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Evaluation of reynolds-averaged Navier-Stokes turbulence models in open channel flow over salmon redds

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journal of Hydrodynamics 2024年第4期36卷 741-756页

作者： Bishal Bhattarai brandon Hilliard Daniele Tonina William j.r.eder ralph Budwig Benjamin T.Martin Tao Xing Department of Mechanical Engineering University of IdahoMoscowUSA Center for Ecohydraulics research University of IdahoBoiseUSA Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Hamm School of Engineering University of MaryBismarckUSA

This study evaluates computational fluid dynamics(CFD)turbulence closures for reynolds-averaged Navier-Stokes(rANS)equations against experimental data to model complex open channel flows,like those occurring over dune-shaped salmon spawning nests called"redds".Open channel flow complexity,characterized by near-bed turbulence,adverse pressure,and free surfaces,requires suitable turbulence closure capable of capturing the flow structure between streambed and water *** evaluated three rANS models:Standard k-,shear-stress transport(SST)k-@and realizable k-,along with four wall treatments for the realizable k-:Standard,and scalable wall functions,enhanced wall treatment,and an unconventional closure combining standard wall function with near-wall mesh resolving the viscous *** all models generally capturing the bulk flow characteristics,considerable discrepancies were evident in their ability to predict specific flow features,such as flow *** realizable k-model,with standard wall function and mesh resolving viscous sublayer,outperformed other closures in predicting near-wall flow separations,velocity fields,and free surface *** realizable k-model with a log-layer resolved mesh predicted the free surface elevation equally well but lacked precision for near-wall *** SST k-@model outperformed in predicting turbulent kinetic energy and provided better predictions of the near-boundary velocity distributions than realizable k-closure with any of the conventional wall treatments but overestimated the separation vortex *** standard k-o model also overestimated near-wall *** study highlights the variability in accuracy among turbulence models,underlining the need for careful model selection based on specific prediction regions.

关键词： Salmon redd numerical simulation turbulence models volume of fluid(VOF)

南大别角闪岩相退变质与热液活动:朱家冲榴辉岩与闪石脉Ar-Ar年代学研究

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地球化学 2006年第5期35卷 517-524页

作者：邱华宁 j.r. Wij.r.ns 中国科学院广州地球化学研究所同位素年代学和地球化学重点实验室广东广州510640 Department of Isotope Geochemistry Vrije UniversiteitDe Boelelaan 10851081 HV AmsterdamThe Netherlands

南大别山朱家冲榴辉岩中产有一条岩脉。电子探针分析结果表明,朱家冲榴辉岩中较大颗粒的白云母和岩脉中的白云母均为钠云母;而榴辉岩中细小颗粒的白云母则为多硅白云母;岩脉中的蓝绿色柱状矿物为闪石(amphibole)。采用激光阶段加热技术... 详细信息

南大别山朱家冲榴辉岩中产有一条岩脉。电子探针分析结果表明,朱家冲榴辉岩中较大颗粒的白云母和岩脉中的白云母均为钠云母;而榴辉岩中细小颗粒的白云母则为多硅白云母;岩脉中的蓝绿色柱状矿物为闪石(amphibole)。采用激光阶段加热技术和真空阶段击碎技术,对朱家冲冷榴辉岩体和岩脉进行了Ar-Ar定年研究。选自榴辉岩和闪石脉的两个钠云母激光加热Ar-Ar年龄均约为200Ma,选自闪石脉的闪石真空击碎流体包裹体Ar-Ar年龄也约为200Ma,代表了热液活动钠云母化发生的时间;而提取流体包裹体后的闪石矿物粉末阶段加热Ar-Ar等时线年龄约为243Ma,则可能代表了朱家冲榴辉岩角闪岩相退变质作用发生的最小年龄。

关键词： Ar-Ar法榴辉岩超高压变质作用朱家冲大别山

NECAB family of neuronal calcium-binding proteins in health and disease

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Neural regeneration research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.E.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

Strategies to enhance monoclonal antibody uptake and distribution in solid tumors

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Cancer Biology & Medicine 2021年第3期18卷 649-664页

作者： brandon M.Bordeau joseph P.Balthasar Department of Pharmaceutical Science University at BuffaloBuffaloNY 14214USA

Despite the significant resources dedicated to the development of monoclonal antibody(m Ab)therapies for solid tumors,the clinical success,thus far,has been *** efficacy of m Ab in solid tumors likely relates to unique aspects of tumor *** tumors have an aberrant vasculature and a dense extracellular matrix that slow both the convective and diffusive transport of m Abs into and within *** m Abs that are directed against cellular antigens,high antigen expression and rapid antigen turnover can result in perivascular cells binding to and eliminating a significant amount of extravasated m Ab,limiting m Ab distribution to portions of the tumor that are distant from functional *** preclinical investigations have reported strategies to improve m Ab uptake and distribution;however,to our knowledge,none have translated into the ***,we provide an overview of several barriers in solid tumors that limit m Ab uptake and distribution and discuss approaches that have been utilized to overcome these barriers in preclinical studies.

