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Multiple sclerosis is at a checkpoint: advancing the program

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Neural regeneration research 2025年第3期20卷 811-812页

作者： brandon C.Smith jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural regeneration research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown rafael j.Yáñez-Muñoz Heidi r.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Evaluating foot reflexology as a proposed treatment for sensorineural hearing loss:A critical review

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World journal of Clinical Cases 2025年第4期13卷 15-17页

作者： Carina McClean brandon Lucke-Wold College of Medicine University of FloridaGainesvilleFL 32610United States Lillian S.Wells Department of Neurosurgery University of FloridaGainesvilleFL 32608United States

This editorial critically evaluates the application of foot reflexology as a treatment for sensorineural hearing loss(SNHL)in infants,as proposed in a case report published in the World of Clinical *** is a condition characterized by damage to the cochlea or the neural pathways that transmit auditory information to the *** etiology of SNHL is often complex,involving genetic mutations,prenatal factors,or perinatal ***,an alternative therapy involving the application of pressure to specific points on the feet,is based on the hypothesis that these points correspond to different organs and systems in the body,including the auditory ***,the biological plausibility and clinical efficacy of foot reflexology in addressing SNHL lack empirical *** editorial examines the pathophysiology of SNHL,assesses the clinical claims of reflexology practitioners,and emphasizes the necessity of evidence-based approaches in treating infant hearing *** complementary therapies may provide ancillary benefits,they should not supplant validated medical treatments in managing SNHL in *** research is needed to evaluate the safety and efficacy of foot reflexology and other alternative therapies in pediatric audiology.

关键词： Sensorineural hearing loss reflexology Congenital hearing loss Alternative medicine Audiology

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长江中下游长江江豚种群数量研究

长江中下游长江江豚种群数量研究

Coarse to Fine: The role of Severe Plastic Deformation in Advancing Titanium-Based Medical Implants - A Comprehensive review

野生动物生态与资源保护第四届全国学术研讨会

作者：赵修江王丁 Barlow,j. Pitman,r.L. Taylor,B.L. 王克雄魏卓张先锋李松海 Barrett.L.A. Akamatsu,T. Turvey,S.T. reeves,r.r. Stewart,B.S. richlen,M. brandon,j.r. 中国科学院水生生物研究所中国科学院研究生院 NOAA Fisheries Southwest Fisheries Science CenterLa Jolla CA 92037USA

长江江豚是唯一的江豚淡水亚种,仅分布于长江中下游及其主要附属湖泊中。为评价其种群现状,2006年11月至12月,我们在长江中下游干流江段进行了截线抽样法考察。考察采用两条大型考察船,航程约3400千米。根据动物密度,考察区域被划分为...

长江江豚是唯一的江豚淡水亚种,仅分布于长江中下游及其主要附属湖泊中。为评价其种群现状,2006年11月至12月,我们在长江中下游干流江段进行了截线抽样法考察。考察采用两条大型考察船,航程约3400千米。根据动物密度,考察区域被划分为三个江段进

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journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 295-306页

作者： Dragana r Mihajlović Bojan I Međo Ivana Lj Cvijović-Alagić Veljko r Djokić Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear Sci-ences-National Institute of the republic of Serbia University of Belgrade11001BeogradSerbia Innovation Centre of the Faculty of Technology and Metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic *** the SPD process,a solid material sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure torsion(HPT)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more *** that grain size control is accepted as a method to obtain materials with desired characteristics,an overview of the properties of ultrafine-grained titanium-based biomaterials to be used in medicine is ***,particular attention is dedicated to the influences of HPT process parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.

关键词： high-pressure torsion process ultrafine-grained titanium-based materials electrochemical anodization physical properties mechanical properties

Direct Numerical Simulation of Convective Heat Transfer in a Zero-Pressure-Gradient Boundary Layer with Supercritical Water

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journal of Thermal Science 2012年第1期21卷 49-59页

作者： C. Azih j.r. Brinkerhoff M.I. Yaras Department of Mechanical and Aerospace Engineering Carleton University

Experimental research has long shown that forced-convective heat transfer in wall-bounded turbulent flows of fluids in the supercritical thermodynamic state is not accurately predicted by correlations that have been developed for single-phase fluids in the subcritical thermodynamic state. In the present computational study, the statistical properties of turbulent flow as well as the development of coherent flow structures in a zero-pressuregradient flat-plate boundary layer are investigated in the absence of body forces, where the working fluid is in the supercritical thermodynamic state. The simulated boundary layers are developed to a friction reynolds number of 250 for two heat-flux to mass-flux ratios corresponding to cases where normal heat transfer and improved heat transfer are observed. In the case where improved heat transfer is observed, spanwise spacing of the near-wall coherent flow structures is reduced due to a relatively less stable flow environment resulting from the lower magnitudes of the wall-normal viscosity-gradient profile.

