的c-H键活化及官能团化反应是一种思路上比较简洁有效、并正在被广泛研究的合成方法。本工作利用可脱除的氨基吡啶作为导向基团,将1,2-二酮转化为烯胺结构,以烯烃或炔烃为烷基化试剂利用Rh(Ⅰ)参与的c-H键活化反应,再结合... 详细信息

过渡金属参与的c-H键活化及官能团化反应是一种思路上比较简洁有效、并正在被广泛研究的合成方法。本工作利用可脱除的氨基吡啶作为导向基团,将1,2-二酮转化为烯胺结构,以烯烃或炔烃为烷基化试剂利用Rh(Ⅰ)参与的c-H键活化反应,再结合后续的导向基团的水解,便实现了对原1,2-二酮结构α-位的烷基化或烯基化。以AlO作为添加剂可以实现烯胺的形成和c-H键活化的一锅完成,而反应依然保持很高的转化率。对于某些以单取代炔烃为原料的烯基化反应,由于炔烃反应活性很高反应难以控制,加入NaI并采用缓慢滴加的操作,能有效解决问题实现该反应优良的转化率。

关键词： c-H键活化 1,2-二酮烷基化或烯基化

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Nitric Oxide Inhibits Apoptosis-Related Gene Expression Vias-Nitrosyiation in a caspase-9 Dependent Fashion

Nitric Oxide Inhibits Apoptosis-Related Gene Expression Vias...

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第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： James A.Radosevich Benjamin J. Vesper Kim Elseth brandon G.Bentz Kenneth W.Altman G. Kenneth Haines center for Molecular Biology of Oral Diseases college of Dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA center for Molecular Biology of Oral Diseases college of Dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA center for Molecular Biology of Oral Diseases college of Dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA Department of Surgery University of Utah 2000 Circle of Hope Dr.Salt Lake CityUT84112USA Department of Otolaryngology Head ＆ Neck Surgery Mt. Sinai School of Medicine One Gustave L. Levy PlaceNew YorkNYUSA Department of Pathology Northwestern University 303 E.Chicago Ave.ChicagoIL60611USA

＜正＞Background/Aims:Nitric Oxide （NO） and its interrelated redox species （collectively denoted as NOx） play a multi - faceted role in cancer progression. NOx production induces mutational events,and it has also been found to simultaneously inhibit apoptosis. In an effort to define the underlying mechanisms of apoptosis inhibition arising from nitric oxide exposure, we here develop a novel mouse model of lung adenocarcinoma. Methods: Four NOx donor compounds （DETA - NONOate, Spermine - NONOate, SNAP, and glyco - SNAP） were exposed to a novel murine lung adenocarcinoma cell line at increasing *** extent of NOx production was measured by the Griess reaction,spectrophotometrically,and via nitrotyrosine *** alkaline single- cell gel electrophoresis assay （the cOMET assay） was used to measure DNA strand breaks （DSB’ s） and was correlated with cell viability. A fluorescence caspase activity assay was used to determine apoptosis and was correlated with apoptosis - related gene products using cDNA microarrays. Results:Kinetics,concentration,and mode of delivery all had an effect on NOx mediated DSB’s. At the highest concentration of NONOate donors, the DSB’ s correlated with cell death in a caspase - 9 dependent fashion. caspase -9 activity appeared to be inhibited by thiol - based NOx donors, and since DTT reversed NO’s effect of apoptosis, inhibition is believed to have occurred via a S - nitrosylation pathway. This change in caspase activity was found to correlate with a number of transcriptional changes, suggesting that several key apoptosis steps are likely under transcriptional control via S - nitrosylation. conclusions: The results of our murine model of lung cancer progression were found to parallel those previously reported in a human lung adenocarcinoma cell line. The model suggests that various apoptosis related gene products are likely regulated through S - nitrosylation in a caspase - 9 dependent manner. With this model in hand, we c

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Anticancer Effects of curcumin, Artemisinin, Genistein, and Resveratrol, and Vitamin c: Free Versus Liposomal Forms

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Advances in Biological chemistry 2017年第1期7卷 27-41页

作者： Jerry T. Thornthwaite Hare R. Shah Spencer R. England Lee H. Roland Seth P. Thibado Thomas K. Ballard brandon T. Goodman cancer Research Institute of West Tennessee Henderson TN USA Union University Department of chemistry Jackson TN USA University of Tennessee Department of Biochemistry Knoxville TN USA