关键词： Solid tumors antibody uptake and distribution monoclonal antibody antibody-drug conjugate

A deep learning framework to emulate density functional theory

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npj Computational Materials 2023年第1期9卷 687-695页

作者： Beatriz G.del rio brandon Phan rampi ramprasad Departamento de Física Teórica Atómica yÓpticaUniversidad de ValladolidPaseo de Belén 747011 ValladolidSpain School of Materials Science and Engineering Georgia Institute of Technology771 Ferst Drive NWAtlantaGA 30332USA

Density functional theory(DFT)has been a critical component of computational materials research and discovery for ***,the computational cost of solving the central Kohn–Sham equation remains a maj.r.obstacle for dynamical studies of complex phenomena ***,we propose an end-to-end machine learning(ML)model that emulates the essence of DFT by mapping the atomic structure of the system to its electronic charge density,followed by the prediction of other properties such as density of states,potential energy,atomic forces,and stress tensor,by using the atomic structure and charge density as *** deep learning model successfully bypasses the explicit solution of the Kohn-Sham equation with orders of magnitude speedup(linear scaling with system size with a small prefactor),while maintaining chemical *** demonstrate the capability of this ML-DFT concept for an extensive database of organic molecules,polymer chains,and polymer crystals.

关键词： functional theory system

Surveillance for highly pathogenic avian influenza in wild birds in the USA

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Integrative Zoology 2009年第4期4卷 426-439页

作者： Thomas j.DELIBErTO Seth r.SWAFFOrD Dale L.NOLTE Kerri PEDErSEN Mark W.LUTMAN brandon B.SCHMIT john A.BArOCH Dennis j.KOHLEr Alan FrANKLIN United States Department of Agriculture Animal and Plant Health Inspection ServiceWildlife ServicesNational Wildlife Disease ProgramFort CollinsUSA United States Department of Agriculture Animal and Plant Health Inspection ServiceWildlife ServicesNational Wildlife Research CenterFort CollinsColoradoUSA

As part of the USA’s National Strategy for Pandemic Influenza,an Interagency Strategic Plan for the Early Detection of Highly Pathogenic H5N1 Avian Influenza in Wild Migratory Birds was developed and ***1April2006 through 31 March 2009,261946 samples fromwild birds and 101457 wild bird fecalsamples were collected in the USA;no highly pathogenic avian influenza was *** United States Department of Agriculture,and state and tribal cooperators accounted for 213115(81%)of the wild bird samples collected;31,27,21 and 21%of the samples were collected from theAtlantic,Pacific,Central and Mississippi flyways,*** than 250 species of wild birds in all 50 states were *** maj.r.ty of wild birds(86%)were dabbling ducks,geese,swans and *** apparent prevalence of low pathogenic avian influenza viruses during biological years 2007 and 2008 was 9.7 and 11.0%,*** apparent prevalence of H5 and H7 subtypes across all species sampled were 0.5 and 0.06%,*** pooled fecal samples(n=101539)positive for low pathogenic avian influenza were 4.0,6.7 and 4.7%for biological years 2006,2007 and 2008,*** highly pathogenic early detection system for wild birds developed and implemented in the USA represents the largest coordinated wildlife disease surveillance system ever *** effort provided evidence that wild birds in the USA were free of highly pathogenic avian influenza virus(given the expected minimum prevalence of 0.001%)at the 99.9%confidence level during the surveillance period.

关键词： disease surveillance highly pathogenic avian influenza H5N1 morbidity and mortality wild bird.

CNN-BiLSTM-Attention Model in Forecasting Wave Height over South-East China Seas

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Computers, Materials & Continua 2022年第10期73卷 2151-2168页

作者： Lina Wang Xilin Deng Peng Ge Changming Dong brandon j.Bethel Leqing Yang jinyue Xia School of Artificial Intelligence(School of Future Technology) Nanjing University of Information Science and Technology Nanjing210044China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai519080China School of Marine Sciences Nanjing University of Information Science and TechnologyNanjing210044China International Business Machines Corporation(IBM) New York10504USA

