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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

作者： j.r.柏廷顿

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Neural regeneration research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny Cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve inj.r. nerve regeneration nerve wrap tacrolimus

Timing of Hepatitis C Virus Treatment in Liver Transplant Candidates in the Era of Direct-acting Antiviral Agents

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journal of Clinical and Translational Hepatology 2017年第4期5卷 363-367页

作者： George Cholankeril Mairin joseph-Talreja brandon j.Perumpail Andy Liu Eric r.Yoo Aijaz Ahmed Aparna Goel Division of Gastroenterology and Hepatology Stanford University School of MedicineStanfordCAUSA Department of Medicine Drexel University College of MedicinePhiladelphiaPAUSA Department of Medicine California Pacific Medical CenterSan FranciscoCAUSA Department of Medicine Santa Clara Valley Medical CenterSan JoseCAUSA

Chronic hepatitis C virus(HCV)infection remains the leading indication for liver transplantation(LT)in the United *** most patients with chronic HCV infection remain asymptomatic,up to one-third develop progressive liver disease resulting in *** is often the only curative treatment once significant hepatic decompensation ***,antiviral therapy for HCV infection has advanced markedly in the past 5 years with the discovery and approval of direct-acting antiviral *** new regimens are well tolerated,of short duration and highly effective,unlike the traditional treatment with pegylated-interferon and *** achieving sustained virological response becomes increasingly attainable for a maj.r.ty of HCV-infected patients,concerns have been raised regarding the optimal timing of treatment for HCV infection in the setting of end-stage liver disease and during the peri-transplant *** one hand,HCV treatment may improve hepatic function and negate the need for LT in some,which is crucial given the scarcity of donor organs and mortality on the waiting list in certain *** the other hand,HCV treatment may result in lowering the priority for LT without improving quality of life,thereby delaying potentially curative LT *** review evaluates the evidence supporting the use of direct-acting antiviral agents in the period before and following LT.

关键词： Hepatitis C virus Direct-acting antiviral therapy Liver transplantation

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小毛驴与我

2013年

作者： (西)胡安·拉蒙·希梅内斯

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变化中的亚洲城市与建筑

世界建筑 1990年第6期 57-59页

作者： j.r.巴拉杨志中印度建筑理事会

亚洲城市的历史可以远溯到东方文明的发端,数千年来,在中国、印度、西亚以及许多其它地区。城市一直影响着各自地区文化的发展。作为个体,它们是强大帝国的中心,是宫廷、民用与军事设施以及文化机构的所在地,是重大宗教的圣地,是艺术与... 详细信息

亚洲城市的历史可以远溯到东方文明的发端,数千年来,在中国、印度、西亚以及许多其它地区。城市一直影响着各自地区文化的发展。作为个体,它们是强大帝国的中心,是宫廷、民用与军事设施以及文化机构的所在地,是重大宗教的圣地,是艺术与工艺中心。或是横跨整个欧亚大陆的水陆交通枢纽上的商埠。

关键词：亚洲城市建筑规划

Alpha-particle decays from excited states in ^(24)Mg

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Science China(Physics,Mechanics & Astronomy) 2011年第S1期54卷 130-135页

作者： LIOTTA r j royal Institute of Technology (KTH) AlbaNova University Center Stockholm S-10691 Sweden

Using a cluster model based on the Woods-Saxon potential, alpha-particle decays from excited states in 24Mg have been system atically investigated. Calculations can in general reproduce experimental data, noticing the fact that the preformation factor P of alpha particle in alpha-decaying nuclei is of order from 100 to 10?2. This can be the evidence for the α+20Ne structure in 24Mg. Meanwhile, the results also show the existence of other configurations, such as 16O+2α. Since the calculated decay widths are very sensitive to the angular momentum carried by the outgoing cluster (α particle), our results could serve as a guide to experimental spin assignments.

关键词： alpha decay cluster structure cluster model 24Mg

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六十年代的危机与评论

华中建筑 1990年第3期 78-84页

作者：威廉·j.r.柯蒂斯陈纲伦哈佛大学

本世纪六十年代初脱颖而出、走向成熟的一批建筑师,尽管他们探索的路子多种多样,尽管他们创作的风格千差万别,但都有一些明显的共同特征。这些建筑师大都出生在1910～1930年之间,因此,他们在早年无不蒙受第二次世界大战的深刻影响。在... 详细信息

本世纪六十年代初脱颖而出、走向成熟的一批建筑师,尽管他们探索的路子多种多样,尽管他们创作的风格千差万别,但都有一些明显的共同特征。这些建筑师大都出生在1910～1930年之间,因此,他们在早年无不蒙受第二次世界大战的深刻影响。在反对每况愈下的“国际式”背景上,这些建筑师建立了自己的建筑语言;在对一种更加健全和复杂的建筑进行探索时,这些建筑师

关键词：矛盾性欧洲建筑师意大利美术家南欧文丘里建筑大师美国建筑

凯恩斯论资本主义经济发展的阶段:凯恩斯方法论的制度基础

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世界社会科学 1991年第3期 38-39页

作者： j.r.克罗蒂 ,左建龙

本文论证的主要议题是:凯恩斯理论是与特定的制度相联系的,并且是视当时的历史条件而定的;凯恩斯对资本主义发展阶段的问题有过论述,他提出了资本主义经济两个不同阶段演进的理论框架。一、凯恩斯的方法论和《通论》凯恩斯的方法论可理... 详细信息

本文论证的主要议题是:凯恩斯理论是与特定的制度相联系的,并且是视当时的历史条件而定的;凯恩斯对资本主义发展阶段的问题有过论述,他提出了资本主义经济两个不同阶段演进的理论框架。一、凯恩斯的方法论和《通论》凯恩斯的方法论可理解为两个不同分析层次的综合。第Ⅰ分析层次,凯恩斯把资本主义经济界定性的特征与那些构筑供给和需求表的假定相结合。第Ⅱ分析层次则是,在上述理论中增加表明特殊经济发展阶段的具体制度、阶级和行动者动机的假设,并且探究这些制度性假设在理论上和行动上所具有的

关键词：凯恩斯资本主义思想体系经济方法论辩证唯物主义

A higher-order porous thermoelastic problem with microtemperatures

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Applied Mathematics and Mechanics(English Edition) 2023年第11期44卷 1911-1926页

作者： j.r.FErNáNDEZ r.QUINTANILLA Department of Applied Mathematics I University of VigoETSI de Telecomunicacion Campus As Lagoas Marcosende s/nVigo 36310Spain Department of Mathematics Polytechnical University of CatalunyaTerrassa 08222BarcelonaSpain

In this paper,we study a porous thermoelastic problem with microtemperatures assuming parabolic higher order in time derivatives for the thermal *** model is derived and written as a coupled linear ***,a uniqueness result is proved by using the logarithmic convexity method in the case that we do not assume that the mechanical energy is positive ***,the existence of the solution is obtained by introducing an energy function and applying the theory of linear semigroups.

关键词： higher order thermoelasticity microtemperature logarithmic convexity method existence and uniqueness

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