cancer prevention supplements, which also provide effective treatment with minimal side effects, are urgently needed. An accurate, fast assay system is described that reveals the ability of chemically defined products, such as curcumin, genistein, resveratrol, artemisinin, and vitamin c, to kill K562 Erythroleukemic cells in vitro. In addition, curcumin and vitamin c were encapsulated into fatty acid micelles named NutraNanoSpheresTM (NNS) using all natural products. A unique viability stain, which allows the rapid staining of dead cells by membrane penetration using Propidium Iodide, was used to measure the cell viability by flow cytometry. cell death by alteration of the cell membranes could be seen within 30 s of exposure to curcumin. The other free components required 0.5 - 70 h to see maximum killing, suggesting a more metabolic and/or apoptotic route of cancer cell destruction. Vitamin c up to 1 × 104 μmol/well did not affect K562 cell viability. The vitamin c-NNS (3.2 nm diameter-60 mg/50 μL) showed an LD50 = 133 μmol/well ± 11 SD (n = 4), which was over 75 times more potent than the free vitamin c. The curcumin-NNS (7.4 nm diameter-25 mg/50 μL) resulted in an LD50 = 41.3 μmol/well ± 5.6 SD (n = 8) and represented a 264 fold increase in activity to destroy the cancer cells. The clinical goal is to develop water-soluble mixtures of anti-cancer compounds in the NNS with their high bioavailability (>90%) and without degradation in the stomach for preventing and curing cancer.

关键词： curcumin Artemisinin cancer Micelle Natural

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Molecular phylogeny, morphology, pigment chemistry and ecology in Hygrophoraceae (Agaricales)

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Fungal Diversity 2014年第1期64卷 1-99页

作者： D.Jean Lodge Mahajabeen Padamsee P.brandon Matheny M.catherine Aime Sharon A.cantrell David Boertmann Alexander Kovalenko Alfredo Vizzini Bryn T.M.Dentinger Paul M.Kirk A.Martyn Ainsworth Jean-Marc Moncalvo Rytas Vilgalys Ellen Larsson Robert Lücking Gareth W.Griffith Matthew E.smith Lorelei L.Norvell Dennis E.Desjardin Scott A.Redhead clark L.Ovrebo Edgar B.Lickey Enrico Ercole Karen W.Hughes Régis courtecuisse Anthony Young Manfred Binder Andrew M.Minnis Daniel L.Lindner Beatriz Ortiz-Santana John Haight Thomas Læssøe Timothy J.Baroni József Geml Tsutomu Hattori center for Forest Mycology Research Northern Research StationUSDA-Forest ServiceLuquilloPR 00773-1377USA Systematics Team Landcare Research231 Morrin RoadAuckland 1072New Zealand Ecology&Evolutionary Biology University of TennesseeKnoxvilleTN 37996-1610USA Department of Botany&Plant Pathology Purdue UniversityWest LafayetteIN 47907USA Science and Technology Universidad del TuraboGuraboPR 00778-3030USA Department of Bioscience Aarhus UniversityFrederiksborgvej 399DK-4000 RoskildeDenmark Komarov Botanical Institute of the Russian Academy of Sciences 2 Prof.Popov Str.St.Petersburg 197376Russia Dipartimento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale P.A.Mattioli 2510125 TorinoItaly Mycology Royal Botanic GardensKewRichmondSurrey TW93DSUK Royal Ontario Museum 100 Queen’s ParkTorontoONCanada Biology Department Duke UniversityDurhamNC 27708-0338USA Biological&Environmental Sciences University of GothenburgGöteborgSweden Science&Eduaction Integrative Research&Collections(Botany)The Field Museum of Natural History1400 Lake Shore Dr.ChicagoIL 60605-2496USA University of Wales AberystwythCeredigion SY233DDUK Department of Plant Pathology University of FloridaGainesvilleFL 32611-0680USA Pacific Northwest Mycology Service 6720 NW Skyline BvdPortlandOR 97229-1309USA Department of Biology San Francisco State University1600 Holloway Ave.San FranciscoCA 94132USA National Mycological Herbarium(DAOM) Science and Technology BranchAgriculture&Agri-FoodsCanada960 Carling AvenueOttawaOntarioCanada ONT K1A 0C6 Department of Biology University of Central OklahomaEdmondOK 73034USA Department of Biology Bridgewater College402 E.College St.BridgewaterVA 22812USA Department of Botany Faculty of Pharmaceutical&Biological SciencesLilleFrance 100 Langton Road BlackbuttQld 4306Australia cBS Fungal Biodiversity centre Evolutionary PhytopathologyInst.of the Royal Netherlands Academy of Arts&Sciences(KNAW)Uppsalalaan 83584 CT UtrechtThe Netherlands