Though numerical wave models have been applied widely to significant wave height prediction,they consume massive computing memory and their accuracy needs to be further *** this paper,a two-dimensional(2D)significant wave height(SWH)prediction model is established for the South and East China *** proposed model is trained by Wave Watch III(WW3)reanalysis data based on a convolutional neural network,the bidirectional long short-term memory and the attention mechanism(CNNBiLSTM-Attention).It adopts the convolutional neural network to extract spatial features of original wave height to reduce the redundant information input into the BiLSTM ***,the BiLSTM model is applied to fully extract the features of the associated information of time series ***,the attention mechanism is used to assign probability weight to the output information of the BiLSTM layer units,and finally,a training model is *** to 24-h prediction experiments are conducted under normal and extreme conditions,*** the normal wave condition,for 3-,6-,12-and 24-h forecasting,the mean values of the correlation coefficients on the test set are 0.996,0.991,0.980,and 0.945,*** corresponding mean values of the root mean square errors are measured at 0.063 m,0.105 m,0.172 m,and 0.281 m,*** the typhoon-forced extreme condition,the model based on CNN-BiLSTM-Attention is trained by typhooninduced SWH extracted from the WW3 reanalysis *** 3-,6-,12-and 24-h forecasting,the mean values of correlation coefficients on the test set are respectively 0.993,0.983,0.958,and 0.921,and the averaged root mean square errors are 0.159 m,0.257 m,0.437 m,and 0.555 m,*** model performs better than that trained by all the WW3 reanalysis *** result suggests that the proposed algorithm can be applied to the 2D wave forecast with higher accuracy and efficiency.

关键词： Conv2D CNN-BiLSTM-Attention wave forecasting significant wave height typhoon

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经济合作与发展组织:教育活动

华东师范大学学报(教育科学版) 1991年第1期 26-26,74页

作者： j.r.加斯孙绍荣

经济合作与发展组织简称(OECD),1961年作为欧洲经济合作组织的后继者而成立。它是24个工业化成员国在经济和社会政治方面开展国际合作的工具。这些成员国是:澳大利亚、奥地利、比利时、加拿大、丹麦、芬兰、法国、联邦德国、希腊、冰岛... 详细信息

经济合作与发展组织简称(OECD),1961年作为欧洲经济合作组织的后继者而成立。它是24个工业化成员国在经济和社会政治方面开展国际合作的工具。这些成员国是:澳大利亚、奥地利、比利时、加拿大、丹麦、芬兰、法国、联邦德国、希腊、冰岛、爱尔兰、意大利、日本、卢森堡、荷兰、新西兰、挪威、葡萄牙、西班牙、瑞典、瑞士、土耳其、联合王国、美国。南斯拉夫是作为准成员国参加的。该组织的活动主要是促进经济发展、就业以及提高生活标准,促进世界经济的正常、和谐的发展。在努力实现这些目标的过程中,

关键词：出版物建筑已出版作品欧洲经济合作组织经济合作与发展组织会员国成员国 OECD

Possibilities and impossibilities of magnetic nanoparticle use in the control of infectious biofilms

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journal of Materials Science & Technology 2021年第10期69卷 69-78页

作者： Kecheng Quan Zexin Zhang Yijin ren Henk j.Busscher Henny C.van der Mei brandon W.Peterson College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China University of Groningen and University Medical Center Groningen Department of Biomedical Engineering9713 AVGroningenthe Netherlands University of Groningen and University Medical Center Groningen Department of OrthodonticsHanzeplein 19713 GZGroningenthe Netherlands

Targeting of chemotherapeutics towards a tumor site by magnetic nanocarriers is considered promising in *** nanoparticles are also considered for use in infection-control as a new means to prevent antimicrobial resistance from becoming the number one cause of death by the year *** this end,magnetic nanoparticles can either be loaded with an antimicrobial for use as a delivery vehicle or modified to acquire intrinsic antimicrobial *** nanoparticles can also be used for the local generation of heat to kill infectious *** appealing for tumor-and infectioncontrol,injection in the blood circulation may yield reticuloendothelial uptake and physical obstruction in organs that yield reduced targeting *** can be prevented with suitable surface ***,precise techniques to direct magnetic nanoparticles towards a target site are *** problem of precise targeting is aggravated in infection-control due to the micrometer-size of infectious biofilms,as opposed to targeting of nanoparticles towards centimeter-sized *** review aims to identify possibilities and impossibilities of magnetic targeting of nanoparticles for *** first review targeting techniques and the spatial resolution they can achieve as well as surface-chemical modifications of magnetic nanoparticles to enhance their targeting efficiency and antimicrobial *** is concluded that targeting problems encountered in tumor-control using magnetic nanoparticles,are neglected in most studies on their potential application in *** biofilm targeting by smart,self-adaptive and pH-responsive,antimicrobial nanocarriers for instance,seems easier to achieve than magnetic *** leads to the conclusion that magnetic targeting of nanoparticles for the control of micrometer-sized infectious biofilms may be less promising than initially ***,using propulsion rather than pr

关键词： Magnetic nanoparticles Magnetic targeting Biofilm Infection Antimicrobials