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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： brandon C.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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Evaluating foot reflexology as a proposed treatment for sensorineural hearing loss:A critical review

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World Journal of Clinical Cases 2025年第4期13卷 15-17页

作者： Carina McClean brandon Lucke-Wold College of Medicine University of FloridaGainesvilleFL 32610United States Lillian S.Wells Department of Neurosurgery University of FloridaGainesvilleFL 32608United States

This editorial critically evaluates the application of foot reflexology as a treatment for sensorineural hearing loss(SNHL)in infants,as proposed in a case report published in the World of Clinical *** is a condition characterized by damage to the cochlea or the neural pathways that transmit auditory information to the *** etiology of SNHL is often complex,involving genetic mutations,prenatal factors,or perinatal ***,an alternative therapy involving the application of pressure to specific points on the feet,is based on the hypothesis that these points correspond to different organs and systems in the body,including the auditory ***,the biological plausibility and clinical efficacy of foot reflexology in addressing SNHL lack empirical *** editorial examines the pathophysiology of SNHL,assesses the clinical claims of reflexology practitioners,and emphasizes the necessity of evidence-based approaches in treating infant hearing *** complementary therapies may provide ancillary benefits,they should not supplant validated medical treatments in managing SNHL in *** research is needed to evaluate the safety and efficacy of foot reflexology and other alternative therapies in pediatric audiology.

关键词： Sensorineural hearing loss Reflexology Congenital hearing loss Alternative medicine Audiology

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.Thomas M.brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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Effect of esketamine on reducing postpartum pain and depression

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World Journal of Clinical Cases 2025年第7期13卷 17-20页

作者： brandon Lucke-Wold Armin Karamian Department of Neurosurgery University of FloridaGainesvilleFL 32608United States School of Medicine Shahid Beheshti University of Medical SciencesTehran 198396-9411TehrānIran

In this editorial,we comment on a recent article by Chen et al,that addressed the effect of intraoperative injection of esketamine on postoperative analgesia and postoperative rehabilitation after cesarean *** management of postcesarean pain is associated with decreased maternal care for the baby,longer hospitalization,and higher risk of developing postpartum *** is a more potent S-enantiomer of ketamine which has shown promising analgesic and antidepressant properties for managing post-cesarean pain and depression in clinical ***,due to its potential adverse effects on the neurological and hemodynamic status of patients,it is recommended that its usage in low doses should be limited to cesarean candidates experiencing unbearable *** any recommendation for routine perioperative use of esketamine,more standardized clinical trials are needed to strengthen our existing knowledge of its effectiveness in reducing postpartum pain and depression.

关键词： Cesarean section Postpartum pain Postpartum depression Postoperative analgesia Esketamine

Hydrogen for a Net-Zero Carbon World

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Engineering 2023年第10期29卷 8-10页

作者： Nigel P.brandon James J.brandon Faculty of Engineering Imperial College LondonSouth Kensington CampusLondon SW72AZUK The First Element Ltd. London N17GUUK

*** hydrogen?The concept of the“hydrogen economy”was first coined by *** Bockris during a talk he gave in 1970 at the General Motors Technical ***’s talk introduced the vision of a world economy in which energy was... 详细信息

关键词： hydrogen Carbon economy

Taxane resistance in castration-resistant prostate cancer: mechanisms and therapeutic strategies

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Acta Pharmaceutica Sinica B 2018年第4期8卷 518-529页

作者： brandon Bumbaca Wei Li Department of Pharmaceutical Sciences College of Pharmacythe University of Tennessee Health Science Center

Despite its good initial response and significant survival benefit in patients with castrationresistant prostate cancer(CRPC), taxane therapy inevitably encounters drug resistance in all *** understandings of taxane resistant mechanisms can significantly facilitate the development of new therapeutic strategies to overcome taxane resistance and improve CRPC patient survival. Multiple pathways of resistance have been identified as potentially crucial areas of intervention. First, taxane resistant tumor cells typically have mutated microtubule binding sites, varying tubulin isotype expression,and upregulation of efflux transporters. These mechanisms contribute to reducing binding affinity and availability of taxanes. Second, taxane resistant tumors have increased stem cell like characteristics,indicating higher potential for further mutation in response to therapy. Third, the androgen receptor pathway is instrumental in the proliferation of CRPC and multiple hypotheses leading to this pathway reactivation have been reported. The connection of this pathway to the AKT pathway has received significant attention due to the upregulation of phosphorylated AKT in CRPC. This review highlights recent advances in elucidating taxane resistant mechanisms and summarizes potential therapeutic strategies for improved treatment of CRPC.