Molecular phylogenies using 1–4 gene regions and information on ecology,morphology and pigment chemistry were used in a partial revision of the agaric family *** phylogenetically supported genera we recognize here in the Hygrophoraceae based on these and previous analyses are:Acantholichen,Ampulloclitocybe,Arrhenia,cantharellula,cantharocybe,chromosera,chrysomphalina,cora,corella,cuphophyllus,cyphellostereum,Dictyonema,Eonema,Gliophorus,Haasiella,Humidicutis,Hygroaster,Hygrocybe,Hygrophorus,Lichenomphalia,Neohygrocybe,Porpolomopsis and Pseudoarmillariella.A new genus that is sister to chromosera is described as *** were made at the ranks of subfamily,tribe,genus,subgenus,section and *** present three new subfamilies,eight tribes(five new),eight subgenera(one new,one new combination and one ***.),26 sections(five new and three new combinations and two ***.)and 14 subsections(two new,two ***.).Species of chromosera,Gliophorus,Humidicutis,and Neohygrocybe are often treated within the genus Hygrocybe;we therefore provide valid names in both classification *** used a minimalist approach in transferring genera and creating new names and ***,we retain in the Hygrophoraceae the basal cuphophylloid grade comprising the genera cuphophyllus,Ampulloclitocybe andcantharocybe,despite weak phylogenetic *** include Aeruginospora and Semiomphalina in Hygrophoraceae based on morphology though molecular data are *** lower hygrophoroid clade is basal to Hygrophoraceae s.s.,comprising the genera Aphroditeola,Macrotyphula,Phyllotopsis,Pleurocybella,Sarcomyxa,Tricholomopsis and Typhula.

关键词： Hygrophoraceae Fungi Revisionary systematics Nomenclatural revision Phylogenetics Pigment chemistry Lamellar trama construction Hymenial morphology Ecology

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与人相处第2版

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丛书名：新世纪生活译丛

2001年

作者：（美）B.托罗波夫（brandon Toropov）郭兵曹秀梅译

今日社会，竞争非常激烈，要想获得成功，必须能够卓有成效地与人合作。这是一本成就事业的指南，它循序渐进地教你掌握与人交往的艺术，帮助你获得下级、同事、老板以及外界人士的支持与协助，使你在日程紧张、工作繁重、资源有限的条... 详细信息

ISBN: (纸本)7801091663

今日社会，竞争非常激烈，要想获得成功，必须能够卓有成效地与人合作。这是一本成就事业的指南，它循序渐进地教你掌握与人交往的艺术，帮助你获得下级、同事、老板以及外界人士的支持与协助，使你在日程紧张、工作繁重、资源有限的条件下，也总能够马到成功！

关键词：人际关系通俗读物

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Incidenee and time-varying predictors of HIV and sexually transmitted infections among male sex workers in Mexico city

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Infectious Diseases of Poverty 2021年第1期10卷 36-45页

作者： Karla Y.Ganley Marta Wilson-Barthes Andrew R.Zullo Sandra G.Sosa-Rubi carlos J.conde-Glez Santa Garcia-cisneros Mark N.Lurie brandon D.L.Marshall Don Operario Kenneth H.Mayer Omar Galarraga Department of Narrative Medicine Columbia UniversityNew YorkNYUSA Department of Epidemiology School of Public HealthBrown UniversityProvide neeRlUSA Department of Health Services Policyand PracticeSchool of Public HealthBrown University121 South Main StreetBox G-121S-2ProvidenceRl 02912USA National Institute of Public Health(INSP) CuernavacaMorelosMexico Department of Behavioral and Social Science School of Public HealthBrown UniversityProvidenceRlUSA Fenway Health and Harvard University BostonMAUSA.

Background:Male sex workers are at high-risk for acquisition of sexually transmitted infections(STIs),including human immunodeficiency virus(HIV).We quantified incidence rates of STIs and identified their time-varying predictors among male sex workers in Mexico ***:From January 2012 to May 2014,male sex workers recruited from the largest HIV clinic and community sites in Mexico city were tested for chlamydia,gonorrhea,syphilis,hepatitis,and HIV at baseline,6-months,and *** nee rates with 95%bootstrapped confide nee limits were *** examined potential timevarying predictors using generalized estimating equations for a population averaged ***:Among 227 male sex workers,median age was 24 and baseline HIV prevalence was 32%.Incidence rates(per 100 person-years)were as follows:HIV[5.23;95%confidence interval(cI):2.15-10.31],chlamydia(5.15;95%cI:2.58-9.34),gonorrhea(3.93;95%cI:1.88-7.83),syphilis(13.04;95%cI:8.24-19.94),hepatitis B(2.11;95%cI:0.53-4.89),hepatitis c(0.95;95%cI:0.00-3.16),any STI except HIV(30.99;95%cI:21.73-40.26),and any STI including HIV(50.08;95%cI:37.6062.55).In the multivariable-adjusted model,incident STI(excluding HIV)were lower among those who reported consistently using condoms during anal and vaginal intercourse(odds ratio=0.03,95%cI:0.00-0.68)compared to those who reported inconsistently using condoms during anal and vaginal ***:Incidence of STIs is high among male sex workers in Mexico *** condom use is an important protective factor for STIs,and should be an important comp on ent of interventions to prevent incide nt infect i ons.

关键词： Male sex worker Men who have sex with men HIV Sexually transmitted infection Transmission Risk factor Mexico

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