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In vitro antimicrobial and synergistic effect of essential oil from the red macroalgae Centroceras clavulatum (C. Agardh) Montagne with conventional antibiotics

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Asian Pacific Journal of Tropical Biomedicine 2021年第9期11卷 414-420页

作者： Ahmed Nafis Fatima El Khalloufi Asmae Aknaf brahim oudra Najat Marraiki Sarah Al-Rashed Abdallah MElgorban Asad Syed Lahcen Hassani Luísa Custódio Microbiology Health and Environment TeamFaculty of Sciences Chouaïb Doukkali UniversityEl JadidaMorocco Laboratory of Chemistry Modeling and Environmental SciencesPolydisciplinary Faculty of KhouribgaSultan Moulay Slimane University of Beni MellalB.P.:14525000KhouribgaMorocco Polydisciplinary Faculty of Nador University Mohammed FirstBP 30062700NadorMorocco Laboratory of Water Biodiversity and Climate Change.Faculty of Sciences Semlalia MarrakechCadi Ayyad UniversityP.O.Box 239040000MarrakechMorocco Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia Laboratory of Microbial Biotechnologies Agrosciencesand Environment(BioMAgE)Faculty of Sciences Semlalia MarrakechCadi Ayyad UniversityP.O.Box 239040000MarrakechMorocco Center of Marine Sciences Faculty of Sciences and TechnologyUniversity of AlgarveEd.7Campus of Gambelas8005-139 FaroPortugal

Objective:To study the chemical profile,antimicrobial properties,and synergistic effect with known antibiotics of essential oil extracted from the marine red macroalgae Centroceras clavulatum(***)Montagne,collected in ***:The chemical composition of the oil was analyzed by gas chromatography-mass *** oil was evaluated for antibacterial(Pseudomonas aeruginosa,Escherichia coli,Bacillus subtilis,Micrococcus luteus,Staphylococcus aureus,and Klebsiella pneumoniae),and antifungal activity(Candida albicans,Candida glabrata,Candida krusei,and Candida parapsilosis),by the disc diffusion *** minimum inhibitory and minimum microbicidal concentrations of the oil were determined,as well as the synergistic effects of its application combined with the antibiotics ciprofloxacin and fluconazole,by the checkerboard ***:Thirty molecules were identified in the essential oil,comprising 96.27%of the total oil *** such as carvacrol(36.06%)were the most abundant compounds,followed by caryophyllene(14.67%),endo-borneol(9.04%),pyroterebic acid(3.23%)and caryophyllene oxide(3.13%).The oil exhibited a moderate antimicrobial activity with inhibition zone diameters ranging from 9.0 to 15.0 *** minimum inhibitory concentration values varied between 0.9 and 14.7 mg/mL,and Bacillus subtilis and Escherichia coli were the more sensitive bacteria with 0.9 and 1.9 mg/mL,*** minimum microbicidal concentration values ranged from 0.4 to 14.7 mg/mL.A significant synergic action was observed when the oil was applied in combination with ciprofloxacin and fluconazole,with fractional inhibitory concentration index values ranging from 0.31 to *** was found in 80%of the combinations and a 2 to 16-fold reduction of antibiotics MIC was ***:Our findings suggest that the essential oil of Centroceras clavulatum should be further appraised for its potential use in the management of multi-drug resistant microo

关键词： Macroalgae Centroceras clavulatum(C.Agardh) Antimicrobial potential Microbial drug resistance Marine natural products Synergism with antibiotics

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