关键词： Castration-resistant prostate cancer Drug efflux transporters Taxane resistance Androgen receptor PI3K/AKT pathway Microtubules Cancer stem cells Efflux transporter

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Subnanometer imaging and controlled dynamical patterning of thermocapillary driven deformation of thin liquid films

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Light(Science & Applications) 2019年第1期8卷 515-525页

作者： Shimon Rubin brandon Hong Yeshaiahu Fainman Department of Electrical and Computer Engineering University of CaliforniaSan Diego9500 Gilman Dr.La JollaCA 92023USA

Exploring and controlling the physical factors that determine the topography of thin liquid dielectric films are of interest in manifold fields of research in physics,applied mathematics,and engineering and have been a key aspect of many technological *** of thin liquid dielectric film topography and local thickness measurements are essential tools for characterizing and interpreting the underlying ***,achieving high sensitivity with respect to subnanometric changes in thickness via standard optical methods is *** propose a combined imaging and optical patterning projection platform that is capable of optically inducing dynamical flows in thin liquid dielectric films and plasmonically resolving the resulting changes in topography and *** particular,we employ the thermocapillary effect in fluids as a novel heat-based method to tune plasmonic resonances and visualize dynamical processes in thin liquid dielectric *** presented results indicate that lightinduced thermocapillary flows can form and translate droplets and create indentation patterns on demand in thin liquid dielectric films of subwavelength thickness and that plasmonic microscopy can image these fluid dynamical processes with a subnanometer sensitivity along the vertical direction.

关键词： films dielectric liquid

CO2 activation on bimetallic CuNi nanoparticles

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Progress in Natural Science:Materials International 2016年第5期26卷 487-492页

作者： Natalie Austin brandon Butina Giannis Mpourmpakis Department of Chemical Engineering University of Pittsburgh

Density functional theory calculations have been performed to investigate the structural, electronic, and CO2adsorption properties of 55-atom bimetallic Cu Ni nanoparticles（NPs） in core-shell and decorated architectures,as well as of their monometallic counterparts. Our results revealed that with respect to the monometallic Cu55and Ni55parents, the formation of decorated Cu12Ni43and core-shell Cu42Ni13are energetically favorable. We found that CO2chemisorbs on monometallic Ni55, core-shell Cu13Ni42, and decorated Cu12Ni43and Cu43Ni12,whereas, it physisorbs on monometallic Cu55and core-shell Cu42Ni13. The presence of surface Ni on the NPs is key in strongly adsorbing and activating the CO2molecule（linear to bent transition and elongation of C=O bonds）. This activation occurs through a charge transfer from the NPs to the CO2molecule, where the local metal d-orbital density localization on surface Ni plays a pivotal role. This work identifies insightful structureproperty relationships for CO2activation and highlights the importance of keeping a balance between NP stability and CO2adsorption behavior in designing catalytic bimetallic NPs that activate CO2.

关键词： Density functional theory Alloys CO2adsorption Catalysis Stability

Natural rubber and the Russian dandelion genome

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National Science Review 2018年第1期5卷 88-89页

作者： brandon S.Gaut Department of Ecology and Evolutionary Biology University of California

The world needs *** is crucial for the tires on the cars,trucks and airplanes that propel modern *** is equally important for daily tasks:latex gloves in the lab,balloons in angioplasty and wetsuits that warm a cold dip in the *** can be made synthetically from petroleum derivatives,but synthetic rubber is not as strong as rubber isolated from *** principal plant source for natural rubber

关键词： Natural rubber and the Russian dandelion genome