关键词： boundary layer turbulence supercritical fluids improved heat transfer DNS

Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research Institute of Translational Neuroscience DANDrITE-Nordic EMBL Partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

Stable gravastars： Guilfoyle＇s electrically charged solutions

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Chinese Physics C 2018年第11期42卷 120-130页

作者： Ayan Banerjee j.r. Villanueva Phongpichit Channuie Kimet jusufi Department of Mathematics Jadavpur University Kolkata-700032 India Instituto de Fisica y Astronomia Facultad de Ciencias Universidad de Valparaiso Gran Bretana 1111 Valparaiso Chile School of Science Walailak University Nakhon Si Thammarat 80160 Thailand Physics Department State University of Tetovo Ilinden Street nn 1200 Macedonia

Compelling alternatives to black holes, namely, gravitational vacuum stars （gravastars）, which are multilayered compact objects, have been proposed to avoid a number of theoretical problems associated with event horizons and singularities. In this work, we construct a spherically symmetric thin-shell charged gravastar model where the vacuum phase transition between the de Sitter interior and the external reissner-Nordstrom spacetime （rN） are matched at a junction surface, by using the cut-and-paste procedure. Gravastar solutions are found among the Guilfoyle exact solutions where the gravitational potential We and the electric potential field Ф obey a particular relation in a simple form a（b-εФ）^2＋b1, where a, b and bl are arbitrary constants. The simplest ansatz of Guilfoyle＇s solution is implemented by the following assumption： that the total energy density 8πρm＋Q^2/r^4 is constant, where Q（r） is the electric charge up to a certain radius r. We show that, for certain ranges of the parameters, we can avoid the horizon formation, which allows us to study the linearized spherically symmetric radial perturbations around static equilibrium solutions. To lend our solution theoretical support, we also analyze the physical and geometrical properties of gravastar configurations.

关键词： gravastar Guilfoyle exact solutions stability analysis

Security Strategy of Digital Medical Contents Based on Blockchain in Generative AI Model

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Computers, Materials & Continua 2025年第1期82卷 259-278页

作者： Hoon Ko Marek r.Ogiela Division of Computer Science and Engineering Sunmoon UniversityAsan31460Republic of Korea AGH University of Krakow Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study presents an innovative approach to enhancing the security of visual medical data in the generative AI environment through the integration of blockchain *** combining the strengths of blockchain and generative AI,the research team aimed to address the timely challenge of safeguarding visual medical *** participating researchers conducted a comprehensive analysis,examining the vulnerabilities of medical AI services,personal information protection issues,and overall security *** multi faceted exploration led to an indepth evaluation of the model’s performance and ***,the correlation between accuracy,detection rate,and error rate was *** analysis revealed insights into the model’s strengths and limitations,while the consideration of standard deviation shed light on the model’s stability and performance *** study proposed practical improvements,emphasizing the reduction of false negatives to enhance detection rate and leveraging blockchain technology to ensure visual data integrity in medical *** blockchain to generative AI-created medical content addresses key personal information protection *** utilizing the distributed ledger system of blockchain,the research team aimed to protect the privacy and integrity of medical data especially medical *** approach not only enhances security but also enables transparent and tamperproof ***,the use of generative AI models ensures the creation of novel medical content without compromising personal information,further safeguarding patient *** conclusion,this study showcases the potential of blockchain-based solutions in the medical field,particularly in securing sensitive medical data and protecting patient *** proposed approach,combining blockchain and generative AI,offers a promising direction toward more robust and secure medical content *** research and advancements

关键词： Digitalmedical content medical diagnostic visualization security analysis generativeAI blockchain vulnerability pattern recognition